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Protein

ADP-ribosylation factor-like protein 11

Gene

Arl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in apoptosis. May act as a tumor suppressor (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi122 – 1254GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 11
Gene namesi
Name:Arl11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2444054. Arl11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 176175ADP-ribosylation factor-like protein 11PRO_0000207480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ6P3A9.
PaxDbiQ6P3A9.
PRIDEiQ6P3A9.

PTM databases

iPTMnetiQ6P3A9.
PhosphoSiteiQ6P3A9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043157.
CleanExiMM_ARL11.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055447.

Structurei

3D structure databases

ProteinModelPortaliQ6P3A9.
SMRiQ6P3A9. Positions 14-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ6P3A9.
KOiK07959.
OMAiWKDYLEG.
OrthoDBiEOG091G0O0X.
PhylomeDBiQ6P3A9.
TreeFamiTF105471.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P3A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVNSRGHK AEAQVVMMGL DSAGKTTILY KLKGNQLVDT LPTVGFNVEP
60 70 80 90 100
LEAPGHVSLT LWDIGGQTQL RATWKDYLEG IDLLVYVLDS TDEARLPEAV
110 120 130 140 150
AELKEVLEDP NMAGVPFLVL ANKQEAPGAL PLLEIRNRLG LEGFQKHCWE
160 170
LRACSALTGQ GLQEALQSLL HLLKSR
Length:176
Mass (Da):19,212
Last modified:July 5, 2004 - v1
Checksum:i11D8E6C970E81C60
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601T → S in BAC34053 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008804 mRNA. Translation: BAE43212.1.
AK050053 mRNA. Translation: BAC34053.1.
BC064093 mRNA. Translation: AAH64093.1.
CCDSiCCDS27182.1.
RefSeqiNP_796311.2. NM_177337.3.
XP_011243330.1. XM_011245028.1.
UniGeneiMm.206566.

Genome annotation databases

EnsembliENSMUST00000055159; ENSMUSP00000055447; ENSMUSG00000043157.
GeneIDi219144.
KEGGimmu:219144.
UCSCiuc007ufu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008804 mRNA. Translation: BAE43212.1.
AK050053 mRNA. Translation: BAC34053.1.
BC064093 mRNA. Translation: AAH64093.1.
CCDSiCCDS27182.1.
RefSeqiNP_796311.2. NM_177337.3.
XP_011243330.1. XM_011245028.1.
UniGeneiMm.206566.

3D structure databases

ProteinModelPortaliQ6P3A9.
SMRiQ6P3A9. Positions 14-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055447.

PTM databases

iPTMnetiQ6P3A9.
PhosphoSiteiQ6P3A9.

Proteomic databases

MaxQBiQ6P3A9.
PaxDbiQ6P3A9.
PRIDEiQ6P3A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055159; ENSMUSP00000055447; ENSMUSG00000043157.
GeneIDi219144.
KEGGimmu:219144.
UCSCiuc007ufu.1. mouse.

Organism-specific databases

CTDi115761.
MGIiMGI:2444054. Arl11.

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ6P3A9.
KOiK07959.
OMAiWKDYLEG.
OrthoDBiEOG091G0O0X.
PhylomeDBiQ6P3A9.
TreeFamiTF105471.

Miscellaneous databases

ChiTaRSiArl11. mouse.
PROiQ6P3A9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043157.
CleanExiMM_ARL11.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL11_MOUSE
AccessioniPrimary (citable) accession number: Q6P3A9
Secondary accession number(s): Q8C7K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.