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Protein

Putative protein arginine N-methyltransferase 9

Gene

PRMT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein methyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein arginine N-methyltransferase 9
Alternative name(s):
Putative protein arginine N-methyltransferase 10 (EC:2.1.1.-)
Gene namesi
Name:PRMT9
Synonyms:PRMT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25099. PRMT9.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664476.

Polymorphism and mutation databases

BioMutaiPRMT10.
DMDMi74758248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 845845Putative protein arginine N-methyltransferase 9PRO_0000325929Add
BLAST

Proteomic databases

MaxQBiQ6P2P2.
PaxDbiQ6P2P2.
PRIDEiQ6P2P2.

PTM databases

PhosphoSiteiQ6P2P2.

Expressioni

Gene expression databases

BgeeiQ6P2P2.
ExpressionAtlasiQ6P2P2. baseline and differential.
GenevestigatoriQ6P2P2.

Organism-specific databases

HPAiHPA036844.
HPA042537.

Interactioni

Protein-protein interaction databases

BioGridi124766. 4 interactions.
STRINGi9606.ENSP00000314396.

Structurei

3D structure databases

ProteinModelPortaliQ6P2P2.
SMRiQ6P2P2. Positions 32-146, 149-428, 582-629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 5834TPR 1Add
BLAST
Repeati67 – 10034TPR 2Add
BLAST
Repeati101 – 13434TPR 3Add
BLAST
Domaini137 – 466330SAM-dependent MTase PRMT-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini530 – 845316SAM-dependent MTase PRMT-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation
Contains 2 SAM-dependent MTase PRMT-type domains.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0500.
GeneTreeiENSGT00530000063495.
HOGENOMiHOG000285961.
InParanoidiQ6P2P2.
OMAiMTVDFNN.
OrthoDBiEOG74FF0J.
PhylomeDBiQ6P2P2.
TreeFamiTF315221.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR025799. Arg_MeTrfase.
IPR029063. SAM-dependent_MTases.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11006. PTHR11006. 1 hit.
PfamiPF07719. TPR_2. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51678. SAM_MT_PRMT. 2 hits.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P2P2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNSRPRSRR DAGGGAGAAG RDELVSRSLQ SAEHCLGVQD FGTAYAHYLL
60 70 80 90 100
VLSLAPELKH DVKETFQYTL FRWAEELDAL SRIQDLLGCY EQALELFPDD
110 120 130 140 150
EVICNSMGEH LFRMGFRDEA AGYFHKAVKL NPDFSDAKEN FYRVANWLVE
160 170 180 190 200
RWHFIMLNDT KRNTIYNAAI QKAVCLGSKS VLDIGAGTGI LSMFAKKAGA
210 220 230 240 250
HSVYACELSK TMYELACDVV AANKMEAGIK LLHTKSLDIE IPKHIPERVS
260 270 280 290 300
LVVTETVDAG LFGEGIVESL IHAWEHLLLQ PKTKGESANC EKYGKVIPAS
310 320 330 340 350
AVIFGMAVEC AEIRRHHRVG IKDIAGIHLP TNVKFQSPAY SSVDTEETIE
360 370 380 390 400
PYTTEKMSRV PGGYLALTEC FEIMTVDFNN LQELKSLATK KPDKIGIPVI
410 420 430 440 450
KEGILDAIMV WFVLQLDDEH SLSTSPSEET CWEQAVYPVQ DLADYWIKPG
460 470 480 490 500
DHVMMEVSCQ DCYLRIQSIS VLGLECEMDV AKSFTQNKDL LSLGNEAELC
510 520 530 540 550
SALANLQTSK PDAVEQTCIL ESTEIALLNN IPYHEGFKMA MSKVLSSLTP
560 570 580 590 600
EKLYQTMDTH CQNEMSSGTG QSNTVQNILE PFYVLDVSEG FSVLPVIAGT
610 620 630 640 650
LGQVKPYSSV EKDQHRIALD LISEANHFPK ETLEFWLRHV EDESAMLQRP
660 670 680 690 700
KSDKLWSIII LDVIEPSGLI QQEIMEKAAI SRCLLQSGGK IFPQYVLMFG
710 720 730 740 750
LLVESQTLLE ENAVQGTERT LGLNIAPFIN QFQVPIRVFL DLSSLPCIPL
760 770 780 790 800
SKPVELLRLD LMTPYLNTSN REVKVYVCKS GRLTAIPFWY HMYLDEEIRL
810 820 830 840
DTSSEASHWK QAAVVLDNPI QVEMGEELVL SIQHHKSNVS ITVKQ
Length:845
Mass (Da):94,501
Last modified:July 5, 2004 - v1
Checksum:i96C509E190D05A53
GO
Isoform 2 (identifier: Q6P2P2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.

