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Q6P3E7 (HDA10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 10

Short name=HD10
EC=3.5.1.98
Gene names
Name:Hdac10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure

Interacts with HDAC2, HDAC3 and NCOR2 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Excluded from the nucleoli By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 666666Histone deacetylase 10
PRO_0000114713

Regions

Region1 – 323323Histone deacetylase

Sites

Active site1351 By similarity

Experimental info

Sequence conflict911N → D in AAH64018. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q6P3E7 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 1F011B546D5D9A17

FASTA66672,109
        10         20         30         40         50         60 
MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCLCL SACEASEEEL 

        70         80         90        100        110        120 
GLVHSPEYIA LVQKTQTLDK EELHALSKQY NAVYFHPDTF HCARLAAGAA LQLVDAVLTG 

       130        140        150        160        170        180 
AVHNGLALVR PPGHHSQRAA ANGFCVFNNV ALAAKHAKQK YGLQRILIVD WDVHHGQGIQ 

       190        200        210        220        230        240 
YIFNDDPSVL YFSWHRYEHG SFWPFLPESD ADAVGQGQGQ GFTVNLPWNQ VGMGNADYLA 

       250        260        270        280        290        300 
AFLHVLLPLA FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV 

       310        320        330        340        350        360 
LEGGYHLESL AQSVCMMVQT LLGDPTPPLL GLMVPCQSAL ESIQSVQTAQ TPYWTSLQQN 

       370        380        390        400        410        420 
VAPVLSSSTH SPEERSLRLL GESPTCAVAE DSLSPLLDQL CLRPAPPICT AVASTVPGAA 

       430        440        450        460        470        480 
LCLPPGVLHQ EGSVLREETE AWARLHKSRF QDEDLATLGK ILCLLDGIMD GQIRNAIATT 

       490        500        510        520        530        540 
TALATAATLD VLIQRCLARR AQRVLCVALG QLDRPLDLAD DGRILWLNIR GKDAAIQSMF 

       550        560        570        580        590        600 
HFSTPLPQTT GGFLSLILGL VLPLAYGFQP DMVLMALGPA HGLQNAQAAL LAAMLRSPVG 

       610        620        630        640        650        660 
GRILAVVEEE SIRLLARSLA QALHGETPPS LGPFSKATPE EIQALMFLKA RLEARWKLLQ 


VAAPPP 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC113069 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04375.1.
BC064018 mRNA. Translation: AAH64018.1.
CCDSCCDS27739.1.
RefSeqNP_954668.2. NM_199198.2.
UniGeneMm.203954.

3D structure databases

ProteinModelPortalQ6P3E7.
SMRQ6P3E7. Positions 30-362.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6P3E7.

Proteomic databases

PRIDEQ6P3E7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906.
GeneID170787.
KEGGmmu:170787.
UCSCuc007xfj.2. mouse.

Organism-specific databases

CTD83933.
MGIMGI:2158340. Hdac10.

Phylogenomic databases

eggNOGCOG0123.
GeneTreeENSGT00530000062809.
HOGENOMHOG000225183.
HOVERGENHBG051892.
InParanoidQ6P3E7.
KOK11407.
OMAGLEQRCL.
OrthoDBEOG7992PT.
TreeFamTF106173.

Gene expression databases

ArrayExpressQ6P3E7.
CleanExMM_HDAC10.
GenevestigatorQ6P3E7.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Other

ChiTaRSHDAC10. mouse.
NextBio370419.
PROQ6P3E7.
SOURCESearch...

Entry information

Entry nameHDA10_MOUSE
AccessionPrimary (citable) accession number: Q6P3E7
Secondary accession number(s): G3X9I8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot