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Q6P3Z8

- Q6P3Z8_MOUSE

UniProt

Q6P3Z8 - Q6P3Z8_MOUSE

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Protein
Submitted name:

Histone acetyltransferase KAT2A

Gene
Kat2a, Gcn5l2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. H3 histone acetyltransferase activity Source: MGI
  3. histone acetyltransferase activity Source: MGI
  4. histone acetyltransferase activity (H4-K12 specific) Source: MGI
  5. N-acetyltransferase activity Source: MGI
  6. protein binding Source: MGI

GO - Biological processi

  1. cell proliferation Source: MGI
  2. histone H3-K14 acetylation Source: MGI
  3. histone H4-K12 acetylation Source: MGI
  4. in utero embryonic development Source: MGI
  5. metencephalon development Source: MGI
  6. midbrain development Source: MGI
  7. multicellular organism growth Source: MGI
  8. nervous system development Source: MGI
  9. neural tube closure Source: MGI
  10. positive regulation of gluconeogenesis Source: MGI
  11. regulation of transcription, DNA-templated Source: InterPro
  12. somitogenesis Source: MGI
  13. telencephalon development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Histone acetyltransferase KAT2AImported
Submitted name:
K(Lysine) acetyltransferase 2AImported
Gene namesi
Name:Kat2aImported
Synonyms:Gcn5l2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1343101. Kat2a.

Subcellular locationi

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
  2. histone acetyltransferase complex Source: MGI
  3. mitotic spindle Source: MGI
  4. nucleus Source: MGI
  5. STAGA complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ6P3Z8.

Family & Domainsi

Keywords - Domaini

BromodomainSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000115051.
HOGENOMiHOG000007151.
HOVERGENiHBG051710.
KOiK06062.
OrthoDBiEOG7ZKS9B.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P3Z8-1 [UniParc]FASTAAdd to Basket

« Hide

MAEPSQAPNP VPAAQPRPLH SPAPAPTSTP APSPASASTP APTPAPAPAP    50
AAAPAGSTGS GGAGVGSGGD PARPGLSQQQ RASQRKAQVR GLPRAKKLEK 100
LGVFSACKAN ETCKCNGWKN PKPPTAPRMD LQQPAANLSE LCRSCEHPLA 150
DHVSHLENVS EDEINRLLGM VVDVENLFMS VHKEEDTDTK QVYFYLFKLL 200
RKCILQMTRP VVEGSLGSPP FEKPNIEQGV LNFVQYKFSH LAPRERQTMF 250
ELSKMFLLCL NYWKLETPAQ FRQRSQSEDV ATYKVNYTRW LCYCHVPQSC 300
DSLPRYETTH VFGRSLLRSI FTVTRRQLLE KFRVEKDKLV PEKRTLILTH 350
FPKFLSMLEE EIYGANSPIW ESGFTMPPSE GTQLVPRPAT VSATVVPSFS 400
PSMGGGSNSS LSLDSAGTEP MPGEKRKLPE NLTLEDAKRL RVMGDIPMEL 450
VNEVMLTITD PAAMLGPETS LLSANAARDE TARLEERRGI IEFHVIGNSL 500
TPKANRRVLL WLVGLQNVFS HQLPRMPKEY IARLVFDPKH KTLALIKDGR 550
VIGGICFRMF PTQGFTEIVF CAVTSNEQVK GYGTHLMNHL KEYHIKHSIL 600
YFLTYADEYA IGYFKKQGFS KDIKVPKSRY LGYIKDYEGA TLMECELNPR 650
IPYTELSHII KKQKEIIKKL IERKQAQIRK VYPGLSCFKE GVRQIPVESV 700
PGIRETGWKP LGKEKGKELK DPDQLYTTLK NLLAQIKSHP SAWPFMEPVK 750
KSEAPDYYEV IRFPIDLKTM TERLRSRYYV TRKLFVADLQ RVIANCREYN 800
PPDSEYCRCA SALEKFFYFK LKEGGLIDK 829
Length:829
Mass (Da):93,323
Last modified:July 5, 2004 - v1
Checksum:iBD96914160B14128
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591469 Genomic DNA. No translation available.
BC063752 mRNA. Translation: AAH63752.1.
AK155842 mRNA. Translation: BAE33458.1.
RefSeqiNP_001033099.1. NM_001038010.2.
NP_064388.2. NM_020004.5.
UniGeneiMm.218837.

Genome annotation databases

EnsembliENSMUST00000006973; ENSMUSP00000006973; ENSMUSG00000020918.
GeneIDi14534.
KEGGimmu:14534.
UCSCiuc007lmb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591469 Genomic DNA. No translation available.
BC063752 mRNA. Translation: AAH63752.1 .
AK155842 mRNA. Translation: BAE33458.1 .
RefSeqi NP_001033099.1. NM_001038010.2.
NP_064388.2. NM_020004.5.
UniGenei Mm.218837.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006973 ; ENSMUSP00000006973 ; ENSMUSG00000020918 .
GeneIDi 14534.
KEGGi mmu:14534.
UCSCi uc007lmb.2. mouse.

Organism-specific databases

CTDi 2648.
MGIi MGI:1343101. Kat2a.

Phylogenomic databases

GeneTreei ENSGT00740000115051.
HOGENOMi HOG000007151.
HOVERGENi HBG051710.
KOi K06062.
OrthoDBi EOG7ZKS9B.

Miscellaneous databases

ChiTaRSi KAT2A. mouse.
NextBioi 286188.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6P3Z8.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view ]
Pfami PF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6P3Z8_MOUSE
AccessioniPrimary (citable) accession number: Q6P3Z8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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