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Q6P3Z8

- Q6P3Z8_MOUSE

UniProt

Q6P3Z8 - Q6P3Z8_MOUSE

Protein
Submitted name:

Histone acetyltransferase KAT2A

Gene

Kat2a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. H3 histone acetyltransferase activity Source: MGI
    3. histone acetyltransferase activity Source: MGI
    4. histone acetyltransferase activity (H4-K12 specific) Source: MGI
    5. N-acetyltransferase activity Source: MGI
    6. protein binding Source: MGI

    GO - Biological processi

    1. cell proliferation Source: MGI
    2. histone H3-K14 acetylation Source: MGI
    3. histone H4-K12 acetylation Source: MGI
    4. in utero embryonic development Source: MGI
    5. metencephalon development Source: MGI
    6. midbrain development Source: MGI
    7. multicellular organism growth Source: MGI
    8. nervous system development Source: MGI
    9. neural tube closure Source: MGI
    10. positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: MGI
    11. somitogenesis Source: MGI
    12. telencephalon development Source: MGI

    Keywords - Molecular functioni

    TransferaseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Histone acetyltransferase KAT2AImported
    Submitted name:
    K(Lysine) acetyltransferase 2AImported
    Gene namesi
    Name:Kat2aImported
    Synonyms:Gcn5l2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1343101. Kat2a.

    Subcellular locationi

    GO - Cellular componenti

    1. Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
    2. histone acetyltransferase complex Source: MGI
    3. mitotic spindle Source: MGI
    4. nucleus Source: MGI
    5. STAGA complex Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P3Z8.

    Family & Domainsi

    Keywords - Domaini

    BromodomainSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115051.
    HOGENOMiHOG000007151.
    HOVERGENiHBG051710.
    KOiK06062.
    OrthoDBiEOG7ZKS9B.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    IPR016376. Hist_acetylase_PCAF.
    IPR009464. PCAF_N.
    [Graphical view]
    PfamiPF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF06466. PCAF_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003048. Histone_acetylase_PCAF. 1 hit.
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P3Z8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEPSQAPNP VPAAQPRPLH SPAPAPTSTP APSPASASTP APTPAPAPAP    50
    AAAPAGSTGS GGAGVGSGGD PARPGLSQQQ RASQRKAQVR GLPRAKKLEK 100
    LGVFSACKAN ETCKCNGWKN PKPPTAPRMD LQQPAANLSE LCRSCEHPLA 150
    DHVSHLENVS EDEINRLLGM VVDVENLFMS VHKEEDTDTK QVYFYLFKLL 200
    RKCILQMTRP VVEGSLGSPP FEKPNIEQGV LNFVQYKFSH LAPRERQTMF 250
    ELSKMFLLCL NYWKLETPAQ FRQRSQSEDV ATYKVNYTRW LCYCHVPQSC 300
    DSLPRYETTH VFGRSLLRSI FTVTRRQLLE KFRVEKDKLV PEKRTLILTH 350
    FPKFLSMLEE EIYGANSPIW ESGFTMPPSE GTQLVPRPAT VSATVVPSFS 400
    PSMGGGSNSS LSLDSAGTEP MPGEKRKLPE NLTLEDAKRL RVMGDIPMEL 450
    VNEVMLTITD PAAMLGPETS LLSANAARDE TARLEERRGI IEFHVIGNSL 500
    TPKANRRVLL WLVGLQNVFS HQLPRMPKEY IARLVFDPKH KTLALIKDGR 550
    VIGGICFRMF PTQGFTEIVF CAVTSNEQVK GYGTHLMNHL KEYHIKHSIL 600
    YFLTYADEYA IGYFKKQGFS KDIKVPKSRY LGYIKDYEGA TLMECELNPR 650
    IPYTELSHII KKQKEIIKKL IERKQAQIRK VYPGLSCFKE GVRQIPVESV 700
    PGIRETGWKP LGKEKGKELK DPDQLYTTLK NLLAQIKSHP SAWPFMEPVK 750
    KSEAPDYYEV IRFPIDLKTM TERLRSRYYV TRKLFVADLQ RVIANCREYN 800
    PPDSEYCRCA SALEKFFYFK LKEGGLIDK 829
    Length:829
    Mass (Da):93,323
    Last modified:July 5, 2004 - v1
    Checksum:iBD96914160B14128
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591469 Genomic DNA. No translation available.
    BC063752 mRNA. Translation: AAH63752.1.
    AK155842 mRNA. Translation: BAE33458.1.
    RefSeqiNP_001033099.1. NM_001038010.2.
    NP_064388.2. NM_020004.5.
    UniGeneiMm.218837.

    Genome annotation databases

    EnsembliENSMUST00000006973; ENSMUSP00000006973; ENSMUSG00000020918.
    GeneIDi14534.
    KEGGimmu:14534.
    UCSCiuc007lmb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591469 Genomic DNA. No translation available.
    BC063752 mRNA. Translation: AAH63752.1 .
    AK155842 mRNA. Translation: BAE33458.1 .
    RefSeqi NP_001033099.1. NM_001038010.2.
    NP_064388.2. NM_020004.5.
    UniGenei Mm.218837.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006973 ; ENSMUSP00000006973 ; ENSMUSG00000020918 .
    GeneIDi 14534.
    KEGGi mmu:14534.
    UCSCi uc007lmb.2. mouse.

    Organism-specific databases

    CTDi 2648.
    MGIi MGI:1343101. Kat2a.

    Phylogenomic databases

    GeneTreei ENSGT00740000115051.
    HOGENOMi HOG000007151.
    HOVERGENi HBG051710.
    KOi K06062.
    OrthoDBi EOG7ZKS9B.

    Miscellaneous databases

    ChiTaRSi KAT2A. mouse.
    NextBioi 286188.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6P3Z8.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    IPR016376. Hist_acetylase_PCAF.
    IPR009464. PCAF_N.
    [Graphical view ]
    Pfami PF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF06466. PCAF_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003048. Histone_acetylase_PCAF. 1 hit.
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EmbryoImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    11. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ6P3Z8_MOUSE
    AccessioniPrimary (citable) accession number: Q6P3Z8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3