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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

alg11

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_283920. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Asparagine-linked glycosylation protein 11 homolog
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:alg11
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5934131. alg11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000295621Add
BLAST

Expressioni

Gene expression databases

BgeeiQ6P312.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000044752.

Structurei

3D structure databases

ProteinModelPortaliQ6P312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0438.
GeneTreeiENSGT00550000075118.
HOGENOMiHOG000209670.
HOVERGENiHBG057178.
InParanoidiQ6P312.
KOiK03844.
OMAiWEALTAF.
OrthoDBiEOG7FFMRF.
TreeFamiTF313056.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGILCLCGM MRLLTALFIP VLIASIGLCL VLVLLFICTR LWIQRKKKQS
60 70 80 90 100
VEIGKDGKKK RVVAFFHPYC NAGGGGERVL WCALRSLQKR YKDAIYVIYT
110 120 130 140 150
GDKDVSEEQI LNGAAARFNI KLSHPVKFIF LEKRGLVEAS FYPRFTLLGQ
160 170 180 190 200
SLGSVVLGWE ALTKCVPDIY IDSMGYAFTL PLFKYVGGCQ VGCYVHYPTI
210 220 230 240 250
SMDMLSVVRS QNARFNNAAF ISNNPVLSRL KLIYYYLFAV IYGWVGSCSD
260 270 280 290 300
VIMVNSTWTF AHILDLWKCS ERTSIVYPPC DVQTFLDINL NQHKDIEEHS
310 320 330 340 350
IVSIGQFRPE KDHPLQICAF AALLKKKTTE KLKLKLILIG GCRNNEDELR
360 370 380 390 400
VSELKKLSSE LGIPVEFKVN IPFAELKKHL SEATIGLHTM WNEHFGIGIV
410 420 430 440 450
ECMAAGTIIL AHNSGGPKLD IVVPYEEHET GFLADSVESY AAAMDYILCL
460 470 480
TPEQRLTIRQ NARRSVARFS DQEFEANFLA SSEPLFM
Length:487
Mass (Da):54,815
Last modified:July 5, 2004 - v1
Checksum:i50102122875412B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064222 mRNA. Translation: AAH64222.1.
RefSeqiNP_989283.1. NM_203952.1.
UniGeneiStr.5877.

Genome annotation databases

EnsembliENSXETT00000044752; ENSXETP00000044752; ENSXETG00000020712.
GeneIDi394898.
KEGGixtr:394898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064222 mRNA. Translation: AAH64222.1.
RefSeqiNP_989283.1. NM_203952.1.
UniGeneiStr.5877.

3D structure databases

ProteinModelPortaliQ6P312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000044752.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000044752; ENSXETP00000044752; ENSXETG00000020712.
GeneIDi394898.
KEGGixtr:394898.

Organism-specific databases

CTDi440138.
XenbaseiXB-GENE-5934131. alg11.

Phylogenomic databases

eggNOGiCOG0438.
GeneTreeiENSGT00550000075118.
HOGENOMiHOG000209670.
HOVERGENiHBG057178.
InParanoidiQ6P312.
KOiK03844.
OMAiWEALTAF.
OrthoDBiEOG7FFMRF.
TreeFamiTF313056.

Enzyme and pathway databases

ReactomeiREACT_283920. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Gene expression databases

BgeeiQ6P312.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiALG11_XENTR
AccessioniPrimary (citable) accession number: Q6P312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.