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Q6P3E7

- HDA10_MOUSE

UniProt

Q6P3E7 - HDA10_MOUSE

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Protein
Histone deacetylase 10
Gene
Hdac10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351 By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. histone deacetylase activity Source: MGI

GO - Biological processi

  1. histone deacetylation Source: MGI
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. oligodendrocyte development Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 10 (EC:3.5.1.98)
Short name:
HD10
Gene namesi
Name:Hdac10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2158340. Hdac10.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Excluded from the nucleoli By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. histone deacetylase complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666Histone deacetylase 10
PRO_0000114713Add
BLAST

Proteomic databases

PRIDEiQ6P3E7.

PTM databases

PhosphoSiteiQ6P3E7.

Expressioni

Gene expression databases

ArrayExpressiQ6P3E7.
CleanExiMM_HDAC10.
GenevestigatoriQ6P3E7.

Interactioni

Subunit structurei

Interacts with HDAC2, HDAC3 and NCOR2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6P3E7.
SMRiQ6P3E7. Positions 30-362.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 323323Histone deacetylase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000225183.
HOVERGENiHBG051892.
InParanoidiQ6P3E7.
KOiK11407.
OMAiGLEQRCL.
OrthoDBiEOG7992PT.
TreeFamiTF106173.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q6P3E7-1 [UniParc]FASTAAdd to Basket

« Hide

MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCLCL    50
SACEASEEEL GLVHSPEYIA LVQKTQTLDK EELHALSKQY NAVYFHPDTF 100
HCARLAAGAA LQLVDAVLTG AVHNGLALVR PPGHHSQRAA ANGFCVFNNV 150
ALAAKHAKQK YGLQRILIVD WDVHHGQGIQ YIFNDDPSVL YFSWHRYEHG 200
SFWPFLPESD ADAVGQGQGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA 250
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV 300
LEGGYHLESL AQSVCMMVQT LLGDPTPPLL GLMVPCQSAL ESIQSVQTAQ 350
TPYWTSLQQN VAPVLSSSTH SPEERSLRLL GESPTCAVAE DSLSPLLDQL 400
CLRPAPPICT AVASTVPGAA LCLPPGVLHQ EGSVLREETE AWARLHKSRF 450
QDEDLATLGK ILCLLDGIMD GQIRNAIATT TALATAATLD VLIQRCLARR 500
AQRVLCVALG QLDRPLDLAD DGRILWLNIR GKDAAIQSMF HFSTPLPQTT 550
GGFLSLILGL VLPLAYGFQP DMVLMALGPA HGLQNAQAAL LAAMLRSPVG 600
GRILAVVEEE SIRLLARSLA QALHGETPPS LGPFSKATPE EIQALMFLKA 650
RLEARWKLLQ VAAPPP 666
Length:666
Mass (Da):72,109
Last modified:October 3, 2012 - v2
Checksum:i1F011B546D5D9A17
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911N → D in AAH64018. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC113069 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04375.1.
BC064018 mRNA. Translation: AAH64018.1.
CCDSiCCDS27739.1.
RefSeqiNP_954668.2. NM_199198.2.
UniGeneiMm.203954.

Genome annotation databases

EnsembliENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906.
GeneIDi170787.
KEGGimmu:170787.
UCSCiuc007xfj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC113069 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04375.1 .
BC064018 mRNA. Translation: AAH64018.1 .
CCDSi CCDS27739.1.
RefSeqi NP_954668.2. NM_199198.2.
UniGenei Mm.203954.

3D structure databases

ProteinModelPortali Q6P3E7.
SMRi Q6P3E7. Positions 30-362.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6P3E7.

Proteomic databases

PRIDEi Q6P3E7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082197 ; ENSMUSP00000080832 ; ENSMUSG00000062906 .
GeneIDi 170787.
KEGGi mmu:170787.
UCSCi uc007xfj.2. mouse.

Organism-specific databases

CTDi 83933.
MGIi MGI:2158340. Hdac10.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062809.
HOGENOMi HOG000225183.
HOVERGENi HBG051892.
InParanoidi Q6P3E7.
KOi K11407.
OMAi GLEQRCL.
OrthoDBi EOG7992PT.
TreeFami TF106173.

Enzyme and pathway databases

Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

ChiTaRSi HDAC10. mouse.
NextBioi 370419.
PROi Q6P3E7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6P3E7.
CleanExi MM_HDAC10.
Genevestigatori Q6P3E7.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiHDA10_MOUSE
AccessioniPrimary (citable) accession number: Q6P3E7
Secondary accession number(s): G3X9I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi