Q6P3H4 (PNCB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Alternative name(s):
Nicotinate phosphoribosyltransferase domain-containing protein 1

Gene names

Name:	naprt1
ORF Names:	zgc:77870

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.
Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the NAPRTase family.
Sequence caution	The sequence AAH63987.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway nicotinate nucleotide salvage Inferred from electronic annotation. Source: InterPro response to oxidative stress Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	Nicotinate phosphoribosyltransferase		PRO_0000315684

Sequences

	Sequence		Length	Mass (Da)
	Q6P3H4 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 314B8D7B82A09E3D	FASTA	546	59,709
	10 20 30 40 50 60 MATSNEAGSV LNRVPPLLTD LYQMAYAYWR AGRHNEPAVF ELFFRDNPFG GGFSLFAGLS 70 80 90 100 110 120 DCLLFLQNFS FSDDDVQYLR SVLPADTDAG FFSYLKELDC SCVSVSAVPE GSVVFARVPL 130 140 150 160 170 180 LEVSGPLAVV QLLETSLLCL VNYASLVCSN AARFRLAAGP RRRLMEMGLR RAQGPDGGLT 190 200 210 220 230 240 ASRYTYIGGF DLTSNALAGR LYGIPVAGTM AHSYITSFSS LEEVWPQTLK PCGGGDSIDF 250 260 270 280 290 300 ICLVKGLLGR VCQLLGSKTN LIREGELAAF LSYAIAYPQN FLPVIDSYSV RCSGLLCFCA 310 320 330 340 350 360 VALALFELQY RPLGVRLDSG DLCRQSLDVR RVFRECSKHF SVPQFESLII VGTNSISEQS 370 380 390 400 410 420 LSELNKKDNE IDVVGVGTHL VTCTRQPSLG CVYKLVEVRG RPRMKLSEDP EKSTLPGRKA 430 440 450 460 470 480 VYRLLDADGH PQMDVLCLCD EAAPAAGVEL QCFSLLGNST LQCSITPAQV SSLRTQVFSC 490 500 510 520 530 540 GQITLPLNSA SESRERAQIS LQMLNPYHKR LQEPHNYTVA LSERLHSLVS DIKKGNSKGS NFLLSN

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC063987 mRNA. Translation: AAH63987.1. Different initiation.
IPI	IPI00482634.
UniGene	Dr.29094.
3D structure databases
HSSP	HSSP built from PDB template 2F7F based on UniProtKB Q830Y8.
ProteinModelPortal	Q6P3H4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ZFIN	ZDB-GENE-040426-1897. naprt1.
Phylogenomic databases
eggNOG	COG1488.
HOVERGEN	HBG062439.
InParanoid	Q6P3H4.
OrthoDB	EOG4GF3FJ.
Enzyme and pathway databases
UniPathway	UPA00253; UER00457.
Family and domain databases
InterPro	IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR006405. Nic_PRibTrfase_put. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 2 hits. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01513. NAPRTase_put. 1 hit.
ProtoNet	Search...
Other
NextBio	20814847.

Entry information

Entry name

PNCB_DANRE

Accession

Primary (citable) accession number: Q6P3H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	April 3, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program