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Protein

SCY1-like protein 2

Gene

SCYL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.2 Publications

GO - Molecular functioni

  • ATP binding Source: InterPro
  • protein kinase activity Source: InterPro
  • receptor binding Source: BHF-UCL

GO - Biological processi

  • endosome to lysosome transport Source: BHF-UCL
  • negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • positive regulation of clathrin-dependent endocytosis Source: BHF-UCL
  • positive regulation of receptor internalization Source: BHF-UCL
  • receptor internalization involved in canonical Wnt signaling pathway Source: BHF-UCL

Enzyme and pathway databases

SignaLinkiQ6P3W7

Names & Taxonomyi

Protein namesi
Recommended name:
SCY1-like protein 2
Alternative name(s):
Coated vesicle-associated kinase of 104 kDa
Gene namesi
Name:SCYL2
Synonyms:CVAK104, KIAA1360
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000136021.18
HGNCiHGNC:19286 SCYL2
MIMi616365 gene
neXtProtiNX_Q6P3W7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136021
PharmGKBiPA134887807

Polymorphism and mutation databases

BioMutaiSCYL2
DMDMi74762350

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524461 – 929SCY1-like protein 2Add BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei677PhosphoserineCombined sources1
Modified residuei708PhosphothreonineCombined sources1

Post-translational modificationi

According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P3W7
MaxQBiQ6P3W7
PaxDbiQ6P3W7
PeptideAtlasiQ6P3W7
PRIDEiQ6P3W7

PTM databases

iPTMnetiQ6P3W7
PhosphoSitePlusiQ6P3W7

Expressioni

Gene expression databases

BgeeiENSG00000136021
CleanExiHS_SCYL2
ExpressionAtlasiQ6P3W7 baseline and differential
GenevisibleiQ6P3W7 HS

Organism-specific databases

HPAiHPA021050

Interactioni

Subunit structurei

Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi120810, 50 interactors
CORUMiQ6P3W7
IntActiQ6P3W7, 30 interactors
MINTiQ6P3W7
STRINGi9606.ENSP00000354061

Structurei

3D structure databases

ProteinModelPortaliQ6P3W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 327Protein kinasePROSITE-ProRule annotationAdd BLAST296
Repeati443 – 479HEATAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni699 – 929Necessary for interaction with AP2 complex and clathrin, interaction with clathrin is necessary for its targeting to the TGN and endosomal membranesAdd BLAST231

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili661 – 701Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2137 Eukaryota
ENOG410XQ9T LUCA
GeneTreeiENSGT00880000138031
HOVERGENiHBG055627
InParanoidiQ6P3W7
KOiK17541
OrthoDBiEOG091G01WY
PhylomeDBiQ6P3W7
TreeFamiTF314178

