ID   ANM9_HUMAN              Reviewed;         845 AA.
AC   Q6P2P2; A8KA39; B3KU92; Q6ZR58; Q8N383; Q9BT55; Q9NT98;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   09-DEC-2015, entry version 113.
DE   RecName: Full=Putative protein arginine N-methyltransferase 9;
DE   AltName: Full=Putative protein arginine N-methyltransferase 10;
DE            EC=2.1.1.-;
GN   Name=PRMT9; Synonyms=PRMT10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Kidney, Skin, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 678-845 (ISOFORM 1).
RC   TISSUE=Amygdala;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=17005254; DOI=10.1016/j.pharmthera.2006.06.007;
RA   Krause C.D., Yang Z.-H., Kim Y.-S., Lee J.-H., Cook J.R., Pestka S.;
RT   "Protein arginine methyltransferases: evolution and assessment of
RT   their pharmacological and therapeutic potential.";
RL   Pharmacol. Ther. 113:50-87(2007).
RN   [7]
RP   IDENTIFICATION.
RX   PubMed=19300908; DOI=10.1007/s00018-009-0010-x;
RA   Wolf S.S.;
RT   "The protein arginine methyltransferase family: an update about
RT   function, new perspectives and the physiological role in humans.";
RL   Cell. Mol. Life Sci. 66:2109-2121(2009).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6P2P2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P2P2-2; Sequence=VSP_053972;
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. Protein arginine N-
CC       methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU01015}.
CC   -!- SIMILARITY: Contains 2 SAM-dependent MTase PRMT-type domains.
CC       {ECO:0000255|PROSITE-ProRule:PRU01015}.
CC   -!- SIMILARITY: Contains 3 TPR repeats. {ECO:0000255|PROSITE-
CC       ProRule:PRU00339}.
CC   -!- CAUTION: This protein should not be confused with FBXO11 (AC
CC       Q86XK2) that was initially named PRMT9. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC87459.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR   EMBL; AK128483; BAC87459.1; ALT_SEQ; mRNA.
DR   EMBL; AK096703; BAG53354.1; -; mRNA.
DR   EMBL; AK292904; BAF85593.1; -; mRNA.
DR   EMBL; AC093835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471056; EAX05013.1; -; Genomic_DNA.
DR   EMBL; BC004337; AAH04337.1; -; mRNA.
DR   EMBL; BC021250; AAH21250.2; -; mRNA.
DR   EMBL; BC064403; AAH64403.1; -; mRNA.
DR   EMBL; AL137452; CAB70744.1; -; mRNA.
DR   EMBL; CH471056; EAX05011.1; -; Genomic_DNA.
DR   CCDS; CCDS3771.1; -. [Q6P2P2-1]
DR   PIR; T46267; T46267.
DR   RefSeq; NP_001291387.1; NM_001304458.1. [Q6P2P2-2]
DR   RefSeq; NP_612373.2; NM_138364.3. [Q6P2P2-1]
DR   UniGene; Hs.591692; -.
DR   ProteinModelPortal; Q6P2P2; -.
DR   SMR; Q6P2P2; 149-428.
DR   BioGrid; 124766; 7.
DR   IntAct; Q6P2P2; 4.
DR   STRING; 9606.ENSP00000314396; -.
DR   PhosphoSite; Q6P2P2; -.
DR   BioMuta; PRMT10; -.
DR   DMDM; 74758248; -.
DR   MaxQB; Q6P2P2; -.
DR   PaxDb; Q6P2P2; -.
DR   PRIDE; Q6P2P2; -.
DR   Ensembl; ENST00000322396; ENSP00000314396; ENSG00000164169. [Q6P2P2-1]
DR   GeneID; 90826; -.
DR   KEGG; hsa:90826; -.
DR   UCSC; uc003ilb.3; human. [Q6P2P2-1]
DR   CTD; 90826; -.
DR   GeneCards; PRMT9; -.
DR   HGNC; HGNC:25099; PRMT9.
DR   HPA; HPA036844; -.
DR   HPA; HPA042537; -.
DR   MIM; 616125; gene.
DR   neXtProt; NX_Q6P2P2; -.
DR   PharmGKB; PA165664476; -.
DR   eggNOG; ENOG410INRY; Eukaryota.
DR   eggNOG; ENOG410Y35C; LUCA.
