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Q6P4G7

- Q6P4G7_HUMAN

UniProt

Q6P4G7 - Q6P4G7_HUMAN

Protein
Submitted name:

TRA@ protein

Gene

TRA@

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131Sulfate 1
    Binding sitei64 – 641Sulfate 2Imported
    Binding sitei64 – 641Sulfate 3
    Binding sitei86 – 861Sulfate 3

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TRA@ proteinImported
    Gene namesi
    Name:TRA@Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NW2X-ray1.40A7-209[»]
    4IIQX-ray2.86A6-213[»]
    4L4VX-ray1.90D/G6-213[»]
    4L8SX-ray2.90A6-213[»]
    4L9LX-ray3.40A6-213[»]
    4LCCX-ray3.26A6-213[»]
    4LCWX-ray2.40D/G6-213[»]
    4NQCX-ray2.50D/G6-213[»]
    4NQDX-ray2.20D/G6-213[»]
    4NQEX-ray2.10D/G6-213[»]
    ProteinModelPortaliQ6P4G7.
    SMRiQ6P4G7. Positions 7-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6P4G7.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 863Sulfate 2 bindingImported

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG017898.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR015370. DUF1968.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF09291. DUF1968. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P4G7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGTTGQNID QPTEMTATEG AIVQINCTYQ TSGFNGLFWY QQHAGEAPTF    50
    LSYNVLDGLE EKGRFSSFLS RSKGYSYLLL KELQMKDSAS YLCAVRDASR 100
    RGGGNKLTFG TGTQLKVELN IQNPDPAVYQ LRDSKSSDKS VCLFTDFDSQ 150
    TNVSQSKDSD VYITDKTVLD MRSMDFKSNS AVAWSNKSDF ACANAFNNSI 200
    IPEDTFFPSP ESSCDVKLVE KSFETDTNLN FQNLSVIGFR ILLLKVAGFN 250
    LLMTLRLWSS 260
    Length:260
    Mass (Da):28,863
    Last modified:July 5, 2004 - v1
    Checksum:i582C36C443115052
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063432 mRNA. Translation: AAH63432.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063432 mRNA. Translation: AAH63432.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NW2 X-ray 1.40 A 7-209 [» ]
    4IIQ X-ray 2.86 A 6-213 [» ]
    4L4V X-ray 1.90 D/G 6-213 [» ]
    4L8S X-ray 2.90 A 6-213 [» ]
    4L9L X-ray 3.40 A 6-213 [» ]
    4LCC X-ray 3.26 A 6-213 [» ]
    4LCW X-ray 2.40 D/G 6-213 [» ]
    4NQC X-ray 2.50 D/G 6-213 [» ]
    4NQD X-ray 2.20 D/G 6-213 [» ]
    4NQE X-ray 2.10 D/G 6-213 [» ]
    ProteinModelPortali Q6P4G7.
    SMRi Q6P4G7. Positions 7-209.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG017898.

    Miscellaneous databases

    ChiTaRSi TRA@. human.
    EvolutionaryTracei Q6P4G7.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR015370. DUF1968.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF09291. DUF1968. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PancreasImported.
    2. "A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule."
      Tynan F.E., Reid H.H., Kjer-Nielsen L., Miles J.J., Wilce M.C., Kostenko L., Borg N.A., Williamson N.A., Beddoe T., Purcell A.W., Burrows S.R., McCluskey J., Rossjohn J.
      Nat. Immunol. 8:268-276(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 7-209.
    3. "Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells."
      Reantragoon R., Corbett A.J., Sakala I.G., Gherardin N.A., Furness J.B., Chen Z., Eckle S.B., Uldrich A.P., Birkinshaw R.W., Patel O., Kostenko L., Meehan B., Kedzierska K., Liu L., Fairlie D.P., Hansen T.H., Godfrey D.I., Rossjohn J., McCluskey J., Kjer-Nielsen L.
      J. Exp. Med. 210:2305-2320(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 6-213.
    4. "MAIT recognition of a stimulatory bacterial antigen bound to MR1."
      Lopez-Sagaseta J., Dulberger C.L., McFedries A., Cushman M., Saghatelian A., Adams E.J.
      J. Immunol. 191:5268-5277(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 6-213.
    5. "Recognition of vitamin B metabolites by mucosal-associated invariant T cells."
      Patel O., Kjer-Nielsen L., Le Nours J., Eckle S.B., Birkinshaw R., Beddoe T., Corbett A.J., Liu L., Miles J.J., Meehan B., Reantragoon R., Sandoval-Romero M.L., Sullivan L.C., Brooks A.G., Chen Z., Fairlie D.P., McCluskey J., Rossjohn J.
      Nat. Commun. 4:2142-2142(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 6-213.
    6. "The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins."
      Lopez-Sagaseta J., Dulberger C.L., Crooks J.E., Parks C.D., Luoma A.M., McFedries A., Van Rhijn I., Saghatelian A., Adams E.J.
      Proc. Natl. Acad. Sci. U.S.A. 110:E1771-E1778(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 6-213.
    7. "T-cell activation by transitory neo-antigens derived from distinct microbial pathways."
      Corbett A.J., Eckle S.B., Birkinshaw R.W., Liu L., Patel O., Mahony J., Chen Z., Reantragoon R., Meehan B., Cao H., Williamson N.A., Strugnell R.A., Van Sinderen D., Mak J.Y., Fairlie D.P., Kjer-Nielsen L., Rossjohn J., McCluskey J.
      Nature 509:361-365(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 6-213.

    Entry informationi

    Entry nameiQ6P4G7_HUMAN
    AccessioniPrimary (citable) accession number: Q6P4G7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3