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Q6P2N6

- AA3RB_HUMAN

UniProt

Q6P2N6 - AA3RB_HUMAN

Protein

Protein ADORA3, isoform 3

Gene

ADORA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ADORA3, isoform 3
    Gene namesi
    Name:ADORA3
    ORF Names:UNQ1931/PRO4406
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:268. ADORA3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24589.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Protein ADORA3, isoform 3PRO_0000416044Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ6P2N6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P2N6.
    BgeeiQ6P2N6.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P2N6.
    SMRiQ6P2N6. Positions 93-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000139368.
    HOVERGENiHBG058258.
    KOiK04268.
    OMAiPRNISTQ.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 3 (identifier: Q6P2N6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGSPAGPIE QKEARWESSW EEQPDWTLGC LSPESQFRIP GLPGCILSFQ    50
    LKVCFLPVMW LFILLSLALI SDAMVMDEKV KRSFVLDTAS AICNYNAHYK 100
    NHPKYWCRGY FRDYCNIIAF SPNSTNHVAL RDTGNQLIVT MSCLTKEDTG 150
    WYWCGIQRDF ARDDMDFTEL IVTDDKGTLA NDFWSGKDLS GNKTRSCKAP 200
    KVVRKADRSR TSILIICILI TGLGIISVIS HLTKRRRSQR NRRVGNTLKP 250
    FSRVLTPKEM APTEQM 266
    Length:266
    Mass (Da):30,327
    Last modified:March 21, 2012 - v2
    Checksum:i8D6506430DD5C208
    GO
    Isoform 1 (identifier: P33765-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P33765.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:318
    Mass (Da):36,185
    GO
    Isoform 2 (identifier: P33765-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P33765.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:347
    Mass (Da):38,976
    GO

    Sequence cautioni

    The sequence AAH41707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH64411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence EAW56500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL390195, AL391063 Genomic DNA. Translation: CAI15626.1.
    AL391063, AL390195 Genomic DNA. Translation: CAI22964.1.
    CH471122 Genomic DNA. Translation: EAW56500.1. Different initiation.
    BC041707 mRNA. Translation: AAH41707.1. Different initiation.
    BC064411 mRNA. Translation: AAH64411.1. Different initiation.
    CCDSiCCDS41369.1. [Q6P2N6-1]
    RefSeqiNP_001075445.1. NM_001081976.1. [Q6P2N6-1]
    UniGeneiHs.281342.

    Genome annotation databases

    EnsembliENST00000369717; ENSP00000358731; ENSG00000121933. [Q6P2N6-1]
    GeneIDi140.
    KEGGihsa:140.
    UCSCiuc001ebg.4. human. [Q6P2N6-1]

    Polymorphism databases

    DMDMi380876892.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL390195 , AL391063 Genomic DNA. Translation: CAI15626.1 .
    AL391063 , AL390195 Genomic DNA. Translation: CAI22964.1 .
    CH471122 Genomic DNA. Translation: EAW56500.1 . Different initiation.
    BC041707 mRNA. Translation: AAH41707.1 . Different initiation.
    BC064411 mRNA. Translation: AAH64411.1 . Different initiation.
    CCDSi CCDS41369.1. [Q6P2N6-1 ]
    RefSeqi NP_001075445.1. NM_001081976.1. [Q6P2N6-1 ]
    UniGenei Hs.281342.

    3D structure databases

    ProteinModelPortali Q6P2N6.
    SMRi Q6P2N6. Positions 93-158.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q6P2N6.

    Polymorphism databases

    DMDMi 380876892.

    Proteomic databases

    PRIDEi Q6P2N6.

    Protocols and materials databases

    DNASUi 140.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369717 ; ENSP00000358731 ; ENSG00000121933 . [Q6P2N6-1 ]
    GeneIDi 140.
    KEGGi hsa:140.
    UCSCi uc001ebg.4. human. [Q6P2N6-1 ]

    Organism-specific databases

    CTDi 140.
    GeneCardsi GC01M112025.
    HGNCi HGNC:268. ADORA3.
    MIMi 600445. gene.
    neXtProti NX_Q6P2N6.
    PharmGKBi PA24589.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000139368.
    HOVERGENi HBG058258.
    KOi K04268.
    OMAi PRNISTQ.

    Miscellaneous databases

    GenomeRNAii 140.
    NextBioi 553.
    PROi Q6P2N6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P2N6.
    Bgeei Q6P2N6.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-266 (ISOFORM 3).
      Tissue: Brain.

    Entry informationi

    Entry nameiAA3RB_HUMAN
    AccessioniPrimary (citable) accession number: Q6P2N6
    Secondary accession number(s): Q5QNY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3