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Protein
Submitted name:

RXRA protein

Gene

RXRA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
RXRA proteinImported
Gene namesi
Name:RXRAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34890.

PTM / Processingi

Proteomic databases

PaxDbiQ6P3U7.
PeptideAtlasiQ6P3U7.
PRIDEiQ6P3U7.

Expressioni

Gene expression databases

BgeeiQ6P3U7.
GenevisibleiQ6P3U7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000419692.

Structurei

3D structure databases

ProteinModelPortaliQ6P3U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 26176Nuclear receptor DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
KOiK08524.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6P3U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ATFATTRRAA ASARRRRHRS RRLPAARARA GRAGGRRARR PLPAPPAGHE
60 70 80 90 100
LVADMDTKHF LPLDFSTQVN SSLTSPTGRG SMAAPSLHPS LGPGIGSPGQ
110 120 130 140 150
LHSPISTLSS PINGMGPPFS VISSPMGPHS MSVPTTPTLG FSTGSPQLSS
160 170 180 190 200
PMNPVSSSED IKPPLGLNGV LKVPAHPSGN MASFTKHICA ICGDRSSGKH
210 220 230 240 250
YGVYSCEGCK GFFKRTVRKD LTYTCRDNKD CLIDKRQRNR CQYCRYQKCL
260 270 280 290 300
AMGMKREAVQ EERQRGKDRN ENEVESTSSA NEDMPVERIL EAELAVEPKT
310 320 330 340 350
ETYVEANMGL NPSSPNDPVT NICQAADKQL FTLVEWAKRI PHFSELPLDD
360 370 380 390 400
QVILLRAGWN ELLIASFSHR SIAVKDGILL ATGLHVHRNS AHSAGVGAIF
410 420 430 440 450
DRVLTELVSK MRDMQMDKTE LGCLRAIVLF NPDSKGLSNP AEVEALREKV
460 470 480 490 500
YASLEAYCKH KYPEQPGRFA KLLLRLPALR SIGLKCLEHL FFFKLIGDTP
510
IDTFLMEMLE APHQMT
Length:516
Mass (Da):56,672
Last modified:July 5, 2004 - v1
Checksum:iC18FB97552E55929
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063827 mRNA. Translation: AAH63827.1.
RefSeqiNP_001278849.1. NM_001291920.1.
NP_001278850.1. NM_001291921.1.
NP_002948.1. NM_002957.5.
UniGeneiHs.590886.

Genome annotation databases

GeneIDi6256.
KEGGihsa:6256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063827 mRNA. Translation: AAH63827.1.
RefSeqiNP_001278849.1. NM_001291920.1.
NP_001278850.1. NM_001291921.1.
NP_002948.1. NM_002957.5.
UniGeneiHs.590886.

3D structure databases

ProteinModelPortaliQ6P3U7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000419692.

Proteomic databases

PaxDbiQ6P3U7.
PeptideAtlasiQ6P3U7.
PRIDEiQ6P3U7.

Protocols and materials databases

DNASUi6256.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6256.
KEGGihsa:6256.

Organism-specific databases

CTDi6256.
PharmGKBiPA34890.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
KOiK08524.

Miscellaneous databases

ChiTaRSiRXRA. human.
GenomeRNAii6256.

Gene expression databases

BgeeiQ6P3U7.
GenevisibleiQ6P3U7. HS.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: UterusImported.

Entry informationi

Entry nameiQ6P3U7_HUMAN
AccessioniPrimary (citable) accession number: Q6P3U7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.