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Protein
Submitted name:

MGC68474 protein

Gene

capn2.2

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105PROSITE-ProRule annotation1
Active sitei262PROSITE-ProRule annotation1
Active sitei286PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi584 – 595PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi614 – 625PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Protein family/group databases

MEROPSiC02.002.

Names & Taxonomyi

Protein namesi
Submitted name:
MGC68474 proteinImported
Gene namesi
Name:capn2.2Imported
Synonyms:capn2Imported, MGC68474Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-993763. capn2.2.

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliQ6P415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 344Calpain catalyticInterPro annotationAdd BLAST300
Domaini571 – 596EF-handInterPro annotationAdd BLAST26
Domaini601 – 636EF-handInterPro annotationAdd BLAST36
Domaini651 – 671EF-handInterPro annotationAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

HOVERGENiHBG012645.
KOiK03853.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGVADRLAK ERARASGFGT NEKALPYLNQ DFEALRNECL QSGSLFKDPS
60 70 80 90 100
FPAIHSSLGF KELGQYSSKT QGVVWKRPTD LCSSPQFIAG GATRTDICQG
110 120 130 140 150
ALGDCWLLAA IASLTLNEQI LSRVVPMDQS FQEKYAGIFH FQFWQYGEWV
160 170 180 190 200
DVVIDDRLPT KDGKLLFVHS AEGTEFWSAL MEKAYAKLNG SYEALSGGTT
210 220 230 240 250
TEGFEDFTGG LAEWYELKKA PSNLFKIIQK ALKSGSLLGC SIDITSAAET
260 270 280 290 300
EAITFQKLVK GHAYSVTAAE EVQYRGSLEK LIRIRNPWGE VEWTGAWSDN
310 320 330 340 350
SSEWNSVDPE VRDKLIKRCD DGEFWMSFND FLRNYSRLEI CNLTPDTLAS
360 370 380 390 400
DKYSKWSLTK MDGSWRRGST AGGCRNFPET FWMNPQYMIK LDEADDDPDD
410 420 430 440 450
NEEGCTFIVG LIQKNRRNQR KMGEDMHTIG FAMYEVPPQL TGQKDVRLSR
460 470 480 490 500
DYILRNKIRE KSETYINLRE VLNRFRLPAG EYVIVPSTFD PHKVGDFCLR
510 520 530 540 550
VFSEKNAETK VPDEEIKADI DEEVNENAID PTFKRMFLAL AGDDKEISPH
560 570 580 590 600
ELFNILQKVI SKREDIKSDG FSMETCRTIV DLLDSDGSGK LGLKEFNILW
610 620 630 640 650
TKILKYQKIY SSVDKDRSGT INSYEMRGAL EGAGFKVNAK IIELLVARFA
660 670 680 690
DEDQNIDFDN FVRCLLRLET MFKIFNKLDT EKTGVVPLKM DTWLSLTVI
Length:699
Mass (Da):79,305
Last modified:July 5, 2004 - v1
Checksum:iFC1920314B57E2F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063733 mRNA. Translation: AAH63733.1.
RefSeqiNP_001083713.1. NM_001090244.1.
UniGeneiXl.52677.

Genome annotation databases

GeneIDi399075.
KEGGixla:399075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063733 mRNA. Translation: AAH63733.1.
RefSeqiNP_001083713.1. NM_001090244.1.
UniGeneiXl.52677.

3D structure databases

ProteinModelPortaliQ6P415.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC02.002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399075.
KEGGixla:399075.

Organism-specific databases

CTDi399075.
XenbaseiXB-GENE-993763. capn2.2.

Phylogenomic databases

HOVERGENiHBG012645.
KOiK03853.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6P415_XENLA
AccessioniPrimary (citable) accession number: Q6P415
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 12, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.