Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box only protein 9

Gene

fbxo9

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 9
Gene namesi
Name:fbxo9
ORF Names:si:ch211-71k24.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-030131-4194. fbxo9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421F-box only protein 9PRO_0000421761Add
BLAST

Proteomic databases

PaxDbiQ6P3K3.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(fbxo9).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093542.

Structurei

3D structure databases

ProteinModelPortaliQ6P3K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati68 – 10134TPRAdd
BLAST
Domaini158 – 20952F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 TPR repeat.Curated

Keywords - Domaini

TPR repeat

Phylogenomic databases

eggNOGiKOG2997. Eukaryota.
ENOG410XPVI. LUCA.
GeneTreeiENSGT00390000014256.
HOGENOMiHOG000047162.
HOVERGENiHBG001041.
InParanoidiQ6P3K3.
KOiK10295.
OMAiLVWIHHS.
OrthoDBiEOG7GXPBB.
PhylomeDBiQ6P3K3.
TreeFamiTF324797.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR001810. F-box_dom.
IPR007330. MIT.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P3K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESNQNTDG AVEEGEDENT GDSNLQMELS AFRAKWMSEL QPSSGGQRSF
60 70 80 90 100
SRNAELRRRQ ETAKEEKARE LFLKAVEEEQ NGAVYEAIKY YKSAMQLVPD
110 120 130 140 150
IEFKINYSRT PDPERGGSYL ESSENNREID DLLTYFQHQL TLGNDAMKLC
160 170 180 190 200
EHETETSQVH ISALPFEVLM YIFRWVVSCD LDLRALEQLS LVCRGFYICA
210 220 230 240 250
RDPEIWRSAC LRVWGRSCTK MLPYSSWREM FLERPRVRFD GVYISKTSYI
260 270 280 290 300
RQGEESLDGF YRAWHQVEYY RYLRFFPDGQ VMMLTTPEDP LVTVPRLRSK
310 320 330 340 350
NSRMDSIMFG HYRLSQDTDN QTKVYVVVSK RKEEKVSEYQ RSRFCRRNPV
360 370 380 390 400
PEAERSFHVG LQLSSGGRQR FNKLVWIHHS CHITYRSTGE TVVTAFDVDK
410 420
MYTPLFFARV KSYTAFSERP L
Length:421
Mass (Da):49,371
Last modified:July 5, 2004 - v1
Checksum:i43AA514CD93F0E03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161E → G in AAH76528 (PubMed:23594743).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR376766 Genomic DNA. Translation: CAX14513.1.
BC063957 mRNA. Translation: AAH63957.1.
BC076528 mRNA. Translation: AAH76528.1.
RefSeqiNP_956012.1. NM_199718.2.
UniGeneiDr.79462.

Genome annotation databases

EnsembliENSDART00000102767; ENSDARP00000093542; ENSDARG00000011055.
GeneIDi325469.
KEGGidre:325469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR376766 Genomic DNA. Translation: CAX14513.1.
BC063957 mRNA. Translation: AAH63957.1.
BC076528 mRNA. Translation: AAH76528.1.
RefSeqiNP_956012.1. NM_199718.2.
UniGeneiDr.79462.

3D structure databases

ProteinModelPortaliQ6P3K3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093542.

Proteomic databases

PaxDbiQ6P3K3.

Protocols and materials databases

DNASUi325469.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000102767; ENSDARP00000093542; ENSDARG00000011055.
GeneIDi325469.
KEGGidre:325469.

Organism-specific databases

CTDi26268.
ZFINiZDB-GENE-030131-4194. fbxo9.

Phylogenomic databases

eggNOGiKOG2997. Eukaryota.
ENOG410XPVI. LUCA.
GeneTreeiENSGT00390000014256.
HOGENOMiHOG000047162.
HOVERGENiHBG001041.
InParanoidiQ6P3K3.
KOiK10295.
OMAiLVWIHHS.
OrthoDBiEOG7GXPBB.
PhylomeDBiQ6P3K3.
TreeFamiTF324797.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi20809299.
PROiQ6P3K3.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR001810. F-box_dom.
IPR007330. MIT.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiFBX9_DANRE
AccessioniPrimary (citable) accession number: Q6P3K3
Secondary accession number(s): Q6DG26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.