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Protein

Uncharacterized protein C16orf46

Gene

C16orf46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C16orf46
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26525. C16orf46.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi123775.
OpenTargetsiENSG00000166455.
PharmGKBiPA142672254.

Polymorphism and mutation databases

BioMutaiC16orf46.
DMDMi147689729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794291 – 395Uncharacterized protein C16orf46Add BLAST395

Proteomic databases

PaxDbiQ6P387.
PeptideAtlasiQ6P387.
PRIDEiQ6P387.

PTM databases

iPTMnetiQ6P387.
PhosphoSitePlusiQ6P387.

Expressioni

Gene expression databases

BgeeiENSG00000166455.
CleanExiHS_C16orf46.
ExpressionAtlasiQ6P387. baseline and differential.
GenevisibleiQ6P387. HS.

Organism-specific databases

HPAiHPA041136.
HPA041379.

Interactioni

Protein-protein interaction databases

BioGridi125833. 1 interactor.
STRINGi9606.ENSP00000299578.

Structurei

3D structure databases

ProteinModelPortaliQ6P387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKKI. Eukaryota.
ENOG411198Z. LUCA.
GeneTreeiENSGT00390000017224.
HOGENOMiHOG000090206.
HOVERGENiHBG081307.
InParanoidiQ6P387.
OMAiCPDERSE.
OrthoDBiEOG091G0F9P.
PhylomeDBiQ6P387.
TreeFamiTF338349.

Family and domain databases

InterProiIPR027836. DUF4529.
[Graphical view]
PfamiPF15032. DUF4529. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P387-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLCQKNETD LENAENNEIQ FTEETEPTYT CPDGKSEKNH VYCLLDVSDI
60 70 80 90 100
TLEQDEKAKE FIIGTGWEEA VQGWGRTSPA ACIWPRKIPK KARVGEGACS
110 120 130 140 150
DCLVCVNLSH WSLQTKPPTE GGPEKDQSSP SQTQAAPQGP STASRAISDI
160 170 180 190 200
CFPTYFRAEK KSLQIKEFIW CNKDWAIPGT NRGKASGNPS GGAHRGLSIP
210 220 230 240 250
GPLTSRALLV LPPLKASLSN ALDVLGKKSK NSFLQSEEKV LDVEKDGCVA
260 270 280 290 300
YAYGLKTADG KGEKRASELA KHPMVNDTPS SPSPAAQISL LTDPEQRCLH
310 320 330 340 350
WSLLSEKNLA CPPDPSNVRY LAALQLLQKR GVQSYKSKFK AKEPRSPVIT
360 370 380 390
RKHVLPKAKQ ENRPQMLETK VFPRPVLPSL TVSRVIIPVS THRIL
Length:395
Mass (Da):43,418
Last modified:March 6, 2007 - v2
Checksum:i9B64E3583082DD26
GO
Isoform 2 (identifier: Q6P387-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-395: VSRVIIPVSTHRIL → HRKKKIK

Show »
Length:388
Mass (Da):42,765
Checksum:iA2EF8A8B2F4182B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217S → L in BAB71401 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03089377T → S.1 PublicationCorresponds to variant rs17855893dbSNPEnsembl.1
Natural variantiVAR_030894288I → T.Corresponds to variant rs7198494dbSNPEnsembl.1
Natural variantiVAR_030895335Y → H.Corresponds to variant rs10459872dbSNPEnsembl.1
Natural variantiVAR_030896357K → E.Corresponds to variant rs9930623dbSNPEnsembl.1
Natural variantiVAR_030897388P → S.Corresponds to variant rs12929250dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023435382 – 395VSRVI…THRIL → HRKKKIK in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057264 mRNA. Translation: BAB71401.1.
BC064143 mRNA. Translation: AAH64143.1.
CCDSiCCDS10932.1. [Q6P387-1]
CCDS42201.1. [Q6P387-2]
RefSeqiNP_001094343.1. NM_001100873.1. [Q6P387-2]
NP_689550.2. NM_152337.2. [Q6P387-1]
XP_005255849.1. XM_005255792.2. [Q6P387-2]
UniGeneiHs.658684.

Genome annotation databases

EnsembliENST00000299578; ENSP00000299578; ENSG00000166455. [Q6P387-1]
ENST00000378611; ENSP00000367874; ENSG00000166455. [Q6P387-2]
GeneIDi123775.
KEGGihsa:123775.
UCSCiuc002fgc.5. human. [Q6P387-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057264 mRNA. Translation: BAB71401.1.
BC064143 mRNA. Translation: AAH64143.1.
CCDSiCCDS10932.1. [Q6P387-1]
CCDS42201.1. [Q6P387-2]
RefSeqiNP_001094343.1. NM_001100873.1. [Q6P387-2]
NP_689550.2. NM_152337.2. [Q6P387-1]
XP_005255849.1. XM_005255792.2. [Q6P387-2]
UniGeneiHs.658684.

3D structure databases

ProteinModelPortaliQ6P387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125833. 1 interactor.
STRINGi9606.ENSP00000299578.

PTM databases

iPTMnetiQ6P387.
PhosphoSitePlusiQ6P387.

Polymorphism and mutation databases

BioMutaiC16orf46.
DMDMi147689729.

Proteomic databases

PaxDbiQ6P387.
PeptideAtlasiQ6P387.
PRIDEiQ6P387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299578; ENSP00000299578; ENSG00000166455. [Q6P387-1]
ENST00000378611; ENSP00000367874; ENSG00000166455. [Q6P387-2]
GeneIDi123775.
KEGGihsa:123775.
UCSCiuc002fgc.5. human. [Q6P387-1]

Organism-specific databases

CTDi123775.
DisGeNETi123775.
GeneCardsiC16orf46.
HGNCiHGNC:26525. C16orf46.
HPAiHPA041136.
HPA041379.
neXtProtiNX_Q6P387.
OpenTargetsiENSG00000166455.
PharmGKBiPA142672254.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKKI. Eukaryota.
ENOG411198Z. LUCA.
GeneTreeiENSGT00390000017224.
HOGENOMiHOG000090206.
HOVERGENiHBG081307.
InParanoidiQ6P387.
OMAiCPDERSE.
OrthoDBiEOG091G0F9P.
PhylomeDBiQ6P387.
TreeFamiTF338349.

Miscellaneous databases

ChiTaRSiC16orf46. human.
GenomeRNAii123775.
PROiQ6P387.

Gene expression databases

BgeeiENSG00000166455.
CleanExiHS_C16orf46.
ExpressionAtlasiQ6P387. baseline and differential.
GenevisibleiQ6P387. HS.

Family and domain databases

InterProiIPR027836. DUF4529.
[Graphical view]
PfamiPF15032. DUF4529. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP046_HUMAN
AccessioniPrimary (citable) accession number: Q6P387
Secondary accession number(s): Q96MA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.