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Protein

Rho GTPase-activating protein 11A

Gene

ARHGAP11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 11A
Alternative name(s):
Rho-type GTPase-activating protein 11A
Gene namesi
Name:ARHGAP11A
Synonyms:KIAA0013
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:15783. ARHGAP11A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982615.

Polymorphism and mutation databases

BioMutaiARHGAP11A.
DMDMi119361641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10231023Rho GTPase-activating protein 11APRO_0000267213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851PhosphoserineCombined sources
Modified residuei306 – 3061PhosphothreonineCombined sources
Modified residuei316 – 3161PhosphoserineCombined sources
Modified residuei318 – 3181PhosphoserineCombined sources
Modified residuei323 – 3231PhosphothreonineCombined sources
Modified residuei339 – 3391PhosphoserineCombined sources
Modified residuei340 – 3401PhosphoserineCombined sources
Modified residuei484 – 4841PhosphoserineCombined sources
Modified residuei508 – 5081PhosphothreonineCombined sources
Modified residuei582 – 5821PhosphoserineCombined sources
Modified residuei585 – 5851PhosphoserineCombined sources
Modified residuei638 – 6381PhosphoserineCombined sources
Modified residuei675 – 6751PhosphoserineCombined sources
Modified residuei847 – 8471PhosphoserineCombined sources
Modified residuei866 – 8661PhosphothreonineCombined sources
Modified residuei868 – 8681PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P4F7.
MaxQBiQ6P4F7.
PaxDbiQ6P4F7.
PeptideAtlasiQ6P4F7.
PRIDEiQ6P4F7.

PTM databases

iPTMnetiQ6P4F7.
PhosphoSiteiQ6P4F7.

Expressioni

Gene expression databases

BgeeiENSG00000198826.
CleanExiHS_ARHGAP11A.
ExpressionAtlasiQ6P4F7. baseline and differential.
GenevisibleiQ6P4F7. HS.

Organism-specific databases

HPAiHPA040419.
HPA040830.

Interactioni

Protein-protein interaction databases

BioGridi115162. 28 interactions.
IntActiQ6P4F7. 24 interactions.
MINTiMINT-3974818.
STRINGi9606.ENSP00000355090.

