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Protein

Zinc finger protein 280C

Gene

Znf280c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1Add BLAST23
Zinc fingeri360 – 383C2H2-type 2Add BLAST24
Zinc fingeri390 – 413C2H2-type 3Add BLAST24
Zinc fingeri420 – 443C2H2-type 4Add BLAST24
Zinc fingeri477 – 499C2H2-type 5Add BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 280C
Alternative name(s):
Suppressor of hairy wing homolog 3
Gene namesi
Name:Znf280c
Synonyms:Kiaa1584, Suhw3, Zfp280c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2387585. Zfp280c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279761 – 742Zinc finger protein 280CAdd BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki85Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6P3Y5.
PeptideAtlasiQ6P3Y5.
PRIDEiQ6P3Y5.

PTM databases

iPTMnetiQ6P3Y5.
PhosphoSitePlusiQ6P3Y5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036916.
CleanExiMM_ZFP280C.
GenevisibleiQ6P3Y5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ6P3Y5. 1 interactor.
MINTiMINT-4116905.
STRINGi10090.ENSMUSP00000075933.

Structurei

3D structure databases

ProteinModelPortaliQ6P3Y5.
SMRiQ6P3Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 37Poly-Glu8
Compositional biasi62 – 244Ser-richAdd BLAST183

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1Add BLAST23
Zinc fingeri360 – 383C2H2-type 2Add BLAST24
Zinc fingeri390 – 413C2H2-type 3Add BLAST24
Zinc fingeri420 – 443C2H2-type 4Add BLAST24
Zinc fingeri477 – 499C2H2-type 5Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063300.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiQ6P3Y5.
OMAiFSTHINC.
OrthoDBiEOG091G01UE.
PhylomeDBiQ6P3Y5.
TreeFamiTF331707.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P3Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKDNSVQEK GLFLSSWKLD NSKMAELFME CEEEELEPWQ QKVEESQSKD
60 70 80 90 100
DDDELIFVGE ISSSKPAISN ILNRCSPGSS SKGLKNGSFN PAISNIFKPT
110 120 130 140 150
SQHYRNPSSN ALVALPSFHP ALKSSESSDG QTVSKLDFTK TSPQEDSGAC
160 170 180 190 200
SVSQSDSTQD IPSSNILQPR TGVDQTLGLK HPSTSKVNSV NPKKPKTSAS
210 220 230 240 250
ISETRPCSSS SSQTAPSGAS SQTVLSNVNT SSVQSAPGSS SLRSCPKCNV
260 270 280 290 300
KFRLLDPLKC HMKRCCPDMI NKFLETLKSE NSKAVSKATT DSDKEKLIML
310 320 330 340 350
VSDFYYGRHE GTIEESQKTH TTFKCFSCTK VLKNNIRFMN HMKHHLELEK
360 370 380 390 400
QNNETWESHT TCQHCYRQYP NPFQLQCHIE STHTPHDFST ICKICELSFE
410 420 430 440 450
TEHMLLQHMK DTHKPGEMPY ICQVCQFRSS IFSDVETHFR SSHENTKNLL
460 470 480 490 500
CPFCLKVSRM ATPYMNHYMR HQKKGIYRCP KCRLQFLTSK EKTEHKLEHR
510 520 530 540 550
TFIKPKELEG LPPGTKVIIR ASLGSSQSRA SSPPSSTIPS TSLQLSVPKS
560 570 580 590 600
KSTTTKNNSK VSANKATTTS PQTVATTTGK PSASKPGTGT TKSKAKPSYK
610 620 630 640 650
QKRQRTRKNK FSIDLKNLRC HQGSHMCIEC RSKIKDFSSH FSTHINCDFC
660 670 680 690 700
KYTTNCNKAF TNHMSSHNDH PSKQLYIFKK QSRARRGITL VCLKCDFLAD
710 720 730 740
TSGLDRMAKH LNQRKTHTCQ VVIENVTERA VTSESASDGL FK
Length:742
Mass (Da):83,146
Last modified:July 5, 2004 - v1
Checksum:i04A82F753CAD6C10
GO
Isoform 2 (identifier: Q6P3Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     686-693: RGITLVCL → SYRKSRNF
     694-742: Missing.

Note: No experimental confirmation available.
Show »
Length:693
Mass (Da):77,895
Checksum:i0253B2C5564DB87F
GO
Isoform 3 (identifier: Q6P3Y5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-19: Missing.

