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Protein

Zinc finger protein 585A

Gene

ZNF585A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri158 – 18023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65623C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri690 – 71223C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri718 – 74023C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri746 – 76823C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 585A
Gene namesi
Name:ZNF585A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26305. ZNF585A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905518.

Polymorphism and mutation databases

DMDMi116242848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 769769Zinc finger protein 585APRO_0000047677Add
BLAST

Proteomic databases

EPDiQ6P3V2.
MaxQBiQ6P3V2.
PaxDbiQ6P3V2.
PeptideAtlasiQ6P3V2.
PRIDEiQ6P3V2.

PTM databases

iPTMnetiQ6P3V2.
PhosphoSiteiQ6P3V2.

Expressioni

Gene expression databases

BgeeiQ6P3V2.
CleanExiHS_ZNF585A.
ExpressionAtlasiQ6P3V2. baseline and differential.
GenevisibleiQ6P3V2. HS.

Organism-specific databases

HPAiHPA046323.

Interactioni

Protein-protein interaction databases

BioGridi128264. 1 interaction.
IntActiQ6P3V2. 1 interaction.
STRINGi9606.ENSP00000292841.

Structurei

3D structure databases

ProteinModelPortaliQ6P3V2.
SMRiQ6P3V2. Positions 20-68, 98-768.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9771KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri158 – 18023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65623C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri690 – 71223C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri718 – 74023C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri746 – 76823C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P3V2.
KOiK09228.
OMAiFGNIFTQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6P3V2.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P3V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPANWTSPQK SSALAPEDHG SSYEGSVSFR DVAIDFSREE WRHLDPSQRN
60 70 80 90 100
LYRDVMLETY SHLLSVGYQV PEAEVVMLEQ GKEPWALQGE RPRQSCPGEK
110 120 130 140 150
LWDHNQCRKI LSYKQVSSQP QKMYPGEKAY ECAKFEKIFT QKSQLKVHLK
160 170 180 190 200
VLAGEKLYVC IECGKAFVQK PEFIIHQKTH MREKPFKCNE CGKSFFQVSS
210 220 230 240 250
LFRHQRIHTG EKLYECSQCG KGFSYNSDLS IHEKIHTGER HHECTDCGKA
260 270 280 290 300
FTQKSTLKMH QKIHTGERSY ICIECGQAFI QKTHLIAHRR IHTGEKPYEC
310 320 330 340 350
SNCGKSFISK SQLQVHQRVH TRVKPYICTE YGKVFSNNSN LVTHKKVQSR
360 370 380 390 400
EKSSICTECG KAFTYRSELI IHQRIHTGEK PYECSDCGKA FTQKSALTVH
410 420 430 440 450
QRIHTGEKSY ICMKCGLAFI QKAHLIAHQI IHTGEKPHKC GHCGKLFTSK
460 470 480 490 500
SQLHVHKRIH TGEKPYMCNK CGKAFTNRSN LITHQKTHTG EKSYICSKCG
510 520 530 540 550
KAFTQRSDLI THQRIHTGEK PYECNTCGKA FTQKSHLNIH QKIHTGERQY
560 570 580 590 600
ECHECGKAFN QKSILIVHQK IHTGEKPYVC TECGRAFIRK SNFITHQRIH
610 620 630 640 650
TGEKPYECSD CGKSFTSKSQ LLVHQPVHTG EKPYVCAECG KAFSGRSNLS
660 670 680 690 700
KHQKTHTGEK PYICSECGKT FRQKSELITH HRIHTGEKPY ECSDCGKSFT
710 720 730 740 750
KKSQLQVHQR IHTGEKPYVC AECGKAFTDR SNLNKHQTTH TGDKPYKCGI
760
CGKGFVQKSV FSVHQSSHA
Length:769
Mass (Da):87,974
Last modified:October 17, 2006 - v2
Checksum:iAE8E19B5D5F95AF7
GO
Isoform 2 (identifier: Q6P3V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
     367-674: Missing.

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):46,686
Checksum:i1BAB9BC5DF908886
GO

Sequence cautioni

The sequence BAB85057.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti763 – 7631V → I in AAH63820 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5555Missing in isoform 2. 1 PublicationVSP_016017Add
BLAST
Alternative sequencei367 – 674308Missing in isoform 2. 1 PublicationVSP_016018Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056389 mRNA. Translation: BAB71174.1.
AK074345 mRNA. Translation: BAB85057.1. Different initiation.
AC012309 Genomic DNA. No translation available.
BC063820 mRNA. Translation: AAH63820.1.
CCDSiCCDS74353.1. [Q6P3V2-1]
RefSeqiNP_001275729.1. NM_001288800.1. [Q6P3V2-1]
NP_689868.1. NM_152655.3.
NP_954577.1. NM_199126.2.
UniGeneiHs.659236.
Hs.729172.

Genome annotation databases

EnsembliENST00000292841; ENSP00000292841; ENSG00000196967. [Q6P3V2-1]
GeneIDi199704.
KEGGihsa:199704.
UCSCiuc002ofm.3. human. [Q6P3V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056389 mRNA. Translation: BAB71174.1.
AK074345 mRNA. Translation: BAB85057.1. Different initiation.
AC012309 Genomic DNA. No translation available.
BC063820 mRNA. Translation: AAH63820.1.
CCDSiCCDS74353.1. [Q6P3V2-1]
RefSeqiNP_001275729.1. NM_001288800.1. [Q6P3V2-1]
NP_689868.1. NM_152655.3.
NP_954577.1. NM_199126.2.
UniGeneiHs.659236.
Hs.729172.

3D structure databases

ProteinModelPortaliQ6P3V2.
SMRiQ6P3V2. Positions 20-68, 98-768.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128264. 1 interaction.
IntActiQ6P3V2. 1 interaction.
STRINGi9606.ENSP00000292841.

PTM databases

iPTMnetiQ6P3V2.
PhosphoSiteiQ6P3V2.

Polymorphism and mutation databases

DMDMi116242848.

Proteomic databases

EPDiQ6P3V2.
MaxQBiQ6P3V2.
PaxDbiQ6P3V2.
PeptideAtlasiQ6P3V2.
PRIDEiQ6P3V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292841; ENSP00000292841; ENSG00000196967. [Q6P3V2-1]
GeneIDi199704.
KEGGihsa:199704.
UCSCiuc002ofm.3. human. [Q6P3V2-1]

Organism-specific databases

CTDi199704.
GeneCardsiZNF585A.
HGNCiHGNC:26305. ZNF585A.
HPAiHPA046323.
neXtProtiNX_Q6P3V2.
PharmGKBiPA134905518.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P3V2.
KOiK09228.
OMAiFGNIFTQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6P3V2.
TreeFamiTF343410.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii199704.
PROiQ6P3V2.

Gene expression databases

BgeeiQ6P3V2.
CleanExiHS_ZNF585A.
ExpressionAtlasiQ6P3V2. baseline and differential.
GenevisibleiQ6P3V2. HS.

Family and domain databases

Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-769 (ISOFORM 1).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiZ585A_HUMAN
AccessioniPrimary (citable) accession number: Q6P3V2
Secondary accession number(s): Q8TE95, Q96MV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.