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Protein
Submitted name:

NOTCH4 protein

Gene

NOTCH4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
NOTCH4 proteinImported
Gene namesi
Name:NOTCH4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500427883424 – 647Sequence analysisAdd BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 62PROSITE-ProRule annotation
Disulfide bondi105 ↔ 114PROSITE-ProRule annotation
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
Disulfide bondi182 ↔ 191PROSITE-ProRule annotation
Disulfide bondi222 ↔ 231PROSITE-ProRule annotation
Disulfide bondi264 ↔ 273PROSITE-ProRule annotation
Disulfide bondi302 ↔ 311PROSITE-ProRule annotation
Disulfide bondi343 ↔ 352PROSITE-ProRule annotation
Disulfide bondi381 ↔ 390PROSITE-ProRule annotation
Disulfide bondi401 ↔ 418PROSITE-ProRule annotation
Disulfide bondi420 ↔ 429PROSITE-ProRule annotation
Disulfide bondi463 ↔ 472PROSITE-ProRule annotation
Disulfide bondi501 ↔ 510PROSITE-ProRule annotation
Disulfide bondi539 ↔ 548PROSITE-ProRule annotation
Disulfide bondi577 ↔ 586PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ6P3V5.
PeptideAtlasiQ6P3V5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364163.

Structurei

3D structure databases

ProteinModelPortaliQ6P3V5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 63EGF-likeInterPro annotationAdd BLAST40
Domaini64 – 115EGF-likeInterPro annotationAdd BLAST52
Domaini118 – 155EGF-likeInterPro annotationAdd BLAST38
Domaini156 – 192EGF-likeInterPro annotationAdd BLAST37
Domaini194 – 232EGF-likeInterPro annotationAdd BLAST39
Domaini234 – 274EGF-likeInterPro annotationAdd BLAST41
Domaini276 – 312EGF-likeInterPro annotationAdd BLAST37
Domaini314 – 353EGF-likeInterPro annotationAdd BLAST40
Domaini355 – 391EGF-likeInterPro annotationAdd BLAST37
Domaini392 – 430EGF-likeInterPro annotationAdd BLAST39
Domaini432 – 473EGF-likeInterPro annotationAdd BLAST42
Domaini475 – 511EGF-likeInterPro annotationAdd BLAST37
Domaini513 – 549EGF-likeInterPro annotationAdd BLAST37
Domaini551 – 587EGF-likeInterPro annotationAdd BLAST37
Domaini589 – 625EGF-likeInterPro annotationAdd BLAST37

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR7G. Eukaryota.
COG0666. LUCA.
HOVERGENiHBG062449.

Family and domain databases

Gene3Di2.60.120.200. 4 hits.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
PfamiView protein in Pfam
PF00008. EGF. 8 hits.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 2 hits.
SMARTiView protein in SMART
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 12 hits.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 9 hits.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 4 hits.

Sequencei

Sequence statusi: Complete.

Q6P3V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPPSLLLLL LLLLLLCVSV VRPRGLLCGS FPEPCANGGT CLSLSLGQGT
60 70 80 90 100
CQCAPGFLGE TCQFPDPCQN AQLCQNGGSC QALLPAPLGL PSSPSPLTPS
110 120 130 140 150
FLCTCLPGFT GERCQAKLED PCPPSFCSKR GRCHIQASGR PQCSCMPGWT
160 170 180 190 200
GEQCQLRDFC SANPCVNGGV CLATYPQIQC HCPPGFEGHA CERDVNECFQ
210 220 230 240 250
DPGPCPKGTS CHNTLGSFQC LCPVGQEGPR CELRAGPCPP RGCSNGGTCQ
260 270 280 290 300
LMPEKDSTFH LCLCPPGFIG PDCEVNPDNC VSHQCQNGGT CQDGLDTYTC
310 320 330 340 350
LCPETWTGWD CSEDVDECET QGPPHCRNGG TCQNSAGSFH CVCVSGWGGT
360 370 380 390 400
SCEENLDDCI AATCAPGSTC IDRVGSFSCL CPPGRTGLLC HLEDMCLSQP
410 420 430 440 450
CHGDAQCSTN PLTGSTLCLC QPGYSGPTCH QDLDECLMAQ QGPSPCEHGG
460 470 480 490 500
SCLNTPGSFN CLCPPGYTGS RCEADHNECL SQPCHPGSTC LDLLATFHCL
510 520 530 540 550
CPPGLEGQLC EVETNECASA PCLNHADCHD LLNGFQCICL PGFSGTRCEE
560 570 580 590 600
DIDECRSSPC ANGGQCQDQP GAFHCKCLPG FEGPRCQTEV DECLSDPCPV
610 620 630 640
GASCLDLPGA FFCLCPSGFT GSQGRHWKEL AEYFIPFGLG QSSLVGV
Length:647
Mass (Da):68,069
Last modified:July 5, 2004 - v1
Checksum:iB71E79AA16E50CE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063815 mRNA. Translation: AAH63815.1.
UniGeneiHs.436100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063815 mRNA. Translation: AAH63815.1.
UniGeneiHs.436100.

3D structure databases

ProteinModelPortaliQ6P3V5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364163.

Proteomic databases

PaxDbiQ6P3V5.
PeptideAtlasiQ6P3V5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IR7G. Eukaryota.
COG0666. LUCA.
HOVERGENiHBG062449.

Family and domain databases

Gene3Di2.60.120.200. 4 hits.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
PfamiView protein in Pfam
PF00008. EGF. 8 hits.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 2 hits.
SMARTiView protein in SMART
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 12 hits.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 9 hits.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6P3V5_HUMAN
AccessioniPrimary (citable) accession number: Q6P3V5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 12, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.