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Protein

Tetratricopeptide repeat protein 27

Gene

TTC27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 27
Short name:
TPR repeat protein 27
Gene namesi
Name:TTC27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25986. TTC27.

Pathology & Biotechi

Organism-specific databases

DisGeNETi55622.
OpenTargetsiENSG00000018699.
PharmGKBiPA145007326.

Polymorphism and mutation databases

BioMutaiTTC27.
DMDMi74758258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002950961 – 843Tetratricopeptide repeat protein 27Add BLAST843

Proteomic databases

EPDiQ6P3X3.
MaxQBiQ6P3X3.
PaxDbiQ6P3X3.
PeptideAtlasiQ6P3X3.
PRIDEiQ6P3X3.

PTM databases

iPTMnetiQ6P3X3.
PhosphoSitePlusiQ6P3X3.

Expressioni

Gene expression databases

BgeeiENSG00000018699.
CleanExiHS_TTC27.
ExpressionAtlasiQ6P3X3. baseline and differential.
GenevisibleiQ6P3X3. HS.

Organism-specific databases

HPAiHPA031246.
HPA055596.

Interactioni

Protein-protein interaction databases

BioGridi120761. 25 interactors.
IntActiQ6P3X3. 3 interactors.
STRINGi9606.ENSP00000313953.

Structurei

3D structure databases

ProteinModelPortaliQ6P3X3.
SMRiQ6P3X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati453 – 486TPR 1Add BLAST34
Repeati492 – 525TPR 2Add BLAST34
Repeati527 – 560TPR 3Add BLAST34
Repeati561 – 594TPR 4Add BLAST34
Repeati596 – 628TPR 5Add BLAST33
Repeati629 – 662TPR 6Add BLAST34

Sequence similaritiesi

Belongs to the TTC27 family.Curated
Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1128. Eukaryota.
ENOG410XNXB. LUCA.
GeneTreeiENSGT00500000044929.
HOGENOMiHOG000067764.
HOVERGENiHBG103158.
InParanoidiQ6P3X3.
OMAiWENYLLT.
OrthoDBiEOG091G03MM.
PhylomeDBiQ6P3X3.
TreeFamiTF105894.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P3X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTPELAILR GFPTEAERQQ WKQEGVVGSE SGSFLQLLLE GNYEAIFLNS
60 70 80 90 100
MTQNIFNSTT TAEEKIDSYL EKQVVTFLDY STDLDTTERQ QLIFLLGVSS
110 120 130 140 150
LQLFVQSNWT GPPVDLHPQD FLSSVLFQQF SEVKGLDAFV LSLLTLDGES
160 170 180 190 200
IYSLTSKPIL LLLARIILVN VRHKLTAIQS LPWWTLRCVN IHQHLLEERS
210 220 230 240 250
PLLFTLAENC IDQVMKLQNL FVDDSGRYLA IQFHLECAYV FLYYYEYRKA
260 270 280 290 300
KDQLDIAKDI SQLQIDLTGA LGKRTRFQEN YVAQLILDVR REGDVLSNCE
310 320 330 340 350
FTPAPTPQEH LTKNLELNDD TILNDIKLAD CEQFQMPDLC AEEIAIILGI
360 370 380 390 400
CTNFQKNNPV HTLTEVELLA FTSCLLSQPK FWAIQTSALI LRTKLEKGST
410 420 430 440 450
RRVERAMRQT QALADQFEDK TTSVLERLKI FYCCQVPPHW AIQRQLASLL
460 470 480 490 500
FELGCTSSAL QIFEKLEMWE DVVICYERAG QHGKAEEILR QELEKKETPS
510 520 530 540 550
LYCLLGDVLG DHSCYDKAWE LSRYRSARAQ RSKALLHLRN KEFQECVECF
560 570 580 590 600
ERSVKINPMQ LGVWFSLGCA YLALEDYQGS AKAFQRCVTL EPDNAEAWNN
610 620 630 640 650
LSTSYIRLKQ KVKAFRTLQE ALKCNYEHWQ IWENYILTST DVGEFSEAIK
660 670 680 690 700
AYHRLLDLRD KYKDVQVLKI LVRAVIDGMT DRSGDVATGL KGKLQELFGR
710 720 730 740 750
VTSRVTNDGE IWRLYAHVYG NGQSEKPDEN EKAFQCLSKA YKCDTQSNCW
760 770 780 790 800
EKDITSFKEV VQRALGLAHV AIKCSKNKSS SQEAVQMLSS VRLNLRGLLS
810 820 830 840
KAKQLFTDVA TGEMSRELAD DITAMDTLVT ELQDLSNQFR NQY
Length:843
Mass (Da):96,632
Last modified:July 5, 2004 - v1
Checksum:i7008E0BC278718C7
GO

