Q6P2N6 (AA3RB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ADORA3, isoform 3

Gene names

Name:	ADORA3
ORF Names:	UNQ1931/PRO4406

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Sequence caution	The sequence AAH41707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH64411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence EAW56500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q6P2N6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P33765-1)

The sequence of this isoform can be found in the external entry P33765.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 2 (identifier: P33765-2)

The sequence of this isoform can be found in the external entry P33765.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Protein ADORA3, isoform 3		PRO_0000416044
Regions
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	213 – 233	21	Helical; Potential
	Domain	88 – 174	87	Ig-like V-type
Amino acid modifications
	Glycosylation	192	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified March 21, 2012. Version 2. Checksum: 8D6506430DD5C208	FASTA	266	30,327
	10 20 30 40 50 60 MEGSPAGPIE QKEARWESSW EEQPDWTLGC LSPESQFRIP GLPGCILSFQ LKVCFLPVMW 70 80 90 100 110 120 LFILLSLALI SDAMVMDEKV KRSFVLDTAS AICNYNAHYK NHPKYWCRGY FRDYCNIIAF 130 140 150 160 170 180 SPNSTNHVAL RDTGNQLIVT MSCLTKEDTG WYWCGIQRDF ARDDMDFTEL IVTDDKGTLA 190 200 210 220 230 240 NDFWSGKDLS GNKTRSCKAP KVVRKADRSR TSILIICILI TGLGIISVIS HLTKRRRSQR 250 260 NRRVGNTLKP FSRVLTPKEM APTEQM
	Isoform 1 [UniParc]. See P33765.		–	–
	Isoform 2 [UniParc]. See P33765.		–	–

References

[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-266 (ISOFORM 3). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL390195, AL391063 Genomic DNA. Translation: CAI15626.1. AL391063, AL390195 Genomic DNA. Translation: CAI22964.1. CH471122 Genomic DNA. Translation: EAW56500.1. Different initiation. BC041707 mRNA. Translation: AAH41707.1. Different initiation. BC064411 mRNA. Translation: AAH64411.1. Different initiation.
IPI	IPI00645655.
RefSeq	NP_001075445.1. NM_001081976.1.
UniGene	Hs.281342.
3D structure databases
ProteinModelPortal	Q6P2N6.
SMR	Q6P2N6. Positions 93-158.
ModBase	Search...
Proteomic databases
PRIDE	Q6P2N6.
Protocols and materials databases
DNASU	140.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369717; ENSP00000358731; ENSG00000121933.
GeneID	140.
KEGG	hsa:140.
Organism-specific databases
CTD	140.
GeneCards	GC01M112025.
HGNC	HGNC:268. ADORA3.
MIM	600445. gene.
neXtProt	NX_Q6P2N6.
PharmGKB	PA24589.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000139368.
HOVERGEN	HBG058258.
KO	K04268.
Gene expression databases
ArrayExpress	Q6P2N6.
Bgee	Q6P2N6.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR013783. Ig-like_fold. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q6P2N6.
ChEMBL	CHEMBL1909045.
GenomeRNAi	140.
NextBio	553.
SOURCE	Search...

Entry information

Entry name

AA3RB_HUMAN

Accession

Primary (citable) accession number: Q6P2N6
Secondary accession number(s): Q5QNY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	May 1, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.