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Q6P3X3

- TTC27_HUMAN

UniProt

Q6P3X3 - TTC27_HUMAN

Protein

Tetratricopeptide repeat protein 27

Gene

TTC27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetratricopeptide repeat protein 27
    Short name:
    TPR repeat protein 27
    Gene namesi
    Name:TTC27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25986. TTC27.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145007326.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 843843Tetratricopeptide repeat protein 27PRO_0000295096Add
    BLAST

    Proteomic databases

    MaxQBiQ6P3X3.
    PaxDbiQ6P3X3.
    PRIDEiQ6P3X3.

    PTM databases

    PhosphoSiteiQ6P3X3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P3X3.
    BgeeiQ6P3X3.
    CleanExiHS_TTC27.
    GenevestigatoriQ6P3X3.

    Organism-specific databases

    HPAiHPA031246.
    HPA055596.

    Interactioni

    Protein-protein interaction databases

    BioGridi120761. 10 interactions.
    IntActiQ6P3X3. 3 interactions.
    STRINGi9606.ENSP00000313953.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P3X3.
    SMRiQ6P3X3. Positions 467-658.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati440 – 46627TPR 1Add
    BLAST
    Repeati467 – 49933TPR 2Add
    BLAST
    Repeati527 – 56034TPR 3Add
    BLAST
    Repeati541 – 57333HAT 1Add
    BLAST
    Repeati561 – 59434TPR 4Add
    BLAST
    Repeati596 – 62833TPR 5Add
    BLAST
    Repeati606 – 63833HAT 2Add
    BLAST
    Repeati629 – 66234TPR 6Add
    BLAST
    Repeati689 – 72133HAT 3Add
    BLAST
    Repeati731 – 76737TPR 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the TTC27 family.Curated
    Contains 3 HAT repeats.Curated
    Contains 7 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000067764.
    HOVERGENiHBG103158.
    InParanoidiQ6P3X3.
    OMAiQIWENYL.
    OrthoDBiEOG725DGZ.
    PhylomeDBiQ6P3X3.
    TreeFamiTF105894.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF00515. TPR_1. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 4 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 4 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P3X3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWTPELAILR GFPTEAERQQ WKQEGVVGSE SGSFLQLLLE GNYEAIFLNS    50
    MTQNIFNSTT TAEEKIDSYL EKQVVTFLDY STDLDTTERQ QLIFLLGVSS 100
    LQLFVQSNWT GPPVDLHPQD FLSSVLFQQF SEVKGLDAFV LSLLTLDGES 150
    IYSLTSKPIL LLLARIILVN VRHKLTAIQS LPWWTLRCVN IHQHLLEERS 200
    PLLFTLAENC IDQVMKLQNL FVDDSGRYLA IQFHLECAYV FLYYYEYRKA 250
    KDQLDIAKDI SQLQIDLTGA LGKRTRFQEN YVAQLILDVR REGDVLSNCE 300
    FTPAPTPQEH LTKNLELNDD TILNDIKLAD CEQFQMPDLC AEEIAIILGI 350
    CTNFQKNNPV HTLTEVELLA FTSCLLSQPK FWAIQTSALI LRTKLEKGST 400
    RRVERAMRQT QALADQFEDK TTSVLERLKI FYCCQVPPHW AIQRQLASLL 450
    FELGCTSSAL QIFEKLEMWE DVVICYERAG QHGKAEEILR QELEKKETPS 500
    LYCLLGDVLG DHSCYDKAWE LSRYRSARAQ RSKALLHLRN KEFQECVECF 550
    ERSVKINPMQ LGVWFSLGCA YLALEDYQGS AKAFQRCVTL EPDNAEAWNN 600
    LSTSYIRLKQ KVKAFRTLQE ALKCNYEHWQ IWENYILTST DVGEFSEAIK 650
    AYHRLLDLRD KYKDVQVLKI LVRAVIDGMT DRSGDVATGL KGKLQELFGR 700
    VTSRVTNDGE IWRLYAHVYG NGQSEKPDEN EKAFQCLSKA YKCDTQSNCW 750
    EKDITSFKEV VQRALGLAHV AIKCSKNKSS SQEAVQMLSS VRLNLRGLLS 800
    KAKQLFTDVA TGEMSRELAD DITAMDTLVT ELQDLSNQFR NQY 843
    Length:843
    Mass (Da):96,632
    Last modified:July 5, 2004 - v1
    Checksum:i7008E0BC278718C7
    GO

    Sequence cautioni

    The sequence BAA91048.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA91315.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti563 – 5631V → A in BAA91315. (PubMed:14702039)Curated
    Sequence conflicti627 – 6271E → G in BAB55206. (PubMed:14702039)Curated
    Sequence conflicti756 – 7561S → P in BAB55206. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti476 – 4761Y → C.
    Corresponds to variant rs2273660 [ dbSNP | Ensembl ].
    VAR_033207
    Natural varianti498 – 4981T → M.
    Corresponds to variant rs34188947 [ dbSNP | Ensembl ].
    VAR_061905
    Natural varianti525 – 5251R → H.1 Publication
    Corresponds to variant rs2273664 [ dbSNP | Ensembl ].
    VAR_033208
    Natural varianti586 – 5861R → H.
    Corresponds to variant rs17012268 [ dbSNP | Ensembl ].
    VAR_052628

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000279 mRNA. Translation: BAA91048.1. Different initiation.
    AK000665 mRNA. Translation: BAA91315.1. Different initiation.
    AK027570 mRNA. Translation: BAB55206.1.
    AL133246 Genomic DNA. No translation available.
    BC001248 mRNA. Translation: AAH01248.2.
    BC063791 mRNA. Translation: AAH63791.1.
    CCDSiCCDS33176.1.
    RefSeqiNP_001180438.1. NM_001193509.1.
    NP_060205.3. NM_017735.4.
    UniGeneiHs.468125.

    Genome annotation databases

    EnsembliENST00000317907; ENSP00000313953; ENSG00000018699.
    GeneIDi55622.
    KEGGihsa:55622.
    UCSCiuc002rom.3. human.

    Polymorphism databases

    DMDMi74758258.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000279 mRNA. Translation: BAA91048.1 . Different initiation.
    AK000665 mRNA. Translation: BAA91315.1 . Different initiation.
    AK027570 mRNA. Translation: BAB55206.1 .
    AL133246 Genomic DNA. No translation available.
    BC001248 mRNA. Translation: AAH01248.2 .
    BC063791 mRNA. Translation: AAH63791.1 .
    CCDSi CCDS33176.1.
    RefSeqi NP_001180438.1. NM_001193509.1.
    NP_060205.3. NM_017735.4.
    UniGenei Hs.468125.

    3D structure databases

    ProteinModelPortali Q6P3X3.
    SMRi Q6P3X3. Positions 467-658.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120761. 10 interactions.
    IntActi Q6P3X3. 3 interactions.
    STRINGi 9606.ENSP00000313953.

    PTM databases

    PhosphoSitei Q6P3X3.

    Polymorphism databases

    DMDMi 74758258.

    Proteomic databases

    MaxQBi Q6P3X3.
    PaxDbi Q6P3X3.
    PRIDEi Q6P3X3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317907 ; ENSP00000313953 ; ENSG00000018699 .
    GeneIDi 55622.
    KEGGi hsa:55622.
    UCSCi uc002rom.3. human.

    Organism-specific databases

    CTDi 55622.
    GeneCardsi GC02P032853.
    HGNCi HGNC:25986. TTC27.
    HPAi HPA031246.
    HPA055596.
    neXtProti NX_Q6P3X3.
    PharmGKBi PA145007326.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000067764.
    HOVERGENi HBG103158.
    InParanoidi Q6P3X3.
    OMAi QIWENYL.
    OrthoDBi EOG725DGZ.
    PhylomeDBi Q6P3X3.
    TreeFami TF105894.

    Miscellaneous databases

    GenomeRNAii 55622.
    NextBioi 60232.
    PROi Q6P3X3.

    Gene expression databases

    ArrayExpressi Q6P3X3.
    Bgeei Q6P3X3.
    CleanExi HS_TTC27.
    Genevestigatori Q6P3X3.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF00515. TPR_1. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 4 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 4 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-525.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix and Uterus.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTTC27_HUMAN
    AccessioniPrimary (citable) accession number: Q6P3X3
    Secondary accession number(s): A6NKJ0
    , Q96SS5, Q9BVF1, Q9NWR4, Q9NXG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3