DR   GeneTree; ENSGT00530000063495; -.
DR   HOGENOM; HOG000285961; -.
DR   InParanoid; Q6P2P2; -.
DR   OMA; WFVLQLD; -.
DR   OrthoDB; EOG74FF0J; -.
DR   PhylomeDB; Q6P2P2; -.
DR   TreeFam; TF315221; -.
DR   GenomeRNAi; 90826; -.
DR   NextBio; 35470040; -.
DR   PRO; PR:Q6P2P2; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; Q6P2P2; -.
DR   ExpressionAtlas; Q6P2P2; baseline and differential.
DR   Genevisible; Q6P2P2; HS.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006479; P:protein methylation; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   InterPro; IPR013026; TPR-contain_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom.
DR   InterPro; IPR013105; TPR_2.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11006; PTHR11006; 1.
DR   Pfam; PF07719; TPR_2; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF53335; SSF53335; 2.
DR   PROSITE; PS51678; SAM_MT_PRMT; 2.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Methyltransferase;
KW   Polymorphism; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW   TPR repeat; Transferase.
FT   CHAIN         1    845       Putative protein arginine N-
FT                                methyltransferase 9.
FT                                /FTId=PRO_0000325929.
FT   REPEAT       25     58       TPR 1.
FT   REPEAT       67    100       TPR 2.
FT   REPEAT      101    134       TPR 3.
FT   DOMAIN      137    466       SAM-dependent MTase PRMT-type 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01015}.
FT   DOMAIN      530    845       SAM-dependent MTase PRMT-type 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01015}.
FT   VAR_SEQ       1    113       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_053972.
FT   VARIANT     483    483       S -> G (in dbSNP:rs17023638).
FT                                /FTId=VAR_039954.
FT   VARIANT     747    747       C -> Y (in dbSNP:rs11557361).
FT                                /FTId=VAR_039955.
FT   CONFLICT    504    504       A -> P (in Ref. 4; AAH21250).
FT                                {ECO:0000305}.
FT   CONFLICT    805    805       E -> G (in Ref. 1; BAF85593).
FT                                {ECO:0000305}.
SQ   SEQUENCE   845 AA;  94501 MW;  96C509E190D05A53 CRC64;
     MSNSRPRSRR DAGGGAGAAG RDELVSRSLQ SAEHCLGVQD FGTAYAHYLL VLSLAPELKH
     DVKETFQYTL FRWAEELDAL SRIQDLLGCY EQALELFPDD EVICNSMGEH LFRMGFRDEA
     AGYFHKAVKL NPDFSDAKEN FYRVANWLVE RWHFIMLNDT KRNTIYNAAI QKAVCLGSKS
     VLDIGAGTGI LSMFAKKAGA HSVYACELSK TMYELACDVV AANKMEAGIK LLHTKSLDIE
     IPKHIPERVS LVVTETVDAG LFGEGIVESL IHAWEHLLLQ PKTKGESANC EKYGKVIPAS
     AVIFGMAVEC AEIRRHHRVG IKDIAGIHLP TNVKFQSPAY SSVDTEETIE PYTTEKMSRV
     PGGYLALTEC FEIMTVDFNN LQELKSLATK KPDKIGIPVI KEGILDAIMV WFVLQLDDEH
     SLSTSPSEET CWEQAVYPVQ DLADYWIKPG DHVMMEVSCQ DCYLRIQSIS VLGLECEMDV
     AKSFTQNKDL LSLGNEAELC SALANLQTSK PDAVEQTCIL ESTEIALLNN IPYHEGFKMA
     MSKVLSSLTP EKLYQTMDTH CQNEMSSGTG QSNTVQNILE PFYVLDVSEG FSVLPVIAGT
     LGQVKPYSSV EKDQHRIALD LISEANHFPK ETLEFWLRHV EDESAMLQRP KSDKLWSIII
     LDVIEPSGLI QQEIMEKAAI SRCLLQSGGK IFPQYVLMFG LLVESQTLLE ENAVQGTERT
     LGLNIAPFIN QFQVPIRVFL DLSSLPCIPL SKPVELLRLD LMTPYLNTSN REVKVYVCKS
     GRLTAIPFWY HMYLDEEIRL DTSSEASHWK QAAVVLDNPI QVEMGEELVL SIQHHKSNVS
     ITVKQ
//