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Q6P3H4

- PNCB_DANRE

UniProt

Q6P3H4 - PNCB_DANRE

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Protein

Nicotinate phosphoribosyltransferase

Gene

naprt

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide salvage Source: InterPro
  3. response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Alternative name(s):
Nicotinate phosphoribosyltransferase domain-containing protein 1
Gene namesi
Name:naprt
Synonyms:naprt1
ORF Names:zgc:77870
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1897. naprt.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Nicotinate phosphoribosyltransferasePRO_0000315684Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6P3H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiCOG1488.
HOVERGENiHBG062439.
InParanoidiQ6P3H4.
PhylomeDBiQ6P3H4.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 2 hits.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P3H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATSNEAGSV LNRVPPLLTD LYQMAYAYWR AGRHNEPAVF ELFFRDNPFG
60 70 80 90 100
GGFSLFAGLS DCLLFLQNFS FSDDDVQYLR SVLPADTDAG FFSYLKELDC
110 120 130 140 150
SCVSVSAVPE GSVVFARVPL LEVSGPLAVV QLLETSLLCL VNYASLVCSN
160 170 180 190 200
AARFRLAAGP RRRLMEMGLR RAQGPDGGLT ASRYTYIGGF DLTSNALAGR
210 220 230 240 250
LYGIPVAGTM AHSYITSFSS LEEVWPQTLK PCGGGDSIDF ICLVKGLLGR
260 270 280 290 300
VCQLLGSKTN LIREGELAAF LSYAIAYPQN FLPVIDSYSV RCSGLLCFCA
310 320 330 340 350
VALALFELQY RPLGVRLDSG DLCRQSLDVR RVFRECSKHF SVPQFESLII
360 370 380 390 400
VGTNSISEQS LSELNKKDNE IDVVGVGTHL VTCTRQPSLG CVYKLVEVRG
410 420 430 440 450
RPRMKLSEDP EKSTLPGRKA VYRLLDADGH PQMDVLCLCD EAAPAAGVEL
460 470 480 490 500
QCFSLLGNST LQCSITPAQV SSLRTQVFSC GQITLPLNSA SESRERAQIS
510 520 530 540
LQMLNPYHKR LQEPHNYTVA LSERLHSLVS DIKKGNSKGS NFLLSN
Length:546
Mass (Da):59,709
Last modified:January 15, 2008 - v2
Checksum:i314B8D7B82A09E3D
GO

Sequence cautioni

The sequence AAH63987.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063987 mRNA. Translation: AAH63987.1. Different initiation.
UniGeneiDr.29094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063987 mRNA. Translation: AAH63987.1 . Different initiation.
UniGenei Dr.29094.

3D structure databases

ProteinModelPortali Q6P3H4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ZFINi ZDB-GENE-040426-1897. naprt.

Phylogenomic databases

eggNOGi COG1488.
HOVERGENi HBG062439.
InParanoidi Q6P3H4.
PhylomeDBi Q6P3H4.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Miscellaneous databases

NextBioi 20814847.
PROi Q6P3H4.

Family and domain databases

InterProi IPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 2 hits.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 2 hits.
TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPNCB_DANRE
AccessioniPrimary (citable) accession number: Q6P3H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3