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Protein

Histone deacetylase 10

Gene

Hdac10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei135By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 10 (EC:3.5.1.98)
Short name:
HD10
Gene namesi
Name:Hdac10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2158340. Hdac10.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Excluded from the nucleoli.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147131 – 666Histone deacetylase 10Add BLAST666

Proteomic databases

MaxQBiQ6P3E7.
PaxDbiQ6P3E7.
PRIDEiQ6P3E7.

PTM databases

PhosphoSitePlusiQ6P3E7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062906.
CleanExiMM_HDAC10.
ExpressionAtlasiQ6P3E7. baseline and differential.
GenevisibleiQ6P3E7. MM.

Interactioni

Subunit structurei

Interacts with HDAC2, HDAC3 and NCOR2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228438. 6 interactors.
IntActiQ6P3E7. 2 interactors.
STRINGi10090.ENSMUSP00000080832.

Structurei

3D structure databases

ProteinModelPortaliQ6P3E7.
SMRiQ6P3E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 323Histone deacetylaseAdd BLAST323

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000225183.
HOVERGENiHBG051892.
InParanoidiQ6P3E7.
KOiK18671.
OMAiGLEQRCL.
OrthoDBiEOG091G0210.
TreeFamiTF106173.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q6P3E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCLCL
60 70 80 90 100
SACEASEEEL GLVHSPEYIA LVQKTQTLDK EELHALSKQY NAVYFHPDTF
110 120 130 140 150
HCARLAAGAA LQLVDAVLTG AVHNGLALVR PPGHHSQRAA ANGFCVFNNV
160 170 180 190 200
ALAAKHAKQK YGLQRILIVD WDVHHGQGIQ YIFNDDPSVL YFSWHRYEHG
210 220 230 240 250
SFWPFLPESD ADAVGQGQGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA
260 270 280 290 300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV
310 320 330 340 350
LEGGYHLESL AQSVCMMVQT LLGDPTPPLL GLMVPCQSAL ESIQSVQTAQ
360 370 380 390 400
TPYWTSLQQN VAPVLSSSTH SPEERSLRLL GESPTCAVAE DSLSPLLDQL
410 420 430 440 450
CLRPAPPICT AVASTVPGAA LCLPPGVLHQ EGSVLREETE AWARLHKSRF
460 470 480 490 500
QDEDLATLGK ILCLLDGIMD GQIRNAIATT TALATAATLD VLIQRCLARR
510 520 530 540 550
AQRVLCVALG QLDRPLDLAD DGRILWLNIR GKDAAIQSMF HFSTPLPQTT
560 570 580 590 600
GGFLSLILGL VLPLAYGFQP DMVLMALGPA HGLQNAQAAL LAAMLRSPVG
610 620 630 640 650
GRILAVVEEE SIRLLARSLA QALHGETPPS LGPFSKATPE EIQALMFLKA
660
RLEARWKLLQ VAAPPP
Length:666
Mass (Da):72,109
Last modified:October 3, 2012 - v2
Checksum:i1F011B546D5D9A17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91N → D in AAH64018 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113069 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04375.1.
BC064018 mRNA. Translation: AAH64018.1.
CCDSiCCDS27739.1.
RefSeqiNP_954668.2. NM_199198.2.
UniGeneiMm.203954.

Genome annotation databases

EnsembliENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906.
GeneIDi170787.
KEGGimmu:170787.
UCSCiuc007xfj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113069 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04375.1.
BC064018 mRNA. Translation: AAH64018.1.
CCDSiCCDS27739.1.
RefSeqiNP_954668.2. NM_199198.2.
UniGeneiMm.203954.

3D structure databases

ProteinModelPortaliQ6P3E7.
SMRiQ6P3E7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228438. 6 interactors.
IntActiQ6P3E7. 2 interactors.
STRINGi10090.ENSMUSP00000080832.

PTM databases

PhosphoSitePlusiQ6P3E7.

Proteomic databases

MaxQBiQ6P3E7.
PaxDbiQ6P3E7.
PRIDEiQ6P3E7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906.
GeneIDi170787.
KEGGimmu:170787.
UCSCiuc007xfj.2. mouse.

Organism-specific databases

CTDi83933.
MGIiMGI:2158340. Hdac10.

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000225183.
HOVERGENiHBG051892.
InParanoidiQ6P3E7.
KOiK18671.
OMAiGLEQRCL.
OrthoDBiEOG091G0210.
TreeFamiTF106173.

Miscellaneous databases

ChiTaRSiHdac10. mouse.
PROiQ6P3E7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062906.
CleanExiMM_HDAC10.
ExpressionAtlasiQ6P3E7. baseline and differential.
GenevisibleiQ6P3E7. MM.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Entry informationi

Entry nameiHDA10_MOUSE
AccessioniPrimary (citable) accession number: Q6P3E7
Secondary accession number(s): G3X9I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.