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Protein

F-box only protein 9

Gene

fbxo9

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DRE-8951664 Neddylation
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 9
Gene namesi
Name:fbxo9
ORF Names:si:ch211-71k24.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-030131-4194 fbxo9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004217611 – 421F-box only protein 9Add BLAST421

Proteomic databases

PaxDbiQ6P3K3

Expressioni

Gene expression databases

BgeeiENSDARG00000011055
ExpressionAtlasiQ6P3K3 baseline and differential

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(fbxo9).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093542

Structurei

3D structure databases

ProteinModelPortaliQ6P3K3
SMRiQ6P3K3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 101TPRAdd BLAST34
Domaini158 – 209F-boxPROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

TPR repeat

Phylogenomic databases

eggNOGiKOG2997 Eukaryota
ENOG410XPVI LUCA
GeneTreeiENSGT00390000014256
HOGENOMiHOG000047162
HOVERGENiHBG001041
InParanoidiQ6P3K3
KOiK10295
OMAiSKTTYLR
OrthoDBiEOG091G0BDF
PhylomeDBiQ6P3K3
TreeFamiTF324797

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR036181 MIT_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P3K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESNQNTDG AVEEGEDENT GDSNLQMELS AFRAKWMSEL QPSSGGQRSF
60 70 80 90 100
SRNAELRRRQ ETAKEEKARE LFLKAVEEEQ NGAVYEAIKY YKSAMQLVPD
110 120 130 140 150
IEFKINYSRT PDPERGGSYL ESSENNREID DLLTYFQHQL TLGNDAMKLC
160 170 180 190 200
EHETETSQVH ISALPFEVLM YIFRWVVSCD LDLRALEQLS LVCRGFYICA
210 220 230 240 250
RDPEIWRSAC LRVWGRSCTK MLPYSSWREM FLERPRVRFD GVYISKTSYI
260 270 280 290 300
RQGEESLDGF YRAWHQVEYY RYLRFFPDGQ VMMLTTPEDP LVTVPRLRSK
310 320 330 340 350
NSRMDSIMFG HYRLSQDTDN QTKVYVVVSK RKEEKVSEYQ RSRFCRRNPV
360 370 380 390 400
PEAERSFHVG LQLSSGGRQR FNKLVWIHHS CHITYRSTGE TVVTAFDVDK
410 420
MYTPLFFARV KSYTAFSERP L
Length:421
Mass (Da):49,371
Last modified:July 5, 2004 - v1
Checksum:i43AA514CD93F0E03
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16E → G in AAH76528 (PubMed:23594743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR376766 Genomic DNA Translation: CAX14513.1
BC063957 mRNA Translation: AAH63957.1
BC076528 mRNA Translation: AAH76528.1
RefSeqiNP_956012.1, NM_199718.2
UniGeneiDr.79462

Genome annotation databases

EnsembliENSDART00000102767; ENSDARP00000093542; ENSDARG00000011055
GeneIDi325469
KEGGidre:325469

Similar proteinsi

Entry informationi

Entry nameiFBX9_DANRE
AccessioniPrimary (citable) accession number: Q6P3K3
Secondary accession number(s): Q6DG26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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