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Protein

Collagen type IV alpha-3-binding protein

Gene

col4a3bp

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate the intracellular trafficking of ceramide in a non-vesicular manner.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen type IV alpha-3-binding protein
Alternative name(s):
Ceramide transfer protein
Gene namesi
Name:col4a3bp
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1002414. col4a3bp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Collagen type IV alpha-3-binding proteinPRO_0000307358Add
BLAST

Proteomic databases

PaxDbiQ6P3Q6.

Expressioni

Gene expression databases

BgeeiQ6P3Q6.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000011086.

Structurei

3D structure databases

ProteinModelPortaliQ6P3Q6.
SMRiQ6P3Q6. Positions 385-617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11795PHPROSITE-ProRule annotationAdd
BLAST
Domaini383 – 611229STARTPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili268 – 30235Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi320 – 3267FFATBy similarity

Domaini

The START domain recognizes ceramide and mediates the intermembrane transfer of ceramide.By similarity
The PH domain targets the Golgi apparatus.By similarity

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 START domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1739. Eukaryota.
ENOG410XQTB. LUCA.
HOGENOMiHOG000008025.
HOVERGENiHBG050753.
InParanoidiQ6P3Q6.
KOiK08283.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.530.20. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P3Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNQSWNSS GSEEDLETES GPPVERCGVL SKWTNYIHGW QDRWVVLKNN
60 70 80 90 100
TLSYYKSEDE TEYGCRGSIC LSKAVITPHE FDECRFDISV NDSVWYLRAQ
110 120 130 140 150
DPDHRQRWID SIEQHKSESG YGSESSLRRH GSMVSLVSGA SGYSATSTSS
160 170 180 190 200
FKKGHSLREK LAEMETFRDI LCRQVDTLQK YFDACADAVS KDELERDKVE
210 220 230 240 250
DDEDDFLHSH PNGDYIHSSI GSKDKLFQHV SPKGINGIDF KGEAITFKAT
260 270 280 290 300
TAGILATLSH CIDLMVKRED SWQKRLDKEI EKRRRVEEAY KNAMTELKKK
310 320 330 340 350
SHFGGPDYEE GPNSLINEEE FFDAVEAALD RQDKIEQSQS EKGRSHWPSS
360 370 380 390 400
LPSTEAYTTA GSHRFVQAPP SCPPPTDLVS SSDEHRFRIQ VEEMVQNHMT
410 420 430 440 450
YSLQDVGGDA NWQLVVEEGE MKVYRREVEE NGIVLDPLKA THSVKGVTGH
460 470 480 490 500
EVCQHFWNVD VRNDWETTIE NFHVVEKLSP NAIIVYQTHK RVWPASQRDV
510 520 530 540 550
LYLSAIRMVP AASENEMDTW IVCNFSVDHD NAPLNRCVRA KINIAMICQT
560 570 580 590 600
LVSPPEGNKE ISRDNIQCKI TYVANVNPGG WAPASVLRAV AKREYPKFLK
610
RFTSYVQEKT AGKSILF
Length:617
Mass (Da):70,153
Last modified:July 5, 2004 - v1
Checksum:i50EBC427B6B43D6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063901 mRNA. Translation: AAH63901.1.
RefSeqiNP_988844.1. NM_203513.1.
UniGeneiStr.6900.

Genome annotation databases

GeneIDi387331.
KEGGixtr:387331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063901 mRNA. Translation: AAH63901.1.
RefSeqiNP_988844.1. NM_203513.1.
UniGeneiStr.6900.

3D structure databases

ProteinModelPortaliQ6P3Q6.
SMRiQ6P3Q6. Positions 385-617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000011086.

Proteomic databases

PaxDbiQ6P3Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi387331.
KEGGixtr:387331.

Organism-specific databases

CTDi10087.
XenbaseiXB-GENE-1002414. col4a3bp.

Phylogenomic databases

eggNOGiKOG1739. Eukaryota.
ENOG410XQTB. LUCA.
HOGENOMiHOG000008025.
HOVERGENiHBG050753.
InParanoidiQ6P3Q6.
KOiK08283.

Gene expression databases

BgeeiQ6P3Q6.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.530.20. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiC43BP_XENTR
AccessioniPrimary (citable) accession number: Q6P3Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.