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Q6P2P2

- ANM9_HUMAN

UniProt

Q6P2P2 - ANM9_HUMAN

Protein

Putative protein arginine N-methyltransferase 9

Gene

PRMT9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein methyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative protein arginine N-methyltransferase 9
    Alternative name(s):
    Putative protein arginine N-methyltransferase 10 (EC:2.1.1.-)
    Gene namesi
    Name:PRMT9
    Synonyms:PRMT10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:25099. PRMT9.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165664476.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 845845Putative protein arginine N-methyltransferase 9PRO_0000325929Add
    BLAST

    Proteomic databases

    MaxQBiQ6P2P2.
    PaxDbiQ6P2P2.
    PRIDEiQ6P2P2.

    PTM databases

    PhosphoSiteiQ6P2P2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P2P2.
    BgeeiQ6P2P2.
    GenevestigatoriQ6P2P2.

    Organism-specific databases

    HPAiHPA036844.
    HPA042537.

    Interactioni

    Protein-protein interaction databases

    BioGridi124766. 2 interactions.
    STRINGi9606.ENSP00000314396.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P2P2.
    SMRiQ6P2P2. Positions 153-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati25 – 5834TPR 1Add
    BLAST
    Repeati67 – 10034TPR 2Add
    BLAST
    Repeati101 – 13434TPR 3Add
    BLAST
    Domaini137 – 466330SAM-dependent MTase PRMT-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini530 – 845316SAM-dependent MTase PRMT-type 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation
    Contains 2 SAM-dependent MTase PRMT-type domains.PROSITE-ProRule annotation
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0500.
    HOGENOMiHOG000285961.
    InParanoidiQ6P2P2.
    OMAiMTVDFNN.
    OrthoDBiEOG74FF0J.
    PhylomeDBiQ6P2P2.
    TreeFamiTF315221.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    3.40.50.150. 1 hit.
    InterProiIPR025799. Arg_MeTrfase.
    IPR010456. Ribosomal-L11_MeTrfase_PrmA.
    IPR029063. SAM-dependent_MTases-like.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR11006. PTHR11006. 1 hit.
    PfamiPF06325. PrmA. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51678. SAM_MT_PRMT. 2 hits.
    PS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P2P2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSNSRPRSRR DAGGGAGAAG RDELVSRSLQ SAEHCLGVQD FGTAYAHYLL    50
    VLSLAPELKH DVKETFQYTL FRWAEELDAL SRIQDLLGCY EQALELFPDD 100
    EVICNSMGEH LFRMGFRDEA AGYFHKAVKL NPDFSDAKEN FYRVANWLVE 150
    RWHFIMLNDT KRNTIYNAAI QKAVCLGSKS VLDIGAGTGI LSMFAKKAGA 200
    HSVYACELSK TMYELACDVV AANKMEAGIK LLHTKSLDIE IPKHIPERVS 250
    LVVTETVDAG LFGEGIVESL IHAWEHLLLQ PKTKGESANC EKYGKVIPAS 300
    AVIFGMAVEC AEIRRHHRVG IKDIAGIHLP TNVKFQSPAY SSVDTEETIE 350
    PYTTEKMSRV PGGYLALTEC FEIMTVDFNN LQELKSLATK KPDKIGIPVI 400
    KEGILDAIMV WFVLQLDDEH SLSTSPSEET CWEQAVYPVQ DLADYWIKPG 450
    DHVMMEVSCQ DCYLRIQSIS VLGLECEMDV AKSFTQNKDL LSLGNEAELC 500
    SALANLQTSK PDAVEQTCIL ESTEIALLNN IPYHEGFKMA MSKVLSSLTP 550
    EKLYQTMDTH CQNEMSSGTG QSNTVQNILE PFYVLDVSEG FSVLPVIAGT 600
    LGQVKPYSSV EKDQHRIALD LISEANHFPK ETLEFWLRHV EDESAMLQRP 650
    KSDKLWSIII LDVIEPSGLI QQEIMEKAAI SRCLLQSGGK IFPQYVLMFG 700
    LLVESQTLLE ENAVQGTERT LGLNIAPFIN QFQVPIRVFL DLSSLPCIPL 750
    SKPVELLRLD LMTPYLNTSN REVKVYVCKS GRLTAIPFWY HMYLDEEIRL 800
    DTSSEASHWK QAAVVLDNPI QVEMGEELVL SIQHHKSNVS ITVKQ 845
    Length:845
    Mass (Da):94,501
    Last modified:July 5, 2004 - v1
    Checksum:i96C509E190D05A53
    GO
    Isoform 2 (identifier: Q6P2P2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-113: Missing.

