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Q6P499

- NPAL3_HUMAN

UniProt

Q6P499 - NPAL3_HUMAN

Protein

NIPA-like protein 3

Gene

NIPAL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. magnesium ion transmembrane transporter activity Source: InterPro

    Protein family/group databases

    TCDBi2.A.7.25.3. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NIPA-like protein 3
    Gene namesi
    Name:NIPAL3
    Synonyms:NPAL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25233. NIPAL3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164723927.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406NIPA-like protein 3PRO_0000242150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Modified residuei372 – 3721Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ6P499.
    PRIDEiQ6P499.

    PTM databases

    PhosphoSiteiQ6P499.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P499.
    BgeeiQ6P499.
    CleanExiHS_NPAL3.
    GenevestigatoriQ6P499.

    Organism-specific databases

    HPAiHPA039978.

    Interactioni

    Protein-protein interaction databases

    BioGridi121434. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P499.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei300 – 32021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 214Poly-Ser

    Sequence similaritiesi

    Belongs to the NIPA family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238068.
    HOGENOMiHOG000230865.
    HOVERGENiHBG069791.
    InParanoidiQ6P499.
    OMAiYMLVEII.
    OrthoDBiEOG7T4MKG.
    PhylomeDBiQ6P499.
    TreeFamiTF313214.

    Family and domain databases

    InterProiIPR008521. Mg_trans_NIPA.
    [Graphical view]
    PANTHERiPTHR12570. PTHR12570. 1 hit.
    PfamiPF05653. Mg_trans_NIPA. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P499-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDGSHSAALK LQQLPPTSSS SAVSEASFSY KENLIGALLA IFGHLVVSIA    50
    LNLQKYCHIR LAGSKDPRAY FKTKTWWLGL FLMLLGELGV FASYAFAPLS 100
    LIVPLSAVSV IASAIIGIIF IKEKWKPKDF LRRYVLSFVG CGLAVVGTYL 150
    LVTFAPNSHE KMTGENVTRH LVSWPFLLYM LVEIILFCLL LYFYKEKNAN 200
    NIVVILLLVA LLGSMTVVTV KAVAGMLVLS IQGNLQLDYP IFYVMFVCMV 250
    ATAVYQAAFL SQASQMYDSS LIASVGYILS TTIAITAGAI FYLDFIGEDV 300
    LHICMFALGC LIAFLGVFLI TRNRKKPIPF EPYISMDAMP GMQNMHDKGM 350
    TVQPELKASF SYGALENNDN ISEIYAPATL PVMQEEHGSR SASGVPYRVL 400
    EHTKKE 406
    Length:406
    Mass (Da):44,742
    Last modified:July 5, 2004 - v1
    Checksum:i42E87B84B01E7C88
    GO
    Isoform 2 (identifier: Q6P499-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:324
    Mass (Da):35,764
    Checksum:iD6F51AF9CA50C347
    GO
    Isoform 3 (identifier: Q6P499-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         213-226: GSMTVVTVKAVAGM → VLLCHPGWSAVVQS
         227-406: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:226
    Mass (Da):24,994
    Checksum:iDE2A2780573E9AE0
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282Missing in isoform 2. 1 PublicationVSP_019445Add
    BLAST
    Alternative sequencei213 – 22614GSMTV…AVAGM → VLLCHPGWSAVVQS in isoform 3. 1 PublicationVSP_019446Add
    BLAST
    Alternative sequencei227 – 406180Missing in isoform 3. 1 PublicationVSP_019447Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312433 mRNA. Translation: BAG35342.1.
    BX640883 mRNA. Translation: CAE45938.1.
    AL031431 Genomic DNA. Translation: CAB48885.1.
    AL031431 Genomic DNA. Translation: CAI21413.1.
    AL031431 Genomic DNA. Translation: CAI21412.1.
    CH471134 Genomic DNA. Translation: EAW95130.1.
    BC001265 mRNA. Translation: AAH01265.1.
    BC063583 mRNA. Translation: AAH63583.1.
    CCDSiCCDS30631.1. [Q6P499-1]
    RefSeqiNP_065181.1. NM_020448.4. [Q6P499-1]
    UniGeneiHs.523442.

    Genome annotation databases

    EnsembliENST00000003912; ENSP00000003912; ENSG00000001461. [Q6P499-2]
    ENST00000358028; ENSP00000350722; ENSG00000001461. [Q6P499-3]
    ENST00000374399; ENSP00000363520; ENSG00000001461. [Q6P499-1]
    GeneIDi57185.
    KEGGihsa:57185.
    UCSCiuc001bjh.3. human. [Q6P499-1]
    uc010oek.2. human. [Q6P499-3]

    Polymorphism databases

    DMDMi74737314.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312433 mRNA. Translation: BAG35342.1 .
    BX640883 mRNA. Translation: CAE45938.1 .
    AL031431 Genomic DNA. Translation: CAB48885.1 .
    AL031431 Genomic DNA. Translation: CAI21413.1 .
    AL031431 Genomic DNA. Translation: CAI21412.1 .
    CH471134 Genomic DNA. Translation: EAW95130.1 .
    BC001265 mRNA. Translation: AAH01265.1 .
    BC063583 mRNA. Translation: AAH63583.1 .
    CCDSi CCDS30631.1. [Q6P499-1 ]
    RefSeqi NP_065181.1. NM_020448.4. [Q6P499-1 ]
    UniGenei Hs.523442.

    3D structure databases

    ProteinModelPortali Q6P499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121434. 1 interaction.

    Protein family/group databases

    TCDBi 2.A.7.25.3. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q6P499.

    Polymorphism databases

    DMDMi 74737314.

    Proteomic databases

    MaxQBi Q6P499.
    PRIDEi Q6P499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000003912 ; ENSP00000003912 ; ENSG00000001461 . [Q6P499-2 ]
    ENST00000358028 ; ENSP00000350722 ; ENSG00000001461 . [Q6P499-3 ]
    ENST00000374399 ; ENSP00000363520 ; ENSG00000001461 . [Q6P499-1 ]
    GeneIDi 57185.
    KEGGi hsa:57185.
    UCSCi uc001bjh.3. human. [Q6P499-1 ]
    uc010oek.2. human. [Q6P499-3 ]

    Organism-specific databases

    CTDi 57185.
    GeneCardsi GC01P024742.
    H-InvDB HIX0000263.
    HGNCi HGNC:25233. NIPAL3.
    HPAi HPA039978.
    neXtProti NX_Q6P499.
    PharmGKBi PA164723927.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238068.
    HOGENOMi HOG000230865.
    HOVERGENi HBG069791.
    InParanoidi Q6P499.
    OMAi YMLVEII.
    OrthoDBi EOG7T4MKG.
    PhylomeDBi Q6P499.
    TreeFami TF313214.

    Miscellaneous databases

    ChiTaRSi NIPAL3. human.
    GenomeRNAii 57185.
    NextBioi 63240.
    PROi Q6P499.

    Gene expression databases

    ArrayExpressi Q6P499.
    Bgeei Q6P499.
    CleanExi HS_NPAL3.
    Genevestigatori Q6P499.

    Family and domain databases

    InterProi IPR008521. Mg_trans_NIPA.
    [Graphical view ]
    PANTHERi PTHR12570. PTHR12570. 1 hit.
    Pfami PF05653. Mg_trans_NIPA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Endometrium.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Lymph and Placenta.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiNPAL3_HUMAN
    AccessioniPrimary (citable) accession number: Q6P499
    Secondary accession number(s): A2A298, Q6MZT9, Q9BVE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3