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Q6P3H4

- PNCB_DANRE

UniProt

Q6P3H4 - PNCB_DANRE

Protein

Nicotinate phosphoribosyltransferase

Gene

naprt

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide salvage Source: InterPro
    3. response to oxidative stress Source: UniProtKB

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
    Short name:
    NAPRTase
    Alternative name(s):
    Nicotinate phosphoribosyltransferase domain-containing protein 1
    Gene namesi
    Name:naprt
    Synonyms:naprt1
    ORF Names:zgc:77870
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040426-1897. naprt1.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 546546Nicotinate phosphoribosyltransferasePRO_0000315684Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P3H4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.Curated

    Phylogenomic databases

    eggNOGiCOG1488.
    HOVERGENiHBG062439.
    InParanoidiQ6P3H4.
    PhylomeDBiQ6P3H4.

    Family and domain databases

    InterProiIPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 2 hits.
    TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6P3H4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSNEAGSV LNRVPPLLTD LYQMAYAYWR AGRHNEPAVF ELFFRDNPFG    50
    GGFSLFAGLS DCLLFLQNFS FSDDDVQYLR SVLPADTDAG FFSYLKELDC 100
    SCVSVSAVPE GSVVFARVPL LEVSGPLAVV QLLETSLLCL VNYASLVCSN 150
    AARFRLAAGP RRRLMEMGLR RAQGPDGGLT ASRYTYIGGF DLTSNALAGR 200
    LYGIPVAGTM AHSYITSFSS LEEVWPQTLK PCGGGDSIDF ICLVKGLLGR 250
    VCQLLGSKTN LIREGELAAF LSYAIAYPQN FLPVIDSYSV RCSGLLCFCA 300
    VALALFELQY RPLGVRLDSG DLCRQSLDVR RVFRECSKHF SVPQFESLII 350
    VGTNSISEQS LSELNKKDNE IDVVGVGTHL VTCTRQPSLG CVYKLVEVRG 400
    RPRMKLSEDP EKSTLPGRKA VYRLLDADGH PQMDVLCLCD EAAPAAGVEL 450
    QCFSLLGNST LQCSITPAQV SSLRTQVFSC GQITLPLNSA SESRERAQIS 500
    LQMLNPYHKR LQEPHNYTVA LSERLHSLVS DIKKGNSKGS NFLLSN 546
    Length:546
    Mass (Da):59,709
    Last modified:January 15, 2008 - v2
    Checksum:i314B8D7B82A09E3D
    GO

    Sequence cautioni

    The sequence AAH63987.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063987 mRNA. Translation: AAH63987.1. Different initiation.
    UniGeneiDr.29094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC063987 mRNA. Translation: AAH63987.1 . Different initiation.
    UniGenei Dr.29094.

    3D structure databases

    ProteinModelPortali Q6P3H4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ZFINi ZDB-GENE-040426-1897. naprt1.

    Phylogenomic databases

    eggNOGi COG1488.
    HOVERGENi HBG062439.
    InParanoidi Q6P3H4.
    PhylomeDBi Q6P3H4.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .

    Miscellaneous databases

    NextBioi 20814847.
    PROi Q6P3H4.

    Family and domain databases

    InterProi IPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 2 hits.
    TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiPNCB_DANRE
    AccessioniPrimary (citable) accession number: Q6P3H4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3