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Protein
Submitted name:

Heat shock protein 5

Gene

hspa5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • response to hypoxia Source: ZFIN
  • response to yeast Source: ZFIN

Keywordsi

Biological processStress responseImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Submitted name:
Heat shock protein 5Imported
Submitted name:
Immunoglobulin binding proteinImported
Gene namesi
Name:hspa5Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-031001-11 hspa5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501410652417 – 650Sequence analysisAdd BLAST634

Expressioni

Gene expression databases

BgeeiENSDARG00000103846

Interactioni

Protein-protein interaction databases

IntActiQ6P3L3 1 interactor.
STRINGi7955.ENSDARP00000017456

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili276 – 303Sequence analysisAdd BLAST28
Coiled coili536 – 556Sequence analysisAdd BLAST21
Coiled coili604 – 624Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00910000144045
HOGENOMiHOG000228135
HOVERGENiHBG051845
OMAiCVGVMQK
OrthoDBiEOG091G0352
TreeFamiTF105044

Family and domain databases

Gene3Di1.20.1270.101 hit
2.60.34.101 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P3L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLCLFLLV AGSVFAEEDD KKESVGTVIG IDLGTTYSCV GVYKNGRVEI
60 70 80 90 100
IANDQGNRIT PSYVAFTTEG ERLIGDAAKN QLTSNPENTV FDAKRLIGRT
110 120 130 140 150
WGDSSVQQDI KYFPFKVIEK KNKPHIQLDI GSGQMKTFAP EEISAMVLTK
160 170 180 190 200
MKETAEAYLG KKVTHAVVTV PAYFNDAQRQ ATKDAGTIAG LNVMRIINEP
210 220 230 240 250
TAAAIAYGLD KRDGEKNILV FDLGGGTFDV SLLTIDNGVF EVVATNGDTH
260 270 280 290 300
LGGEDFDQRV MEHFIKLYKK KTGKDVRKDN RAVQKLRREV EKAKRALSAQ
310 320 330 340 350
HQARIEIESF FEGEDFSETL TRAKFEELNM DLFRSTMKPV QKVLEDSDLK
360 370 380 390 400
KPDIDEIVLV GGSTRIPKIQ QLVKEFFNGK EPSRGINPDE AVAYGAAVQA
410 420 430 440 450
GVLSGEEETG DLVLLDVCPL TLGIETVGGV MTKLIPRNTV VPTKKSQIFS
460 470 480 490 500
TASDNQPTVT IKVYEGERPL TKDNHLLGTF DLTGIPPAPR GVPQIEVTFE
510 520 530 540 550
IDVNGILRVT AEDKGTGNKN KITITNDQNR LTPEDIERMV NEAERFADED
560 570 580 590 600
KKLKERIDSR NELESYAYSL KNQIGDKEKL GGKLSSEDKE AIEKAVEEKI
610 620 630 640 650
EWLEAHQDAD LEEFQAKKKE LEEVVQPIVS KLYGSAGGPP PEEAEEKDEL
Length:650
Mass (Da):71,991
Last modified:July 5, 2004 - v1
Checksum:iBE623E3128F28FAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ323163 Genomic DNA No translation available.
BC063946 mRNA Translation: AAH63946.1
AY648749 mRNA Translation: AAT68067.1
UniGeneiDr.67791

Genome annotation databases

EnsembliENSDART00000169404; ENSDARP00000131952; ENSDARG00000103846

Similar proteinsi

Entry informationi

Entry nameiQ6P3L3_DANRE
AccessioniPrimary (citable) accession number: Q6P3L3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported