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Protein

Calcium/calmodulin-dependent protein kinase type 1B

Gene

PNCK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by Ca2+/calmodulin.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441ATPPROSITE-ProRule annotation
Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 299ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6P2M8.
SIGNORiQ6P2M8.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type 1B (EC:2.7.11.17)
Alternative name(s):
CaM kinase I beta
Short name:
CaM kinase IB
Short name:
CaM-KI beta
Short name:
CaMKI-beta
Pregnancy up-regulated non-ubiquitously-expressed CaM kinase
Gene namesi
Name:PNCK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13415. PNCK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988711.

Chemistry

GuidetoPHARMACOLOGYi2172.

Polymorphism and mutation databases

BioMutaiPNCK.
DMDMi67466915.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Calcium/calmodulin-dependent protein kinase type 1BPRO_0000086079Add
BLAST

Post-translational modificationi

Phosphorylated by CAMKK1.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P2M8.
PeptideAtlasiQ6P2M8.
PRIDEiQ6P2M8.

PTM databases

iPTMnetiQ6P2M8.
PhosphoSiteiQ6P2M8.

Expressioni

Gene expression databases

BgeeiQ6P2M8.
CleanExiHS_PNCK.
ExpressionAtlasiQ6P2M8. baseline and differential.
GenevisibleiQ6P2M8. HS.

Organism-specific databases

HPAiHPA007458.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000405950.

Structurei

3D structure databases

ProteinModelPortaliQ6P2M8.
SMRiQ6P2M8. Positions 6-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 270256Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni290 – 31122Calmodulin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118944.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ6P2M8.
KOiK08795.
OMAiHHIRKLG.
PhylomeDBiQ6P2M8.
TreeFamiTF314166.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P2M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLKKHTED ISSVYEIRER LGSGAFSEVV LAQERGSAHL VALKCIPKKA
60 70 80 90 100
LRGKEALVEN EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD
110 120 130 140 150
RIMERGSYTE KDASHLVGQV LGAVSYLHSL GIVHRDLKPE NLLYATPFED
160 170 180 190 200
SKIMVSDFGL SKIQAGNMLG TACGTPGYVA PELLEQKPYG KAVDVWALGV
210 220 230 240 250
ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS ESAKDFIRHL
260 270 280 290 300
LERDPQKRFT CQQALRHLWI SGDTAFDRDI LGSVSEQIRK NFARTHWKRA
310 320 330 340
FNATSFLRHI RKLGQIPEGE GASEQGMARH SHSGLRAGQP PKW
Note: Gene prediction based on similarity to mouse ortholog.
Length:343
Mass (Da):38,500
Last modified:February 1, 2005 - v2
Checksum:iE954AEE89DE608C9
GO
Isoform 2 (identifier: Q6P2M8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: V → AEPVTLSGMAACVPVRASVCLWPP

Show »
Length:366
Mass (Da):40,838
Checksum:iF9F61FA92579FDE9
GO
Isoform 3 (identifier: Q6P2M8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:241
Mass (Da):27,161
Checksum:i6AA7E6AFE0CEB409
GO
Isoform 4 (identifier: Q6P2M8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEAAFGQVAG...RIPAIALQDM

Show »
Length:426
Mass (Da):46,957
Checksum:iA2958437908C9C67
GO
Isoform 5 (identifier: Q6P2M8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWRRVCGGLAGRRPSGDM

Note: No experimental confirmation available.
Show »
Length:360
Mass (Da):40,356
Checksum:iD27E099934F3A64A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271L → P in BAG58930 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti262 – 2621Q → H.1 Publication
Corresponds to variant rs56060609 [ dbSNP | Ensembl ].
VAR_040598

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 3. 1 PublicationVSP_012634Add
BLAST
Alternative sequencei1 – 11M → MEAAFGQVAGSACPRRGGEG RDWKAESLADLWPKSSPGDS HRWCKGPGAGPAGPQLREAA RASSGLGGGGRHPSRIPAIA LQDM in isoform 4. 1 PublicationVSP_039091
Alternative sequencei1 – 11M → MWRRVCGGLAGRRPSGDM in isoform 5. 1 PublicationVSP_043373
Alternative sequencei179 – 1791V → AEPVTLSGMAACVPVRASVC LWPP in isoform 2. 1 PublicationVSP_012635

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296203 mRNA. Translation: BAG58930.1.
AK303746 mRNA. Translation: BAG64718.1.
CR611192 mRNA. No translation available.
U52111 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72838.1.
CH471172 Genomic DNA. Translation: EAW72839.1.
CH471172 Genomic DNA. Translation: EAW72841.1.
CH471172 Genomic DNA. Translation: EAW72842.1.
CH471172 Genomic DNA. Translation: EAW72843.1.
CH471172 Genomic DNA. Translation: EAW72845.1.
BC064422 mRNA. Translation: AAH64422.1.
CCDSiCCDS35503.2. [Q6P2M8-5]
CCDS48189.1. [Q6P2M8-6]
RefSeqiNP_001034671.3. NM_001039582.3. [Q6P2M8-5]
NP_001129212.1. NM_001135740.1. [Q6P2M8-6]
XP_005274708.1. XM_005274651.1. [Q6P2M8-1]
XP_006724872.1. XM_006724809.2. [Q6P2M8-1]
XP_011529411.1. XM_011531109.1. [Q6P2M8-1]
XP_011529412.1. XM_011531110.1. [Q6P2M8-1]
XP_011529413.1. XM_011531111.1. [Q6P2M8-1]
XP_011529414.1. XM_011531112.1. [Q6P2M8-1]
XP_011529415.1. XM_011531113.1. [Q6P2M8-1]
UniGeneiHs.436667.

Genome annotation databases

EnsembliENST00000340888; ENSP00000340586; ENSG00000130822. [Q6P2M8-1]
ENST00000370142; ENSP00000359161; ENSG00000130822. [Q6P2M8-2]
ENST00000370145; ENSP00000359164; ENSG00000130822. [Q6P2M8-6]
ENST00000370150; ENSP00000359169; ENSG00000130822. [Q6P2M8-1]
ENST00000447676; ENSP00000405950; ENSG00000130822. [Q6P2M8-5]
GeneIDi139728.
KEGGihsa:139728.
UCSCiuc011myt.3. human. [Q6P2M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296203 mRNA. Translation: BAG58930.1.
AK303746 mRNA. Translation: BAG64718.1.
CR611192 mRNA. No translation available.
U52111 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72838.1.
CH471172 Genomic DNA. Translation: EAW72839.1.
CH471172 Genomic DNA. Translation: EAW72841.1.
CH471172 Genomic DNA. Translation: EAW72842.1.
CH471172 Genomic DNA. Translation: EAW72843.1.
CH471172 Genomic DNA. Translation: EAW72845.1.
BC064422 mRNA. Translation: AAH64422.1.
CCDSiCCDS35503.2. [Q6P2M8-5]
CCDS48189.1. [Q6P2M8-6]
RefSeqiNP_001034671.3. NM_001039582.3. [Q6P2M8-5]
NP_001129212.1. NM_001135740.1. [Q6P2M8-6]
XP_005274708.1. XM_005274651.1. [Q6P2M8-1]
XP_006724872.1. XM_006724809.2. [Q6P2M8-1]
XP_011529411.1. XM_011531109.1. [Q6P2M8-1]
XP_011529412.1. XM_011531110.1. [Q6P2M8-1]
XP_011529413.1. XM_011531111.1. [Q6P2M8-1]
XP_011529414.1. XM_011531112.1. [Q6P2M8-1]
XP_011529415.1. XM_011531113.1. [Q6P2M8-1]
UniGeneiHs.436667.

3D structure databases

ProteinModelPortaliQ6P2M8.
SMRiQ6P2M8. Positions 6-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000405950.

Chemistry

GuidetoPHARMACOLOGYi2172.

PTM databases

iPTMnetiQ6P2M8.
PhosphoSiteiQ6P2M8.

Polymorphism and mutation databases

BioMutaiPNCK.
DMDMi67466915.

Proteomic databases

PaxDbiQ6P2M8.
PeptideAtlasiQ6P2M8.
PRIDEiQ6P2M8.

Protocols and materials databases

DNASUi139728.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340888; ENSP00000340586; ENSG00000130822. [Q6P2M8-1]
ENST00000370142; ENSP00000359161; ENSG00000130822. [Q6P2M8-2]
ENST00000370145; ENSP00000359164; ENSG00000130822. [Q6P2M8-6]
ENST00000370150; ENSP00000359169; ENSG00000130822. [Q6P2M8-1]
ENST00000447676; ENSP00000405950; ENSG00000130822. [Q6P2M8-5]
GeneIDi139728.
KEGGihsa:139728.
UCSCiuc011myt.3. human. [Q6P2M8-1]

Organism-specific databases

CTDi139728.
GeneCardsiPNCK.
HGNCiHGNC:13415. PNCK.
HPAiHPA007458.
MIMi300680. gene.
neXtProtiNX_Q6P2M8.
PharmGKBiPA134988711.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118944.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ6P2M8.
KOiK08795.
OMAiHHIRKLG.
PhylomeDBiQ6P2M8.
TreeFamiTF314166.

Enzyme and pathway databases

SignaLinkiQ6P2M8.
SIGNORiQ6P2M8.

Miscellaneous databases

ChiTaRSiPNCK. human.
GenomeRNAii139728.
PROiQ6P2M8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P2M8.
CleanExiHS_PNCK.
ExpressionAtlasiQ6P2M8. baseline and differential.
GenevisibleiQ6P2M8. HS.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    Tissue: Liver and Thalamus.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  6. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-262.

Entry informationi

Entry nameiKCC1B_HUMAN
AccessioniPrimary (citable) accession number: Q6P2M8
Secondary accession number(s): B4DJR8
, B4E1A6, B7WPG0, D3DWU7, Q8N4R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 6, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.