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Protein

MAP kinase-interacting serine/threonine-protein kinase 2

Gene

mknk2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei112ATPPROSITE-ProRule annotation1
Active sitei204Proton acceptorPROSITE-ProRule annotation1
Metal bindingi298ZincBy similarity1
Metal bindingi310ZincBy similarity1
Metal bindingi313ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 97ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processTranslation regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase-interacting serine/threonine-protein kinase 2 (EC:2.7.11.1)
Alternative name(s):
MAP kinase signal-integrating kinase 2
Short name:
MAPK signal-integrating kinase 2
Short name:
Mnk2
Gene namesi
Name:mknk2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866072. mknk2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002269661 – 467MAP kinase-interacting serine/threonine-protein kinase 2Add BLAST467

Structurei

3D structure databases

ProteinModelPortaliQ6P431.
SMRiQ6P431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 367Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG106949.
KOiK04372.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKKTTEMK GFHRSFKGQN PFDAAYEMEA RNMESVFNFD CPSRPDVPSS
60 70 80 90 100
APIDIPDAKK RTKKKKRCRA TDSFTGRFDD MYQLQQEILG EGAYAKVQSC
110 120 130 140 150
INLITNKEYA VKIIEKRPGH SRSRVFREVE MLYQCQGHSN VLELIEFFEE
160 170 180 190 200
EDKFYLVFEK MCGGSILNHI HRRRHFNERE ASFVVRDIAE ALNYLHNKGI
210 220 230 240 250
AHRDLKPENI LCESPHQVSP VKICDFDLGS GIKLNSDCSP ISTPELLTPC
260 270 280 290 300
GSAEYMAPEV VEAFNEEASI YDKRCDLWSL GVILYIMLSG YPPFVGHCGS
310 320 330 340 350
DCGWDRGEAC PACQNMLFVS IQEGKYEFPE KDWAHISYGA KDLISKLLLR
360 370 380 390 400
DAKKRLSAAQ VLQHPWVQGN APYNTLPTPI ILQRNSSAKD LTSFAAEAIA
410 420 430 440 450
MNRQLMEREE EEEGTENSSL CPFVVKATSC SMQLSPPSES KLAKRRQQGS
460
KGGISPPSLA PLLIVSD
Length:467
Mass (Da):52,671
Last modified:July 5, 2004 - v1
Checksum:iECD94A40C293246C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063717 mRNA. Translation: AAH63717.1.
BC077783 mRNA. Translation: AAH77783.1.
RefSeqiNP_001083700.1. NM_001090231.1.
UniGeneiXl.55283.

Genome annotation databases

GeneIDi399068.
KEGGixla:399068.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMKNK2_XENLA
AccessioniPrimary (citable) accession number: Q6P431
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: March 15, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families