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Protein

NIPA-like protein 3

Gene

NIPAL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_268444. Miscellaneous transport and binding events.

Protein family/group databases

TCDBi2.A.7.25.3. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
NIPA-like protein 3
Gene namesi
Name:NIPAL3
Synonyms:NPAL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25233. NIPAL3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723927.

Polymorphism and mutation databases

BioMutaiNIPAL3.
DMDMi74737314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406NIPA-like protein 3PRO_0000242150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Modified residuei372 – 3721Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6P499.
PRIDEiQ6P499.

PTM databases

PhosphoSiteiQ6P499.

Expressioni

Gene expression databases

BgeeiQ6P499.
CleanExiHS_NPAL3.
ExpressionAtlasiQ6P499. baseline and differential.
GenevestigatoriQ6P499.

Organism-specific databases

HPAiHPA039978.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EDAQ928383EBI-10252783,EBI-529425

Protein-protein interaction databases

BioGridi121434. 3 interactions.
IntActiQ6P499. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6P499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 214Poly-Ser

Sequence similaritiesi

Belongs to the NIPA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238068.
GeneTreeiENSGT00550000074395.
HOGENOMiHOG000230865.
HOVERGENiHBG069791.
InParanoidiQ6P499.
OMAiYMLVEII.
OrthoDBiEOG7T4MKG.
PhylomeDBiQ6P499.
TreeFamiTF313214.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P499-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGSHSAALK LQQLPPTSSS SAVSEASFSY KENLIGALLA IFGHLVVSIA
60 70 80 90 100
LNLQKYCHIR LAGSKDPRAY FKTKTWWLGL FLMLLGELGV FASYAFAPLS
110 120 130 140 150
LIVPLSAVSV IASAIIGIIF IKEKWKPKDF LRRYVLSFVG CGLAVVGTYL
160 170 180 190 200
LVTFAPNSHE KMTGENVTRH LVSWPFLLYM LVEIILFCLL LYFYKEKNAN
210 220 230 240 250
NIVVILLLVA LLGSMTVVTV KAVAGMLVLS IQGNLQLDYP IFYVMFVCMV
260 270 280 290 300
ATAVYQAAFL SQASQMYDSS LIASVGYILS TTIAITAGAI FYLDFIGEDV
310 320 330 340 350
LHICMFALGC LIAFLGVFLI TRNRKKPIPF EPYISMDAMP GMQNMHDKGM
360 370 380 390 400
TVQPELKASF SYGALENNDN ISEIYAPATL PVMQEEHGSR SASGVPYRVL

EHTKKE
Length:406
Mass (Da):44,742
Last modified:July 5, 2004 - v1
Checksum:i42E87B84B01E7C88
GO
Isoform 2 (identifier: Q6P499-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.

Show »
Length:324
Mass (Da):35,764
Checksum:iD6F51AF9CA50C347
GO
Isoform 3 (identifier: Q6P499-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-226: GSMTVVTVKAVAGM → VLLCHPGWSAVVQS
     227-406: Missing.

Note: No experimental confirmation available.

Show »
Length:226
Mass (Da):24,994
Checksum:iDE2A2780573E9AE0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform 2. 1 PublicationVSP_019445Add
BLAST
Alternative sequencei213 – 22614GSMTV…AVAGM → VLLCHPGWSAVVQS in isoform 3. 1 PublicationVSP_019446Add
BLAST
Alternative sequencei227 – 406180Missing in isoform 3. 1 PublicationVSP_019447Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312433 mRNA. Translation: BAG35342.1.
BX640883 mRNA. Translation: CAE45938.1.
AL031431 Genomic DNA. Translation: CAB48885.1.
AL031431 Genomic DNA. Translation: CAI21413.1.
AL031431 Genomic DNA. Translation: CAI21412.1.
CH471134 Genomic DNA. Translation: EAW95130.1.
BC001265 mRNA. Translation: AAH01265.1.
BC063583 mRNA. Translation: AAH63583.1.
CCDSiCCDS30631.1. [Q6P499-1]
RefSeqiNP_065181.1. NM_020448.4. [Q6P499-1]
UniGeneiHs.523442.

Genome annotation databases

EnsembliENST00000003912; ENSP00000003912; ENSG00000001461. [Q6P499-2]
ENST00000358028; ENSP00000350722; ENSG00000001461. [Q6P499-3]
ENST00000374399; ENSP00000363520; ENSG00000001461. [Q6P499-1]
GeneIDi57185.
KEGGihsa:57185.
UCSCiuc001bjh.3. human. [Q6P499-1]
uc010oek.2. human. [Q6P499-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312433 mRNA. Translation: BAG35342.1.
BX640883 mRNA. Translation: CAE45938.1.
AL031431 Genomic DNA. Translation: CAB48885.1.
AL031431 Genomic DNA. Translation: CAI21413.1.
AL031431 Genomic DNA. Translation: CAI21412.1.
CH471134 Genomic DNA. Translation: EAW95130.1.
BC001265 mRNA. Translation: AAH01265.1.
BC063583 mRNA. Translation: AAH63583.1.
CCDSiCCDS30631.1. [Q6P499-1]
RefSeqiNP_065181.1. NM_020448.4. [Q6P499-1]
UniGeneiHs.523442.

3D structure databases

ProteinModelPortaliQ6P499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121434. 3 interactions.
IntActiQ6P499. 1 interaction.

Protein family/group databases

TCDBi2.A.7.25.3. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteiQ6P499.

Polymorphism and mutation databases

BioMutaiNIPAL3.
DMDMi74737314.

Proteomic databases

MaxQBiQ6P499.
PRIDEiQ6P499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000003912; ENSP00000003912; ENSG00000001461. [Q6P499-2]
ENST00000358028; ENSP00000350722; ENSG00000001461. [Q6P499-3]
ENST00000374399; ENSP00000363520; ENSG00000001461. [Q6P499-1]
GeneIDi57185.
KEGGihsa:57185.
UCSCiuc001bjh.3. human. [Q6P499-1]
uc010oek.2. human. [Q6P499-3]

Organism-specific databases

CTDi57185.
GeneCardsiGC01P024742.
H-InvDBHIX0000263.
HGNCiHGNC:25233. NIPAL3.
HPAiHPA039978.
neXtProtiNX_Q6P499.
PharmGKBiPA164723927.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238068.
GeneTreeiENSGT00550000074395.
HOGENOMiHOG000230865.
HOVERGENiHBG069791.
InParanoidiQ6P499.
OMAiYMLVEII.
OrthoDBiEOG7T4MKG.
PhylomeDBiQ6P499.
TreeFamiTF313214.

Enzyme and pathway databases

ReactomeiREACT_268444. Miscellaneous transport and binding events.

Miscellaneous databases

ChiTaRSiNIPAL3. human.
GenomeRNAii57185.
NextBioi63240.
PROiQ6P499.

Gene expression databases

BgeeiQ6P499.
CleanExiHS_NPAL3.
ExpressionAtlasiQ6P499. baseline and differential.
GenevestigatoriQ6P499.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrium.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Lymph and Placenta.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiNPAL3_HUMAN
AccessioniPrimary (citable) accession number: Q6P499
Secondary accession number(s): A2A298, Q6MZT9, Q9BVE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.