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Q6P3E7

- HDA10_MOUSE

UniProt

Q6P3E7 - HDA10_MOUSE

Protein

Histone deacetylase 10

Gene

Hdac10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei135 – 1351By similarity

    GO - Molecular functioni

    1. histone deacetylase activity Source: MGI
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. histone deacetylation Source: MGI
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. oligodendrocyte development Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 10 (EC:3.5.1.98)
    Short name:
    HD10
    Gene namesi
    Name:Hdac10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2158340. Hdac10.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Excluded from the nucleoli.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. histone deacetylase complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 666666Histone deacetylase 10PRO_0000114713Add
    BLAST

    Proteomic databases

    PRIDEiQ6P3E7.

    PTM databases

    PhosphoSiteiQ6P3E7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P3E7.
    CleanExiMM_HDAC10.
    GenevestigatoriQ6P3E7.

    Interactioni

    Subunit structurei

    Interacts with HDAC2, HDAC3 and NCOR2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P3E7.
    SMRiQ6P3E7. Positions 30-362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 323323Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00530000062809.
    HOGENOMiHOG000225183.
    HOVERGENiHBG051892.
    InParanoidiQ6P3E7.
    KOiK11407.
    OMAiGLEQRCL.
    OrthoDBiEOG7992PT.
    TreeFamiTF106173.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q6P3E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCLCL    50
    SACEASEEEL GLVHSPEYIA LVQKTQTLDK EELHALSKQY NAVYFHPDTF 100
    HCARLAAGAA LQLVDAVLTG AVHNGLALVR PPGHHSQRAA ANGFCVFNNV 150
    ALAAKHAKQK YGLQRILIVD WDVHHGQGIQ YIFNDDPSVL YFSWHRYEHG 200
    SFWPFLPESD ADAVGQGQGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA 250
    FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV 300
    LEGGYHLESL AQSVCMMVQT LLGDPTPPLL GLMVPCQSAL ESIQSVQTAQ 350
    TPYWTSLQQN VAPVLSSSTH SPEERSLRLL GESPTCAVAE DSLSPLLDQL 400
    CLRPAPPICT AVASTVPGAA LCLPPGVLHQ EGSVLREETE AWARLHKSRF 450
    QDEDLATLGK ILCLLDGIMD GQIRNAIATT TALATAATLD VLIQRCLARR 500
    AQRVLCVALG QLDRPLDLAD DGRILWLNIR GKDAAIQSMF HFSTPLPQTT 550
    GGFLSLILGL VLPLAYGFQP DMVLMALGPA HGLQNAQAAL LAAMLRSPVG 600
    GRILAVVEEE SIRLLARSLA QALHGETPPS LGPFSKATPE EIQALMFLKA 650
    RLEARWKLLQ VAAPPP 666
    Length:666
    Mass (Da):72,109
    Last modified:October 3, 2012 - v2
    Checksum:i1F011B546D5D9A17
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911N → D in AAH64018. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113069 Genomic DNA. No translation available.
    CH466550 Genomic DNA. Translation: EDL04375.1.
    BC064018 mRNA. Translation: AAH64018.1.
    CCDSiCCDS27739.1.
    RefSeqiNP_954668.2. NM_199198.2.
    UniGeneiMm.203954.

    Genome annotation databases

    EnsembliENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906.
    GeneIDi170787.
    KEGGimmu:170787.
    UCSCiuc007xfj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113069 Genomic DNA. No translation available.
    CH466550 Genomic DNA. Translation: EDL04375.1 .
    BC064018 mRNA. Translation: AAH64018.1 .
    CCDSi CCDS27739.1.
    RefSeqi NP_954668.2. NM_199198.2.
    UniGenei Mm.203954.

    3D structure databases

    ProteinModelPortali Q6P3E7.
    SMRi Q6P3E7. Positions 30-362.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6P3E7.

    Proteomic databases

    PRIDEi Q6P3E7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082197 ; ENSMUSP00000080832 ; ENSMUSG00000062906 .
    GeneIDi 170787.
    KEGGi mmu:170787.
    UCSCi uc007xfj.2. mouse.

    Organism-specific databases

    CTDi 83933.
    MGIi MGI:2158340. Hdac10.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00530000062809.
    HOGENOMi HOG000225183.
    HOVERGENi HBG051892.
    InParanoidi Q6P3E7.
    KOi K11407.
    OMAi GLEQRCL.
    OrthoDBi EOG7992PT.
    TreeFami TF106173.

    Enzyme and pathway databases

    Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Miscellaneous databases

    ChiTaRSi HDAC10. mouse.
    NextBioi 370419.
    PROi Q6P3E7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P3E7.
    CleanExi MM_HDAC10.
    Genevestigatori Q6P3E7.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiHDA10_MOUSE
    AccessioniPrimary (citable) accession number: Q6P3E7
    Secondary accession number(s): G3X9I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3