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Q6P3X3

- TTC27_HUMAN

UniProt

Q6P3X3 - TTC27_HUMAN

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Protein
Tetratricopeptide repeat protein 27
Gene
TTC27
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 27
Short name:
TPR repeat protein 27
Gene namesi
Name:TTC27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25986. TTC27.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145007326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 843843Tetratricopeptide repeat protein 27
PRO_0000295096Add
BLAST

Proteomic databases

MaxQBiQ6P3X3.
PaxDbiQ6P3X3.
PRIDEiQ6P3X3.

PTM databases

PhosphoSiteiQ6P3X3.

Expressioni

Gene expression databases

ArrayExpressiQ6P3X3.
BgeeiQ6P3X3.
CleanExiHS_TTC27.
GenevestigatoriQ6P3X3.

Organism-specific databases

HPAiHPA031246.
HPA055596.

Interactioni

Protein-protein interaction databases

BioGridi120761. 10 interactions.
IntActiQ6P3X3. 3 interactions.
STRINGi9606.ENSP00000313953.

Structurei

3D structure databases

ProteinModelPortaliQ6P3X3.
SMRiQ6P3X3. Positions 467-658.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati440 – 46627TPR 1
Add
BLAST
Repeati467 – 49933TPR 2
Add
BLAST
Repeati527 – 56034TPR 3
Add
BLAST
Repeati541 – 57333HAT 1
Add
BLAST
Repeati561 – 59434TPR 4
Add
BLAST
Repeati596 – 62833TPR 5
Add
BLAST
Repeati606 – 63833HAT 2
Add
BLAST
Repeati629 – 66234TPR 6
Add
BLAST
Repeati689 – 72133HAT 3
Add
BLAST
Repeati731 – 76737TPR 7
Add
BLAST

Sequence similaritiesi

Belongs to the TTC27 family.
Contains 3 HAT repeats.
Contains 7 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
HOGENOMiHOG000067764.
HOVERGENiHBG103158.
InParanoidiQ6P3X3.
OMAiQIWENYL.
OrthoDBiEOG725DGZ.
PhylomeDBiQ6P3X3.
TreeFamiTF105894.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P3X3-1 [UniParc]FASTAAdd to Basket

« Hide

MWTPELAILR GFPTEAERQQ WKQEGVVGSE SGSFLQLLLE GNYEAIFLNS    50
MTQNIFNSTT TAEEKIDSYL EKQVVTFLDY STDLDTTERQ QLIFLLGVSS 100
LQLFVQSNWT GPPVDLHPQD FLSSVLFQQF SEVKGLDAFV LSLLTLDGES 150
IYSLTSKPIL LLLARIILVN VRHKLTAIQS LPWWTLRCVN IHQHLLEERS 200
PLLFTLAENC IDQVMKLQNL FVDDSGRYLA IQFHLECAYV FLYYYEYRKA 250
KDQLDIAKDI SQLQIDLTGA LGKRTRFQEN YVAQLILDVR REGDVLSNCE 300
FTPAPTPQEH LTKNLELNDD TILNDIKLAD CEQFQMPDLC AEEIAIILGI 350
CTNFQKNNPV HTLTEVELLA FTSCLLSQPK FWAIQTSALI LRTKLEKGST 400
RRVERAMRQT QALADQFEDK TTSVLERLKI FYCCQVPPHW AIQRQLASLL 450
FELGCTSSAL QIFEKLEMWE DVVICYERAG QHGKAEEILR QELEKKETPS 500
LYCLLGDVLG DHSCYDKAWE LSRYRSARAQ RSKALLHLRN KEFQECVECF 550
ERSVKINPMQ LGVWFSLGCA YLALEDYQGS AKAFQRCVTL EPDNAEAWNN 600
LSTSYIRLKQ KVKAFRTLQE ALKCNYEHWQ IWENYILTST DVGEFSEAIK 650
AYHRLLDLRD KYKDVQVLKI LVRAVIDGMT DRSGDVATGL KGKLQELFGR 700
VTSRVTNDGE IWRLYAHVYG NGQSEKPDEN EKAFQCLSKA YKCDTQSNCW 750
EKDITSFKEV VQRALGLAHV AIKCSKNKSS SQEAVQMLSS VRLNLRGLLS 800
KAKQLFTDVA TGEMSRELAD DITAMDTLVT ELQDLSNQFR NQY 843
Length:843
Mass (Da):96,632
Last modified:July 5, 2004 - v1
Checksum:i7008E0BC278718C7
GO

