Q6P4A7 (SFXN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sideroflexin-4

Alternative name(s):
Breast cancer resistance marker 1

Gene names

Name:	SFXN4
Synonyms:	BCRM1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential iron transporter By similarity.
Subcellular location	Mitochondrion membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the sideroflexin family.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Membrane Mitochondrion
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Iron
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cation transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P4A7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P4A7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     85-93: Missing.
     313-337: IQYCSLEEKIQSPTEETEIFYHRGV → VT

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6P4A7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Sideroflexin-4		PRO_0000177041
Regions
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	133 – 153	21	Helical; Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential
	Transmembrane	293 – 313	21	Helical; Potential
Amino acid modifications
	Modified residue	197	1	N6-acetyllysine Ref.5
Natural variations
	Alternative sequence	1 – 116	116	Missing in isoform 3.		VSP_014608
	Alternative sequence	85 – 93	9	Missing in isoform 2.		VSP_014609
	Alternative sequence	313 – 337	25	IQYCS…YHRGV → VT in isoform 2.		VSP_014610

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 77A08F150D241277	FASTA	337	37,998
	10 20 30 40 50 60 MSLEQEEETQ PGRLLGRRDA VPAFIEPNVR FWITERQSFI RRFLQWTELL DPTNVFISVE 70 80 90 100 110 120 SIENSRQLLC TNEDVSSPAS ADQRIQEAWK RSLATVHPDS SNLIPKLFRP AAFLPFMAPT 130 140 150 160 170 180 VFLSMTPLKG IKSVILPQVF LCAYMAAFNS INGNRSYTCK PLERSLLMAG AVASSTFLGV 190 200 210 220 230 240 IPQFVQMKYG LTGPWIKRLL PVIFLVQASG MNVYMSRSLE SIKGIAVMDK EGNVLGHSRI 250 260 270 280 290 300 AGTKAVRETL ASRIVLFGTS ALIPEVFTYF FKRTQYFRKN PGSLWILKLS CTVLAMGLMV 310 320 330 PFSFSIFPQI GQIQYCSLEE KIQSPTEETE IFYHRGV
	Isoform 2 [UniParc]. Checksum: A0E3CFE491DDB508	FASTA	305	34,104
	10 20 30 40 50 60 MSLEQEEETQ PGRLLGRRDA VPAFIEPNVR FWITERQSFI RRFLQWTELL DPTNVFISVE 70 80 90 100 110 120 SIENSRQLLC TNEDVSSPAS ADQRATVHPD SSNLIPKLFR PAAFLPFMAP TVFLSMTPLK 130 140 150 160 170 180 GIKSVILPQV FLCAYMAAFN SINGNRSYTC KPLERSLLMA GAVASSTFLG VIPQFVQMKY 190 200 210 220 230 240 GLTGPWIKRL LPVIFLVQAS GMNVYMSRSL ESIKGIAVMD KEGNVLGHSR IAGTKAVRET 250 260 270 280 290 300 LASRIVLFGT SALIPEVFTY FFKRTQYFRK NPGSLWILKL SCTVLAMGLM VPFSFSIFPQ IGQVT
	Isoform 3 [UniParc]. Checksum: A6E9596C3E438E0F	FASTA	221	24,587
	10 20 30 40 50 60 MAPTVFLSMT PLKGIKSVIL PQVFLCAYMA AFNSINGNRS YTCKPLERSL LMAGAVASST 70 80 90 100 110 120 FLGVIPQFVQ MKYGLTGPWI KRLLPVIFLV QASGMNVYMS RSLESIKGIA VMDKEGNVLG 130 140 150 160 170 180 HSRIAGTKAV RETLASRIVL FGTSALIPEV FTYFFKRTQY FRKNPGSLWI LKLSCTVLAM 190 200 210 220 GLMVPFSFSI FPQIGQIQYC SLEEKIQSPT EETEIFYHRG V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BCRM-1, a novel tumor marker for refractory cancers." Auclair D., Gong Y., Dai M., Kraeft S.-K., Chen L.B. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Mammary tumor.
[2]	"Molecular cloning and characterization of a novel human putative transmembrane protein homologous to mouse sideroflexin associated with sideroblastic anemia." Zheng H., Ji C., Zou X., Wu M., Jin Z., Yin G., Li J., Feng C., Cheng H., Gu S., Xie Y., Mao Y. DNA Seq. 14:369-373(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-197, MASS SPECTROMETRY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF336980 mRNA. Translation: AAP23066.1. AY269785 mRNA. Translation: AAP97074.1. AL355598, AL355861 Genomic DNA. Translation: CAI14126.1. AL355861, AL355598 Genomic DNA. Translation: CAI15801.1. BC063562 mRNA. Translation: AAH63562.1.
IPI	IPI00412741. IPI00607781. IPI00743741.
RefSeq	NP_998814.1. NM_213649.1.
UniGene	Hs.655168.
3D structure databases
ProteinModelPortal	Q6P4A7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6P4A7. 2 interactions.
STRING	9606.ENSP00000347924.
PTM databases
PhosphoSite	Q6P4A7.
Polymorphism databases
DMDM	71153761.
Proteomic databases
PaxDb	Q6P4A7.
PRIDE	Q6P4A7.
Protocols and materials databases
DNASU	119559.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355697; ENSP00000347924; ENSG00000183605.
GeneID	119559.
KEGG	hsa:119559.
UCSC	uc001ldy.3. human.
Organism-specific databases
CTD	119559.
GeneCards	GC10M120890.
HGNC	HGNC:16088. SFXN4.
HPA	HPA018028. HPA020872.
neXtProt	NX_Q6P4A7.
PharmGKB	PA38093.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG315418.
HOGENOM	HOG000010305.
HOVERGEN	HBG104924.
InParanoid	Q6P4A7.
OMA	NVRFWIT.
OrthoDB	EOG40S0G3.
PhylomeDB	Q6P4A7.
Gene expression databases
ArrayExpress	Q6P4A7.
Bgee	Q6P4A7.
CleanEx	HS_SFXN4.
Genevestigator	Q6P4A7.
GermOnline	ENSG00000183605. Homo sapiens.
Family and domain databases
InterPro	IPR004686. Mtc. [Graphical view]
PANTHER	PTHR11153. PTHR11153. 1 hit.
Pfam	PF03820. Mtc. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SFXN4. human.
GenomeRNAi	119559.
NextBio	80437.

Entry information

Entry name

SFXN4_HUMAN

Accession

Primary (citable) accession number: Q6P4A7
Secondary accession number(s): Q6WSU4, Q86TD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.