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Q6P2I7 (EBLN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endogenous Bornavirus-like nucleoprotein 2
Alternative name(s):
Endogenous Borna-like N element-2
Short name=EBLN-2
Gene names
Name:EBLN2
ORF Names:GK006
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.

Miscellaneous

Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-2 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Endogenous Bornavirus-like nucleoprotein 2
PRO_0000358716

Experimental info

Sequence conflict1761A → G in AAK83528. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6P2I7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7937378569396D7D

FASTA27230,450
        10         20         30         40         50         60 
MGYFLKLYAY VNSHSLFVWV CDRSYKRSFR PMILNKIKEL SRNQFSTMSH LRKDSQPSSP 

        70         80         90        100        110        120 
GDDAMDRSGL PDLQGRFELS GKNRQYPLDA LEPQPSIGDI KDIKKAAKSM LDPAHKSHFH 

       130        140        150        160        170        180 
PVTPSLVFLC FIFDGLHQAL LSVGVSKRSN TVVGNENEER GTPYASRFKD MPNFIALEKS 

       190        200        210        220        230        240 
SVLRHCCDLL IGIAAGSSDK ICTSSLQVQR RFKAMMASIG RLSHGESADL LISCNAESAI 

       250        260        270 
GWISSRPWVG ELMFTLLFGD FESPLHKLRK SS 

« Hide

References

« Hide 'large scale' references
[1]Xu X., Huang J., Rong Y., Xiao H., Chen Z., Han Z.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hepatoma.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-272.
Tissue: Embryo.
[5]"Endogenous non-retroviral RNA virus elements in mammalian genomes."
Horie M., Honda T., Suzuki Y., Kobayashi Y., Daito T., Oshida T., Ikuta K., Jern P., Gojobori T., Coffin J.M., Tomonaga K.
Nature 463:84-87(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SIMILARITY WITH BORNAVIRUS NUCLEOCAPSID.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY036895 mRNA. Translation: AAK83528.1.
AC103559 Genomic DNA. No translation available.
BC051316 mRNA. Translation: AAH51316.1.
BC064501 mRNA. Translation: AAH64501.1.
AK001075 mRNA. Translation: BAA91494.1.
RefSeqNP_060499.3. NM_018029.3.
UniGeneHs.658858.

3D structure databases

ProteinModelPortalQ6P2I7.
SMRQ6P2I7. Positions 78-264.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120408. 6 interactions.

PTM databases

PhosphoSiteQ6P2I7.

Polymorphism databases

DMDM74737218.

Proteomic databases

PRIDEQ6P2I7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000533473; ENSP00000432104; ENSG00000255423.
GeneID55096.
KEGGhsa:55096.
UCSCuc003dpj.3. human.

Organism-specific databases

CTD55096.
GeneCardsGC03P073111.
H-InvDBHIX0008034.
HGNCHGNC:25493. EBLN2.
MIM613250. gene.
neXtProtNX_Q6P2I7.
GenAtlasSearch...

Phylogenomic databases

OMAAAKSMLD.
OrthoDBEOG7N63N4.
PhylomeDBQ6P2I7.

Gene expression databases

BgeeQ6P2I7.
GenevestigatorQ6P2I7.

Family and domain databases

Gene3D1.10.3040.10. 1 hit.
InterProIPR009441. P40_nucleoprot_BD-vir.
IPR015969. P40_nucleoprot_sub1_BD-vir.
[Graphical view]
PfamPF06407. BDV_P40. 1 hit.
[Graphical view]
SUPFAMSSF101399. SSF101399. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi55096.
NextBio58685.
PROQ6P2I7.
SOURCESearch...

Entry information

Entry nameEBLN2_HUMAN
AccessionPrimary (citable) accession number: Q6P2I7
Secondary accession number(s): Q8WWH3, Q9NW89
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM