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Q6P3X3

- TTC27_HUMAN

UniProt

Q6P3X3 - TTC27_HUMAN

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Protein

Tetratricopeptide repeat protein 27

Gene

TTC27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 27
Short name:
TPR repeat protein 27
Gene namesi
Name:TTC27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25986. TTC27.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145007326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 843843Tetratricopeptide repeat protein 27PRO_0000295096Add
BLAST

Proteomic databases

MaxQBiQ6P3X3.
PaxDbiQ6P3X3.
PRIDEiQ6P3X3.

PTM databases

PhosphoSiteiQ6P3X3.

Expressioni

Gene expression databases

BgeeiQ6P3X3.
CleanExiHS_TTC27.
ExpressionAtlasiQ6P3X3. baseline and differential.
GenevestigatoriQ6P3X3.

Organism-specific databases

HPAiHPA031246.
HPA055596.

Interactioni

Protein-protein interaction databases

BioGridi120761. 10 interactions.
IntActiQ6P3X3. 3 interactions.
STRINGi9606.ENSP00000313953.

Structurei

3D structure databases

ProteinModelPortaliQ6P3X3.
SMRiQ6P3X3. Positions 467-658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati440 – 46627TPR 1Add
BLAST
Repeati467 – 49933TPR 2Add
BLAST
Repeati527 – 56034TPR 3Add
BLAST
Repeati541 – 57333HAT 1Add
BLAST
Repeati561 – 59434TPR 4Add
BLAST
Repeati596 – 62833TPR 5Add
BLAST
Repeati606 – 63833HAT 2Add
BLAST
Repeati629 – 66234TPR 6Add
BLAST
Repeati689 – 72133HAT 3Add
BLAST
Repeati731 – 76737TPR 7Add
BLAST

Sequence similaritiesi

Belongs to the TTC27 family.Curated
Contains 3 HAT repeats.Curated
Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00500000044929.
HOGENOMiHOG000067764.
HOVERGENiHBG103158.
InParanoidiQ6P3X3.
OMAiQIWENYL.
OrthoDBiEOG725DGZ.
PhylomeDBiQ6P3X3.
TreeFamiTF105894.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P3X3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWTPELAILR GFPTEAERQQ WKQEGVVGSE SGSFLQLLLE GNYEAIFLNS
60 70 80 90 100
MTQNIFNSTT TAEEKIDSYL EKQVVTFLDY STDLDTTERQ QLIFLLGVSS
110 120 130 140 150
LQLFVQSNWT GPPVDLHPQD FLSSVLFQQF SEVKGLDAFV LSLLTLDGES
160 170 180 190 200
IYSLTSKPIL LLLARIILVN VRHKLTAIQS LPWWTLRCVN IHQHLLEERS
210 220 230 240 250
PLLFTLAENC IDQVMKLQNL FVDDSGRYLA IQFHLECAYV FLYYYEYRKA
260 270 280 290 300
KDQLDIAKDI SQLQIDLTGA LGKRTRFQEN YVAQLILDVR REGDVLSNCE
310 320 330 340 350
FTPAPTPQEH LTKNLELNDD TILNDIKLAD CEQFQMPDLC AEEIAIILGI
360 370 380 390 400
CTNFQKNNPV HTLTEVELLA FTSCLLSQPK FWAIQTSALI LRTKLEKGST
410 420 430 440 450
RRVERAMRQT QALADQFEDK TTSVLERLKI FYCCQVPPHW AIQRQLASLL
460 470 480 490 500
FELGCTSSAL QIFEKLEMWE DVVICYERAG QHGKAEEILR QELEKKETPS
510 520 530 540 550
LYCLLGDVLG DHSCYDKAWE LSRYRSARAQ RSKALLHLRN KEFQECVECF
560 570 580 590 600
ERSVKINPMQ LGVWFSLGCA YLALEDYQGS AKAFQRCVTL EPDNAEAWNN
610 620 630 640 650
LSTSYIRLKQ KVKAFRTLQE ALKCNYEHWQ IWENYILTST DVGEFSEAIK
660 670 680 690 700
AYHRLLDLRD KYKDVQVLKI LVRAVIDGMT DRSGDVATGL KGKLQELFGR
710 720 730 740 750
VTSRVTNDGE IWRLYAHVYG NGQSEKPDEN EKAFQCLSKA YKCDTQSNCW
760 770 780 790 800
EKDITSFKEV VQRALGLAHV AIKCSKNKSS SQEAVQMLSS VRLNLRGLLS
810 820 830 840
KAKQLFTDVA TGEMSRELAD DITAMDTLVT ELQDLSNQFR NQY
Length:843
Mass (Da):96,632
Last modified:July 5, 2004 - v1
Checksum:i7008E0BC278718C7
GO

Sequence cautioni

The sequence BAA91048.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91315.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti563 – 5631V → A in BAA91315. (PubMed:14702039)Curated
Sequence conflicti627 – 6271E → G in BAB55206. (PubMed:14702039)Curated
Sequence conflicti756 – 7561S → P in BAB55206. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti476 – 4761Y → C.
Corresponds to variant rs2273660 [ dbSNP | Ensembl ].
VAR_033207
Natural varianti498 – 4981T → M.
Corresponds to variant rs34188947 [ dbSNP | Ensembl ].
VAR_061905
Natural varianti525 – 5251R → H.1 Publication
Corresponds to variant rs2273664 [ dbSNP | Ensembl ].
VAR_033208
Natural varianti586 – 5861R → H.
Corresponds to variant rs17012268 [ dbSNP | Ensembl ].
VAR_052628

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000279 mRNA. Translation: BAA91048.1. Different initiation.
AK000665 mRNA. Translation: BAA91315.1. Different initiation.
AK027570 mRNA. Translation: BAB55206.1.
AL133246 Genomic DNA. No translation available.
BC001248 mRNA. Translation: AAH01248.2.
BC063791 mRNA. Translation: AAH63791.1.
CCDSiCCDS33176.1.
RefSeqiNP_001180438.1. NM_001193509.1.
NP_060205.3. NM_017735.4.
UniGeneiHs.468125.

Genome annotation databases

EnsembliENST00000317907; ENSP00000313953; ENSG00000018699.
GeneIDi55622.
KEGGihsa:55622.
UCSCiuc002rom.3. human.

Polymorphism databases

DMDMi74758258.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000279 mRNA. Translation: BAA91048.1 . Different initiation.
AK000665 mRNA. Translation: BAA91315.1 . Different initiation.
AK027570 mRNA. Translation: BAB55206.1 .
AL133246 Genomic DNA. No translation available.
BC001248 mRNA. Translation: AAH01248.2 .
BC063791 mRNA. Translation: AAH63791.1 .
CCDSi CCDS33176.1.
RefSeqi NP_001180438.1. NM_001193509.1.
NP_060205.3. NM_017735.4.
UniGenei Hs.468125.

3D structure databases

ProteinModelPortali Q6P3X3.
SMRi Q6P3X3. Positions 467-658.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120761. 10 interactions.
IntActi Q6P3X3. 3 interactions.
STRINGi 9606.ENSP00000313953.

PTM databases

PhosphoSitei Q6P3X3.

Polymorphism databases

DMDMi 74758258.

Proteomic databases

MaxQBi Q6P3X3.
PaxDbi Q6P3X3.
PRIDEi Q6P3X3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317907 ; ENSP00000313953 ; ENSG00000018699 .
GeneIDi 55622.
KEGGi hsa:55622.
UCSCi uc002rom.3. human.

Organism-specific databases

CTDi 55622.
GeneCardsi GC02P032853.
HGNCi HGNC:25986. TTC27.
HPAi HPA031246.
HPA055596.
neXtProti NX_Q6P3X3.
PharmGKBi PA145007326.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0457.
GeneTreei ENSGT00500000044929.
HOGENOMi HOG000067764.
HOVERGENi HBG103158.
InParanoidi Q6P3X3.
OMAi QIWENYL.
OrthoDBi EOG725DGZ.
PhylomeDBi Q6P3X3.
TreeFami TF105894.

Miscellaneous databases

GenomeRNAii 55622.
NextBioi 60232.
PROi Q6P3X3.

Gene expression databases

Bgeei Q6P3X3.
CleanExi HS_TTC27.
ExpressionAtlasi Q6P3X3. baseline and differential.
Genevestigatori Q6P3X3.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF00515. TPR_1. 1 hit.
[Graphical view ]
SMARTi SM00028. TPR. 4 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-525.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix and Uterus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTC27_HUMAN
AccessioniPrimary (citable) accession number: Q6P3X3
Secondary accession number(s): A6NKJ0
, Q96SS5, Q9BVF1, Q9NWR4, Q9NXG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3