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Protein
Submitted name:

NOTCH4 protein

Gene

NOTCH4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
NOTCH4 proteinImported
Gene namesi
Name:NOTCH4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 647624Sequence analysisPRO_5004278834Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ6P3V5.
PeptideAtlasiQ6P3V5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364163.

Structurei

3D structure databases

ProteinModelPortaliQ6P3V5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 6340EGF-likeInterPro annotationAdd
BLAST
Domaini64 – 11552EGF-likeInterPro annotationAdd
BLAST
Domaini118 – 15538EGF-likeInterPro annotationAdd
BLAST
Domaini156 – 19237EGF-likeInterPro annotationAdd
BLAST
Domaini194 – 23239EGF-likeInterPro annotationAdd
BLAST
Domaini234 – 27441EGF-likeInterPro annotationAdd
BLAST
Domaini276 – 31237EGF-likeInterPro annotationAdd
BLAST
Domaini314 – 35340EGF-likeInterPro annotationAdd
BLAST
Domaini355 – 39137EGF-likeInterPro annotationAdd
BLAST
Domaini392 – 43039EGF-likeInterPro annotationAdd
BLAST
Domaini432 – 47342EGF-likeInterPro annotationAdd
BLAST
Domaini475 – 51137EGF-likeInterPro annotationAdd
BLAST
Domaini513 – 54937EGF-likeInterPro annotationAdd
BLAST
Domaini551 – 58737EGF-likeInterPro annotationAdd
BLAST
Domaini589 – 62537EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR7G. Eukaryota.
COG0666. LUCA.
HOVERGENiHBG062449.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00008. EGF. 8 hits.
PF07645. EGF_CA. 4 hits.
PF12661. hEGF. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 15 hits.
SM00179. EGF_CA. 12 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 9 hits.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P3V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPPSLLLLL LLLLLLCVSV VRPRGLLCGS FPEPCANGGT CLSLSLGQGT
60 70 80 90 100
CQCAPGFLGE TCQFPDPCQN AQLCQNGGSC QALLPAPLGL PSSPSPLTPS
110 120 130 140 150
FLCTCLPGFT GERCQAKLED PCPPSFCSKR GRCHIQASGR PQCSCMPGWT
160 170 180 190 200
GEQCQLRDFC SANPCVNGGV CLATYPQIQC HCPPGFEGHA CERDVNECFQ
210 220 230 240 250
DPGPCPKGTS CHNTLGSFQC LCPVGQEGPR CELRAGPCPP RGCSNGGTCQ
260 270 280 290 300
LMPEKDSTFH LCLCPPGFIG PDCEVNPDNC VSHQCQNGGT CQDGLDTYTC
310 320 330 340 350
LCPETWTGWD CSEDVDECET QGPPHCRNGG TCQNSAGSFH CVCVSGWGGT
360 370 380 390 400
SCEENLDDCI AATCAPGSTC IDRVGSFSCL CPPGRTGLLC HLEDMCLSQP
410 420 430 440 450
CHGDAQCSTN PLTGSTLCLC QPGYSGPTCH QDLDECLMAQ QGPSPCEHGG
460 470 480 490 500
SCLNTPGSFN CLCPPGYTGS RCEADHNECL SQPCHPGSTC LDLLATFHCL
510 520 530 540 550
CPPGLEGQLC EVETNECASA PCLNHADCHD LLNGFQCICL PGFSGTRCEE
560 570 580 590 600
DIDECRSSPC ANGGQCQDQP GAFHCKCLPG FEGPRCQTEV DECLSDPCPV
610 620 630 640
GASCLDLPGA FFCLCPSGFT GSQGRHWKEL AEYFIPFGLG QSSLVGV
Length:647
Mass (Da):68,069
Last modified:July 5, 2004 - v1
Checksum:iB71E79AA16E50CE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063815 mRNA. Translation: AAH63815.1.
UniGeneiHs.436100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063815 mRNA. Translation: AAH63815.1.
UniGeneiHs.436100.

3D structure databases

ProteinModelPortaliQ6P3V5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364163.

Proteomic databases

PaxDbiQ6P3V5.
PeptideAtlasiQ6P3V5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IR7G. Eukaryota.
COG0666. LUCA.
HOVERGENiHBG062449.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00008. EGF. 8 hits.
PF07645. EGF_CA. 4 hits.
PF12661. hEGF. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 15 hits.
SM00179. EGF_CA. 12 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 9 hits.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Peripheral Nervous SystemImported.

Entry informationi

Entry nameiQ6P3V5_HUMAN
AccessioniPrimary (citable) accession number: Q6P3V5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.