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Protein

Protein CASC4

Gene

CASC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CASC4
Alternative name(s):
Cancer susceptibility candidate gene 4 protein
Gene namesi
Name:CASC4
ORF Names:UNQ2573/PRO6308
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:24892. CASC4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence analysisAdd
BLAST
Transmembranei15 – 3521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini36 – 433398LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672200.

Polymorphism and mutation databases

BioMutaiCASC4.
DMDMi74737334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Protein CASC4PRO_0000291843Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei233 – 2331PhosphoserineCombined sources
Modified residuei275 – 2751PhosphoserineCombined sources
Modified residuei328 – 3281PhosphoserineCombined sources
Modified residuei332 – 3321PhosphoserineCombined sources
Modified residuei366 – 3661PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6P4E1.
MaxQBiQ6P4E1.
PaxDbiQ6P4E1.
PeptideAtlasiQ6P4E1.
PRIDEiQ6P4E1.

PTM databases

iPTMnetiQ6P4E1.
PhosphoSiteiQ6P4E1.

Expressioni

Gene expression databases

BgeeiQ6P4E1.
CleanExiHS_CASC4.
ExpressionAtlasiQ6P4E1. baseline and differential.
GenevisibleiQ6P4E1. HS.

Organism-specific databases

HPAiHPA043015.
HPA049488.

Interactioni

Protein-protein interaction databases

BioGridi125233. 6 interactions.
STRINGi9606.ENSP00000299957.

Structurei

3D structure databases

ProteinModelPortaliQ6P4E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili35 – 198164Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the GOLM1/CASC4 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHYU. Eukaryota.
ENOG4111SUN. LUCA.
GeneTreeiENSGT00530000063675.
HOGENOMiHOG000111308.
HOVERGENiHBG057061.
InParanoidiQ6P4E1.
OMAiMPGIEDS.
PhylomeDBiQ6P4E1.
TreeFamiTF331127.

Family and domain databases

InterProiIPR026141. CASC4.
IPR026139. GOLM1/CASC4.
[Graphical view]
PANTHERiPTHR15896. PTHR15896. 1 hit.
PTHR15896:SF7. PTHR15896:SF7. 1 hit.
PRINTSiPR02084. GOLM1CASC4.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P4E1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGFGANRRA GRLPSLVLVV LLVVIVVLAF NYWSISSRHV LLQEEVAELQ
60 70 80 90 100
GQVQRTEVAR GRLEKRNSDL LLLVDTHKKQ IDQKEADYGR LSSRLQAREG
110 120 130 140 150
LGKRCEDDKV KLQNNISYQM ADIHHLKEQL AELRQEFLRQ EDQLQDYRKN
160 170 180 190 200
NTYLVKRLEY ESFQCGQQMK ELRAQHEENI KKLADQFLEE QKQETQKIQS
210 220 230 240 250
NDGKELDINN QVVPKNIPKV AENVADKNEE PSSNHIPHGK EQIKRGGDAG
260 270 280 290 300
MPGIEENDLA KVDDLPPALR KPPISVSQHE SHQAISHLPT GQPLSPNMPP
310 320 330 340 350
DSHINHNGNP GTSKQNPSSP LQRLIPGSNL DSEPRIQTDI LKQATKDRVS
360 370 380 390 400
DFHKLKQSRF FDENESPVDP QHGSKLADYN GDDGNVGEYE ADKQAELAYN
410 420 430
EEEDGDGGEE DVQGERGPGL HAITMKPTSK FFG
Length:433
Mass (Da):48,864
Last modified:July 5, 2004 - v1
Checksum:i3895383DC2D3F106
GO
Isoform 2 (identifier: Q6P4E1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-381: SRFFDENESPVDPQHGSKLADYNG → NDEERELQMDPADYGKQHFNDVL
     382-433: Missing.

Show »
Length:380
Mass (Da):43,333
Checksum:iB99B88414F734501
GO
Isoform 3 (identifier: Q6P4E1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-177: FQCGQQMKELRAQHE → KRPKRFNQMMERNWI
     178-433: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,934
Checksum:iDF8452919A90949A
GO
Isoform 4 (identifier: Q6P4E1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-433: GERGPGLHAITMKPTSKFFG → DDEERELQMDPADYGKQHFNDVL

Note: No experimental confirmation available.Curated
Show »
Length:436
Mass (Da):49,498
Checksum:iE11DABFDD27CF70A
GO
Isoform 5 (identifier: Q6P4E1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MVGFGANRRAGRLPSLVLVVLL → M
     414-433: GERGPGLHAITMKPTSKFFG → DDEERELQMDPADYGKQHFNDVL

