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Q6P2P2

- ANM9_HUMAN

UniProt

Q6P2P2 - ANM9_HUMAN

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Protein
Putative protein arginine N-methyltransferase 9
Gene
PRMT9, PRMT10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein methyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein arginine N-methyltransferase 9
Alternative name(s):
Putative protein arginine N-methyltransferase 10 (EC:2.1.1.-)
Gene namesi
Name:PRMT9
Synonyms:PRMT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:25099. PRMT9.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 845845Putative protein arginine N-methyltransferase 9
PRO_0000325929Add
BLAST

Proteomic databases

MaxQBiQ6P2P2.
PaxDbiQ6P2P2.
PRIDEiQ6P2P2.

PTM databases

PhosphoSiteiQ6P2P2.

Expressioni

Gene expression databases

ArrayExpressiQ6P2P2.
BgeeiQ6P2P2.
GenevestigatoriQ6P2P2.

Organism-specific databases

HPAiHPA036844.
HPA042537.

Interactioni

Protein-protein interaction databases

BioGridi124766. 2 interactions.
STRINGi9606.ENSP00000314396.

Structurei

3D structure databases

ProteinModelPortaliQ6P2P2.
SMRiQ6P2P2. Positions 153-471.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 5834TPR 1
Add
BLAST
Repeati67 – 10034TPR 2
Add
BLAST
Repeati101 – 13434TPR 3
Add
BLAST
Domaini137 – 466330SAM-dependent MTase PRMT-type 1
Add
BLAST
Domaini530 – 845316SAM-dependent MTase PRMT-type 2
Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0500.
HOGENOMiHOG000285961.
InParanoidiQ6P2P2.
OMAiMTVDFNN.
OrthoDBiEOG74FF0J.
PhylomeDBiQ6P2P2.
TreeFamiTF315221.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR025799. Arg_MeTrfase.
IPR010456. Ribosomal-L11_MeTrfase_PrmA.
IPR029063. SAM-dependent_MTases-like.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11006. PTHR11006. 1 hit.
PfamiPF06325. PrmA. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51678. SAM_MT_PRMT. 2 hits.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P2P2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSNSRPRSRR DAGGGAGAAG RDELVSRSLQ SAEHCLGVQD FGTAYAHYLL    50
VLSLAPELKH DVKETFQYTL FRWAEELDAL SRIQDLLGCY EQALELFPDD 100
EVICNSMGEH LFRMGFRDEA AGYFHKAVKL NPDFSDAKEN FYRVANWLVE 150
RWHFIMLNDT KRNTIYNAAI QKAVCLGSKS VLDIGAGTGI LSMFAKKAGA 200
HSVYACELSK TMYELACDVV AANKMEAGIK LLHTKSLDIE IPKHIPERVS 250
LVVTETVDAG LFGEGIVESL IHAWEHLLLQ PKTKGESANC EKYGKVIPAS 300
AVIFGMAVEC AEIRRHHRVG IKDIAGIHLP TNVKFQSPAY SSVDTEETIE 350
PYTTEKMSRV PGGYLALTEC FEIMTVDFNN LQELKSLATK KPDKIGIPVI 400
KEGILDAIMV WFVLQLDDEH SLSTSPSEET CWEQAVYPVQ DLADYWIKPG 450
DHVMMEVSCQ DCYLRIQSIS VLGLECEMDV AKSFTQNKDL LSLGNEAELC 500
SALANLQTSK PDAVEQTCIL ESTEIALLNN IPYHEGFKMA MSKVLSSLTP 550
EKLYQTMDTH CQNEMSSGTG QSNTVQNILE PFYVLDVSEG FSVLPVIAGT 600
LGQVKPYSSV EKDQHRIALD LISEANHFPK ETLEFWLRHV EDESAMLQRP 650
KSDKLWSIII LDVIEPSGLI QQEIMEKAAI SRCLLQSGGK IFPQYVLMFG 700
LLVESQTLLE ENAVQGTERT LGLNIAPFIN QFQVPIRVFL DLSSLPCIPL 750
SKPVELLRLD LMTPYLNTSN REVKVYVCKS GRLTAIPFWY HMYLDEEIRL 800
DTSSEASHWK QAAVVLDNPI QVEMGEELVL SIQHHKSNVS ITVKQ 845
Length:845
Mass (Da):94,501
Last modified:July 5, 2004 - v1
Checksum:i96C509E190D05A53
GO
Isoform 2 (identifier: Q6P2P2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.

