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Q6P2N6

- AA3RB_HUMAN

UniProt

Q6P2N6 - AA3RB_HUMAN

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Protein

Protein ADORA3, isoform 3

Gene

ADORA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ADORA3, isoform 3
Gene namesi
Name:ADORA3
ORF Names:UNQ1931/PRO4406
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:268. ADORA3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Protein ADORA3, isoform 3PRO_0000416044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6P2N6.

Expressioni

Gene expression databases

BgeeiQ6P2N6.
ExpressionAtlasiQ6P2N6. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ6P2N6.
SMRiQ6P2N6. Positions 93-158.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074524.
HOGENOMiHOG000139368.
HOVERGENiHBG058258.
KOiK04268.
OMAiPRNISTQ.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: Q6P2N6) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGSPAGPIE QKEARWESSW EEQPDWTLGC LSPESQFRIP GLPGCILSFQ
60 70 80 90 100
LKVCFLPVMW LFILLSLALI SDAMVMDEKV KRSFVLDTAS AICNYNAHYK
110 120 130 140 150
NHPKYWCRGY FRDYCNIIAF SPNSTNHVAL RDTGNQLIVT MSCLTKEDTG
160 170 180 190 200
WYWCGIQRDF ARDDMDFTEL IVTDDKGTLA NDFWSGKDLS GNKTRSCKAP
210 220 230 240 250
KVVRKADRSR TSILIICILI TGLGIISVIS HLTKRRRSQR NRRVGNTLKP
260
FSRVLTPKEM APTEQM
Length:266
Mass (Da):30,327
Last modified:March 21, 2012 - v2
Checksum:i8D6506430DD5C208
GO
Isoform 1 (identifier: P33765-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P33765.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:318
Mass (Da):36,185
GO
Isoform 2 (identifier: P33765-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P33765.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:347
Mass (Da):38,976
GO

Sequence cautioni

The sequence AAH41707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH64411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence EAW56500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL390195, AL391063 Genomic DNA. Translation: CAI15626.1.
AL391063, AL390195 Genomic DNA. Translation: CAI22964.1.
CH471122 Genomic DNA. Translation: EAW56500.1. Different initiation.
BC041707 mRNA. Translation: AAH41707.1. Different initiation.
BC064411 mRNA. Translation: AAH64411.1. Different initiation.
CCDSiCCDS41369.1. [Q6P2N6-1]
RefSeqiNP_001075445.1. NM_001081976.1. [Q6P2N6-1]
UniGeneiHs.281342.

Genome annotation databases

EnsembliENST00000369717; ENSP00000358731; ENSG00000121933. [Q6P2N6-1]
GeneIDi140.
KEGGihsa:140.
UCSCiuc001ebg.4. human. [Q6P2N6-1]

Polymorphism databases

DMDMi380876892.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL390195 , AL391063 Genomic DNA. Translation: CAI15626.1 .
AL391063 , AL390195 Genomic DNA. Translation: CAI22964.1 .
CH471122 Genomic DNA. Translation: EAW56500.1 . Different initiation.
BC041707 mRNA. Translation: AAH41707.1 . Different initiation.
BC064411 mRNA. Translation: AAH64411.1 . Different initiation.
CCDSi CCDS41369.1. [Q6P2N6-1 ]
RefSeqi NP_001075445.1. NM_001081976.1. [Q6P2N6-1 ]
UniGenei Hs.281342.

3D structure databases

ProteinModelPortali Q6P2N6.
SMRi Q6P2N6. Positions 93-158.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q6P2N6.

Polymorphism databases

DMDMi 380876892.

Proteomic databases

PRIDEi Q6P2N6.

Protocols and materials databases

DNASUi 140.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369717 ; ENSP00000358731 ; ENSG00000121933 . [Q6P2N6-1 ]
GeneIDi 140.
KEGGi hsa:140.
UCSCi uc001ebg.4. human. [Q6P2N6-1 ]

Organism-specific databases

CTDi 140.
GeneCardsi GC01M112025.
HGNCi HGNC:268. ADORA3.
MIMi 600445. gene.
neXtProti NX_Q6P2N6.
PharmGKBi PA24589.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00550000074524.
HOGENOMi HOG000139368.
HOVERGENi HBG058258.
KOi K04268.
OMAi PRNISTQ.

Miscellaneous databases

GenomeRNAii 140.
NextBioi 553.
PROi Q6P2N6.
SOURCEi Search...

Gene expression databases

Bgeei Q6P2N6.
ExpressionAtlasi Q6P2N6. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR013783. Ig-like_fold.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-266 (ISOFORM 3).
    Tissue: Brain.

Entry informationi

Entry nameiAA3RB_HUMAN
AccessioniPrimary (citable) accession number: Q6P2N6
Secondary accession number(s): Q5QNY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3