Structurei

Secondary structure

1
1023
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1916Combined sources
Helixi51 – 533Combined sources
Beta strandi56 – 594Combined sources
Turni60 – 623Combined sources
Beta strandi63 – 664Combined sources
Helixi67 – 7610Combined sources
Helixi77 – 793Combined sources
Helixi92 – 10413Combined sources
Helixi114 – 12714Combined sources
Beta strandi128 – 1303Combined sources
Helixi135 – 1373Combined sources
Helixi138 – 1447Combined sources
Helixi149 – 16012Combined sources
Helixi165 – 18319Combined sources
Helixi185 – 1884Combined sources
Helixi192 – 20413Combined sources
Helixi215 – 23319Combined sources
Helixi235 – 2373Combined sources
Helixi243 – 2464Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EAPX-ray2.30A/B/C/D1-253[»]
ProteinModelPortaliQ6P4F7.
SMRiQ6P4F7. Positions 3-248.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6P4F7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 239191Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2710. Eukaryota.
ENOG410YVI5. LUCA.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000231616.
HOVERGENiHBG062938.
InParanoidiQ6P4F7.
OMAiSYRMSWT.
OrthoDBiEOG091G0F5G.
PhylomeDBiQ6P4F7.
TreeFamiTF332212.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P4F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWDQRLVRLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP
60 70 80 90 100
FNALPHSAVP EYGHIPSFLV DACTSLEDHI HTEGLFRKSG SVIRLKALKN
110 120 130 140 150
KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE
160 170 180 190 200
EKNKATLLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA
210 220 230 240 250
PNLLQTSEGH EKMSSNTEKK LRLQAAVVQT LIDYASDIGR VPDFILEKIP
260 270 280 290 300
AMLGIDGLCA TPSLEGFEEG EYETPGEYKR KRRQSVGDFV SGALNKFKPN
310 320 330 340 350
RTPSITPQEE RIAQLSESPV ILTPNAKRTL PVDSSHGFSS KKRKSIKHNF
360 370 380 390 400
NFELLPSNLF NSSSTPVSVH IDTSSEGSSQ SSLSPVLIGG NHLITAGVPR
410 420 430 440 450
RSKRIAGKKV CRVESGKAGC FSPKISHKEK VRRSLRLKFN LGKNGREVNG
460 470 480 490 500
CSGVNRYESV GWRLANQQSL KNRIESVKTG LLFSPDVDEK LPKKGSEKIS
510 520 530 540 550
KSEETLLTPE RLVGTNYRMS WTGPNNSSFQ EVDANEASSM VENLEVENSL
560 570 580 590 600
EPDIMVEKSP ATSCELTPSN LNNKHNSNIT SSPLSGDENN MTKETLVKVQ
610 620 630 640 650
KAFSESGSNL HALMNQRQSS VTNVGKVKLT EPSYLEDSPE ENLFETNDLT
660 670 680 690 700
IVESKEKYEH HTGKGEKCFS ERDFSPLQTQ TFNRETTIKC YSTQMKMEHE
710 720 730 740 750
KDIHSNMPKD YLSKQEFSSD EEIKKQQSPK DKLNNKLKEN ENMMEGNLPK
760 770 780 790 800
CAAHSKDEAR SSFSQQSTCV VTNLSKPRPM RIAKQQSLET CEKTVSESSQ
810 820 830 840 850
MTEHRKVSDH IQWFNKLSLN EPNRIKVKSP LKFQRTPVRQ SVRRINSLLE
860 870 880 890 900
YSRQPTGHKL ASLGDTASPL VKSVSCDGAL SSCIESASKD SSVSCIKSGP
910 920 930 940 950
KEQKSMSCEE SNIGAISKSS MELPSKSFLK MRKHPDSVNA SLRSTTVYKQ
960 970 980 990 1000
KILSDGQVKV PLDDLTNHDI VKPVVNNNMG ISSGINNRVL RRPSERGRAW
1010 1020
YKGSPKHPIG KTQLLPTSKP VDL
Length:1,023
Mass (Da):113,866
Last modified:December 12, 2006 - v2
Checksum:i053C89371B5F614F
GO
Isoform 2 (identifier: Q6P4F7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     496-501: SEKISK → TFTYYC
     502-1023: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):55,525
Checksum:i44930C9BA98F2E41
GO
Isoform 3 (identifier: Q6P4F7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: Missing.

Note: No experimental confirmation available.
Show »
Length:834
Mass (Da):92,697
Checksum:i4F00E8BB4175EE72
GO

Sequence cautioni

The sequence BAA13442 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti605 – 6051E → K in a breast cancer sample; somatic mutation. 1 Publication
VAR_035546

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 189189Missing in isoform 3. 1 PublicationVSP_055370Add
BLAST
Alternative sequencei496 – 5016SEKISK → TFTYYC in isoform 2. 1 PublicationVSP_054102
Alternative sequencei502 – 1023522Missing in isoform 2. 1 PublicationVSP_054103Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87717 mRNA. Translation: BAA13442.2. Different initiation.
AK303025 mRNA. Translation: BAG64151.1.
AK316437 mRNA. Translation: BAH14808.1.
AC123768 Genomic DNA. No translation available.
BC039563 mRNA. Translation: AAH39563.1.
BC063444 mRNA. Translation: AAH63444.1.
CCDSiCCDS10028.1. [Q6P4F7-1]
CCDS58349.1. [Q6P4F7-2]
CCDS66730.1. [Q6P4F7-3]
PIRiA59431.
RefSeqiNP_001273408.1. NM_001286479.1. [Q6P4F7-3]
NP_001273409.1. NM_001286480.1. [Q6P4F7-3]
NP_055598.1. NM_014783.4. [Q6P4F7-1]
NP_955389.1. NM_199357.1. [Q6P4F7-2]
UniGeneiHs.591130.