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):47,308
Checksum:i0E65E3642D8E6316
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 4 (identifier: Q6P4E1-4)
Sequence conflicti429 – 4291K → E in AL832333 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222MVGFG…LVVLL → M in isoform 5. 1 PublicationVSP_055228Add
BLAST
Alternative sequencei163 – 17715FQCGQ…RAQHE → KRPKRFNQMMERNWI in isoform 3. 1 PublicationVSP_026259Add
BLAST
Alternative sequencei178 – 433256Missing in isoform 3. 1 PublicationVSP_026260Add
BLAST
Alternative sequencei358 – 38124SRFFD…ADYNG → NDEERELQMDPADYGKQHFN DVL in isoform 2. 1 PublicationVSP_026261Add
BLAST
Alternative sequencei382 – 43352Missing in isoform 2. 1 PublicationVSP_026262Add
BLAST
Alternative sequencei414 – 43320GERGP…SKFFG → DDEERELQMDPADYGKQHFN DVL in isoform 4 and isoform 5. 2 PublicationsVSP_045243Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358086 mRNA. Translation: AAQ88453.1.
AK298564 mRNA. Translation: BAG60758.1.
AL832333 mRNA. No translation available.
AC025043 Genomic DNA. No translation available.
AC090519 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77258.1.
BC012124 mRNA. Translation: AAH12124.1.
BC063480 mRNA. Translation: AAH63480.1.
CCDSiCCDS10108.1. [Q6P4E1-4]
CCDS10109.1. [Q6P4E1-2]
RefSeqiNP_612432.2. NM_138423.3. [Q6P4E1-4]
NP_816929.1. NM_177974.2. [Q6P4E1-2]
UniGeneiHs.512867.

Genome annotation databases

EnsembliENST00000299957; ENSP00000299957; ENSG00000166734. [Q6P4E1-4]
ENST00000345795; ENSP00000335063; ENSG00000166734. [Q6P4E1-2]
ENST00000557945; ENSP00000453720; ENSG00000166734. [Q6P4E1-3]
GeneIDi113201.
KEGGihsa:113201.
UCSCiuc001ztp.4. human. [Q6P4E1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358086 mRNA. Translation: AAQ88453.1.
AK298564 mRNA. Translation: BAG60758.1.
AL832333 mRNA. No translation available.
AC025043 Genomic DNA. No translation available.
AC090519 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77258.1.
BC012124 mRNA. Translation: AAH12124.1.
BC063480 mRNA. Translation: AAH63480.1.
CCDSiCCDS10108.1. [Q6P4E1-4]
CCDS10109.1. [Q6P4E1-2]
RefSeqiNP_612432.2. NM_138423.3. [Q6P4E1-4]
NP_816929.1. NM_177974.2. [Q6P4E1-2]
UniGeneiHs.512867.

3D structure databases

ProteinModelPortaliQ6P4E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125233. 6 interactions.
STRINGi9606.ENSP00000299957.

PTM databases

iPTMnetiQ6P4E1.
PhosphoSiteiQ6P4E1.

Polymorphism and mutation databases

BioMutaiCASC4.
DMDMi74737334.

Proteomic databases

EPDiQ6P4E1.
MaxQBiQ6P4E1.
PaxDbiQ6P4E1.
PeptideAtlasiQ6P4E1.
PRIDEiQ6P4E1.

Protocols and materials databases

DNASUi113201.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299957; ENSP00000299957; ENSG00000166734. [Q6P4E1-4]
ENST00000345795; ENSP00000335063; ENSG00000166734. [Q6P4E1-2]
ENST00000557945; ENSP00000453720; ENSG00000166734. [Q6P4E1-3]
GeneIDi113201.
KEGGihsa:113201.
UCSCiuc001ztp.4. human. [Q6P4E1-1]

Organism-specific databases

CTDi113201.
GeneCardsiCASC4.
HGNCiHGNC:24892. CASC4.
HPAiHPA043015.
HPA049488.
neXtProtiNX_Q6P4E1.
PharmGKBiPA142672200.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHYU. Eukaryota.
ENOG4111SUN. LUCA.
GeneTreeiENSGT00530000063675.
HOGENOMiHOG000111308.
HOVERGENiHBG057061.
InParanoidiQ6P4E1.
OMAiMPGIEDS.
PhylomeDBiQ6P4E1.
TreeFamiTF331127.

Miscellaneous databases

ChiTaRSiCASC4. human.
GenomeRNAii113201.
PROiQ6P4E1.

Gene expression databases

BgeeiQ6P4E1.
CleanExiHS_CASC4.
ExpressionAtlasiQ6P4E1. baseline and differential.
GenevisibleiQ6P4E1. HS.

Family and domain databases

InterProiIPR026141. CASC4.
IPR026139. GOLM1/CASC4.
[Graphical view]
PANTHERiPTHR15896. PTHR15896. 1 hit.
PTHR15896:SF7. PTHR15896:SF7. 1 hit.
PRINTSiPR02084. GOLM1CASC4.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Blood and Kidney.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332 AND SER-366, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233; SER-275; SER-328; SER-332 AND SER-366, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCASC4_HUMAN
AccessioniPrimary (citable) accession number: Q6P4E1
Secondary accession number(s): B4DPZ6
, G5E934, Q6UY45, Q96EM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.