Reviewed, UniProtKB/Swiss-Prot Q6P4F2 (ADXL_HUMAN)

Names and origin

Protein names

Recommended name:
    Adrenodoxin-like protein, mitochondrial
Alternative name(s):
    Ferredoxin-1-like protein

Gene names

Name:

FDX1L

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Cofactor	Binds 1 2Fe-2S cluster By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the adrenodoxin/putidaredoxin family. Contains 1 2Fe-2S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 52	52	Mitochondrion Potential
	Chain	53 – 183	131	Adrenodoxin-like protein, mitochondrial		PRO_0000325952
Regions
	Domain	68 – 170	103	2Fe-2S ferredoxin-type
Sites
	Metal binding	105	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	111	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	114	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	151	1	Iron-sulfur (2Fe-2S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6P4F2-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 2B5F37C0061C65EF	FASTA	183	19,521
	10 20 30 40 50 60 MAASMARGGV SARVLLQAAR GTWWNRPGGT SGSGEGVALG TTRKFQATGS RPAGEEDAGG 70 80 90 100 110 120 PERPGDVVNV VFVDRSGQRI PVSGRVGDNV LHLAQRHGVD LEGACEASLA CSTCHVYVSE 130 140 150 160 170 180 DHLDLLPPPE EREDDMLDMA PLLQENSRLG CQIVLTPELE GAEFTLPKIT RNFYVDGHVP KPH

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC063460 mRNA. Translation: AAH63460.1.
IPI	IPI00894257.
RefSeq	NP_001026904.1.
UniGene	Hs.654865
3D structure databases
HSSP	HSSP built from PDB template 1XLQ based on UniProtKB P00259.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6P4F2.
Proteomic databases
PRIDE	Q6P4F2.
Genome annotation databases
Ensembl	ENST00000393708; ENSP00000377311; ENSG00000167807; Homo sapiens. [Genome view]
GeneID	112812.
KEGG	hsa:112812.
UCSC	uc002mny.1. human.
Organism-specific databases
CTD	112812.
GeneCards	GC19M010278.
HGNC	HGNC:30546. FDX1L.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q6P4F2.
HOVERGEN	Q6P4F2.
OMA	DMAPALK
Gene expression databases
ArrayExpress	Q6P4F2.
Bgee	Q6P4F2.
CleanEx	HS_FDX1L.
Genevestigator	Q6P4F2.
Family and domain databases
InterPro	IPR001055. Adrenodoxin. IPR018298. Adrenodoxin_Fe-S_BS. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
Pfam	PF00111. Fer2. 1 hit. [Graphical view]
PRINTS	PR00355. ADRENODOXIN.
PROSITE	PS51085. 2FE2S_FER_2. 1 hit. PS00814. ADX. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	78669.

Entry information

Entry name

ADXL_HUMAN

Accession

Primary (citable) accession number: Q6P4F2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 5, 2004
Last modified:	November 24, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.