Q6P3W6 (NBPFA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroblastoma breakpoint family member 10

Gene names

Name:

NBPF10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	841 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm Probable.
Miscellaneous	Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.
Sequence similarities	Belongs to the NBPF family. Contains 6 NBPF domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P3W6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P3W6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     76-93: QFKEEKLAEQLKQAEELR → MFCNSTGRLPGQPAEEIQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 841	841	Neuroblastoma breakpoint family member 10		PRO_0000288045
Regions
	Domain	165 – 259	95	NBPF 1
	Domain	436 – 528	93	NBPF 2
	Domain	529 – 600	72	NBPF 3
	Domain	601 – 692	92	NBPF 4
	Domain	695 – 750	56	NBPF 5
	Domain	751 – 841	91	NBPF 6
	Coiled coil	70 – 130	61	Potential
	Coiled coil	339 – 401	63	Potential
	Compositional bias	535 – 539	5	Poly-Glu
	Compositional bias	550 – 555	6	Poly-Glu
	Compositional bias	757 – 760	4	Poly-Glu
Natural variations
	Alternative sequence	1 – 75	75	Missing in isoform 2.		VSP_025629
	Alternative sequence	76 – 93	18	QFKEE…AEELR → MFCNSTGRLPGQPAEEIQ in isoform 2.		VSP_025630

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 29, 2007. Version 2. Checksum: D5299D267B0A7678	FASTA	841	96,426
	10 20 30 40 50 60 MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFGNLKE RCFVTQLAGF LANQQKKYNY 70 80 90 100 110 120 EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLR EKLREGRDAS 130 140 150 160 170 180 RSLNEHLQAL LTLDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEAE 190 200 210 220 230 240 KVQKSSAPRE VQKTEESKVP EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL 250 260 270 280 290 300 VVDRESSHDE CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLHPQLA 310 320 330 340 350 360 EKKQQFRNLK ERCFVTQLAG FLANQQKKYK YEECKDLIKS MLRNERQFKE EKLAEQLKQA 370 380 390 400 410 420 EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA 430 440 450 460 470 480 EGCRLAQHLV QKLSPENDND DDEDVQVELA EKVQKSSAPR EMQKAEEKEV PEDSQEECAI 490 500 510 520 530 540 TYSNSHGPYD SNQPHRKTKI TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK 550 560 570 580 590 600 GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPEMLASYQS YSSTFHSLEE QQVCMAVDIG 610 620 630 640 650 660 RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLDRCY STPSGCLELT DSCQPYRSAF 670 680 690 700 710 720 YVLEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD EKEPEVLQDS LDRCYSTPSG 730 740 750 760 770 780 YLELPDLGQP YSSAVYSLEE QYLGLALDVD RTKKDQEEEE DQGPPCPRLS RELLEVVEPE 790 800 810 820 830 840 VLQDSLDRCY STPSSCLEQP DSCQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR S
	Isoform 2 [UniParc]. Checksum: B706E36D9FEA7789	FASTA	766	87,365
	10 20 30 40 50 60 MFCNSTGRLP GQPAEEIQQY KVLVHSQERE LTQLREKLRE GRDASRSLNE HLQALLTLDE 70 80 90 100 110 120 PDKSQGQDLQ EQLAEGCRLA QHLVQKLSPE NDEDEDEDVQ VEEAEKVQKS SAPREVQKTE 130 140 150 160 170 180 ESKVPEDSLE ECAITCSNSH GPCDSNQPHK NIKITFEEDE VNSTLVVDRE SSHDECQDAL 190 200 210 220 230 240 NILPVPGPTS SATNVSMVVS AGPLSSEKAE MNILEINEKL HPQLAEKKQQ FRNLKERCFV 250 260 270 280 290 300 TQLAGFLANQ QKKYKYEECK DLIKSMLRNE RQFKEEKLAE QLKQAEELRQ YKVLVHAQER 310 320 330 340 350 360 ELTQLREKLR EGRDASRSLN EHLQALLTPD EPDKSQGQDL QEQLAEGCRL AQHLVQKLSP 370 380 390 400 410 420 ENDNDDDEDV QVELAEKVQK SSAPREMQKA EEKEVPEDSQ EECAITYSNS HGPYDSNQPH 430 440 450 460 470 480 RKTKITFEED KVDSTLIGSS SHVEWEDAVH IIPENESDDE EEEEKGPVSP RNLQESEEEE 490 500 510 520 530 540 VPQESWDEGY STLSIPPEML ASYQSYSSTF HSLEEQQVCM AVDIGRHRWD QVKKEDQEAT 550 560 570 580 590 600 GPRLSRELLD EKGPEVLQDS LDRCYSTPSG CLELTDSCQP YRSAFYVLEQ QRVGLAVDMD 610 620 630 640 650 660 EIEKYQEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV 670 680 690 700 710 720 YSLEEQYLGL ALDVDRTKKD QEEEEDQGPP CPRLSRELLE VVEPEVLQDS LDRCYSTPSS 730 740 750 760 CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK RRGRRS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-835 (ISOFORM 1). Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000726 mRNA. Translation: BAA91343.1. BX546486 Genomic DNA. Translation: CAI16968.1. BX546486 Genomic DNA. Translation: CAI16969.1. BC063799 mRNA. Translation: AAH63799.1. Different termination.
IPI	IPI00657663. IPI01008889.
UniGene	Hs.534675. Hs.714127. Hs.721588.
3D structure databases
ProteinModelPortal	Q6P3W6.
ModBase	Search...
PTM databases
PhosphoSite	Q6P3W6.
Polymorphism databases
DMDM	152123240.
Proteomic databases
PRIDE	Q6P3W6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc001eqf.3. human. uc010paw.2. human.
Organism-specific databases
GeneCards	GC01P145293.
HGNC	HGNC:31992. NBPF10.
MIM	614000. gene.
neXtProt	NX_Q6P3W6.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000049041.
HOVERGEN	HBG058300.
Gene expression databases
ArrayExpress	Q6P3W6.
Bgee	Q6P3W6.
CleanEx	HS_NBPF10.
Genevestigator	Q6P3W6.
Family and domain databases
InterPro	IPR010630. NBPF_dom. [Graphical view]
Pfam	PF06758. DUF1220. 6 hits. [Graphical view]
PROSITE	PS51316. NBPF. 6 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

NBPFA_HUMAN

Accession

Primary (citable) accession number: Q6P3W6
Secondary accession number(s): Q5RHC0, Q9NWN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	April 3, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.