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Protein

Histone deacetylase 10

Gene

Hdac10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351By similarity

GO - Molecular functioni

  1. enzyme binding Source: MGI
  2. histone deacetylase activity Source: MGI
  3. histone deacetylase binding Source: MGI
  4. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  6. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  7. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  8. protein deacetylase activity Source: MGI

GO - Biological processi

  1. histone deacetylation Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  4. oligodendrocyte development Source: Ensembl
  5. protein deacetylation Source: MGI
  6. regulation of transcription, DNA-templated Source: MGI
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_257106. HDACs deacetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 10 (EC:3.5.1.98)
Short name:
HD10
Gene namesi
Name:Hdac10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2158340. Hdac10.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Excluded from the nucleoli.By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. histone deacetylase complex Source: MGI
  3. nucleoplasm Source: MGI
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666Histone deacetylase 10PRO_0000114713Add
BLAST

Proteomic databases

MaxQBiQ6P3E7.
PRIDEiQ6P3E7.

PTM databases

PhosphoSiteiQ6P3E7.

Expressioni

Gene expression databases

CleanExiMM_HDAC10.
ExpressionAtlasiQ6P3E7. baseline and differential.
GenevestigatoriQ6P3E7.

Interactioni

Subunit structurei

Interacts with HDAC2, HDAC3 and NCOR2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6P3E7.
SMRiQ6P3E7. Positions 30-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 323323Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000225183.
HOVERGENiHBG051892.
InParanoidiQ6P3E7.
KOiK18671.
OMAiGLEQRCL.
OrthoDBiEOG7992PT.
TreeFamiTF106173.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q6P3E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCLCL
60 70 80 90 100
SACEASEEEL GLVHSPEYIA LVQKTQTLDK EELHALSKQY NAVYFHPDTF
110 120 130 140 150
HCARLAAGAA LQLVDAVLTG AVHNGLALVR PPGHHSQRAA ANGFCVFNNV
160 170 180 190 200
ALAAKHAKQK YGLQRILIVD WDVHHGQGIQ YIFNDDPSVL YFSWHRYEHG
210 220 230 240 250
SFWPFLPESD ADAVGQGQGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA
260 270 280 290 300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV
310 320 330 340 350
LEGGYHLESL AQSVCMMVQT LLGDPTPPLL GLMVPCQSAL ESIQSVQTAQ
360 370 380 390 400
TPYWTSLQQN VAPVLSSSTH SPEERSLRLL GESPTCAVAE DSLSPLLDQL
410 420 430 440 450
CLRPAPPICT AVASTVPGAA LCLPPGVLHQ EGSVLREETE AWARLHKSRF
460 470 480 490 500
QDEDLATLGK ILCLLDGIMD GQIRNAIATT TALATAATLD VLIQRCLARR
510 520 530 540 550
AQRVLCVALG QLDRPLDLAD DGRILWLNIR GKDAAIQSMF HFSTPLPQTT
560 570 580 590 600
GGFLSLILGL VLPLAYGFQP DMVLMALGPA HGLQNAQAAL LAAMLRSPVG
610 620 630 640 650
GRILAVVEEE SIRLLARSLA QALHGETPPS LGPFSKATPE EIQALMFLKA
660
RLEARWKLLQ VAAPPP
Length:666
Mass (Da):72,109
Last modified:October 3, 2012 - v2
Checksum:i1F011B546D5D9A17
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911N → D in AAH64018 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113069 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04375.1.
BC064018 mRNA. Translation: AAH64018.1.
CCDSiCCDS27739.1.
RefSeqiNP_954668.2. NM_199198.2.
UniGeneiMm.203954.

Genome annotation databases

EnsembliENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906.
GeneIDi170787.
KEGGimmu:170787.
UCSCiuc007xfj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113069 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04375.1.
BC064018 mRNA. Translation: AAH64018.1.
CCDSiCCDS27739.1.
RefSeqiNP_954668.2. NM_199198.2.
UniGeneiMm.203954.

3D structure databases

ProteinModelPortaliQ6P3E7.
SMRiQ6P3E7. Positions 30-362.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6P3E7.

Proteomic databases

MaxQBiQ6P3E7.
PRIDEiQ6P3E7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906.
GeneIDi170787.
KEGGimmu:170787.
UCSCiuc007xfj.2. mouse.

Organism-specific databases

CTDi83933.
MGIiMGI:2158340. Hdac10.

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000225183.
HOVERGENiHBG051892.
InParanoidiQ6P3E7.
KOiK18671.
OMAiGLEQRCL.
OrthoDBiEOG7992PT.
TreeFamiTF106173.

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_257106. HDACs deacetylate histones.

Miscellaneous databases

ChiTaRSiHdac10. mouse.
NextBioi370419.
PROiQ6P3E7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HDAC10.
ExpressionAtlasiQ6P3E7. baseline and differential.
GenevestigatoriQ6P3E7.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiHDA10_MOUSE
AccessioniPrimary (citable) accession number: Q6P3E7
Secondary accession number(s): G3X9I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: February 4, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.