Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PiggyBac transposable element-derived protein 2

Gene

PGBD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
PiggyBac transposable element-derived protein 2
Gene namesi
Name:PGBD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19399. PGBD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134877743.

Polymorphism and mutation databases

BioMutaiPGBD2.
DMDMi74749095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592PiggyBac transposable element-derived protein 2PRO_0000288053Add
BLAST

Proteomic databases

MaxQBiQ6P3X8.
PaxDbiQ6P3X8.
PeptideAtlasiQ6P3X8.
PRIDEiQ6P3X8.

PTM databases

iPTMnetiQ6P3X8.
PhosphoSiteiQ6P3X8.

Expressioni

Gene expression databases

BgeeiQ6P3X8.
CleanExiHS_PGBD2.
ExpressionAtlasiQ6P3X8. baseline and differential.
GenevisibleiQ6P3X8. HS.

Organism-specific databases

HPAiHPA029888.
HPA029889.
HPA029890.

Interactioni

Protein-protein interaction databases

BioGridi129355. 1 interaction.
STRINGi9606.ENSP00000331643.

Structurei

3D structure databases

ProteinModelPortaliQ6P3X8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00530000063278.
HOGENOMiHOG000065760.
HOVERGENiHBG059393.
InParanoidiQ6P3X8.
OMAiHRICCQD.
OrthoDBiEOG78WKR6.
PhylomeDBiQ6P3X8.
TreeFamiTF328011.

Family and domain databases

InterProiIPR029526. PGBD.
[Graphical view]
PfamiPF13843. DDE_Tnp_1_7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P3X8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTSRDVIA GRGIHSKVKS AKLLEVLNAM EEEESNNNRE EIFIAPPDNA
60 70 80 90 100
AGEFTDEDSG DEDSQRGAHL PGSVLHASVL CEDSGTGEDN DDLELQPAKK
110 120 130 140 150
RQKAVVKPQR IWTKRDIRPD FGSWTASDPH IEDLKSQELS PVGLFELFFD
160 170 180 190 200
EGTINFIVNE TNRYAWQKNV NLSLTAQELK CVLGILILSG YISYPRRRMF
210 220 230 240 250
WETSPDSHHH LVADAIRRDR FELIFSYLHF ADNNELDASD RFAKVRPLII
260 270 280 290 300
RMNCNFQKHA PLEEFYSFGE SMCEYFGHRG SKQLHRGKPV RLGYKIWCGT
310 320 330 340 350
TSRGYLVWFE PSQGTLFTKP DRSLDLGGSM VIKFVDALQE RGFLPYHIFF
360 370 380 390 400
DKVFTSVKLM SILRKKGVKA TGTVREYRTE RCPLKDPKEL KKMKRGSFDY
410 420 430 440 450
KVDESEEIIV CRWHDSSVVN ICSNAVGIEP VRLTSRHSGA AKTRTQVHQP
460 470 480 490 500
SLVKLYQEKV GGVGRMDQNI AKYKVKIRGM KWYSSFIGYV IDAALNNAWQ
510 520 530 540 550
LHRICCQDAQ VDLLAFRRYI ACVYLESNAD TTSQGRRSRR LETESRFDMI
560 570 580 590
GHWIIHQDKR TRCALCHSQT NTRCEKCQKG VHAKCFREYH IR
Length:592
Mass (Da):68,011
Last modified:July 5, 2004 - v1
Checksum:i59B8B2AEB823963D
GO
Isoform 2 (identifier: Q6P3X8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.

