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Q6P3R8

- NEK5_HUMAN

UniProt

Q6P3R8 - NEK5_HUMAN

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Protein

Serine/threonine-protein kinase Nek5

Gene

NEK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei128 – 1281Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of cysteine-type endopeptidase activity Source: Ensembl
  2. positive regulation of striated muscle cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6P3R8.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek5 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 5
Short name:
NimA-related protein kinase 5
Gene namesi
Name:NEK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:7748. NEK5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Serine/threonine-protein kinase Nek5PRO_0000259765Add
BLAST

Proteomic databases

PaxDbiQ6P3R8.
PeptideAtlasiQ6P3R8.
PRIDEiQ6P3R8.

PTM databases

PhosphoSiteiQ6P3R8.

Expressioni

Gene expression databases

BgeeiQ6P3R8.
CleanExiHS_NEK5.
ExpressionAtlasiQ6P3R8. baseline.
GenevestigatoriQ6P3R8.

Organism-specific databases

HPAiHPA035565.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347767.

Structurei

3D structure databases

ProteinModelPortaliQ6P3R8.
SMRiQ6P3R8. Positions 1-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 259256Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000113763.
InParanoidiQ6P3R8.
KOiK08857.
OMAiLDKCISD.
OrthoDBiEOG7D59P5.
PhylomeDBiQ6P3R8.
TreeFamiTF106472.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P3R8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKYDVIKAI GQGAFGKAYL AKGKSDSKHC VIKEINFEKM PIQEKEASKK
60 70 80 90 100
EVILLEKMKH PNIVAFFNSF QENGRLFIVM EYCDGGDLMK RINRQRGVLF
110 120 130 140 150
SEDQILGWFV QISLGLKHIH DRKILHRDIK AQNIFLSKNG MVAKLGDFGI
160 170 180 190 200
ARVLNNSMEL ARTCIGTPYY LSPEICQNKP YNNKTDIWSL GCVLYELCTL
210 220 230 240 250
KHPFEGNNLQ QLVLKICQAH FAPISPGFSR ELHSLISQLF QVSPRDRPSI
260 270 280 290 300
NSILKRPFLE NLIPKYLTPE VIQEEFSHML ICRAGAPASR HAGKVVQKCK
310 320 330 340 350
IQKVRFQGKC PPRSRISVPI KRNAILHRNE WRPPAGAQKA RSIKMIERPK
360 370 380 390 400
IAAVCGHYDY YYAQLDMLRR RAHKPSYHPI PQENTGVEDY GQETRHGPSP
410 420 430 440 450
SQWPAEYLQR KFEAQQYKLK VEKQLGLRPS SAEPNYNQRQ ELRSNGEEPR
460 470 480 490 500
FQELPFRKNE MKEQEYWKQL EEIRQQYHND MKEIRKKMGR EPEENSKISH
510 520 530 540 550
KTYLVKKSNL PVHQDASEGE APVQMEFRSC CPGWSAMARS WLTATSASQD
560 570 580 590 600
IEKDLKQMRL QNTKESKNPE QKYKAKKGVK FEINLDKCIS DENILQEEEA
610 620 630 640 650
MDIPNETLTF EDGMKFKEYE CVKEHGDYTD KAFEKLHCPE AGFSTQTVAA
660 670 680 690 700
VGNRRQWDGG APQTLLQMMA VADITSTCPT GPDSESVLSV SRQEGKTKDP

YSPVLILM
Length:708
Mass (Da):81,445
Last modified:July 5, 2004 - v1
Checksum:iD9A5B3606414D128
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti255 – 2551K → Q.
Corresponds to variant rs34756139 [ dbSNP | Ensembl ].
VAR_051652
Natural varianti290 – 2901R → H.1 Publication
VAR_040922
Natural varianti531 – 5311C → R.1 Publication
VAR_040923

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139082 Genomic DNA. Translation: CAI12892.2.
BC063885 mRNA. Translation: AAH63885.1.
CCDSiCCDS31979.1.
RefSeqiNP_954983.1. NM_199289.1.
UniGeneiHs.672144.

Genome annotation databases

EnsembliENST00000355568; ENSP00000347767; ENSG00000197168.
ENST00000617045; ENSP00000477810; ENSG00000197168.
GeneIDi341676.
KEGGihsa:341676.
UCSCiuc001vge.3. human.

Polymorphism databases

DMDMi74758252.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139082 Genomic DNA. Translation: CAI12892.2 .
BC063885 mRNA. Translation: AAH63885.1 .
CCDSi CCDS31979.1.
RefSeqi NP_954983.1. NM_199289.1.
UniGenei Hs.672144.

3D structure databases

ProteinModelPortali Q6P3R8.
SMRi Q6P3R8. Positions 1-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000347767.

Chemistry

BindingDBi Q6P3R8.
ChEMBLi CHEMBL5044.
GuidetoPHARMACOLOGYi 2120.

PTM databases

PhosphoSitei Q6P3R8.

Polymorphism databases

DMDMi 74758252.

Proteomic databases

PaxDbi Q6P3R8.
PeptideAtlasi Q6P3R8.
PRIDEi Q6P3R8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355568 ; ENSP00000347767 ; ENSG00000197168 .
ENST00000617045 ; ENSP00000477810 ; ENSG00000197168 .
GeneIDi 341676.
KEGGi hsa:341676.
UCSCi uc001vge.3. human.

Organism-specific databases

CTDi 341676.
GeneCardsi GC13M052610.
HGNCi HGNC:7748. NEK5.
HPAi HPA035565.
neXtProti NX_Q6P3R8.
PharmGKBi PA31549.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118997.
HOGENOMi HOG000113763.
InParanoidi Q6P3R8.
KOi K08857.
OMAi LDKCISD.
OrthoDBi EOG7D59P5.
PhylomeDBi Q6P3R8.
TreeFami TF106472.

Enzyme and pathway databases

SignaLinki Q6P3R8.

Miscellaneous databases

GenomeRNAii 341676.
NextBioi 98189.
PROi Q6P3R8.

Gene expression databases

Bgeei Q6P3R8.
CleanExi HS_NEK5.
ExpressionAtlasi Q6P3R8. baseline.
Genevestigatori Q6P3R8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-290 AND ARG-531.

Entry informationi

Entry nameiNEK5_HUMAN
AccessioniPrimary (citable) accession number: Q6P3R8
Secondary accession number(s): Q5TAP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3