Reviewed, UniProtKB/Swiss-Prot Q6P3H4 (PNCB_DANRE)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11
Alternative name(s):
    Nicotinate phosphoribosyltransferase domain-containing protein 1

Gene names

Name:	naprt1
ORF Names:	zgc:77870

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.
Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	Nicotinate phosphoribosyltransferase		PRO_0000315684

Sequences

	Sequence		Length	Mass (Da)
	Q6P3H4-1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 314B8D7B82A09E3D	FASTA	546	59,709
	10 20 30 40 50 60 MATSNEAGSV LNRVPPLLTD LYQMAYAYWR AGRHNEPAVF ELFFRDNPFG GGFSLFAGLS 70 80 90 100 110 120 DCLLFLQNFS FSDDDVQYLR SVLPADTDAG FFSYLKELDC SCVSVSAVPE GSVVFARVPL 130 140 150 160 170 180 LEVSGPLAVV QLLETSLLCL VNYASLVCSN AARFRLAAGP RRRLMEMGLR RAQGPDGGLT 190 200 210 220 230 240 ASRYTYIGGF DLTSNALAGR LYGIPVAGTM AHSYITSFSS LEEVWPQTLK PCGGGDSIDF 250 260 270 280 290 300 ICLVKGLLGR VCQLLGSKTN LIREGELAAF LSYAIAYPQN FLPVIDSYSV RCSGLLCFCA 310 320 330 340 350 360 VALALFELQY RPLGVRLDSG DLCRQSLDVR RVFRECSKHF SVPQFESLII VGTNSISEQS 370 380 390 400 410 420 LSELNKKDNE IDVVGVGTHL VTCTRQPSLG CVYKLVEVRG RPRMKLSEDP EKSTLPGRKA 430 440 450 460 470 480 VYRLLDADGH PQMDVLCLCD EAAPAAGVEL QCFSLLGNST LQCSITPAQV SSLRTQVFSC 490 500 510 520 530 540 GQITLPLNSA SESRERAQIS LQMLNPYHKR LQEPHNYTVA LSERLHSLVS DIKKGNSKGS NFLLSN

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC063987 mRNA. Translation: AAH63987.1. Different initiation.
IPI	IPI00482634.
RefSeq	NP_957184.1.
UniGene	Dr.29094
3D structure databases
HSSP	HSSP built from PDB template 2F7F based on UniProtKB Q830Y8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6P3H4.
Genome annotation databases
Ensembl	ENSDART00000038157; ENSDARP00000035128; ENSDARG00000027930; Danio rerio. [Genome view]
GeneID	393864.
KEGG	dre:393864.
Organism-specific databases
ZFIN	ZDB-GENE-040426-1897. zgc:77870.
Phylogenomic databases
eggNOG	fiNOG14216.
HOVERGEN	Q6P3H4.
InParanoid	Q6P3H4.
Enzyme and pathway databases
BRENDA	2.4.2.11. 96826.
Gene expression databases
Bgee	Q6P3H4.
Family and domain databases
InterPro	IPR015977. Nic_PRibTrfase-like. IPR006405. Nic_PRibTrfase_put. [Graphical view]
Pfam	PF04095. NAPRTase. 2 hits. [Graphical view]
TIGRFAMs	TIGR01513. NAPRTase_put. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_DANRE

Accession

Primary (citable) accession number: Q6P3H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	February 9, 2010
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project