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Q6P3W6

- NBPFA_HUMAN

UniProt

Q6P3W6 - NBPFA_HUMAN

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Protein

Neuroblastoma breakpoint family member 10

Gene

NBPF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 10
Gene namesi
Name:NBPF10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:31992. NBPF10.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 841841Neuroblastoma breakpoint family member 10PRO_0000288045Add
BLAST

Proteomic databases

MaxQBiQ6P3W6.
PRIDEiQ6P3W6.

PTM databases

PhosphoSiteiQ6P3W6.

Expressioni

Gene expression databases

BgeeiQ6P3W6.
CleanExiHS_NBPF10.
GenevestigatoriQ6P3W6.

Structurei

3D structure databases

ProteinModelPortaliQ6P3W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 25995NBPF 1PROSITE-ProRule annotationAdd
BLAST
Domaini436 – 52893NBPF 2PROSITE-ProRule annotationAdd
BLAST
Domaini529 – 60072NBPF 3PROSITE-ProRule annotationAdd
BLAST
Domaini601 – 69292NBPF 4PROSITE-ProRule annotationAdd
BLAST
Domaini695 – 75056NBPF 5PROSITE-ProRule annotationAdd
BLAST
Domaini751 – 84191NBPF 6PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili70 – 13061Sequence AnalysisAdd
BLAST
Coiled coili339 – 40163Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi535 – 5395Poly-Glu
Compositional biasi550 – 5556Poly-Glu
Compositional biasi757 – 7604Poly-Glu

Sequence similaritiesi

Belongs to the NBPF family.Curated
Contains 6 NBPF domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ6P3W6.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 6 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P3W6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFGNLKE RCFVTQLAGF
60 70 80 90 100
LANQQKKYNY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH
110 120 130 140 150
SQERELTQLR EKLREGRDAS RSLNEHLQAL LTLDEPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLAQHLVQ KLSPENDEDE DEDVQVEEAE KVQKSSAPRE VQKTEESKVP
210 220 230 240 250
EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL VVDRESSHDE
260 270 280 290 300
CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLHPQLA
310 320 330 340 350
EKKQQFRNLK ERCFVTQLAG FLANQQKKYK YEECKDLIKS MLRNERQFKE
360 370 380 390 400
EKLAEQLKQA EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA
410 420 430 440 450
LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND DDEDVQVELA
460 470 480 490 500
EKVQKSSAPR EMQKAEEKEV PEDSQEECAI TYSNSHGPYD SNQPHRKTKI
510 520 530 540 550
TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK GPVSPRNLQE
560 570 580 590 600
SEEEEVPQES WDEGYSTLSI PPEMLASYQS YSSTFHSLEE QQVCMAVDIG
610 620 630 640 650
RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLDRCY STPSGCLELT
660 670 680 690 700
DSCQPYRSAF YVLEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD
710 720 730 740 750
EKEPEVLQDS LDRCYSTPSG YLELPDLGQP YSSAVYSLEE QYLGLALDVD
760 770 780 790 800
RTKKDQEEEE DQGPPCPRLS RELLEVVEPE VLQDSLDRCY STPSSCLEQP
810 820 830 840
DSCQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR S
Length:841
Mass (Da):96,426
Last modified:May 29, 2007 - v2
Checksum:iD5299D267B0A7678
GO
Isoform 2 (identifier: Q6P3W6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     76-93: QFKEEKLAEQLKQAEELR → MFCNSTGRLPGQPAEEIQ

Note: No experimental confirmation available.

Show »
Length:766
Mass (Da):87,365
Checksum:iB706E36D9FEA7789
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7575Missing in isoform 2. 1 PublicationVSP_025629Add
BLAST
Alternative sequencei76 – 9318QFKEE…AEELR → MFCNSTGRLPGQPAEEIQ in isoform 2. 1 PublicationVSP_025630Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000726 mRNA. Translation: BAA91343.1.
BX546486 Genomic DNA. Translation: CAI16968.1.
BX546486 Genomic DNA. Translation: CAI16969.1.
BC063799 mRNA. Translation: AAH63799.1. Different termination.
UniGeneiHs.445080.
Hs.534675.
Hs.714127.
Hs.721588.

Genome annotation databases

UCSCiuc010oxn.2. human. [Q6P3W6-1]
uc010paw.3. human. [Q6P3W6-2]

Polymorphism databases

DMDMi152123240.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000726 mRNA. Translation: BAA91343.1 .
BX546486 Genomic DNA. Translation: CAI16968.1 .
BX546486 Genomic DNA. Translation: CAI16969.1 .
BC063799 mRNA. Translation: AAH63799.1 . Different termination.
UniGenei Hs.445080.
Hs.534675.
Hs.714127.
Hs.721588.

3D structure databases

ProteinModelPortali Q6P3W6.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6P3W6.

Polymorphism databases

DMDMi 152123240.

Proteomic databases

MaxQBi Q6P3W6.
PRIDEi Q6P3W6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc010oxn.2. human. [Q6P3W6-1 ]
uc010paw.3. human. [Q6P3W6-2 ]

Organism-specific databases

GeneCardsi GC01P145297.
HGNCi HGNC:31992. NBPF10.
MIMi 614000. gene.
neXtProti NX_Q6P3W6.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000049041.
HOVERGENi HBG058300.
InParanoidi Q6P3W6.

Miscellaneous databases

PROi Q6P3W6.
SOURCEi Search...

Gene expression databases

Bgeei Q6P3W6.
CleanExi HS_NBPF10.
Genevestigatori Q6P3W6.

Family and domain databases

InterProi IPR010630. NBPF_dom.
[Graphical view ]
Pfami PF06758. DUF1220. 6 hits.
[Graphical view ]
PROSITEi PS51316. NBPF. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-835 (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiNBPFA_HUMAN
AccessioniPrimary (citable) accession number: Q6P3W6
Secondary accession number(s): Q5RHC0, Q9NWN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3