ID   TTC27_HUMAN             Reviewed;         843 AA.
AC   Q6P3X3; A6NKJ0; Q96SS5; Q9BVF1; Q9NWR4; Q9NXG4;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 160.
DE   RecName: Full=Tetratricopeptide repeat protein 27;
DE            Short=TPR repeat protein 27;
GN   Name=TTC27;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-525.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- INTERACTION:
CC       Q6P3X3; Q5S007: LRRK2; NbExp=3; IntAct=EBI-1057046, EBI-5323863;
CC   -!- SIMILARITY: Belongs to the TTC27 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA91048.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAA91315.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK000279; BAA91048.1; ALT_INIT; mRNA.
DR   EMBL; AK000665; BAA91315.1; ALT_INIT; mRNA.
DR   EMBL; AK027570; BAB55206.1; -; mRNA.
DR   EMBL; AL133246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC001248; AAH01248.2; -; mRNA.
DR   EMBL; BC063791; AAH63791.1; -; mRNA.
DR   CCDS; CCDS33176.1; -.
DR   RefSeq; NP_001180438.1; NM_001193509.1.
DR   RefSeq; NP_060205.3; NM_017735.4.
DR   AlphaFoldDB; Q6P3X3; -.
DR   SMR; Q6P3X3; -.
DR   BioGRID; 120761; 125.
DR   IntAct; Q6P3X3; 29.
DR   MINT; Q6P3X3; -.
DR   STRING; 9606.ENSP00000313953; -.
DR   GlyGen; Q6P3X3; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q6P3X3; -.
DR   PhosphoSitePlus; Q6P3X3; -.
DR   BioMuta; TTC27; -.
DR   DMDM; 74758258; -.
DR   EPD; Q6P3X3; -.
DR   jPOST; Q6P3X3; -.
DR   MassIVE; Q6P3X3; -.
DR   MaxQB; Q6P3X3; -.
DR   PaxDb; 9606-ENSP00000313953; -.
DR   PeptideAtlas; Q6P3X3; -.
DR   ProteomicsDB; 66938; -.
DR   Pumba; Q6P3X3; -.
DR   Antibodypedia; 29210; 83 antibodies from 20 providers.
DR   DNASU; 55622; -.
DR   Ensembl; ENST00000317907.9; ENSP00000313953.4; ENSG00000018699.13.
DR   GeneID; 55622; -.
DR   KEGG; hsa:55622; -.
DR   MANE-Select; ENST00000317907.9; ENSP00000313953.4; NM_017735.5; NP_060205.3.
DR   UCSC; uc002rom.4; human.
DR   AGR; HGNC:25986; -.
DR   CTD; 55622; -.
DR   DisGeNET; 55622; -.
DR   GeneCards; TTC27; -.
DR   HGNC; HGNC:25986; TTC27.
DR   HPA; ENSG00000018699; Low tissue specificity.
DR   neXtProt; NX_Q6P3X3; -.
DR   OpenTargets; ENSG00000018699; -.
DR   PharmGKB; PA145007326; -.
DR   VEuPathDB; HostDB:ENSG00000018699; -.
DR   eggNOG; KOG1128; Eukaryota.
DR   GeneTree; ENSGT00500000044929; -.
DR   HOGENOM; CLU_004905_2_0_1; -.
DR   InParanoid; Q6P3X3; -.
DR   OMA; NNRYARA; -.
DR   OrthoDB; 23605at2759; -.
DR   PhylomeDB; Q6P3X3; -.
DR   TreeFam; TF105894; -.
DR   PathwayCommons; Q6P3X3; -.
DR   SignaLink; Q6P3X3; -.
DR   BioGRID-ORCS; 55622; 825 hits in 1160 CRISPR screens.
DR   ChiTaRS; TTC27; human.
DR   GenomeRNAi; 55622; -.
DR   Pharos; Q6P3X3; Tdark.
DR   PRO; PR:Q6P3X3; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q6P3X3; Protein.
