Reviewed, UniProtKB/Swiss-Prot Q6P3E7 (HDA10_MOUSE)

Names and origin

Protein names

Recommended name:
    Histone deacetylase 10
      Short name=HD10
    EC=3.5.1.98

Gene names

Name:

Hdac10

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	666 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subunit structure	Interacts with HDAC2, HDAC3 and NCOR2 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Excluded from the nucleoli By similarity.
Sequence similarities	Belongs to the histone deacetylase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 666	666	Histone deacetylase 10		PRO_0000114713
Regions
	Region	1 – 323	323	Histone deacetylase
Sites
	Active site	135	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6P3E7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 21A7B35ACBF77A14	FASTA	666	72,110
	10 20 30 40 50 60 MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCLCL SACEASEEEL 70 80 90 100 110 120 GLVHSPEYIA LVQKTQTLDK EELHALSKQY DAVYFHPDTF HCARLAAGAA LQLVDAVLTG 130 140 150 160 170 180 AVHNGLALVR PPGHHSQRAA ANGFCVFNNV ALAAKHAKQK YGLQRILIVD WDVHHGQGIQ 190 200 210 220 230 240 YIFNDDPSVL YFSWHRYEHG SFWPFLPESD ADAVGQGQGQ GFTVNLPWNQ VGMGNADYLA 250 260 270 280 290 300 AFLHVLLPLA FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV 310 320 330 340 350 360 LEGGYHLESL AQSVCMMVQT LLGDPTPPLL GLMVPCQSAL ESIQSVQTAQ TPYWTSLQQN 370 380 390 400 410 420 VAPVLSSSTH SPEERSLRLL GESPTCAVAE DSLSPLLDQL CLRPAPPICT AVASTVPGAA 430 440 450 460 470 480 LCLPPGVLHQ EGSVLREETE AWARLHKSRF QDEDLATLGK ILCLLDGIMD GQIRNAIATT 490 500 510 520 530 540 TALATAATLD VLIQRCLARR AQRVLCVALG QLDRPLDLAD DGRILWLNIR GKDAAIQSMF 550 560 570 580 590 600 HFSTPLPQTT GGFLSLILGL VLPLAYGFQP DMVLMALGPA HGLQNAQAAL LAAMLRSPVG 610 620 630 640 650 660 GRILAVVEEE SIRLLARSLA QALHGETPPS LGPFSKATPE EIQALMFLKA RLEARWKLLQ VAAPPP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC064018 mRNA. Translation: AAH64018.1.
IPI	IPI00396751.
UniGene	Mm.203954
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6P3E7.
Proteomic databases
PRIDE	Q6P3E7.
Genome annotation databases
Ensembl	ENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906; Mus musculus. [Genome view]
KEGG	mmu:170787.
UCSC	uc007xfj.1. mouse.
Organism-specific databases
CTD	170787.
MGI	MGI:2158340. Hdac10.
Phylogenomic databases
HOGENOM	Q6P3E7.
HOVERGEN	Q6P3E7.
Gene expression databases
ArrayExpress	Q6P3E7.
Bgee	Q6P3E7.
CleanEx	MM_HDAC10.
Genevestigator	Q6P3E7.
GermOnline	ENSMUSG00000062906. Mus musculus.
Family and domain databases
InterPro	IPR000286. His_deacetylse. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PRINTS	PR01270. HDASUPER.
ProtoNet	Search...
Other Resources
NextBio	370419.
SOURCE	Search...

Entry information

Entry name

HDA10_MOUSE

Accession

Primary (citable) accession number: Q6P3E7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)