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Q6P3Z8 (Q6P3Z8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

K(Lysine) acetyltransferase 2A EMBL AAH63752.1
Gene names
Name:Kat2a EMBL AAH63752.1 Ensembl ENSMUSP00000006973 MGI 1343101
Synonyms:Gcn5l2 MGI 1343101
OrganismMus musculus (Mouse) [Reference proteome] EMBL AAH63752.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length829 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   DomainBromodomain SAAS SAAS001487
   Molecular functionTransferase EMBL AAH63752.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Inferred from mutant phenotype PubMed 17325035. Source: MGI

histone H3-K14 acetylation

Inferred from direct assay PubMed 17325035. Source: MGI

histone H4-K12 acetylation

Inferred from direct assay PubMed 17325035. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 17325035. Source: MGI

metencephalon development

Inferred from mutant phenotype PubMed 17325035. Source: MGI

midbrain development

Inferred from mutant phenotype PubMed 17325035. Source: MGI

multicellular organism growth

Inferred from mutant phenotype PubMed 17325035. Source: MGI

nervous system development

Inferred from mutant phenotype PubMed 17325035. Source: MGI

neural tube closure

Inferred from mutant phenotype PubMed 17325035. Source: MGI

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: InterPro

somitogenesis

Inferred from mutant phenotype PubMed 17325035. Source: MGI

telencephalon development

Inferred from mutant phenotype PubMed 17325035. Source: MGI

   Cellular_componentAda2/Gcn5/Ada3 transcription activator complex

Inferred from direct assay PubMed 20508642PubMed 20562830. Source: MGI

STAGA complex

Inferred from direct assay PubMed 19103755. Source: MGI

histone acetyltransferase complex

Inferred from direct assay PubMed 9742083. Source: MGI

mitotic spindle

Inferred from direct assay PubMed 20562830. Source: MGI

nucleus

Inferred from direct assay PubMed 19103755PubMed 20562830. Source: MGI

   Molecular_functionH3 histone acetyltransferase activity

Inferred from direct assay PubMed 17325035. Source: MGI

N-acetyltransferase activity

Inferred from direct assay PubMed 20562830. Source: MGI

chromatin binding

Inferred from direct assay PubMed 16109736PubMed 23637336. Source: MGI

histone acetyltransferase activity

Inferred from direct assay PubMed 9742083. Source: MGI

histone acetyltransferase activity (H4-K12 specific)

Inferred from direct assay PubMed 17325035. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6P3Z8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BD96914160B14128

FASTA82993,323
        10         20         30         40         50         60 
MAEPSQAPNP VPAAQPRPLH SPAPAPTSTP APSPASASTP APTPAPAPAP AAAPAGSTGS 

        70         80         90        100        110        120 
GGAGVGSGGD PARPGLSQQQ RASQRKAQVR GLPRAKKLEK LGVFSACKAN ETCKCNGWKN 

       130        140        150        160        170        180 
PKPPTAPRMD LQQPAANLSE LCRSCEHPLA DHVSHLENVS EDEINRLLGM VVDVENLFMS 

       190        200        210        220        230        240 
VHKEEDTDTK QVYFYLFKLL RKCILQMTRP VVEGSLGSPP FEKPNIEQGV LNFVQYKFSH 

       250        260        270        280        290        300 
LAPRERQTMF ELSKMFLLCL NYWKLETPAQ FRQRSQSEDV ATYKVNYTRW LCYCHVPQSC 

       310        320        330        340        350        360 
DSLPRYETTH VFGRSLLRSI FTVTRRQLLE KFRVEKDKLV PEKRTLILTH FPKFLSMLEE 

       370        380        390        400        410        420 
EIYGANSPIW ESGFTMPPSE GTQLVPRPAT VSATVVPSFS PSMGGGSNSS LSLDSAGTEP 

       430        440        450        460        470        480 
MPGEKRKLPE NLTLEDAKRL RVMGDIPMEL VNEVMLTITD PAAMLGPETS LLSANAARDE 

       490        500        510        520        530        540 
TARLEERRGI IEFHVIGNSL TPKANRRVLL WLVGLQNVFS HQLPRMPKEY IARLVFDPKH 

       550        560        570        580        590        600 
KTLALIKDGR VIGGICFRMF PTQGFTEIVF CAVTSNEQVK GYGTHLMNHL KEYHIKHSIL 

       610        620        630        640        650        660 
YFLTYADEYA IGYFKKQGFS KDIKVPKSRY LGYIKDYEGA TLMECELNPR IPYTELSHII 

       670        680        690        700        710        720 
KKQKEIIKKL IERKQAQIRK VYPGLSCFKE GVRQIPVESV PGIRETGWKP LGKEKGKELK 

       730        740        750        760        770        780 
DPDQLYTTLK NLLAQIKSHP SAWPFMEPVK KSEAPDYYEV IRFPIDLKTM TERLRSRYYV 

       790        800        810        820 
TRKLFVADLQ RVIANCREYN PPDSEYCRCA SALEKFFYFK LKEGGLIDK 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE33458.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE33458.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE33458.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE33458.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE33458.1.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo EMBL AAH63752.1.
[7]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE33458.1.
[8]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE33458.1.
[9]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE33458.1.
[10]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000006973.
[11]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000006973.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591469 Genomic DNA. No translation available.
BC063752 mRNA. Translation: AAH63752.1.
AK155842 mRNA. Translation: BAE33458.1.
RefSeqNP_001033099.1. NM_001038010.2.
NP_064388.2. NM_020004.5.
UniGeneMm.218837.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006973; ENSMUSP00000006973; ENSMUSG00000020918.
GeneID14534.
KEGGmmu:14534.
UCSCuc007lmb.2. mouse.

Organism-specific databases

CTD2648.
MGIMGI:1343101. Kat2a.

Phylogenomic databases

GeneTreeENSGT00740000115051.
HOGENOMHOG000007151.
HOVERGENHBG051710.
KOK06062.
OrthoDBEOG7ZKS9B.

Gene expression databases

GenevestigatorQ6P3Z8.

Family and domain databases

Gene3D1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view]
PfamPF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view]
PIRSFPIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKAT2A. mouse.
NextBio286188.
SOURCESearch...

Entry information

Entry nameQ6P3Z8_MOUSE
AccessionPrimary (citable) accession number: Q6P3Z8
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)