Show »
Length:732
Mass (Da):81,857
Checksum:iEF627AD71327807F
GO

Sequence cautioni

The sequence BAC87459.1 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti504 – 5041A → P in AAH21250 (PubMed:15489334).Curated
Sequence conflicti805 – 8051E → G in BAF85593 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti483 – 4831S → G.
Corresponds to variant rs17023638 [ dbSNP | Ensembl ].
VAR_039954
Natural varianti747 – 7471C → Y.
Corresponds to variant rs11557361 [ dbSNP | Ensembl ].
VAR_039955

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 113113Missing in isoform 2. 1 PublicationVSP_053972Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128483 mRNA. Translation: BAC87459.1. Sequence problems.
AK096703 mRNA. Translation: BAG53354.1.
AK292904 mRNA. Translation: BAF85593.1.
AC093835 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05013.1.
BC004337 mRNA. Translation: AAH04337.1.
BC021250 mRNA. Translation: AAH21250.2.
BC064403 mRNA. Translation: AAH64403.1.
AL137452 mRNA. Translation: CAB70744.1.
CH471056 Genomic DNA. Translation: EAX05011.1.
CCDSiCCDS3771.1. [Q6P2P2-1]
PIRiT46267.
RefSeqiNP_612373.2. NM_138364.2. [Q6P2P2-1]
UniGeneiHs.591692.

Genome annotation databases

EnsembliENST00000322396; ENSP00000314396; ENSG00000164169. [Q6P2P2-1]
GeneIDi90826.
KEGGihsa:90826.
UCSCiuc003ilb.3. human. [Q6P2P2-1]

Polymorphism and mutation databases

BioMutaiPRMT10.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128483 mRNA. Translation: BAC87459.1. Sequence problems.
AK096703 mRNA. Translation: BAG53354.1.
AK292904 mRNA. Translation: BAF85593.1.
AC093835 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05013.1.
BC004337 mRNA. Translation: AAH04337.1.
BC021250 mRNA. Translation: AAH21250.2.
BC064403 mRNA. Translation: AAH64403.1.
AL137452 mRNA. Translation: CAB70744.1.
CH471056 Genomic DNA. Translation: EAX05011.1.
CCDSiCCDS3771.1. [Q6P2P2-1]
PIRiT46267.
RefSeqiNP_612373.2. NM_138364.2. [Q6P2P2-1]
UniGeneiHs.591692.

3D structure databases

ProteinModelPortaliQ6P2P2.
SMRiQ6P2P2. Positions 32-146, 149-428, 582-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124766. 4 interactions.
STRINGi9606.ENSP00000314396.

PTM databases

PhosphoSiteiQ6P2P2.

Polymorphism and mutation databases

BioMutaiPRMT10.
DMDMi74758248.

Proteomic databases

MaxQBiQ6P2P2.
PaxDbiQ6P2P2.
PRIDEiQ6P2P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322396; ENSP00000314396; ENSG00000164169. [Q6P2P2-1]
GeneIDi90826.
KEGGihsa:90826.
UCSCiuc003ilb.3. human. [Q6P2P2-1]

Organism-specific databases

CTDi90826.
GeneCardsiGC04M148558.
HGNCiHGNC:25099. PRMT9.
HPAiHPA036844.
HPA042537.
MIMi616125. gene.
neXtProtiNX_Q6P2P2.
PharmGKBiPA165664476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0500.
GeneTreeiENSGT00530000063495.
HOGENOMiHOG000285961.
InParanoidiQ6P2P2.
OMAiMTVDFNN.
OrthoDBiEOG74FF0J.
PhylomeDBiQ6P2P2.
TreeFamiTF315221.

Miscellaneous databases

GenomeRNAii90826.
NextBioi35470040.
PROiQ6P2P2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P2P2.
ExpressionAtlasiQ6P2P2. baseline and differential.
GenevestigatoriQ6P2P2.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR025799. Arg_MeTrfase.
IPR029063. SAM-dependent_MTases.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11006. PTHR11006. 1 hit.
PfamiPF07719. TPR_2. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51678. SAM_MT_PRMT. 2 hits.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Trachea.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney, Skin and Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 678-845 (ISOFORM 1).
    Tissue: Amygdala.
  6. "Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential."
    Krause C.D., Yang Z.-H., Kim Y.-S., Lee J.-H., Cook J.R., Pestka S.
    Pharmacol. Ther. 113:50-87(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans."
    Wolf S.S.
    Cell. Mol. Life Sci. 66:2109-2121(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiANM9_HUMAN
AccessioniPrimary (citable) accession number: Q6P2P2
Secondary accession number(s): A8KA39
, B3KU92, Q6ZR58, Q8N383, Q9BT55, Q9NT98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This protein should not be confused with FBXO11 (AC Q86XK2) that was initially named PRMT9.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.