Note: No experimental confirmation available.
Show »
Length:733
Mass (Da):82,114
Checksum:i865EA149FF38A4B6
GO

Sequence cautioni

The sequence BAC98209 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01761911 – 19Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_017620686 – 693RGITLVCL → SYRKSRNF in isoform 2. 1 Publication8
Alternative sequenceiVSP_017621694 – 742Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129399 mRNA. Translation: BAC98209.1. Different initiation.
AK141491 mRNA. Translation: BAE24700.1.
AL669901 Genomic DNA. Translation: CAM22224.1.
AL669901 Genomic DNA. Translation: CAM22225.1.
BC028839 mRNA. Translation: AAH28839.1.
BC051397 mRNA. Translation: AAH51397.1.
BC063775 mRNA. Translation: AAH63775.1.
CCDSiCCDS30111.1. [Q6P3Y5-1]
CCDS53064.1. [Q6P3Y5-3]
CCDS53065.1. [Q6P3Y5-2]
RefSeqiNP_001160120.1. NM_001166648.1. [Q6P3Y5-1]
NP_001160121.1. NM_001166649.1. [Q6P3Y5-3]
NP_001160122.1. NM_001166650.1. [Q6P3Y5-2]
NP_705760.2. NM_153532.3. [Q6P3Y5-1]
XP_006541521.1. XM_006541458.3. [Q6P3Y5-1]
XP_006541522.1. XM_006541459.3. [Q6P3Y5-1]
XP_006541524.1. XM_006541461.3. [Q6P3Y5-1]
XP_006541528.1. XM_006541465.3. [Q6P3Y5-2]
UniGeneiMm.293819.

Genome annotation databases

EnsembliENSMUST00000072292; ENSMUSP00000072138; ENSMUSG00000036916. [Q6P3Y5-3]
ENSMUST00000076635; ENSMUSP00000075933; ENSMUSG00000036916. [Q6P3Y5-1]
ENSMUST00000088898; ENSMUSP00000086288; ENSMUSG00000036916. [Q6P3Y5-1]
ENSMUST00000114940; ENSMUSP00000110590; ENSMUSG00000036916. [Q6P3Y5-2]
GeneIDi208968.
KEGGimmu:208968.
UCSCiuc009tcj.1. mouse. [Q6P3Y5-2]
uc009tck.1. mouse. [Q6P3Y5-1]
uc009tcm.2. mouse. [Q6P3Y5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129399 mRNA. Translation: BAC98209.1. Different initiation.
AK141491 mRNA. Translation: BAE24700.1.
AL669901 Genomic DNA. Translation: CAM22224.1.
AL669901 Genomic DNA. Translation: CAM22225.1.
BC028839 mRNA. Translation: AAH28839.1.
BC051397 mRNA. Translation: AAH51397.1.
BC063775 mRNA. Translation: AAH63775.1.
CCDSiCCDS30111.1. [Q6P3Y5-1]
CCDS53064.1. [Q6P3Y5-3]
CCDS53065.1. [Q6P3Y5-2]
RefSeqiNP_001160120.1. NM_001166648.1. [Q6P3Y5-1]
NP_001160121.1. NM_001166649.1. [Q6P3Y5-3]
NP_001160122.1. NM_001166650.1. [Q6P3Y5-2]
NP_705760.2. NM_153532.3. [Q6P3Y5-1]
XP_006541521.1. XM_006541458.3. [Q6P3Y5-1]
XP_006541522.1. XM_006541459.3. [Q6P3Y5-1]
XP_006541524.1. XM_006541461.3. [Q6P3Y5-1]
XP_006541528.1. XM_006541465.3. [Q6P3Y5-2]
UniGeneiMm.293819.

3D structure databases

ProteinModelPortaliQ6P3Y5.
SMRiQ6P3Y5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P3Y5. 1 interactor.
MINTiMINT-4116905.
STRINGi10090.ENSMUSP00000075933.

PTM databases

iPTMnetiQ6P3Y5.
PhosphoSitePlusiQ6P3Y5.

Proteomic databases

PaxDbiQ6P3Y5.
PeptideAtlasiQ6P3Y5.
PRIDEiQ6P3Y5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072292; ENSMUSP00000072138; ENSMUSG00000036916. [Q6P3Y5-3]
ENSMUST00000076635; ENSMUSP00000075933; ENSMUSG00000036916. [Q6P3Y5-1]
ENSMUST00000088898; ENSMUSP00000086288; ENSMUSG00000036916. [Q6P3Y5-1]
ENSMUST00000114940; ENSMUSP00000110590; ENSMUSG00000036916. [Q6P3Y5-2]
GeneIDi208968.
KEGGimmu:208968.
UCSCiuc009tcj.1. mouse. [Q6P3Y5-2]
uc009tck.1. mouse. [Q6P3Y5-1]
uc009tcm.2. mouse. [Q6P3Y5-3]

Organism-specific databases

CTDi208968.
MGIiMGI:2387585. Zfp280c.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063300.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiQ6P3Y5.
OMAiFSTHINC.
OrthoDBiEOG091G01UE.
PhylomeDBiQ6P3Y5.
TreeFamiTF331707.

Miscellaneous databases

PROiQ6P3Y5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036916.
CleanExiMM_ZFP280C.
GenevisibleiQ6P3Y5. MM.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ280C_MOUSE
AccessioniPrimary (citable) accession number: Q6P3Y5
Secondary accession number(s): B1AU28
, B1AU29, Q6ZPM2, Q8K145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.