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Protein

ADP-ribosylation factor-like protein 11

Gene

Arl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in apoptosis. May act as a tumor suppressor (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 11
Gene namesi
Name:Arl11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2444054. Arl11.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074802 – 176ADP-ribosylation factor-like protein 11Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ6P3A9.
PaxDbiQ6P3A9.
PRIDEiQ6P3A9.

PTM databases

iPTMnetiQ6P3A9.
PhosphoSitePlusiQ6P3A9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043157.
CleanExiMM_ARL11.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055447.

Structurei

3D structure databases

ProteinModelPortaliQ6P3A9.
SMRiQ6P3A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00900000140921.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ6P3A9.
KOiK07959.
OMAiWKDYLEG.
OrthoDBiEOG091G0O0X.
PhylomeDBiQ6P3A9.
TreeFamiTF105471.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P3A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVNSRGHK AEAQVVMMGL DSAGKTTILY KLKGNQLVDT LPTVGFNVEP
60 70 80 90 100
LEAPGHVSLT LWDIGGQTQL RATWKDYLEG IDLLVYVLDS TDEARLPEAV
110 120 130 140 150
AELKEVLEDP NMAGVPFLVL ANKQEAPGAL PLLEIRNRLG LEGFQKHCWE
160 170
LRACSALTGQ GLQEALQSLL HLLKSR
Length:176
Mass (Da):19,212
Last modified:July 5, 2004 - v1
Checksum:i11D8E6C970E81C60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60T → S in BAC34053 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008804 mRNA. Translation: BAE43212.1.
AK050053 mRNA. Translation: BAC34053.1.
BC064093 mRNA. Translation: AAH64093.1.
CCDSiCCDS27182.1.
RefSeqiNP_796311.2. NM_177337.3.
XP_011243330.1. XM_011245028.1.
UniGeneiMm.206566.

Genome annotation databases

EnsembliENSMUST00000055159; ENSMUSP00000055447; ENSMUSG00000043157.
ENSMUST00000224727; ENSMUSP00000153531; ENSMUSG00000043157.
GeneIDi219144.
KEGGimmu:219144.
UCSCiuc007ufu.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiARL11_MOUSE
AccessioniPrimary (citable) accession number: Q6P3A9
Secondary accession number(s): Q8C7K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families