Rho GTPase-activating protein 11A - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q6P4F7 (RHGBA_HUMAN)

Last modified November 24, 2009. Version 47. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Rho GTPase-activating protein 11A
Alternative name(s):
Rho-type GTPase-activating protein 11A

Gene names

Name:	ARHGAP11A
Synonyms:	KIAA0013

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1023 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Sequence similarities

Contains 1 Rho-GAP domain.

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Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1023

1023

Rho GTPase-activating protein 11A

PRO_0000267213

Regions

Domain

49 – 239

191

Rho-GAP

Amino acid modifications

Modified residue

285

Phosphoserine Ref.5 Ref.6

Modified residue

306

Phosphothreonine Ref.4

Modified residue

316

Phosphoserine Ref.6

Modified residue

318

Phosphoserine Ref.6

Modified residue

323

Phosphothreonine Ref.6

Modified residue

339

Phosphoserine Ref.6

Modified residue

340

Phosphoserine Ref.6

Modified residue

415

Phosphoserine Ref.6

Modified residue

422

Phosphoserine Ref.6

Modified residue

484

Phosphoserine Ref.6 Ref.4

Modified residue

508

Phosphothreonine Ref.6 Ref.4

Modified residue

559

Phosphoserine

Modified residue

569

Phosphoserine

Modified residue

582

Phosphoserine Ref.6

Modified residue

585

Phosphoserine Ref.6

Modified residue

675

Phosphoserine Ref.5 Ref.6 Ref.4 Ref.3

Modified residue

847

Phosphoserine

Modified residue

868

Phosphoserine Ref.4

Natural variations

Natural variant

605

E → K in a breast cancer sample; somatic mutation. Ref.9

VAR_035546

Experimental info

Sequence conflict

496 – 501

SEKISK → TFTYYC in AAH63444. Ref.2

Secondary structure

1023

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q6P4F7-1 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: 053C89371B5F614F
Show »

FASTA

1,023

113,866

        10         20         30         40         50         60 
MWDQRLVRLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP FNALPHSAVP 

        70         80         90        100        110        120 
EYGHIPSFLV DACTSLEDHI HTEGLFRKSG SVIRLKALKN KVDHGEGCLS SAPPCDIAGL 

       130        140        150        160        170        180 
LKQFFRELPE PILPADLHEA LLKAQQLGTE EKNKATLLLS CLLADHTVHV LRYFFNFLRN 

       190        200        210        220        230        240 
VSLRSSENKM DSSNLAVIFA PNLLQTSEGH EKMSSNTEKK LRLQAAVVQT LIDYASDIGR 

       250        260        270        280        290        300 
VPDFILEKIP AMLGIDGLCA TPSLEGFEEG EYETPGEYKR KRRQSVGDFV SGALNKFKPN 

       310        320        330        340        350        360 
RTPSITPQEE RIAQLSESPV ILTPNAKRTL PVDSSHGFSS KKRKSIKHNF NFELLPSNLF 

       370        380        390        400        410        420 
NSSSTPVSVH IDTSSEGSSQ SSLSPVLIGG NHLITAGVPR RSKRIAGKKV CRVESGKAGC 

       430        440        450        460        470        480 
FSPKISHKEK VRRSLRLKFN LGKNGREVNG CSGVNRYESV GWRLANQQSL KNRIESVKTG 

       490        500        510        520        530        540 
LLFSPDVDEK LPKKGSEKIS KSEETLLTPE RLVGTNYRMS WTGPNNSSFQ EVDANEASSM 

       550        560        570        580        590        600 
VENLEVENSL EPDIMVEKSP ATSCELTPSN LNNKHNSNIT SSPLSGDENN MTKETLVKVQ 

       610        620        630        640        650        660 
KAFSESGSNL HALMNQRQSS VTNVGKVKLT EPSYLEDSPE ENLFETNDLT IVESKEKYEH 

       670        680        690        700        710        720 
HTGKGEKCFS ERDFSPLQTQ TFNRETTIKC YSTQMKMEHE KDIHSNMPKD YLSKQEFSSD 

       730        740        750        760        770        780 
EEIKKQQSPK DKLNNKLKEN ENMMEGNLPK CAAHSKDEAR SSFSQQSTCV VTNLSKPRPM 

       790        800        810        820        830        840 
RIAKQQSLET CEKTVSESSQ MTEHRKVSDH IQWFNKLSLN EPNRIKVKSP LKFQRTPVRQ 

       850        860        870        880        890        900 
SVRRINSLLE YSRQPTGHKL ASLGDTASPL VKSVSCDGAL SSCIESASKD SSVSCIKSGP 

       910        920        930        940        950        960 
KEQKSMSCEE SNIGAISKSS MELPSKSFLK MRKHPDSVNA SLRSTTVYKQ KILSDGQVKV 

       970        980        990       1000       1010       1020 
PLDDLTNHDI VKPVVNNNMG ISSGINNRVL RRPSERGRAW YKGSPKHPIG KTQLLPTSKP 


VDL

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References

[1]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Uterus.
[3]	"Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675, MASS SPECTROMETRY. Tissue: Epithelium.
[4]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-306; SER-484; THR-508; SER-675 AND SER-868, MASS SPECTROMETRY.
[5]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285 AND SER-675, MASS SPECTROMETRY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285; SER-316; SER-318; THR-323; SER-339; SER-340; SER-415; SER-422; SER-484; THR-508; SER-582; SER-585 AND SER-675, MASS SPECTROMETRY.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318; THR-323; SER-559 AND SER-569, MASS SPECTROMETRY.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285; SER-318; THR-323; SER-675 AND SER-847, MASS SPECTROMETRY. Tissue: T-cell.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-605.

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Cross-references

Sequence databases

D87717 mRNA. Translation: BAA13442.2. Different initiation.
BC039563 mRNA. Translation: AAH39563.1.
BC063444 mRNA. Translation: AAH63444.1.

IPI

IPI00477330.

PIR

A59431.

RefSeq

NP_055598.1.
NP_955389.1.

UniGene

Hs.591130

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3EAP	X-ray	2.30	A/B/C/D	1-253	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q6P4F7.

PTM databases

PhosphoSite

Q6P4F7.

Proteomic databases

PRIDE

Q6P4F7.

Genome annotation databases

Ensembl

ENST00000361627; ENSP00000355090; ENSG00000198826; Homo sapiens. [Genome view]

GeneID

9824.

KEGG

hsa:9824.

UCSC

uc001zgy.1. human.

Organism-specific databases

CTD

9824.

GeneCards

GC15P030694.

HGNC

HGNC:15783. ARHGAP11A.

MIM

610589. gene.

PharmGKB

PA134982615.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q6P4F7.

OMA

GSTRVCK

OrthoDB

EOG980MGF

Enzyme and pathway databases

Reactome

REACT_11044. Signaling by Rho GTPases.

Gene expression databases

ArrayExpress

Q6P4F7.

Bgee

Q6P4F7.

CleanEx

HS_ARHGAP11A.

Genevestigator

Q6P4F7.

GermOnline

ENSG00000198826. Homo sapiens.

Family and domain databases

InterPro

IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP.
[Graphical view]

Pfam

PF00620. RhoGAP. 1 hit.
[Graphical view]

SMART

SM00324. RhoGAP. 1 hit.
[Graphical view]

PROSITE

PS50238. RHOGAP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

37002.

SOURCE

Search...

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Entry information

Entry name

RHGBA_HUMAN

Accession

Primary (citable) accession number: Q6P4F7
Secondary accession number(s): Q6PI96, Q9Y3S6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	November 24, 2009
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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