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Protein

Tetraspanin

Gene

cd63

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • hatching Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
TetraspaninUniRule annotation
Gene namesi
Name:cd63Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-030131-180. cd63.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 34HelicalUniRule annotationAdd BLAST23
Transmembranei54 – 74HelicalUniRule annotationAdd BLAST21
Transmembranei81 – 105HelicalUniRule annotationAdd BLAST25
Transmembranei202 – 227HelicalUniRule annotationAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000025147.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000031764.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
KOiK06497.
OMAiTHQLFEC.
OrthoDBiEOG091G12WV.
TreeFamiTF352891.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P2T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVEGGAKCV KYLLFFFNFI FWLCGLALIV LGILVHVSLH NTAILQGASG
60 70 80 90 100
SPMVLIVVGV IIFFISFFGC CGAWKENQCM VVTFAIILSL IVITEIGAGI
110 120 130 140 150
AGYIFRGKVN ELLDQSFNTM IAGYNKTEEY RTTLDSIQKQ LKCCGGNSSS
160 170 180 190 200
DWVNFSADHI SVPDSCCKNV TKNCGIGAMT KPTVIYLEGC QPILETRIKE
210 220 230
NILWIAVGAL VIGFVQITGI VLACILSRAI RSGYEVM
Length:237
Mass (Da):25,758
Last modified:July 5, 2004 - v1
Checksum:iBA4782AEB5E86E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU469363 Genomic DNA. No translation available.
BC056698 mRNA. Translation: AAH56698.1.
BC064300 mRNA. Translation: AAH64300.1.
RefSeqiNP_955837.1. NM_199543.1.
UniGeneiDr.76749.

Genome annotation databases

EnsembliENSDART00000031047; ENSDARP00000031764; ENSDARG00000025147.
GeneIDi321461.
KEGGidre:321461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU469363 Genomic DNA. No translation available.
BC056698 mRNA. Translation: AAH56698.1.
BC064300 mRNA. Translation: AAH64300.1.
RefSeqiNP_955837.1. NM_199543.1.
UniGeneiDr.76749.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000031764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000031047; ENSDARP00000031764; ENSDARG00000025147.
GeneIDi321461.
KEGGidre:321461.

Organism-specific databases

CTDi967.
ZFINiZDB-GENE-030131-180. cd63.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
KOiK06497.
OMAiTHQLFEC.
OrthoDBiEOG091G12WV.
TreeFamiTF352891.

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-6798695. Neutrophil degranulation.

Gene expression databases

BgeeiENSDARG00000025147.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6P2T9_DANRE
AccessioniPrimary (citable) accession number: Q6P2T9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.