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Protein

Protein FAM173B

Gene

FAM173B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM173B
Gene namesi
Name:FAM173B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000150756.13.
HGNCiHGNC:27029. FAM173B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi134145.
OpenTargetsiENSG00000150756.
PharmGKBiPA162387281.

Polymorphism and mutation databases

BioMutaiFAM173B.
DMDMi190360174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215361 – 233Protein FAM173BAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6P4H8.
PaxDbiQ6P4H8.
PeptideAtlasiQ6P4H8.
PRIDEiQ6P4H8.

PTM databases

iPTMnetiQ6P4H8.
PhosphoSitePlusiQ6P4H8.

Expressioni

Gene expression databases

BgeeiENSG00000150756.
CleanExiHS_FAM173B.
ExpressionAtlasiQ6P4H8. baseline and differential.
GenevisibleiQ6P4H8. HS.

Organism-specific databases

HPAiHPA074513.

Interactioni

Protein-protein interaction databases

IntActiQ6P4H8. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6P4H8.
SMRiQ6P4H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM173 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4058. Eukaryota.
ENOG4111IHU. LUCA.
GeneTreeiENSGT00390000014771.
HOGENOMiHOG000234394.
HOVERGENiHBG056031.
InParanoidiQ6P4H8.
OMAiGVNTVWF.
OrthoDBiEOG091G0S3L.
PhylomeDBiQ6P4H8.
TreeFamiTF314984.

Family and domain databases

InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P4H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGGGIPLE TLKEESQSRH VLPASFEVNS LQKSNWGFLL TGLVGGTLVA
60 70 80 90 100
VYAVATPFVT PALRKVCLPF VPATTKQIEN VVKMLRCRRG SLVDIGSGDG
110 120 130 140 150
RIVIAAAKKG FTAVGYELNP WLVWYSRYRA WREGVHGSAK FYISDLWKVT
160 170 180 190 200
FSQYSNVVIF GVPQMMLQLE KKLERELEDD ARVIACRFPF PHWTPDHVTG
210 220 230
EGIDTVWAYD ASTFRGREKR PCTSMHFQLP IQA
Length:233
Mass (Da):26,110
Last modified:February 26, 2008 - v2
Checksum:i7F4D1F9E3AC87854
GO
Isoform 2 (identifier: Q6P4H8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-165: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):24,212
Checksum:iDF7D7AFA887C693A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03934575T → M2 PublicationsCorresponds to variant dbSNP:rs2438652Ensembl.1
Natural variantiVAR_039346105A → V. Corresponds to variant dbSNP:rs16884350Ensembl.1
Natural variantiVAR_039347114V → A. Corresponds to variant dbSNP:rs17360625Ensembl.1
Natural variantiVAR_039348229L → M. Corresponds to variant dbSNP:rs15757Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044724149 – 165Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300042 mRNA. Translation: BAG61853.1.
AK302012 mRNA. Translation: BAG63414.1.
AC012640 Genomic DNA. No translation available.
AC034229 Genomic DNA. No translation available.
CH471102 Genomic DNA. Translation: EAX08074.1.
BC063406 mRNA. Translation: AAH63406.1.
CCDSiCCDS43301.1. [Q6P4H8-1]
CCDS58942.1. [Q6P4H8-2]
RefSeqiNP_001245317.1. NM_001258388.1. [Q6P4H8-2]
NP_954584.2. NM_199133.3. [Q6P4H8-1]
UniGeneiHs.481569.

Genome annotation databases

EnsembliENST00000510047; ENSP00000420876; ENSG00000150756. [Q6P4H8-2]
ENST00000511437; ENSP00000422338; ENSG00000150756. [Q6P4H8-1]
GeneIDi134145.
KEGGihsa:134145.
UCSCiuc003jeo.4. human. [Q6P4H8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF173B_HUMAN
AccessioniPrimary (citable) accession number: Q6P4H8
Secondary accession number(s): B4DT41, B4DXK2, E9PBZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 27, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families