Q6P2P2 (ANM10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative protein arginine N-methyltransferase 10
EC=2.1.1.-

Gene names

Name:

PRMT10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	845 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the protein arginine N-methyltransferase family. Contains 3 TPR repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat TPR repeat
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	protein methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P2P2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P2P2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-356: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 845	845	Putative protein arginine N-methyltransferase 10		PRO_0000325929
Regions
	Repeat	25 – 58	34	TPR 1
	Repeat	67 – 100	34	TPR 2
	Repeat	101 – 134	34	TPR 3
Natural variations
	Alternative sequence	1 – 356	356	Missing in isoform 2.		VSP_032487
	Natural variant	483	1	S → G. Corresponds to variant rs17023638 [ dbSNP | Ensembl ].		VAR_039954
	Natural variant	747	1	C → Y. Corresponds to variant rs11557361 [ dbSNP | Ensembl ].		VAR_039955
Experimental info
	Sequence conflict	504	1	A → P in AAH21250. Ref.3
	Sequence conflict	805	1	E → G in BAF85593. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 96C509E190D05A53	FASTA	845	94,501
	10 20 30 40 50 60 MSNSRPRSRR DAGGGAGAAG RDELVSRSLQ SAEHCLGVQD FGTAYAHYLL VLSLAPELKH 70 80 90 100 110 120 DVKETFQYTL FRWAEELDAL SRIQDLLGCY EQALELFPDD EVICNSMGEH LFRMGFRDEA 130 140 150 160 170 180 AGYFHKAVKL NPDFSDAKEN FYRVANWLVE RWHFIMLNDT KRNTIYNAAI QKAVCLGSKS 190 200 210 220 230 240 VLDIGAGTGI LSMFAKKAGA HSVYACELSK TMYELACDVV AANKMEAGIK LLHTKSLDIE 250 260 270 280 290 300 IPKHIPERVS LVVTETVDAG LFGEGIVESL IHAWEHLLLQ PKTKGESANC EKYGKVIPAS 310 320 330 340 350 360 AVIFGMAVEC AEIRRHHRVG IKDIAGIHLP TNVKFQSPAY SSVDTEETIE PYTTEKMSRV 370 380 390 400 410 420 PGGYLALTEC FEIMTVDFNN LQELKSLATK KPDKIGIPVI KEGILDAIMV WFVLQLDDEH 430 440 450 460 470 480 SLSTSPSEET CWEQAVYPVQ DLADYWIKPG DHVMMEVSCQ DCYLRIQSIS VLGLECEMDV 490 500 510 520 530 540 AKSFTQNKDL LSLGNEAELC SALANLQTSK PDAVEQTCIL ESTEIALLNN IPYHEGFKMA 550 560 570 580 590 600 MSKVLSSLTP EKLYQTMDTH CQNEMSSGTG QSNTVQNILE PFYVLDVSEG FSVLPVIAGT 610 620 630 640 650 660 LGQVKPYSSV EKDQHRIALD LISEANHFPK ETLEFWLRHV EDESAMLQRP KSDKLWSIII 670 680 690 700 710 720 LDVIEPSGLI QQEIMEKAAI SRCLLQSGGK IFPQYVLMFG LLVESQTLLE ENAVQGTERT 730 740 750 760 770 780 LGLNIAPFIN QFQVPIRVFL DLSSLPCIPL SKPVELLRLD LMTPYLNTSN REVKVYVCKS 790 800 810 820 830 840 GRLTAIPFWY HMYLDEEIRL DTSSEASHWK QAAVVLDNPI QVEMGEELVL SIQHHKSNVS ITVKQ
	Isoform 2 [UniParc]. Checksum: 7814683377BF7902	FASTA	489	55,008
	10 20 30 40 50 60 MSRVPGGYLA LTECFEIMTV DFNNLQELKS LATKKPDKIG IPVIKEGILD AIMVWFVLQL 70 80 90 100 110 120 DDEHSLSTSP SEETCWEQAV YPVQDLADYW IKPGDHVMME VSCQDCYLRI QSISVLGLEC 130 140 150 160 170 180 EMDVAKSFTQ NKDLLSLGNE AELCSALANL QTSKPDAVEQ TCILESTEIA LLNNIPYHEG 190 200 210 220 230 240 FKMAMSKVLS SLTPEKLYQT MDTHCQNEMS SGTGQSNTVQ NILEPFYVLD VSEGFSVLPV 250 260 270 280 290 300 IAGTLGQVKP YSSVEKDQHR IALDLISEAN HFPKETLEFW LRHVEDESAM LQRPKSDKLW 310 320 330 340 350 360 SIIILDVIEP SGLIQQEIME KAAISRCLLQ SGGKIFPQYV LMFGLLVESQ TLLEENAVQG 370 380 390 400 410 420 TERTLGLNIA PFINQFQVPI RVFLDLSSLP CIPLSKPVEL LRLDLMTPYL NTSNREVKVY 430 440 450 460 470 480 VCKSGRLTAI PFWYHMYLDE EIRLDTSSEA SHWKQAAVVL DNPIQVEMGE ELVLSIQHHK SNVSITVKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Trachea.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney, Skin and Uterus.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 678-845 (ISOFORM 1). Tissue: Amygdala.
[5]	"Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential." Krause C.D., Yang Z.-H., Kim Y.-S., Lee J.-H., Cook J.R., Pestka S. Pharmacol. Ther. 113:50-87(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK128483 mRNA. Translation: BAC87459.1. AK292904 mRNA. Translation: BAF85593.1. CH471056 Genomic DNA. Translation: EAX05013.1. BC004337 mRNA. Translation: AAH04337.1. BC021250 mRNA. Translation: AAH21250.2. BC064403 mRNA. Translation: AAH64403.1. AL137452 mRNA. Translation: CAB70744.1.
IPI	IPI00395476. IPI00887756.
PIR	T46267.
RefSeq	NP_612373.2. NM_138364.2.
UniGene	Hs.591692.
3D structure databases
ProteinModelPortal	Q6P2P2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000314396.
PTM databases
PhosphoSite	Q6P2P2.
Polymorphism databases
DMDM	74758248.
Proteomic databases
PaxDb	Q6P2P2.
PRIDE	Q6P2P2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322396; ENSP00000314396; ENSG00000164169.
GeneID	90826.
KEGG	hsa:90826.
UCSC	uc003ilb.3. human.
Organism-specific databases
CTD	90826.
GeneCards	GC04M148559.
HGNC	HGNC:25099. PRMT10.
HPA	HPA036844.
neXtProt	NX_Q6P2P2.
PharmGKB	PA165664476.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0500.
HOGENOM	HOG000285961.
InParanoid	Q6P2P2.
OMA	MTVDFNN.
OrthoDB	EOG4NKBTX.
PhylomeDB	Q6P2P2.
Gene expression databases
ArrayExpress	Q6P2P2.
Bgee	Q6P2P2.
Genevestigator	Q6P2P2.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR025799. Arg_MeTrfase. IPR010456. Ribosomal-L11_MeTrfase_PrmA. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR013105. TPR_2. IPR019734. TPR_repeat. [Graphical view]
PANTHER	PTHR11006. PTHR11006. 1 hit.
Pfam	PF06325. PrmA. 1 hit. PF07719. TPR_2. 1 hit. [Graphical view]
PROSITE	PS50005. TPR. 2 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	90826.
NextBio	76975.

Entry information

Entry name

ANM10_HUMAN

Accession

Primary (citable) accession number: Q6P2P2
Secondary accession number(s): A8KA39 , Q6ZR58, Q8N383, Q9BT55, Q9NT98

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.