Genome annotation databases

EnsembliENST00000361627; ENSP00000355090; ENSG00000198826. [Q6P4F7-1]
ENST00000543522; ENSP00000440073; ENSG00000198826. [Q6P4F7-3]
ENST00000565905; ENSP00000455754; ENSG00000198826. [Q6P4F7-3]
ENST00000567348; ENSP00000454575; ENSG00000198826. [Q6P4F7-2]
ENST00000611363; ENSP00000480085; ENSG00000275568. [Q6P4F7-3]
ENST00000619401; ENSP00000479117; ENSG00000275568. [Q6P4F7-1]
ENST00000622253; ENSP00000481011; ENSG00000275568. [Q6P4F7-3]
ENST00000633634; ENSP00000488640; ENSG00000282168. [Q6P4F7-1]
GeneIDi9824.
KEGGihsa:9824.
UCSCiuc001zgw.4. human. [Q6P4F7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87717 mRNA. Translation: BAA13442.2. Different initiation.
AK303025 mRNA. Translation: BAG64151.1.
AK316437 mRNA. Translation: BAH14808.1.
AC123768 Genomic DNA. No translation available.
BC039563 mRNA. Translation: AAH39563.1.
BC063444 mRNA. Translation: AAH63444.1.
CCDSiCCDS10028.1. [Q6P4F7-1]
CCDS58349.1. [Q6P4F7-2]
CCDS66730.1. [Q6P4F7-3]
PIRiA59431.
RefSeqiNP_001273408.1. NM_001286479.1. [Q6P4F7-3]
NP_001273409.1. NM_001286480.1. [Q6P4F7-3]
NP_055598.1. NM_014783.4. [Q6P4F7-1]
NP_955389.1. NM_199357.1. [Q6P4F7-2]
UniGeneiHs.591130.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EAPX-ray2.30A/B/C/D1-253[»]
ProteinModelPortaliQ6P4F7.
SMRiQ6P4F7. Positions 3-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115162. 28 interactions.
IntActiQ6P4F7. 24 interactions.
MINTiMINT-3974818.
STRINGi9606.ENSP00000355090.

PTM databases

iPTMnetiQ6P4F7.
PhosphoSiteiQ6P4F7.

Polymorphism and mutation databases

BioMutaiARHGAP11A.
DMDMi119361641.

Proteomic databases

EPDiQ6P4F7.
MaxQBiQ6P4F7.
PaxDbiQ6P4F7.
PeptideAtlasiQ6P4F7.
PRIDEiQ6P4F7.

Protocols and materials databases

DNASUi9824.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361627; ENSP00000355090; ENSG00000198826. [Q6P4F7-1]
ENST00000543522; ENSP00000440073; ENSG00000198826. [Q6P4F7-3]
ENST00000565905; ENSP00000455754; ENSG00000198826. [Q6P4F7-3]
ENST00000567348; ENSP00000454575; ENSG00000198826. [Q6P4F7-2]
ENST00000611363; ENSP00000480085; ENSG00000275568. [Q6P4F7-3]
ENST00000619401; ENSP00000479117; ENSG00000275568. [Q6P4F7-1]
ENST00000622253; ENSP00000481011; ENSG00000275568. [Q6P4F7-3]
ENST00000633634; ENSP00000488640; ENSG00000282168. [Q6P4F7-1]
GeneIDi9824.
KEGGihsa:9824.
UCSCiuc001zgw.4. human. [Q6P4F7-1]

Organism-specific databases

CTDi9824.
GeneCardsiARHGAP11A.
HGNCiHGNC:15783. ARHGAP11A.
HPAiHPA040419.
HPA040830.
MIMi610589. gene.
neXtProtiNX_Q6P4F7.
PharmGKBiPA134982615.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2710. Eukaryota.
ENOG410YVI5. LUCA.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000231616.
HOVERGENiHBG062938.
InParanoidiQ6P4F7.
OMAiSYRMSWT.
OrthoDBiEOG091G0F5G.
PhylomeDBiQ6P4F7.
TreeFamiTF332212.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiARHGAP11A. human.
EvolutionaryTraceiQ6P4F7.
GenomeRNAii9824.
PROiQ6P4F7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198826.
CleanExiHS_ARHGAP11A.
ExpressionAtlasiQ6P4F7. baseline and differential.
GenevisibleiQ6P4F7. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHGBA_HUMAN
AccessioniPrimary (citable) accession number: Q6P4F7
Secondary accession number(s): B4DZN9, Q6PI96, Q9Y3S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.