Sequence cautioni

The sequence BAA91048 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91315 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti563V → A in BAA91315 (PubMed:14702039).Curated1
Sequence conflicti627E → G in BAB55206 (PubMed:14702039).Curated1
Sequence conflicti756S → P in BAB55206 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033207476Y → C.Corresponds to variant rs2273660dbSNPEnsembl.1
Natural variantiVAR_061905498T → M.Corresponds to variant rs34188947dbSNPEnsembl.1
Natural variantiVAR_033208525R → H.1 PublicationCorresponds to variant rs2273664dbSNPEnsembl.1
Natural variantiVAR_052628586R → H.Corresponds to variant rs17012268dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000279 mRNA. Translation: BAA91048.1. Different initiation.
AK000665 mRNA. Translation: BAA91315.1. Different initiation.
AK027570 mRNA. Translation: BAB55206.1.
AL133246 Genomic DNA. No translation available.
BC001248 mRNA. Translation: AAH01248.2.
BC063791 mRNA. Translation: AAH63791.1.
CCDSiCCDS33176.1.
RefSeqiNP_001180438.1. NM_001193509.1.
NP_060205.3. NM_017735.4.
UniGeneiHs.468125.

Genome annotation databases

EnsembliENST00000317907; ENSP00000313953; ENSG00000018699.
GeneIDi55622.
KEGGihsa:55622.
UCSCiuc002rom.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000279 mRNA. Translation: BAA91048.1. Different initiation.
AK000665 mRNA. Translation: BAA91315.1. Different initiation.
AK027570 mRNA. Translation: BAB55206.1.
AL133246 Genomic DNA. No translation available.
BC001248 mRNA. Translation: AAH01248.2.
BC063791 mRNA. Translation: AAH63791.1.
CCDSiCCDS33176.1.
RefSeqiNP_001180438.1. NM_001193509.1.
NP_060205.3. NM_017735.4.
UniGeneiHs.468125.

3D structure databases

ProteinModelPortaliQ6P3X3.
SMRiQ6P3X3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120761. 25 interactors.
IntActiQ6P3X3. 3 interactors.
STRINGi9606.ENSP00000313953.

PTM databases

iPTMnetiQ6P3X3.
PhosphoSitePlusiQ6P3X3.

Polymorphism and mutation databases

BioMutaiTTC27.
DMDMi74758258.

Proteomic databases

EPDiQ6P3X3.
MaxQBiQ6P3X3.
PaxDbiQ6P3X3.
PeptideAtlasiQ6P3X3.
PRIDEiQ6P3X3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317907; ENSP00000313953; ENSG00000018699.
GeneIDi55622.
KEGGihsa:55622.
UCSCiuc002rom.4. human.

Organism-specific databases

CTDi55622.
DisGeNETi55622.
GeneCardsiTTC27.
HGNCiHGNC:25986. TTC27.
HPAiHPA031246.
HPA055596.
neXtProtiNX_Q6P3X3.
OpenTargetsiENSG00000018699.
PharmGKBiPA145007326.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1128. Eukaryota.
ENOG410XNXB. LUCA.
GeneTreeiENSGT00500000044929.
HOGENOMiHOG000067764.
HOVERGENiHBG103158.
InParanoidiQ6P3X3.
OMAiWENYLLT.
OrthoDBiEOG091G03MM.
PhylomeDBiQ6P3X3.
TreeFamiTF105894.

Miscellaneous databases

GenomeRNAii55622.
PROiQ6P3X3.

Gene expression databases

BgeeiENSG00000018699.
CleanExiHS_TTC27.
ExpressionAtlasiQ6P3X3. baseline and differential.
GenevisibleiQ6P3X3. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC27_HUMAN
AccessioniPrimary (citable) accession number: Q6P3X3
Secondary accession number(s): A6NKJ0
, Q96SS5, Q9BVF1, Q9NWR4, Q9NXG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.