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Protein

NIPA-like protein 3

Gene

NIPAL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Protein family/group databases

TCDBi2.A.7.25.3 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
NIPA-like protein 3
Gene namesi
Name:NIPAL3
Synonyms:NPAL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000001461.16
HGNCiHGNC:25233 NIPAL3
neXtProtiNX_Q6P499

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57185
OpenTargetsiENSG00000001461
PharmGKBiPA164723927

Polymorphism and mutation databases

BioMutaiNIPAL3
DMDMi74737314

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002421501 – 406NIPA-like protein 3Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei372PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6P499
PaxDbiQ6P499
PeptideAtlasiQ6P499
PRIDEiQ6P499

PTM databases

iPTMnetiQ6P499
PhosphoSitePlusiQ6P499

Expressioni

Gene expression databases

BgeeiENSG00000001461
CleanExiHS_NPAL3
ExpressionAtlasiQ6P499 baseline and differential
GenevisibleiQ6P499 HS

Organism-specific databases

HPAiHPA039978

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EDAQ928385EBI-10252783,EBI-529425

Protein-protein interaction databases

BioGridi121434, 4 interactors
IntActiQ6P499, 3 interactors
STRINGi9606.ENSP00000363520

Structurei

3D structure databases

ProteinModelPortaliQ6P499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 21Poly-Ser4

Sequence similaritiesi

Belongs to the NIPA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2922 Eukaryota
ENOG410XNR8 LUCA
GeneTreeiENSGT00550000074395
HOGENOMiHOG000230865
HOVERGENiHBG069791
InParanoidiQ6P499
OMAiYMLVEII
OrthoDBiEOG091G09Z6
PhylomeDBiQ6P499
TreeFamiTF313214

Family and domain databases

InterProiView protein in InterPro
IPR008521 Mg_trans_NIPA
PANTHERiPTHR12570 PTHR12570, 1 hit
PfamiView protein in Pfam
PF05653 Mg_trans_NIPA, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P499-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGSHSAALK LQQLPPTSSS SAVSEASFSY KENLIGALLA IFGHLVVSIA
60 70 80 90 100
LNLQKYCHIR LAGSKDPRAY FKTKTWWLGL FLMLLGELGV FASYAFAPLS
110 120 130 140 150
LIVPLSAVSV IASAIIGIIF IKEKWKPKDF LRRYVLSFVG CGLAVVGTYL
160 170 180 190 200
LVTFAPNSHE KMTGENVTRH LVSWPFLLYM LVEIILFCLL LYFYKEKNAN
210 220 230 240 250
NIVVILLLVA LLGSMTVVTV KAVAGMLVLS IQGNLQLDYP IFYVMFVCMV
260 270 280 290 300
ATAVYQAAFL SQASQMYDSS LIASVGYILS TTIAITAGAI FYLDFIGEDV
310 320 330 340 350
LHICMFALGC LIAFLGVFLI TRNRKKPIPF EPYISMDAMP GMQNMHDKGM
360 370 380 390 400
TVQPELKASF SYGALENNDN ISEIYAPATL PVMQEEHGSR SASGVPYRVL

EHTKKE
Length:406
Mass (Da):44,742
Last modified:July 5, 2004 - v1
Checksum:i42E87B84B01E7C88
GO
Isoform 2 (identifier: Q6P499-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):35,764
Checksum:iD6F51AF9CA50C347
GO
Isoform 3 (identifier: Q6P499-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-226: GSMTVVTVKAVAGM → VLLCHPGWSAVVQS
     227-406: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):24,994
Checksum:iDE2A2780573E9AE0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194451 – 82Missing in isoform 2. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_019446213 – 226GSMTV…AVAGM → VLLCHPGWSAVVQS in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_019447227 – 406Missing in isoform 3. 1 PublicationAdd BLAST180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312433 mRNA Translation: BAG35342.1
BX640883 mRNA Translation: CAE45938.1
AL031431 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95130.1
BC001265 mRNA Translation: AAH01265.1
BC063583 mRNA Translation: AAH63583.1
CCDSiCCDS30631.1 [Q6P499-1]
CCDS81280.1 [Q6P499-3]
CCDS81282.1 [Q6P499-2]
RefSeqiNP_001309783.1, NM_001322854.1 [Q6P499-1]
NP_001309784.1, NM_001322855.1 [Q6P499-1]
NP_001309785.1, NM_001322856.1 [Q6P499-1]
NP_001309786.1, NM_001322857.1 [Q6P499-1]
NP_001309791.1, NM_001322862.1 [Q6P499-2]
NP_001309792.1, NM_001322863.1 [Q6P499-2]
NP_001309794.1, NM_001322865.1 [Q6P499-3]
NP_065181.1, NM_020448.4 [Q6P499-1]
UniGeneiHs.523442

Genome annotation databases

EnsembliENST00000003912; ENSP00000003912; ENSG00000001461 [Q6P499-2]
ENST00000358028; ENSP00000350722; ENSG00000001461 [Q6P499-3]
ENST00000374399; ENSP00000363520; ENSG00000001461 [Q6P499-1]
GeneIDi57185
KEGGihsa:57185
UCSCiuc001bjh.4 human [Q6P499-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNPAL3_HUMAN
AccessioniPrimary (citable) accession number: Q6P499
Secondary accession number(s): A2A298, Q6MZT9, Q9BVE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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