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Q6P3W6

- NBPFA_HUMAN

UniProt

Q6P3W6 - NBPFA_HUMAN

Protein

Neuroblastoma breakpoint family member 10

Gene

NBPF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroblastoma breakpoint family member 10
    Gene namesi
    Name:NBPF10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:31992. NBPF10.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 841841Neuroblastoma breakpoint family member 10PRO_0000288045Add
    BLAST

    Proteomic databases

    MaxQBiQ6P3W6.
    PRIDEiQ6P3W6.

    PTM databases

    PhosphoSiteiQ6P3W6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P3W6.
    BgeeiQ6P3W6.
    CleanExiHS_NBPF10.
    GenevestigatoriQ6P3W6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P3W6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 25995NBPF 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini436 – 52893NBPF 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini529 – 60072NBPF 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini601 – 69292NBPF 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini695 – 75056NBPF 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini751 – 84191NBPF 6PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili70 – 13061Sequence AnalysisAdd
    BLAST
    Coiled coili339 – 40163Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi535 – 5395Poly-Glu
    Compositional biasi550 – 5556Poly-Glu
    Compositional biasi757 – 7604Poly-Glu

    Sequence similaritiesi

    Belongs to the NBPF family.Curated
    Contains 6 NBPF domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    HOGENOMiHOG000049041.
    HOVERGENiHBG058300.

    Family and domain databases

    InterProiIPR010630. NBPF_dom.
    [Graphical view]
    PfamiPF06758. DUF1220. 6 hits.
    [Graphical view]
    PROSITEiPS51316. NBPF. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P3W6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFGNLKE RCFVTQLAGF    50
    LANQQKKYNY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH 100
    SQERELTQLR EKLREGRDAS RSLNEHLQAL LTLDEPDKSQ GQDLQEQLAE 150
    GCRLAQHLVQ KLSPENDEDE DEDVQVEEAE KVQKSSAPRE VQKTEESKVP 200
    EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL VVDRESSHDE 250
    CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLHPQLA 300
    EKKQQFRNLK ERCFVTQLAG FLANQQKKYK YEECKDLIKS MLRNERQFKE 350
    EKLAEQLKQA EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA 400
    LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND DDEDVQVELA 450
    EKVQKSSAPR EMQKAEEKEV PEDSQEECAI TYSNSHGPYD SNQPHRKTKI 500
    TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK GPVSPRNLQE 550
    SEEEEVPQES WDEGYSTLSI PPEMLASYQS YSSTFHSLEE QQVCMAVDIG 600
    RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLDRCY STPSGCLELT 650
    DSCQPYRSAF YVLEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD 700
    EKEPEVLQDS LDRCYSTPSG YLELPDLGQP YSSAVYSLEE QYLGLALDVD 750
    RTKKDQEEEE DQGPPCPRLS RELLEVVEPE VLQDSLDRCY STPSSCLEQP 800
    DSCQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR S 841
    Length:841
    Mass (Da):96,426
    Last modified:May 29, 2007 - v2
    Checksum:iD5299D267B0A7678
    GO
    Isoform 2 (identifier: Q6P3W6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-75: Missing.
         76-93: QFKEEKLAEQLKQAEELR → MFCNSTGRLPGQPAEEIQ

    Note: No experimental confirmation available.

    Show »
    Length:766
    Mass (Da):87,365
    Checksum:iB706E36D9FEA7789
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7575Missing in isoform 2. 1 PublicationVSP_025629Add
    BLAST
    Alternative sequencei76 – 9318QFKEE…AEELR → MFCNSTGRLPGQPAEEIQ in isoform 2. 1 PublicationVSP_025630Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000726 mRNA. Translation: BAA91343.1.
    BX546486 Genomic DNA. Translation: CAI16968.1.
    BX546486 Genomic DNA. Translation: CAI16969.1.
    BC063799 mRNA. Translation: AAH63799.1. Different termination.
    UniGeneiHs.445080.
    Hs.534675.
    Hs.714127.
    Hs.721588.

    Genome annotation databases

    UCSCiuc010oxn.2. human. [Q6P3W6-1]
    uc010paw.3. human. [Q6P3W6-2]

    Polymorphism databases

    DMDMi152123240.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000726 mRNA. Translation: BAA91343.1 .
    BX546486 Genomic DNA. Translation: CAI16968.1 .
    BX546486 Genomic DNA. Translation: CAI16969.1 .
    BC063799 mRNA. Translation: AAH63799.1 . Different termination.
    UniGenei Hs.445080.
    Hs.534675.
    Hs.714127.
    Hs.721588.

    3D structure databases

    ProteinModelPortali Q6P3W6.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6P3W6.

    Polymorphism databases

    DMDMi 152123240.

    Proteomic databases

    MaxQBi Q6P3W6.
    PRIDEi Q6P3W6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc010oxn.2. human. [Q6P3W6-1 ]
    uc010paw.3. human. [Q6P3W6-2 ]

    Organism-specific databases

    GeneCardsi GC01P145294.
    HGNCi HGNC:31992. NBPF10.
    MIMi 614000. gene.
    neXtProti NX_Q6P3W6.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000049041.
    HOVERGENi HBG058300.

    Miscellaneous databases

    PROi Q6P3W6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P3W6.
    Bgeei Q6P3W6.
    CleanExi HS_NBPF10.
    Genevestigatori Q6P3W6.

    Family and domain databases

    InterProi IPR010630. NBPF_dom.
    [Graphical view ]
    Pfami PF06758. DUF1220. 6 hits.
    [Graphical view ]
    PROSITEi PS51316. NBPF. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-835 (ISOFORM 1).
      Tissue: Uterus.

    Entry informationi

    Entry nameiNBPFA_HUMAN
    AccessioniPrimary (citable) accession number: Q6P3W6
    Secondary accession number(s): Q5RHC0, Q9NWN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3