Show »
Length:341
Mass (Da):39,563
Checksum:i5AED31C4AD569B2E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 251251Missing in isoform 2. 2 PublicationsVSP_025631Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123219 mRNA. Translation: BAG53880.1.
BX647065 mRNA. Translation: CAE46192.1.
AL672183 Genomic DNA. Translation: CAI18711.1.
AL672183 Genomic DNA. Translation: CAI18712.1.
CH471257 Genomic DNA. Translation: EAW57544.1.
BC063785 mRNA. Translation: AAH63785.1.
CCDSiCCDS31128.1. [Q6P3X8-1]
CCDS31129.1. [Q6P3X8-2]
RefSeqiNP_001017434.1. NM_001017434.1. [Q6P3X8-2]
NP_733843.1. NM_170725.2. [Q6P3X8-1]
XP_006711823.1. XM_006711760.2. [Q6P3X8-1]
XP_011542461.1. XM_011544159.1. [Q6P3X8-1]
XP_011542462.1. XM_011544160.1. [Q6P3X8-1]
XP_011542463.1. XM_011544161.1. [Q6P3X8-1]
UniGeneiHs.602037.

Genome annotation databases

EnsembliENST00000329291; ENSP00000331643; ENSG00000185220. [Q6P3X8-1]
ENST00000355360; ENSP00000355424; ENSG00000185220. [Q6P3X8-2]
GeneIDi267002.
KEGGihsa:267002.
UCSCiuc001ifg.4. human. [Q6P3X8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123219 mRNA. Translation: BAG53880.1.
BX647065 mRNA. Translation: CAE46192.1.
AL672183 Genomic DNA. Translation: CAI18711.1.
AL672183 Genomic DNA. Translation: CAI18712.1.
CH471257 Genomic DNA. Translation: EAW57544.1.
BC063785 mRNA. Translation: AAH63785.1.
CCDSiCCDS31128.1. [Q6P3X8-1]
CCDS31129.1. [Q6P3X8-2]
RefSeqiNP_001017434.1. NM_001017434.1. [Q6P3X8-2]
NP_733843.1. NM_170725.2. [Q6P3X8-1]
XP_006711823.1. XM_006711760.2. [Q6P3X8-1]
XP_011542461.1. XM_011544159.1. [Q6P3X8-1]
XP_011542462.1. XM_011544160.1. [Q6P3X8-1]
XP_011542463.1. XM_011544161.1. [Q6P3X8-1]
UniGeneiHs.602037.

3D structure databases

ProteinModelPortaliQ6P3X8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129355. 1 interaction.
STRINGi9606.ENSP00000331643.

PTM databases

iPTMnetiQ6P3X8.
PhosphoSiteiQ6P3X8.

Polymorphism and mutation databases

BioMutaiPGBD2.
DMDMi74749095.

Proteomic databases

MaxQBiQ6P3X8.
PaxDbiQ6P3X8.
PeptideAtlasiQ6P3X8.
PRIDEiQ6P3X8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329291; ENSP00000331643; ENSG00000185220. [Q6P3X8-1]
ENST00000355360; ENSP00000355424; ENSG00000185220. [Q6P3X8-2]
GeneIDi267002.
KEGGihsa:267002.
UCSCiuc001ifg.4. human. [Q6P3X8-1]

Organism-specific databases

CTDi267002.
GeneCardsiPGBD2.
HGNCiHGNC:19399. PGBD2.
HPAiHPA029888.
HPA029889.
HPA029890.
neXtProtiNX_Q6P3X8.
PharmGKBiPA134877743.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00530000063278.
HOGENOMiHOG000065760.
HOVERGENiHBG059393.
InParanoidiQ6P3X8.
OMAiHRICCQD.
OrthoDBiEOG78WKR6.
PhylomeDBiQ6P3X8.
TreeFamiTF328011.

Miscellaneous databases

ChiTaRSiPGBD2. human.
GenomeRNAii267002.
PROiQ6P3X8.

Gene expression databases

BgeeiQ6P3X8.
CleanExiHS_PGBD2.
ExpressionAtlasiQ6P3X8. baseline and differential.
GenevisibleiQ6P3X8. HS.

Family and domain databases

InterProiIPR029526. PGBD.
[Graphical view]
PfamiPF13843. DDE_Tnp_1_7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiPGBD2_HUMAN
AccessioniPrimary (citable) accession number: Q6P3X8
Secondary accession number(s): B3KVR8, Q6MZF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.