Sequence cautioni

The sequence BAA91048.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA91315.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti476 – 4761Y → C.
Corresponds to variant rs2273660 [ dbSNP | Ensembl ].
VAR_033207
Natural varianti498 – 4981T → M.
Corresponds to variant rs34188947 [ dbSNP | Ensembl ].
VAR_061905
Natural varianti525 – 5251R → H.1 Publication
Corresponds to variant rs2273664 [ dbSNP | Ensembl ].
VAR_033208
Natural varianti586 – 5861R → H.
Corresponds to variant rs17012268 [ dbSNP | Ensembl ].
VAR_052628

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti563 – 5631V → A in BAA91315. 1 Publication
Sequence conflicti627 – 6271E → G in BAB55206. 1 Publication
Sequence conflicti756 – 7561S → P in BAB55206. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000279 mRNA. Translation: BAA91048.1. Different initiation.
AK000665 mRNA. Translation: BAA91315.1. Different initiation.
AK027570 mRNA. Translation: BAB55206.1.
AL133246 Genomic DNA. No translation available.
BC001248 mRNA. Translation: AAH01248.2.
BC063791 mRNA. Translation: AAH63791.1.
CCDSiCCDS33176.1.
RefSeqiNP_001180438.1. NM_001193509.1.
NP_060205.3. NM_017735.4.
UniGeneiHs.468125.

Genome annotation databases

EnsembliENST00000317907; ENSP00000313953; ENSG00000018699.
GeneIDi55622.
KEGGihsa:55622.
UCSCiuc002rom.3. human.

Polymorphism databases

DMDMi74758258.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000279 mRNA. Translation: BAA91048.1 . Different initiation.
AK000665 mRNA. Translation: BAA91315.1 . Different initiation.
AK027570 mRNA. Translation: BAB55206.1 .
AL133246 Genomic DNA. No translation available.
BC001248 mRNA. Translation: AAH01248.2 .
BC063791 mRNA. Translation: AAH63791.1 .
CCDSi CCDS33176.1.
RefSeqi NP_001180438.1. NM_001193509.1.
NP_060205.3. NM_017735.4.
UniGenei Hs.468125.

3D structure databases

ProteinModelPortali Q6P3X3.
SMRi Q6P3X3. Positions 467-658.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120761. 10 interactions.
IntActi Q6P3X3. 3 interactions.
STRINGi 9606.ENSP00000313953.

PTM databases

PhosphoSitei Q6P3X3.

Polymorphism databases

DMDMi 74758258.

Proteomic databases

MaxQBi Q6P3X3.
PaxDbi Q6P3X3.
PRIDEi Q6P3X3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317907 ; ENSP00000313953 ; ENSG00000018699 .
GeneIDi 55622.
KEGGi hsa:55622.
UCSCi uc002rom.3. human.

Organism-specific databases

CTDi 55622.
GeneCardsi GC02P032853.
HGNCi HGNC:25986. TTC27.
HPAi HPA031246.
HPA055596.
neXtProti NX_Q6P3X3.
PharmGKBi PA145007326.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0457.
HOGENOMi HOG000067764.
HOVERGENi HBG103158.
InParanoidi Q6P3X3.
OMAi QIWENYL.
OrthoDBi EOG725DGZ.
PhylomeDBi Q6P3X3.
TreeFami TF105894.

Miscellaneous databases

GenomeRNAii 55622.
NextBioi 60232.
PROi Q6P3X3.

Gene expression databases

ArrayExpressi Q6P3X3.
Bgeei Q6P3X3.
CleanExi HS_TTC27.
Genevestigatori Q6P3X3.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF00515. TPR_1. 1 hit.
[Graphical view ]
SMARTi SM00028. TPR. 4 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-525.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix and Uterus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTC27_HUMAN
AccessioniPrimary (citable) accession number: Q6P3X3
Secondary accession number(s): A6NKJ0
, Q96SS5, Q9BVF1, Q9NWR4, Q9NXG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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