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Q6P4G7 (Q6P4G7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region84 – 863Sulfate 2 binding PDB 4IIQ PDB 4LCC

Sites

Binding site131Sulfate 1
Binding site641Sulfate 2 PDB 4IIQ PDB 4LCC
Binding site641Sulfate 3
Binding site861Sulfate 3

Sequences

Sequence LengthMass (Da)Tools
Q6P4G7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 582C36C443115052

FASTA26028,863
        10         20         30         40         50         60 
MGGTTGQNID QPTEMTATEG AIVQINCTYQ TSGFNGLFWY QQHAGEAPTF LSYNVLDGLE 

        70         80         90        100        110        120 
EKGRFSSFLS RSKGYSYLLL KELQMKDSAS YLCAVRDASR RGGGNKLTFG TGTQLKVELN 

       130        140        150        160        170        180 
IQNPDPAVYQ LRDSKSSDKS VCLFTDFDSQ TNVSQSKDSD VYITDKTVLD MRSMDFKSNS 

       190        200        210        220        230        240 
AVAWSNKSDF ACANAFNNSI IPEDTFFPSP ESSCDVKLVE KSFETDTNLN FQNLSVIGFR 

       250        260 
ILLLKVAGFN LLMTLRLWSS 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas EMBL AAH63432.1.
[2]"A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule."
Tynan F.E., Reid H.H., Kjer-Nielsen L., Miles J.J., Wilce M.C., Kostenko L., Borg N.A., Williamson N.A., Beddoe T., Purcell A.W., Burrows S.R., McCluskey J., Rossjohn J.
Nat. Immunol. 8:268-276(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 7-209.
[3]"Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells."
Reantragoon R., Corbett A.J., Sakala I.G., Gherardin N.A., Furness J.B., Chen Z., Eckle S.B., Uldrich A.P., Birkinshaw R.W., Patel O., Kostenko L., Meehan B., Kedzierska K., Liu L., Fairlie D.P., Hansen T.H., Godfrey D.I., Rossjohn J., McCluskey J., Kjer-Nielsen L.
J. Exp. Med. 210:2305-2320(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 6-213.
[4]"MAIT recognition of a stimulatory bacterial antigen bound to MR1."
Lopez-Sagaseta J., Dulberger C.L., McFedries A., Cushman M., Saghatelian A., Adams E.J.
J. Immunol. 191:5268-5277(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 6-213 IN COMPLEX WITH SULFATE.
[5]"Recognition of vitamin B metabolites by mucosal-associated invariant T cells."
Patel O., Kjer-Nielsen L., Le Nours J., Eckle S.B., Birkinshaw R., Beddoe T., Corbett A.J., Liu L., Miles J.J., Meehan B., Reantragoon R., Sandoval-Romero M.L., Sullivan L.C., Brooks A.G., Chen Z., Fairlie D.P., McCluskey J., Rossjohn J.
Nat. Commun. 4:2142-2142(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 6-213.
[6]"The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins."
Lopez-Sagaseta J., Dulberger C.L., Crooks J.E., Parks C.D., Luoma A.M., McFedries A., Van Rhijn I., Saghatelian A., Adams E.J.
Proc. Natl. Acad. Sci. U.S.A. 110:E1771-E1778(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 6-213 IN COMPLEX WITH SULFATE.
[7]"T-cell activation by transitory neo-antigens derived from distinct microbial pathways."
Corbett A.J., Eckle S.B., Birkinshaw R.W., Liu L., Patel O., Mahony J., Chen Z., Reantragoon R., Meehan B., Cao H., Williamson N.A., Strugnell R.A., Van Sinderen D., Mak J.Y., Fairlie D.P., Kjer-Nielsen L., Rossjohn J., McCluskey J.
Nature 509:361-365(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 6-213.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC063432 mRNA. Translation: AAH63432.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2NW2X-ray1.40A7-209[»]
4IIQX-ray2.86A6-213[»]
4L4VX-ray1.90D/G6-213[»]
4L8SX-ray2.90A6-213[»]
4L9LX-ray3.40A6-213[»]
4LCCX-ray3.26A6-213[»]
4LCWX-ray2.40D/G6-213[»]
4NQCX-ray2.50D/G6-213[»]
4NQDX-ray2.20D/G6-213[»]
4NQEX-ray2.10D/G6-213[»]
ProteinModelPortalQ6P4G7.
SMRQ6P4G7. Positions 7-209.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG017898.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR015370. DUF1968.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF09291. DUF1968. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRA@. human.
EvolutionaryTraceQ6P4G7.

Entry information

Entry nameQ6P4G7_HUMAN
AccessionPrimary (citable) accession number: Q6P4G7
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.