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Q6P312

- ALG11_XENTR

UniProt

Q6P312 - ALG11_XENTR

Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

alg11

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

    GO - Molecular functioni

    1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_228008. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

    Protein family/group databases

    CAZyiGT4. Glycosyltransferase Family 4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
    Alternative name(s):
    Asparagine-linked glycosylation protein 11 homolog
    Glycolipid 2-alpha-mannosyltransferase
    Gene namesi
    Name:alg11
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5934131. alg11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000295621Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ6P312.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000044752.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P312.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0438.
    GeneTreeiENSGT00550000075118.
    HOGENOMiHOG000209670.
    HOVERGENiHBG057178.
    InParanoidiQ6P312.
    KOiK03844.
    OMAiSEDSYAA.
    OrthoDBiEOG7FFMRF.
    TreeFamiTF313056.

    Family and domain databases

    InterProiIPR001296. Glyco_trans_1.
    [Graphical view]
    PfamiPF00534. Glycos_transf_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P312-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGILCLCGM MRLLTALFIP VLIASIGLCL VLVLLFICTR LWIQRKKKQS    50
    VEIGKDGKKK RVVAFFHPYC NAGGGGERVL WCALRSLQKR YKDAIYVIYT 100
    GDKDVSEEQI LNGAAARFNI KLSHPVKFIF LEKRGLVEAS FYPRFTLLGQ 150
    SLGSVVLGWE ALTKCVPDIY IDSMGYAFTL PLFKYVGGCQ VGCYVHYPTI 200
    SMDMLSVVRS QNARFNNAAF ISNNPVLSRL KLIYYYLFAV IYGWVGSCSD 250
    VIMVNSTWTF AHILDLWKCS ERTSIVYPPC DVQTFLDINL NQHKDIEEHS 300
    IVSIGQFRPE KDHPLQICAF AALLKKKTTE KLKLKLILIG GCRNNEDELR 350
    VSELKKLSSE LGIPVEFKVN IPFAELKKHL SEATIGLHTM WNEHFGIGIV 400
    ECMAAGTIIL AHNSGGPKLD IVVPYEEHET GFLADSVESY AAAMDYILCL 450
    TPEQRLTIRQ NARRSVARFS DQEFEANFLA SSEPLFM 487
    Length:487
    Mass (Da):54,815
    Last modified:July 5, 2004 - v1
    Checksum:i50102122875412B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC064222 mRNA. Translation: AAH64222.1.
    RefSeqiNP_989283.1. NM_203952.1.
    UniGeneiStr.5877.

    Genome annotation databases

    EnsembliENSXETT00000044752; ENSXETP00000044752; ENSXETG00000020712.
    GeneIDi394898.
    KEGGixtr:394898.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC064222 mRNA. Translation: AAH64222.1 .
    RefSeqi NP_989283.1. NM_203952.1.
    UniGenei Str.5877.

    3D structure databases

    ProteinModelPortali Q6P312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000044752.

    Protein family/group databases

    CAZyi GT4. Glycosyltransferase Family 4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000044752 ; ENSXETP00000044752 ; ENSXETG00000020712 .
    GeneIDi 394898.
    KEGGi xtr:394898.

    Organism-specific databases

    CTDi 440138.
    Xenbasei XB-GENE-5934131. alg11.

    Phylogenomic databases

    eggNOGi COG0438.
    GeneTreei ENSGT00550000075118.
    HOGENOMi HOG000209670.
    HOVERGENi HBG057178.
    InParanoidi Q6P312.
    KOi K03844.
    OMAi SEDSYAA.
    OrthoDBi EOG7FFMRF.
    TreeFami TF313056.

    Enzyme and pathway databases

    Reactomei REACT_228008. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

    Gene expression databases

    Bgeei Q6P312.

    Family and domain databases

    InterProi IPR001296. Glyco_trans_1.
    [Graphical view ]
    Pfami PF00534. Glycos_transf_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiALG11_XENTR
    AccessioniPrimary (citable) accession number: Q6P312
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3