    Show »
    Length:732
    Mass (Da):81,857
    Checksum:iEF627AD71327807F
    GO

    Sequence cautioni

    The sequence BAC87459.1 differs from that shown. Reason: Intron retention.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti504 – 5041A → P in AAH21250. (PubMed:15489334)Curated
    Sequence conflicti805 – 8051E → G in BAF85593. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti483 – 4831S → G.
    Corresponds to variant rs17023638 [ dbSNP | Ensembl ].
    VAR_039954
    Natural varianti747 – 7471C → Y.
    Corresponds to variant rs11557361 [ dbSNP | Ensembl ].
    VAR_039955

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 113113Missing in isoform 2. 1 PublicationVSP_053972Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128483 mRNA. Translation: BAC87459.1. Sequence problems.
    AK096703 mRNA. Translation: BAG53354.1.
    AK292904 mRNA. Translation: BAF85593.1.
    AC093835 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05013.1.
    BC004337 mRNA. Translation: AAH04337.1.
    BC021250 mRNA. Translation: AAH21250.2.
    BC064403 mRNA. Translation: AAH64403.1.
    AL137452 mRNA. Translation: CAB70744.1.
    CH471056 Genomic DNA. Translation: EAX05011.1.
    CCDSiCCDS3771.1. [Q6P2P2-1]
    PIRiT46267.
    RefSeqiNP_612373.2. NM_138364.2. [Q6P2P2-1]
    XP_005263396.1. XM_005263339.1. [Q6P2P2-2]
    UniGeneiHs.591692.

    Genome annotation databases

    EnsembliENST00000322396; ENSP00000314396; ENSG00000164169. [Q6P2P2-1]
    GeneIDi90826.
    KEGGihsa:90826.
    UCSCiuc003ilb.3. human. [Q6P2P2-1]

    Polymorphism databases

    DMDMi74758248.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128483 mRNA. Translation: BAC87459.1 . Sequence problems.
    AK096703 mRNA. Translation: BAG53354.1 .
    AK292904 mRNA. Translation: BAF85593.1 .
    AC093835 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05013.1 .
    BC004337 mRNA. Translation: AAH04337.1 .
    BC021250 mRNA. Translation: AAH21250.2 .
    BC064403 mRNA. Translation: AAH64403.1 .
    AL137452 mRNA. Translation: CAB70744.1 .
    CH471056 Genomic DNA. Translation: EAX05011.1 .
    CCDSi CCDS3771.1. [Q6P2P2-1 ]
    PIRi T46267.
    RefSeqi NP_612373.2. NM_138364.2. [Q6P2P2-1 ]
    XP_005263396.1. XM_005263339.1. [Q6P2P2-2 ]
    UniGenei Hs.591692.

    3D structure databases

    ProteinModelPortali Q6P2P2.
    SMRi Q6P2P2. Positions 153-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124766. 2 interactions.
    STRINGi 9606.ENSP00000314396.

    PTM databases

    PhosphoSitei Q6P2P2.

    Polymorphism databases

    DMDMi 74758248.

    Proteomic databases

    MaxQBi Q6P2P2.
    PaxDbi Q6P2P2.
    PRIDEi Q6P2P2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322396 ; ENSP00000314396 ; ENSG00000164169 . [Q6P2P2-1 ]
    GeneIDi 90826.
    KEGGi hsa:90826.
    UCSCi uc003ilb.3. human. [Q6P2P2-1 ]

    Organism-specific databases

    CTDi 90826.
    GeneCardsi GC04M148559.
    HGNCi HGNC:25099. PRMT9.
    HPAi HPA036844.
    HPA042537.
    neXtProti NX_Q6P2P2.
    PharmGKBi PA165664476.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0500.
    HOGENOMi HOG000285961.
    InParanoidi Q6P2P2.
    OMAi MTVDFNN.
    OrthoDBi EOG74FF0J.
    PhylomeDBi Q6P2P2.
    TreeFami TF315221.

    Miscellaneous databases

    GenomeRNAii 90826.
    NextBioi 35470040.
    PROi Q6P2P2.

    Gene expression databases

    ArrayExpressi Q6P2P2.
    Bgeei Q6P2P2.
    Genevestigatori Q6P2P2.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    3.40.50.150. 1 hit.
    InterProi IPR025799. Arg_MeTrfase.
    IPR010456. Ribosomal-L11_MeTrfase_PrmA.
    IPR029063. SAM-dependent_MTases-like.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR11006. PTHR11006. 1 hit.
    Pfami PF06325. PrmA. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51678. SAM_MT_PRMT. 2 hits.
    PS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Trachea.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney, Skin and Uterus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 678-845 (ISOFORM 1).
      Tissue: Amygdala.
    6. "Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential."
      Krause C.D., Yang Z.-H., Kim Y.-S., Lee J.-H., Cook J.R., Pestka S.
      Pharmacol. Ther. 113:50-87(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiANM9_HUMAN
    AccessioniPrimary (citable) accession number: Q6P2P2
    Secondary accession number(s): A8KA39
    , B3KU92, Q6ZR58, Q8N383, Q9BT55, Q9NT98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    This protein should not be confused with FBXO11 (AC Q86XK2) that was initially named PRMT9.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3