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Q6P3H4 (PNCB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Alternative name(s):
Nicotinate phosphoribosyltransferase domain-containing protein 1
Gene names
Name:naprt1
ORF Names:zgc:77870
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the NAPRTase family.

Sequence caution

The sequence AAH63987.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 546546Nicotinate phosphoribosyltransferase
PRO_0000315684

Sequences

Sequence LengthMass (Da)Tools
Q6P3H4 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 314B8D7B82A09E3D

FASTA54659,709
        10         20         30         40         50         60 
MATSNEAGSV LNRVPPLLTD LYQMAYAYWR AGRHNEPAVF ELFFRDNPFG GGFSLFAGLS 

        70         80         90        100        110        120 
DCLLFLQNFS FSDDDVQYLR SVLPADTDAG FFSYLKELDC SCVSVSAVPE GSVVFARVPL 

       130        140        150        160        170        180 
LEVSGPLAVV QLLETSLLCL VNYASLVCSN AARFRLAAGP RRRLMEMGLR RAQGPDGGLT 

       190        200        210        220        230        240 
ASRYTYIGGF DLTSNALAGR LYGIPVAGTM AHSYITSFSS LEEVWPQTLK PCGGGDSIDF 

       250        260        270        280        290        300 
ICLVKGLLGR VCQLLGSKTN LIREGELAAF LSYAIAYPQN FLPVIDSYSV RCSGLLCFCA 

       310        320        330        340        350        360 
VALALFELQY RPLGVRLDSG DLCRQSLDVR RVFRECSKHF SVPQFESLII VGTNSISEQS 

       370        380        390        400        410        420 
LSELNKKDNE IDVVGVGTHL VTCTRQPSLG CVYKLVEVRG RPRMKLSEDP EKSTLPGRKA 

       430        440        450        460        470        480 
VYRLLDADGH PQMDVLCLCD EAAPAAGVEL QCFSLLGNST LQCSITPAQV SSLRTQVFSC 

       490        500        510        520        530        540 
GQITLPLNSA SESRERAQIS LQMLNPYHKR LQEPHNYTVA LSERLHSLVS DIKKGNSKGS 


NFLLSN 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC063987 mRNA. Translation: AAH63987.1. Different initiation.
UniGeneDr.29094.

3D structure databases

ProteinModelPortalQ6P3H4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ZFINZDB-GENE-040426-1897. naprt1.

Phylogenomic databases

eggNOGCOG1488.
HOVERGENHBG062439.
InParanoidQ6P3H4.
PhylomeDBQ6P3H4.

Enzyme and pathway databases

UniPathwayUPA00253; UER00457.

Family and domain databases

InterProIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 2 hits.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 2 hits.
TIGRFAMsTIGR01513. NAPRTase_put. 1 hit.
ProtoNetSearch...

Other

NextBio20814847.
PROQ6P3H4.

Entry information

Entry namePNCB_DANRE
AccessionPrimary (citable) accession number: Q6P3H4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways