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Protein

Collagen type IV alpha-3-binding protein

Gene

col4a3bp

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate the intracellular trafficking of ceramide in a non-vesicular manner.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei466CeramideBy similarity1
Binding sitei487CeramideBy similarity1
Binding sitei524CeramideBy similarity1
Binding sitei572CeramideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen type IV alpha-3-binding protein
Alternative name(s):
Ceramide transfer protein
Gene namesi
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1002414. col4a3bp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073581 – 617Collagen type IV alpha-3-binding proteinAdd BLAST617

Proteomic databases

PaxDbiQ6P3Q6.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000011086.

Structurei

3D structure databases

ProteinModelPortaliQ6P3Q6.
SMRiQ6P3Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 117PHPROSITE-ProRule annotationAdd BLAST95
Domaini383 – 611STARTPROSITE-ProRule annotationAdd BLAST229

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili268 – 302Sequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi320 – 326FFATBy similarity7

Domaini

The START domain recognizes ceramide and mediates the intermembrane transfer of ceramide.By similarity
The PH domain targets the Golgi apparatus.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1739. Eukaryota.
ENOG410XQTB. LUCA.
HOGENOMiHOG000008025.
HOVERGENiHBG050753.
InParanoidiQ6P3Q6.
KOiK08283.
OrthoDBiEOG091G063Z.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.530.20. 1 hit.
InterProiView protein in InterPro
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
IPR023393. START-like_dom_sf.
IPR002913. START_lipid-bd_dom.
PfamiView protein in Pfam
PF00169. PH. 1 hit.
PF01852. START. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00234. START. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 1 hit.
PS50848. START. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P3Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNQSWNSS GSEEDLETES GPPVERCGVL SKWTNYIHGW QDRWVVLKNN
60 70 80 90 100
TLSYYKSEDE TEYGCRGSIC LSKAVITPHE FDECRFDISV NDSVWYLRAQ
110 120 130 140 150
DPDHRQRWID SIEQHKSESG YGSESSLRRH GSMVSLVSGA SGYSATSTSS
160 170 180 190 200
FKKGHSLREK LAEMETFRDI LCRQVDTLQK YFDACADAVS KDELERDKVE
210 220 230 240 250
DDEDDFLHSH PNGDYIHSSI GSKDKLFQHV SPKGINGIDF KGEAITFKAT
260 270 280 290 300
TAGILATLSH CIDLMVKRED SWQKRLDKEI EKRRRVEEAY KNAMTELKKK
310 320 330 340 350
SHFGGPDYEE GPNSLINEEE FFDAVEAALD RQDKIEQSQS EKGRSHWPSS
360 370 380 390 400
LPSTEAYTTA GSHRFVQAPP SCPPPTDLVS SSDEHRFRIQ VEEMVQNHMT
410 420 430 440 450
YSLQDVGGDA NWQLVVEEGE MKVYRREVEE NGIVLDPLKA THSVKGVTGH
460 470 480 490 500
EVCQHFWNVD VRNDWETTIE NFHVVEKLSP NAIIVYQTHK RVWPASQRDV
510 520 530 540 550
LYLSAIRMVP AASENEMDTW IVCNFSVDHD NAPLNRCVRA KINIAMICQT
560 570 580 590 600
LVSPPEGNKE ISRDNIQCKI TYVANVNPGG WAPASVLRAV AKREYPKFLK
610
RFTSYVQEKT AGKSILF
Length:617
Mass (Da):70,153
Last modified:July 5, 2004 - v1
Checksum:i50EBC427B6B43D6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063901 mRNA. Translation: AAH63901.1.
RefSeqiNP_988844.1. NM_203513.1.
UniGeneiStr.6900.

Genome annotation databases

GeneIDi387331.
KEGGixtr:387331.

Similar proteinsi

Entry informationi

Entry nameiC43BP_XENTR
AccessioniPrimary (citable) accession number: Q6P3Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome