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Protein

Tetratricopeptide repeat protein 27

Gene

TTC27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 27
Short name:
TPR repeat protein 27
Gene namesi
Name:TTC27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000018699.11
HGNCiHGNC:25986 TTC27
neXtProtiNX_Q6P3X3

Pathology & Biotechi

Organism-specific databases

DisGeNETi55622
OpenTargetsiENSG00000018699
PharmGKBiPA145007326

Polymorphism and mutation databases

BioMutaiTTC27
DMDMi74758258

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002950961 – 843Tetratricopeptide repeat protein 27Add BLAST843

Proteomic databases

EPDiQ6P3X3
MaxQBiQ6P3X3
PaxDbiQ6P3X3
PeptideAtlasiQ6P3X3
PRIDEiQ6P3X3

PTM databases

iPTMnetiQ6P3X3
PhosphoSitePlusiQ6P3X3

Expressioni

Gene expression databases

BgeeiENSG00000018699
CleanExiHS_TTC27
ExpressionAtlasiQ6P3X3 baseline and differential
GenevisibleiQ6P3X3 HS

Organism-specific databases

HPAiHPA031246

Interactioni

Protein-protein interaction databases

BioGridi120761, 40 interactors
IntActiQ6P3X3, 13 interactors
STRINGi9606.ENSP00000313953

Structurei

3D structure databases

ProteinModelPortaliQ6P3X3
SMRiQ6P3X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati453 – 486TPR 1Add BLAST34
Repeati492 – 525TPR 2Add BLAST34
Repeati527 – 560TPR 3Add BLAST34
Repeati561 – 594TPR 4Add BLAST34
Repeati596 – 628TPR 5Add BLAST33
Repeati629 – 662TPR 6Add BLAST34

Sequence similaritiesi

Belongs to the TTC27 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1128 Eukaryota
ENOG410XNXB LUCA
GeneTreeiENSGT00500000044929
HOGENOMiHOG000067764
HOVERGENiHBG103158
InParanoidiQ6P3X3
OMAiLEMWEDA
OrthoDBiEOG091G03MM
PhylomeDBiQ6P3X3
TreeFamiTF105894

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR013105 TPR_2
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF07719 TPR_2, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P3X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTPELAILR GFPTEAERQQ WKQEGVVGSE SGSFLQLLLE GNYEAIFLNS
60 70 80 90 100
MTQNIFNSTT TAEEKIDSYL EKQVVTFLDY STDLDTTERQ QLIFLLGVSS
110 120 130 140 150
LQLFVQSNWT GPPVDLHPQD FLSSVLFQQF SEVKGLDAFV LSLLTLDGES
160 170 180 190 200
IYSLTSKPIL LLLARIILVN VRHKLTAIQS LPWWTLRCVN IHQHLLEERS
210 220 230 240 250
PLLFTLAENC IDQVMKLQNL FVDDSGRYLA IQFHLECAYV FLYYYEYRKA
260 270 280 290 300
KDQLDIAKDI SQLQIDLTGA LGKRTRFQEN YVAQLILDVR REGDVLSNCE
310 320 330 340 350
FTPAPTPQEH LTKNLELNDD TILNDIKLAD CEQFQMPDLC AEEIAIILGI
360 370 380 390 400
CTNFQKNNPV HTLTEVELLA FTSCLLSQPK FWAIQTSALI LRTKLEKGST
410 420 430 440 450
RRVERAMRQT QALADQFEDK TTSVLERLKI FYCCQVPPHW AIQRQLASLL
460 470 480 490 500
FELGCTSSAL QIFEKLEMWE DVVICYERAG QHGKAEEILR QELEKKETPS
510 520 530 540 550
LYCLLGDVLG DHSCYDKAWE LSRYRSARAQ RSKALLHLRN KEFQECVECF
560 570 580 590 600
ERSVKINPMQ LGVWFSLGCA YLALEDYQGS AKAFQRCVTL EPDNAEAWNN
610 620 630 640 650
LSTSYIRLKQ KVKAFRTLQE ALKCNYEHWQ IWENYILTST DVGEFSEAIK
660 670 680 690 700
AYHRLLDLRD KYKDVQVLKI LVRAVIDGMT DRSGDVATGL KGKLQELFGR
710 720 730 740 750
VTSRVTNDGE IWRLYAHVYG NGQSEKPDEN EKAFQCLSKA YKCDTQSNCW
760 770 780 790 800
EKDITSFKEV VQRALGLAHV AIKCSKNKSS SQEAVQMLSS VRLNLRGLLS
810 820 830 840
KAKQLFTDVA TGEMSRELAD DITAMDTLVT ELQDLSNQFR NQY
Length:843
Mass (Da):96,632
Last modified:July 5, 2004 - v1
Checksum:i7008E0BC278718C7
GO

Sequence cautioni

The sequence BAA91048 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91315 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti563V → A in BAA91315 (PubMed:14702039).Curated1
Sequence conflicti627E → G in BAB55206 (PubMed:14702039).Curated1
Sequence conflicti756S → P in BAB55206 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033207476Y → C. Corresponds to variant dbSNP:rs2273660Ensembl.1
Natural variantiVAR_061905498T → M. Corresponds to variant dbSNP:rs34188947Ensembl.1
Natural variantiVAR_033208525R → H1 PublicationCorresponds to variant dbSNP:rs2273664Ensembl.1
Natural variantiVAR_052628586R → H. Corresponds to variant dbSNP:rs17012268Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000279 mRNA Translation: BAA91048.1 Different initiation.
AK000665 mRNA Translation: BAA91315.1 Different initiation.
AK027570 mRNA Translation: BAB55206.1
AL133246 Genomic DNA No translation available.
BC001248 mRNA Translation: AAH01248.2
BC063791 mRNA Translation: AAH63791.1
CCDSiCCDS33176.1
RefSeqiNP_001180438.1, NM_001193509.1
NP_060205.3, NM_017735.4
UniGeneiHs.468125

Genome annotation databases

EnsembliENST00000317907; ENSP00000313953; ENSG00000018699
GeneIDi55622
KEGGihsa:55622
UCSCiuc002rom.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTTC27_HUMAN
AccessioniPrimary (citable) accession number: Q6P3X3
Secondary accession number(s): A6NKJ0
, Q96SS5, Q9BVF1, Q9NWR4, Q9NXG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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