Show »
Length:732
Mass (Da):81,857
Checksum:iEF627AD71327807F
GO

Sequence cautioni

The sequence BAC87459.1 differs from that shown. Reason: Intron retention.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti483 – 4831S → G.
Corresponds to variant rs17023638 [ dbSNP | Ensembl ].
VAR_039954
Natural varianti747 – 7471C → Y.
Corresponds to variant rs11557361 [ dbSNP | Ensembl ].
VAR_039955

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 113113Missing in isoform 2.
VSP_053972Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti504 – 5041A → P in AAH21250. 1 Publication
Sequence conflicti805 – 8051E → G in BAF85593. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128483 mRNA. Translation: BAC87459.1. Sequence problems.
AK096703 mRNA. Translation: BAG53354.1.
AK292904 mRNA. Translation: BAF85593.1.
AC093835 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05013.1.
BC004337 mRNA. Translation: AAH04337.1.
BC021250 mRNA. Translation: AAH21250.2.
BC064403 mRNA. Translation: AAH64403.1.
AL137452 mRNA. Translation: CAB70744.1.
CH471056 Genomic DNA. Translation: EAX05011.1.
CCDSiCCDS3771.1. [Q6P2P2-1]
PIRiT46267.
RefSeqiNP_612373.2. NM_138364.2. [Q6P2P2-1]
XP_005263396.1. XM_005263339.1. [Q6P2P2-2]
UniGeneiHs.591692.

Genome annotation databases

EnsembliENST00000322396; ENSP00000314396; ENSG00000164169. [Q6P2P2-1]
ENST00000541232; ENSP00000439508; ENSG00000164169.
GeneIDi90826.
KEGGihsa:90826.
UCSCiuc003ilb.3. human. [Q6P2P2-1]

Polymorphism databases

DMDMi74758248.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128483 mRNA. Translation: BAC87459.1 . Sequence problems.
AK096703 mRNA. Translation: BAG53354.1 .
AK292904 mRNA. Translation: BAF85593.1 .
AC093835 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05013.1 .
BC004337 mRNA. Translation: AAH04337.1 .
BC021250 mRNA. Translation: AAH21250.2 .
BC064403 mRNA. Translation: AAH64403.1 .
AL137452 mRNA. Translation: CAB70744.1 .
CH471056 Genomic DNA. Translation: EAX05011.1 .
CCDSi CCDS3771.1. [Q6P2P2-1 ]
PIRi T46267.
RefSeqi NP_612373.2. NM_138364.2. [Q6P2P2-1 ]
XP_005263396.1. XM_005263339.1. [Q6P2P2-2 ]
UniGenei Hs.591692.

3D structure databases

ProteinModelPortali Q6P2P2.
SMRi Q6P2P2. Positions 153-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124766. 2 interactions.
STRINGi 9606.ENSP00000314396.

PTM databases

PhosphoSitei Q6P2P2.

Polymorphism databases

DMDMi 74758248.

Proteomic databases

MaxQBi Q6P2P2.
PaxDbi Q6P2P2.
PRIDEi Q6P2P2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322396 ; ENSP00000314396 ; ENSG00000164169 . [Q6P2P2-1 ]
ENST00000541232 ; ENSP00000439508 ; ENSG00000164169 .
GeneIDi 90826.
KEGGi hsa:90826.
UCSCi uc003ilb.3. human. [Q6P2P2-1 ]

Organism-specific databases

CTDi 90826.
GeneCardsi GC04M148559.
HGNCi HGNC:25099. PRMT9.
HPAi HPA036844.
HPA042537.
neXtProti NX_Q6P2P2.
PharmGKBi PA165664476.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0500.
HOGENOMi HOG000285961.
InParanoidi Q6P2P2.
OMAi MTVDFNN.
OrthoDBi EOG74FF0J.
PhylomeDBi Q6P2P2.
TreeFami TF315221.

Miscellaneous databases

GenomeRNAii 90826.
NextBioi 35470040.
PROi Q6P2P2.

Gene expression databases

ArrayExpressi Q6P2P2.
Bgeei Q6P2P2.
Genevestigatori Q6P2P2.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
3.40.50.150. 1 hit.
InterProi IPR025799. Arg_MeTrfase.
IPR010456. Ribosomal-L11_MeTrfase_PrmA.
IPR029063. SAM-dependent_MTases-like.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR11006. PTHR11006. 1 hit.
Pfami PF06325. PrmA. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51678. SAM_MT_PRMT. 2 hits.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Trachea.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney, Skin and Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 678-845 (ISOFORM 1).
    Tissue: Amygdala.
  6. "Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential."
    Krause C.D., Yang Z.-H., Kim Y.-S., Lee J.-H., Cook J.R., Pestka S.
    Pharmacol. Ther. 113:50-87(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiANM9_HUMAN
AccessioniPrimary (citable) accession number: Q6P2P2
Secondary accession number(s): A8KA39
, B3KU92, Q6ZR58, Q8N383, Q9BT55, Q9NT98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This protein should not be confused with FBXO11 (AC Q86XK2) that was initially named PRMT9.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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