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Protein

Eukaryotic translation initiation factor 3 subunit H

Gene

eif3h

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Protein family/group databases

MEROPSiM67.971

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit HUniRule annotation
Short name:
eIF3hUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 3UniRule annotation
eIF-3-gamma
eIF3 p40 subunitUniRule annotation
Gene namesi
Name:eif3h
Synonyms:eif3s3
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-958115 eif3h

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003651801 – 335Eukaryotic translation initiation factor 3 subunit HAdd BLAST335

Proteomic databases

PaxDbiQ6P381

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.UniRule annotation

Protein-protein interaction databases

STRINGi8364.ENSXETP00000016127

Structurei

3D structure databases

ProteinModelPortaliQ6P381
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 156MPNPROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Belongs to the eIF-3 subunit H family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1560 Eukaryota
ENOG410XSR9 LUCA
HOGENOMiHOG000248787
HOVERGENiHBG000883
InParanoidiQ6P381
KOiK03247

Family and domain databases

CDDicd08065 MPN_eIF3h, 1 hit
HAMAPiMF_03007 eIF3h, 1 hit
InterProiView protein in InterPro
IPR027524 eIF3h
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
PANTHERiPTHR10410:SF3 PTHR10410:SF3, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARTRETGN TATVAETAVK QVQIDGMVVL KIIKHYQEEG HGSEVVQGVL
60 70 80 90 100
LGLVVDDRLE ITNCFPFPQH TEDDVDFDEV QYQMEMMRSL RHVNIDHLHV
110 120 130 140 150
GWYQSTFYGT FVSRALLDSQ FSYQHAIEES VVLIYDPIKT GQGSLSLKAY
160 170 180 190 200
RLTPKLMEVC KEKDFSAEGL KKANIAFEDM FEEVPIIIKN SHLINVLAWE
210 220 230 240 250
LDKKAPVTEK HELLNLSSSN HLEKSLQLLM DRVDELSQDI VKYNTYLRNI
260 270 280 290 300
SKQQQQKHQY TQRRQQENLQ RQSRGETSLP EEDVNKLFKP PVPPSRMDSL
310 320 330
LIAGQINTYI QHIKEFTSQN LGKLFMAEAM QDPTI
Length:335
Mass (Da):38,538
Last modified:July 5, 2004 - v1
Checksum:i18D4D446D6561BE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064151 mRNA Translation: AAH64151.1
RefSeqiNP_989359.1, NM_204028.1
UniGeneiStr.1956

Genome annotation databases

GeneIDi394989
KEGGixtr:394989

Similar proteinsi

Entry informationi

Entry nameiEIF3H_XENTR
AccessioniPrimary (citable) accession number: Q6P381
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health