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Protein

F-box only protein 42

Gene

FBXO42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.1 Publication

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 42
Alternative name(s):
Just one F-box and Kelch domain-containing protein
Gene namesi
Name:FBXO42
Synonyms:FBX42, JFK, KIAA1332
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29249. FBXO42.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951560.

Polymorphism and mutation databases

BioMutaiFBXO42.
DMDMi51701398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717F-box only protein 42PRO_0000119942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei365 – 3651PhosphoserineCombined sources
Modified residuei373 – 3731PhosphoserineCombined sources
Modified residuei378 – 3781PhosphothreonineCombined sources
Modified residuei552 – 5521PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P3S6.
MaxQBiQ6P3S6.
PaxDbiQ6P3S6.
PeptideAtlasiQ6P3S6.
PRIDEiQ6P3S6.

PTM databases

iPTMnetiQ6P3S6.
PhosphoSiteiQ6P3S6.

Expressioni

Gene expression databases

BgeeiQ6P3S6.
CleanExiHS_FBXO42.
ExpressionAtlasiQ6P3S6. baseline and differential.
GenevisibleiQ6P3S6. HS.

Organism-specific databases

HPAiHPA025071.
HPA053703.

Interactioni

Subunit structurei

Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPJQ063303EBI-2506081,EBI-632552

Protein-protein interaction databases

BioGridi119962. 13 interactions.
IntActiQ6P3S6. 2 interactions.
STRINGi9606.ENSP00000364742.

Structurei

3D structure databases

ProteinModelPortaliQ6P3S6.
SMRiQ6P3S6. Positions 217-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 9350F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati132 – 18453Kelch 1Add
BLAST
Repeati186 – 24257Kelch 2Add
BLAST
Repeati244 – 29350Kelch 3Add
BLAST
Repeati295 – 34248Kelch 4Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 4 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00440000039706.
HOVERGENiHBG051582.
InParanoidiQ6P3S6.
KOiK10317.
OMAiPWAWQPL.
OrthoDBiEOG708VZC.
PhylomeDBiQ6P3S6.
TreeFamiTF324505.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR001810. F-box_dom.
IPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF07646. Kelch_2. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P3S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSDSEDD SFMAVDQEET VLEGTMDQDE EPHPVLEAEE TRHNRSMSEL
60 70 80 90 100
PEEVLEYILS FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG
110 120 130 140 150
NIQWESRTYP YPGTPITQRF SHSACYYDAN QSMYVFGGCT QSSCNAAFND
160 170 180 190 200
LWRLDLNSKE WIRPLASGSY PSPKAGATLV VYKDLLVLFG GWTRPSPYPL
210 220 230 240 250
HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI DDKMIVFGGS
260 270 280 290 300
LGSRQMSNDV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDATILILG
310 320 330 340 350
GCGGPNALFK DAWLLHMHSG PWAWQPLKVE NEEHGAPELW CHPACRVGQC
360 370 380 390 400
VVVFSQAPSG RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE
410 420 430 440 450
APCVNGRWGT LRPRAQRQTP SGSREGSLSP ARGDGSPILN GGSLSPGTAA
460 470 480 490 500
VGGSSLDSPV QAISPSTPSA PEGYDLKIGL SLAPRRGSLP DQKDLRLGSI
510 520 530 540 550
DLNWDLKPAS SSNPMDGMDN RTVGGSMRHP PEQTNGVHTP PHVASALAGA
560 570 580 590 600
VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPGSPGS QSLSSGETVP
610 620 630 640 650
IPRPGPAQGD GHSLPPIARR LGHHPPQSLN VGKPLYQSMN CKPMQMYVLD
660 670 680 690 700
IKDTKEKGRV KWKVFNSSSV VGPPETSLHT VVQGRGELII FGGLMDKKQN
710
VKYYPKTNAL YFVRAKR
Length:717
Mass (Da):77,839
Last modified:July 5, 2004 - v1
Checksum:i938D0A018FC3DCBD
GO

Sequence cautioni

The sequence CAI22561.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti454 – 4541Missing in AAH43410 (PubMed:15489334).Curated
Sequence conflicti509 – 5091A → T in CAD38731 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti471 – 4711P → A.3 Publications
Corresponds to variant rs12069239 [ dbSNP | Ensembl ].
VAR_024447

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055598 mRNA. Translation: BAG51542.1.
AL358794, AL109627 Genomic DNA. Translation: CAH73774.1.
AL109627, AL358794 Genomic DNA. Translation: CAI22560.1.
AL109627 Genomic DNA. Translation: CAI22561.1. Sequence problems.
BC006174 mRNA. Translation: AAH06174.1.
BC032439 mRNA. Translation: AAH32439.1.
BC043410 mRNA. Translation: AAH43410.1.
BC063864 mRNA. Translation: AAH63864.1.
AB037753 mRNA. Translation: BAA92570.1.
AL833874 mRNA. Translation: CAD38731.1.
CCDSiCCDS30613.1.
RefSeqiNP_061867.1. NM_018994.2.
XP_006710761.1. XM_006710698.2.
UniGeneiHs.522384.

Genome annotation databases

EnsembliENST00000375592; ENSP00000364742; ENSG00000037637.
GeneIDi54455.
KEGGihsa:54455.
UCSCiuc001ayg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055598 mRNA. Translation: BAG51542.1.
AL358794, AL109627 Genomic DNA. Translation: CAH73774.1.
AL109627, AL358794 Genomic DNA. Translation: CAI22560.1.
AL109627 Genomic DNA. Translation: CAI22561.1. Sequence problems.
BC006174 mRNA. Translation: AAH06174.1.
BC032439 mRNA. Translation: AAH32439.1.
BC043410 mRNA. Translation: AAH43410.1.
BC063864 mRNA. Translation: AAH63864.1.
AB037753 mRNA. Translation: BAA92570.1.
AL833874 mRNA. Translation: CAD38731.1.
CCDSiCCDS30613.1.
RefSeqiNP_061867.1. NM_018994.2.
XP_006710761.1. XM_006710698.2.
UniGeneiHs.522384.

3D structure databases

ProteinModelPortaliQ6P3S6.
SMRiQ6P3S6. Positions 217-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119962. 13 interactions.
IntActiQ6P3S6. 2 interactions.
STRINGi9606.ENSP00000364742.

PTM databases

iPTMnetiQ6P3S6.
PhosphoSiteiQ6P3S6.

Polymorphism and mutation databases

BioMutaiFBXO42.
DMDMi51701398.

Proteomic databases

EPDiQ6P3S6.
MaxQBiQ6P3S6.
PaxDbiQ6P3S6.
PeptideAtlasiQ6P3S6.
PRIDEiQ6P3S6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375592; ENSP00000364742; ENSG00000037637.
GeneIDi54455.
KEGGihsa:54455.
UCSCiuc001ayg.4. human.

Organism-specific databases

CTDi54455.
GeneCardsiFBXO42.
HGNCiHGNC:29249. FBXO42.
HPAiHPA025071.
HPA053703.
MIMi609109. gene.
neXtProtiNX_Q6P3S6.
PharmGKBiPA134951560.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00440000039706.
HOVERGENiHBG051582.
InParanoidiQ6P3S6.
KOiK10317.
OMAiPWAWQPL.
OrthoDBiEOG708VZC.
PhylomeDBiQ6P3S6.
TreeFamiTF324505.

Miscellaneous databases

ChiTaRSiFBXO42. human.
GenomeRNAii54455.
PROiQ6P3S6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P3S6.
CleanExiHS_FBXO42.
ExpressionAtlasiQ6P3S6. baseline and differential.
GenevisibleiQ6P3S6. HS.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR001810. F-box_dom.
IPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF07646. Kelch_2. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-471.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-471.
    Tissue: Brain, PNS and Uterus.
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-717.
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 352-717, VARIANT ALA-471.
    Tissue: Melanoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; SER-373 AND THR-378, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation."
    Sun L., Shi L., Li W., Yu W., Liang J., Zhang H., Yang X., Wang Y., Li R., Yao X., Yi X., Shang Y.
    Proc. Natl. Acad. Sci. U.S.A. 106:10195-10200(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SCF COMPLEX, INTERACTION WITH TP53.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365 AND SER-373, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiFBX42_HUMAN
AccessioniPrimary (citable) accession number: Q6P3S6
Secondary accession number(s): B3KP30
, Q5TEU8, Q86XI0, Q8N3N4, Q8N5F8, Q9BRM0, Q9P2L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.