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Q6P4F1 (FUT10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 18, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-(1,3)-fucosyltransferase 10
EC=2.4.1.-
Alternative name(s):
Fucosyltransferase X
Short name=Fuc-TX
Short name=FucT-X
Galactoside 3-L-fucosyltransferase 10
Short name=Fucosyltransferase 10
Gene names
Name:FUT10
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable fucosyltransferase By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein Ref.6.

Sequence similarities

Belongs to the glycosyltransferase 10 family.

Sequence caution

The sequence CAD24023.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6P4F1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6P4F1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     27-27: Q → ALDTVENLMKVTGPPQGVTDSMQCFNDQRPLSNTRSSEHIKE
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6P4F1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-126: LKKEGLTFNR...HMTKAFLFYG → MGIGQLPHYA...ESPPLAENDG
     405-419: GLPPKRWEAEDTHLS → VSKSKVGIEPAGWPS
     420-479: Missing.
Isoform 4 (identifier: Q6P4F1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     405-419: GLPPKRWEAEDTHLS → VSKSKVGIEPAGWPS
     420-479: Missing.
Isoform 5 (identifier: Q6P4F1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     405-419: GLPPKRWEAEDTHLS → VSKSKVGIEPAGWPS
     420-479: Missing.
Isoform 6 (identifier: Q6P4F1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
Isoform 7 (identifier: Q6P4F1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     127-143: TDFNIDSLPLPRKAHHD → KQDFRLSPLFAVVFLQS
     144-479: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Alpha-(1,3)-fucosyltransferase 10
PRO_0000299002

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 3123Helical; Signal-anchor for type II membrane protein; Potential
Topological domain32 – 479448Lumenal Potential

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 6262Missing in isoform 3.
VSP_027498
Alternative sequence1 – 5151Missing in isoform 7.
VSP_027499
Alternative sequence1 – 2828Missing in isoform 4 and isoform 6.
VSP_027500
Alternative sequence271Q → ALDTVENLMKVTGPPQGVTD SMQCFNDQRPLSNTRSSEHI KE in isoform 2.
VSP_027501
Alternative sequence63 – 12664LKKEG…FLFYG → MGIGQLPHYALVVPADGGDW EVRPMWSRCLFLHHQPDLPP SSHDQSIPLLWSQEESPPLA ENDG in isoform 3.
VSP_027502
Alternative sequence127 – 14317TDFNI…KAHHD → KQDFRLSPLFAVVFLQS in isoform 7.
VSP_027503
Alternative sequence144 – 479336Missing in isoform 7.
VSP_027504
Alternative sequence405 – 41915GLPPK…DTHLS → VSKSKVGIEPAGWPS in isoform 3, isoform 4 and isoform 5.
VSP_027505
Alternative sequence420 – 47960Missing in isoform 3, isoform 4 and isoform 5.
VSP_027506
Natural variant591L → F. Ref.1
Corresponds to variant rs16880994 [ dbSNP | Ensembl ].
VAR_034759
Natural variant2681Y → H.
Corresponds to variant rs16880853 [ dbSNP | Ensembl ].
VAR_034760
Natural variant3681L → V. Ref.1 Ref.5
Corresponds to variant rs17855838 [ dbSNP | Ensembl ].
VAR_034761
Natural variant3711R → P. Ref.5
Corresponds to variant rs17855839 [ dbSNP | Ensembl ].
VAR_034762

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: 205594E0CE587208

FASTA47956,094
        10         20         30         40         50         60 
MVRIQRRKLL ASCLCVTATV FLLVTLQVMV ELGKFERKEF KSSSLQDGHT KMEEAPTHLN 

        70         80         90        100        110        120 
SFLKKEGLTF NRKRKWELDS YPIMLWWSPL TGETGRLGQC GADACFFTIN RTYLHHHMTK 

       130        140        150        160        170        180 
AFLFYGTDFN IDSLPLPRKA HHDWAVFHEE SPKNNYKLFH KPVITLFNYT ATFSRHSHLP 

       190        200        210        220        230        240 
LTTQYLESIE VLKSLRYLVP LQSKNKLRKR LAPLVYVQSD CDPPSDRDSY VRELMTYIEV 

       250        260        270        280        290        300 
DSYGECLRNK DLPQQLKNPA SMDADGFYRI IAQYKFILAF ENAVCDDYIT EKFWRPLKLG 

       310        320        330        340        350        360 
VVPVYYGSPS ITDWLPSNKS AILVSEFSHP RELASYIRRL DSDDRLYEAY VEWKLKGEIS 

       370        380        390        400        410        420 
NQRLLTALRE RKWGVQDVNQ DNYIDAFECM VCTKVWANIR LQEKGLPPKR WEAEDTHLSC 

       430        440        450        460        470 
PEPTVFAFSP LRTPPLSSLR EMWISSFEQS KKEAQALRWL VDRNQNFSSQ EFWGLVFKD

« Hide

Isoform 2 [UniParc].

