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Q6P312

- ALG11_XENTR

UniProt

Q6P312 - ALG11_XENTR

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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

alg11

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

GO - Molecular functioni

  1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_228008. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Asparagine-linked glycosylation protein 11 homolog
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:alg11
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5934131. alg11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000295621Add
BLAST

Expressioni

Gene expression databases

BgeeiQ6P312.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000044752.

Structurei

3D structure databases

ProteinModelPortaliQ6P312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0438.
GeneTreeiENSGT00550000075118.
HOGENOMiHOG000209670.
HOVERGENiHBG057178.
InParanoidiQ6P312.
KOiK03844.
OMAiSEDSYAA.
OrthoDBiEOG7FFMRF.
TreeFamiTF313056.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P312-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGILCLCGM MRLLTALFIP VLIASIGLCL VLVLLFICTR LWIQRKKKQS
60 70 80 90 100
VEIGKDGKKK RVVAFFHPYC NAGGGGERVL WCALRSLQKR YKDAIYVIYT
110 120 130 140 150
GDKDVSEEQI LNGAAARFNI KLSHPVKFIF LEKRGLVEAS FYPRFTLLGQ
160 170 180 190 200
SLGSVVLGWE ALTKCVPDIY IDSMGYAFTL PLFKYVGGCQ VGCYVHYPTI
210 220 230 240 250
SMDMLSVVRS QNARFNNAAF ISNNPVLSRL KLIYYYLFAV IYGWVGSCSD
260 270 280 290 300
VIMVNSTWTF AHILDLWKCS ERTSIVYPPC DVQTFLDINL NQHKDIEEHS
310 320 330 340 350
IVSIGQFRPE KDHPLQICAF AALLKKKTTE KLKLKLILIG GCRNNEDELR
360 370 380 390 400
VSELKKLSSE LGIPVEFKVN IPFAELKKHL SEATIGLHTM WNEHFGIGIV
410 420 430 440 450
ECMAAGTIIL AHNSGGPKLD IVVPYEEHET GFLADSVESY AAAMDYILCL
460 470 480
TPEQRLTIRQ NARRSVARFS DQEFEANFLA SSEPLFM
Length:487
Mass (Da):54,815
Last modified:July 5, 2004 - v1
Checksum:i50102122875412B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064222 mRNA. Translation: AAH64222.1.
RefSeqiNP_989283.1. NM_203952.1.
UniGeneiStr.5877.

Genome annotation databases

EnsembliENSXETT00000044752; ENSXETP00000044752; ENSXETG00000020712.
GeneIDi394898.
KEGGixtr:394898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064222 mRNA. Translation: AAH64222.1 .
RefSeqi NP_989283.1. NM_203952.1.
UniGenei Str.5877.

3D structure databases

ProteinModelPortali Q6P312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000044752.

Protein family/group databases

CAZyi GT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000044752 ; ENSXETP00000044752 ; ENSXETG00000020712 .
GeneIDi 394898.
KEGGi xtr:394898.

Organism-specific databases

CTDi 440138.
Xenbasei XB-GENE-5934131. alg11.

Phylogenomic databases

eggNOGi COG0438.
GeneTreei ENSGT00550000075118.
HOGENOMi HOG000209670.
HOVERGENi HBG057178.
InParanoidi Q6P312.
KOi K03844.
OMAi SEDSYAA.
OrthoDBi EOG7FFMRF.
TreeFami TF313056.

Enzyme and pathway databases

Reactomei REACT_228008. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Gene expression databases

Bgeei Q6P312.

Family and domain databases

InterProi IPR001296. Glyco_trans_1.
[Graphical view ]
Pfami PF00534. Glycos_transf_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiALG11_XENTR
AccessioniPrimary (citable) accession number: Q6P312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3