DR   Bgee; ENSG00000018699; Expressed in primordial germ cell in gonad and 169 other cell types or tissues.
DR   ExpressionAtlas; Q6P3X3; baseline and differential.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR013105; TPR_2.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR044244; TTC27/Emw1.
DR   PANTHER; PTHR16193:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 27; 1.
DR   PANTHER; PTHR16193; UNCHARACTERIZED; 1.
DR   Pfam; PF07719; TPR_2; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
DR   Genevisible; Q6P3X3; HS.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..843
FT                   /note="Tetratricopeptide repeat protein 27"
FT                   /id="PRO_0000295096"
FT   REPEAT          453..486
FT                   /note="TPR 1"
FT   REPEAT          492..525
FT                   /note="TPR 2"
FT   REPEAT          527..560
FT                   /note="TPR 3"
FT   REPEAT          561..594
FT                   /note="TPR 4"
FT   REPEAT          596..628
FT                   /note="TPR 5"
FT   REPEAT          629..662
FT                   /note="TPR 6"
FT   VARIANT         476
FT                   /note="Y -> C (in dbSNP:rs2273660)"
FT                   /id="VAR_033207"
FT   VARIANT         498
FT                   /note="T -> M (in dbSNP:rs34188947)"
FT                   /id="VAR_061905"
FT   VARIANT         525
FT                   /note="R -> H (in dbSNP:rs2273664)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_033208"
FT   VARIANT         586
FT                   /note="R -> H (in dbSNP:rs17012268)"
FT                   /id="VAR_052628"
FT   CONFLICT        563
FT                   /note="V -> A (in Ref. 1; BAA91315)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        627
FT                   /note="E -> G (in Ref. 1; BAB55206)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        756
FT                   /note="S -> P (in Ref. 1; BAB55206)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   843 AA;  96632 MW;  7008E0BC278718C7 CRC64;
     MWTPELAILR GFPTEAERQQ WKQEGVVGSE SGSFLQLLLE GNYEAIFLNS MTQNIFNSTT
     TAEEKIDSYL EKQVVTFLDY STDLDTTERQ QLIFLLGVSS LQLFVQSNWT GPPVDLHPQD
     FLSSVLFQQF SEVKGLDAFV LSLLTLDGES IYSLTSKPIL LLLARIILVN VRHKLTAIQS
     LPWWTLRCVN IHQHLLEERS PLLFTLAENC IDQVMKLQNL FVDDSGRYLA IQFHLECAYV
     FLYYYEYRKA KDQLDIAKDI SQLQIDLTGA LGKRTRFQEN YVAQLILDVR REGDVLSNCE
     FTPAPTPQEH LTKNLELNDD TILNDIKLAD CEQFQMPDLC AEEIAIILGI CTNFQKNNPV
     HTLTEVELLA FTSCLLSQPK FWAIQTSALI LRTKLEKGST RRVERAMRQT QALADQFEDK
     TTSVLERLKI FYCCQVPPHW AIQRQLASLL FELGCTSSAL QIFEKLEMWE DVVICYERAG
     QHGKAEEILR QELEKKETPS LYCLLGDVLG DHSCYDKAWE LSRYRSARAQ RSKALLHLRN
     KEFQECVECF ERSVKINPMQ LGVWFSLGCA YLALEDYQGS AKAFQRCVTL EPDNAEAWNN
     LSTSYIRLKQ KVKAFRTLQE ALKCNYEHWQ IWENYILTST DVGEFSEAIK AYHRLLDLRD
     KYKDVQVLKI LVRAVIDGMT DRSGDVATGL KGKLQELFGR VTSRVTNDGE IWRLYAHVYG
     NGQSEKPDEN EKAFQCLSKA YKCDTQSNCW EKDITSFKEV VQRALGLAHV AIKCSKNKSS
     SQEAVQMLSS VRLNLRGLLS KAKQLFTDVA TGEMSRELAD DITAMDTLVT ELQDLSNQFR
     NQY
//