Checksum: 28C18FA4A26AAA19
Show »

FASTA52060,623
Isoform 3 [UniParc].

Checksum: DD4F2FDF085594D8
Show »

FASTA35741,347
Isoform 4 [UniParc].

Checksum: 332C1B4FCDCA45C5
Show »

FASTA39145,696
Isoform 5 [UniParc].

Checksum: 6E17FF8315B553E5
Show »

FASTA41948,854
Isoform 6 [UniParc].

Checksum: D22DD5C22C2922A0
Show »

FASTA45152,936
Isoform 7 [UniParc].

Checksum: 10976CD2E611F582
Show »

FASTA9210,819

References

« Hide 'large scale' references
[1]"Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism."
Roos C., Kolmer M., Mattila P., Renkonen R.
J. Biol. Chem. 277:3168-3175(2002) [PubMed: 11698403] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), VARIANTS PHE-59 AND VAL-368.
Tissue: Brain.
[2]"Cloning, expression and genomic organization of two new human alpha3-fucosyltransferases (FUT10 and FUT11)."
Martinez-Duncker I., Candelier J.-J., Oriol R., Mollicone R.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Trachea.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 7), VARIANTS VAL-368 AND PRO-371.
Tissue: Brain and Ovary.
[6]"Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse."
Baboval T., Smith F.I.
Mamm. Genome 13:538-541(2002) [PubMed: 12370785] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ431184 mRNA. Translation: CAD24023.1. Different initiation.
AJ512465 mRNA. Translation: CAD54669.1.
AJ535838 mRNA. Translation: CAD59771.1.
AJ535839 mRNA. Translation: CAD59772.1.
AJ582015 mRNA. Translation: CAE46499.1.
AK292993 mRNA. Translation: BAF85682.1.
CH471080 Genomic DNA. Translation: EAW63404.1.
BC004884 mRNA. Translation: AAH04884.2.
BC063462 mRNA. Translation: AAH63462.1.
IPIIPI00152615.
IPI00217027.
IPI00440692.
IPI00746897.
IPI00855757.
IPI00855877.
IPI00855896.
RefSeqNP_116053.3. NM_032664.3.
UniGeneHs.458713.

3D structure databases

ProteinModelPortalQ6P4F1.
SMRQ6P4F1. Positions 210-394.
ModBaseSearch...

Protein family/group databases

CAZyGT10. Glycosyltransferase Family 10.

PTM databases

PhosphoSiteQ6P4F1.

Polymorphism databases

DMDM156630455.

Proteomic databases

PRIDEQ6P4F1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327671; ENSP00000332757; ENSG00000172728.
GeneID84750.
KEGGhsa:84750.
UCSCuc003xjc.3. human.
uc003xjd.3. human.
uc003xjf.3. human.
uc003xjg.3. human.
uc003xjh.3. human.
uc003xji.1. human.

Organism-specific databases

CTD84750.
GeneCardsGC08M033286.
H-InvDBHIX0007444.
HGNCHGNC:19234. FUT10.
neXtProtNX_Q6P4F1.
PharmGKBPA134872572.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327601.
GeneTreeENSGT00550000074250.
HOVERGENHBG055521.
KOK09669.
PhylomeDBQ6P4F1.

Gene expression databases

ArrayExpressQ6P4F1.
BgeeQ6P4F1.
CleanExHS_FUT10.
GenevestigatorQ6P4F1.

Family and domain databases

InterProIPR017176. Alpha-1_3-FUT_met.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERPTHR11929. Glyco_trans_10. 1 hit.
PfamPF00852. Glyco_transf_10. 1 hit.
[Graphical view]
PIRSFPIRSF037332. Alpha1_3FUT_met. 1 hit.
ProtoNetSearch...

Other

NextBio74892.

Entry information

Entry nameFUT10_HUMAN
AccessionPrimary (citable) accession number: Q6P4F1
Secondary accession number(s): A8KAC8 expand/collapse secondary AC list , Q70GG3, Q8IVI6, Q8IVI7, Q8IVJ3, Q8TE43, Q9BSR3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: April 18, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

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