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Protein

MAP kinase-interacting serine/threonine-protein kinase 2

Gene

mknk2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei112 – 1121ATPPROSITE-ProRule annotation
Active sitei204 – 2041Proton acceptorPROSITE-ProRule annotation
Metal bindingi298 – 2981ZincBy similarity
Metal bindingi310 – 3101ZincBy similarity
Metal bindingi313 – 3131ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 979ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase-interacting serine/threonine-protein kinase 2 (EC:2.7.11.1)
Alternative name(s):
MAP kinase signal-integrating kinase 2
Short name:
MAPK signal-integrating kinase 2
Short name:
Mnk2
Gene namesi
Name:mknk2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866072. mknk2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467MAP kinase-interacting serine/threonine-protein kinase 2PRO_0000226966Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6P431.
SMRiQ6P431. Positions 70-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 367285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG106949.
KOiK04372.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKKTTEMK GFHRSFKGQN PFDAAYEMEA RNMESVFNFD CPSRPDVPSS
60 70 80 90 100
APIDIPDAKK RTKKKKRCRA TDSFTGRFDD MYQLQQEILG EGAYAKVQSC
110 120 130 140 150
INLITNKEYA VKIIEKRPGH SRSRVFREVE MLYQCQGHSN VLELIEFFEE
160 170 180 190 200
EDKFYLVFEK MCGGSILNHI HRRRHFNERE ASFVVRDIAE ALNYLHNKGI
210 220 230 240 250
AHRDLKPENI LCESPHQVSP VKICDFDLGS GIKLNSDCSP ISTPELLTPC
260 270 280 290 300
GSAEYMAPEV VEAFNEEASI YDKRCDLWSL GVILYIMLSG YPPFVGHCGS
310 320 330 340 350
DCGWDRGEAC PACQNMLFVS IQEGKYEFPE KDWAHISYGA KDLISKLLLR
360 370 380 390 400
DAKKRLSAAQ VLQHPWVQGN APYNTLPTPI ILQRNSSAKD LTSFAAEAIA
410 420 430 440 450
MNRQLMEREE EEEGTENSSL CPFVVKATSC SMQLSPPSES KLAKRRQQGS
460
KGGISPPSLA PLLIVSD
Length:467
Mass (Da):52,671
Last modified:July 5, 2004 - v1
Checksum:iECD94A40C293246C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063717 mRNA. Translation: AAH63717.1.
BC077783 mRNA. Translation: AAH77783.1.
RefSeqiNP_001083700.1. NM_001090231.1.
UniGeneiXl.55283.

Genome annotation databases

GeneIDi399068.
KEGGixla:399068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063717 mRNA. Translation: AAH63717.1.
BC077783 mRNA. Translation: AAH77783.1.
RefSeqiNP_001083700.1. NM_001090231.1.
UniGeneiXl.55283.

3D structure databases

ProteinModelPortaliQ6P431.
SMRiQ6P431. Positions 70-368.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399068.
KEGGixla:399068.

Organism-specific databases

CTDi2872.
XenbaseiXB-GENE-866072. mknk2.

Phylogenomic databases

HOVERGENiHBG106949.
KOiK04372.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMKNK2_XENLA
AccessioniPrimary (citable) accession number: Q6P431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.