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P3W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESMLNKLKS TVTKVTADVT SAVMGNPVTR EFDVGRHIAS GGNGLAWKIF
60 70 80 90 100
NGTKKSTKQE VAVFVFDKKL IDKYQKFEKD QIIDSLKRGV QQLTRLRHPR
110 120 130 140 150
LLTVQHPLEE SRDCLAFCTE PVFASLANVL GNWENLPSPI SPDIKDYKLY
160 170 180 190 200
DVETKYGLLQ VSEGLSFLHS SVKMVHGNIT PENIILNKSG AWKIMGFDFC
210 220 230 240 250
VSSTNPSEQE PKFPCKEWDP NLPSLCLPNP EYLAPEYILS VSCETASDMY
260 270 280 290 300
SLGTVMYAVF NKGKPIFEVN KQDIYKSFSR QLDQLSRLGS SSLTNIPEEV
310 320 330 340 350
REHVKLLLNV TPTVRPDADQ MTKIPFFDDV GAVTLQYFDT LFQRDNLQKS
360 370 380 390 400
QFFKGLPKVL PKLPKRVIVQ RILPCLTSEF VNPDMVPFVL PNVLLIAEEC
410 420 430 440 450
TKEEYVKLIL PELGPVFKQQ EPIQILLIFL QKMDLLLTKT PPDEIKNSVL
460 470 480 490 500
PMVYRALEAP SIQIQELCLN IIPTFANLID YPSMKNALIP RIKNACLQTS
510 520 530 540 550
SLAVRVNSLV CLGKILEYLD KWFVLDDILP FLQQIPSKEP AVLMGILGIY
560 570 580 590 600
KCTFTHKKLG ITKEQLAGKV LPHLIPLSIE NNLNLNQFNS FISVIKEMLN
610 620 630 640 650
RLESEHKTKL EQLHIMQEQQ KSLDIGNQMN VSEEMKVTNI GNQQIDKVFN
660 670 680 690 700
NIGADLLTGS ESENKEDGLQ NKHKRASLTL EEKQKLAKEQ EQAQKLKSQQ
710 720 730 740 750
PLKPQVHTPV ATVKQTKDLT DTLMDNMSSL TSLSVSTPKS SASSTFTSVP
760 770 780 790 800
SMGIGMMFST PTDNTKRNLT NGLNANMGFQ TSGFNMPVNT NQNFYSSPST
810 820 830 840 850
VGVTKMTLGT PPTLPNFNAL SVPPAGAKQT QQRPTDMSAL NNLFGPQKPK
860 870 880 890 900
VSMNQLSQQK PNQWLNQFVP PQGSPTMGSS VMGTQMNVIG QSAFGMQGNP
910 920
FFNPQNFAQP PTTMTNSSSA SNDLKDLFG
Length:929
Mass (Da):103,709
Last modified:July 5, 2004 - v1
Checksum:i980B481BF7044628
GO

Sequence cautioni

The sequence BAA91778 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14869 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55194 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139 – 145PISPDIK → LMSGDIG in BAA92598 (PubMed:10718198).Curated7
Sequence conflicti186L → S in BAB14869 (PubMed:14702039).Curated1
Sequence conflicti424Q → QASNM in BAA92598 (PubMed:10718198).Curated1
Sequence conflicti439K → R in BAB14869 (PubMed:14702039).Curated1
Sequence conflicti554F → L in AAH12387 (PubMed:15489334).Curated1
Sequence conflicti628Q → R in BAB14869 (PubMed:14702039).Curated1
Sequence conflicti638T → I in AAH12387 (PubMed:15489334).Curated1
Sequence conflicti747T → A in BAA91778 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041368357P → L2 PublicationsCorresponds to variant dbSNP:rs33968174Ensembl.1
Natural variantiVAR_041369720T → S1 PublicationCorresponds to variant dbSNP:rs763873645Ensembl.1
Natural variantiVAR_041370863Q → H in a lung adenocarcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001597 mRNA Translation: BAA91778.1 Different initiation.
AK024274 mRNA Translation: BAB14869.1 Different initiation.
AK027551 mRNA Translation: BAB55194.1 Different initiation.
AK292980 mRNA Translation: BAF85669.1
CH471054 Genomic DNA Translation: EAW97633.1
BC012387 mRNA Translation: AAH12387.3
BC063798 mRNA Translation: AAH63798.1
AB037781 mRNA Translation: BAA92598.1
CCDSiCCDS9076.1
RefSeqiNP_001304713.1, NM_001317784.1
NP_001317182.1, NM_001330253.1
NP_001317183.1, NM_001330254.1
NP_001317185.1, NM_001330256.1
NP_060458.3, NM_017988.5
UniGeneiHs.506481

Genome annotation databases

EnsembliENST00000360820; ENSP00000354061; ENSG00000136021
GeneIDi55681
KEGGihsa:55681
UCSCiuc001thn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSCYL2_HUMAN
AccessioniPrimary (citable) accession number: Q6P3W7
Secondary accession number(s): A8KAB5
, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health