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Q6P2I7

- EBLN2_HUMAN

UniProt

Q6P2I7 - EBLN2_HUMAN

Protein

Endogenous Bornavirus-like nucleoprotein 2

Gene

EBLN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endogenous Bornavirus-like nucleoprotein 2
    Alternative name(s):
    Endogenous Borna-like N element-2
    Short name:
    EBLN-2
    Gene namesi
    Name:EBLN2
    ORF Names:GK006
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:25493. EBLN2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Endogenous Bornavirus-like nucleoprotein 2PRO_0000358716Add
    BLAST

    Proteomic databases

    PRIDEiQ6P2I7.

    PTM databases

    PhosphoSiteiQ6P2I7.

    Expressioni

    Gene expression databases

    BgeeiQ6P2I7.
    GenevestigatoriQ6P2I7.

    Interactioni

    Protein-protein interaction databases

    BioGridi120408. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P2I7.
    SMRiQ6P2I7. Positions 78-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    OMAiNENEERG.
    OrthoDBiEOG7N63N4.
    PhylomeDBiQ6P2I7.

    Family and domain databases

    Gene3Di1.10.3040.10. 1 hit.
    InterProiIPR009441. P40_nucleoprot_BD-vir.
    IPR015969. P40_nucleoprot_sub1_BD-vir.
    [Graphical view]
    PfamiPF06407. BDV_P40. 1 hit.
    [Graphical view]
    SUPFAMiSSF101399. SSF101399. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6P2I7-1 [UniParc]FASTAAdd to Basket

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    MGYFLKLYAY VNSHSLFVWV CDRSYKRSFR PMILNKIKEL SRNQFSTMSH    50
    LRKDSQPSSP GDDAMDRSGL PDLQGRFELS GKNRQYPLDA LEPQPSIGDI 100
    KDIKKAAKSM LDPAHKSHFH PVTPSLVFLC FIFDGLHQAL LSVGVSKRSN 150
    TVVGNENEER GTPYASRFKD MPNFIALEKS SVLRHCCDLL IGIAAGSSDK 200
    ICTSSLQVQR RFKAMMASIG RLSHGESADL LISCNAESAI GWISSRPWVG 250
    ELMFTLLFGD FESPLHKLRK SS 272
    Length:272
    Mass (Da):30,450
    Last modified:July 5, 2004 - v1
    Checksum:i7937378569396D7D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761A → G in AAK83528. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY036895 mRNA. Translation: AAK83528.1.
    AC103559 Genomic DNA. No translation available.
    BC051316 mRNA. Translation: AAH51316.1.
    BC064501 mRNA. Translation: AAH64501.1.
    AK001075 mRNA. Translation: BAA91494.1.
    CCDSiCCDS54608.1.
    RefSeqiNP_060499.3. NM_018029.3.
    UniGeneiHs.658858.

    Genome annotation databases

    EnsembliENST00000533473; ENSP00000432104; ENSG00000255423.
    GeneIDi55096.
    KEGGihsa:55096.
    UCSCiuc003dpj.3. human.

    Polymorphism databases

    DMDMi74737218.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY036895 mRNA. Translation: AAK83528.1 .
    AC103559 Genomic DNA. No translation available.
    BC051316 mRNA. Translation: AAH51316.1 .
    BC064501 mRNA. Translation: AAH64501.1 .
    AK001075 mRNA. Translation: BAA91494.1 .
    CCDSi CCDS54608.1.
    RefSeqi NP_060499.3. NM_018029.3.
    UniGenei Hs.658858.

    3D structure databases

    ProteinModelPortali Q6P2I7.
    SMRi Q6P2I7. Positions 78-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120408. 6 interactions.

    PTM databases

    PhosphoSitei Q6P2I7.

    Polymorphism databases

    DMDMi 74737218.

    Proteomic databases

    PRIDEi Q6P2I7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000533473 ; ENSP00000432104 ; ENSG00000255423 .
    GeneIDi 55096.
    KEGGi hsa:55096.
    UCSCi uc003dpj.3. human.

    Organism-specific databases

    CTDi 55096.
    GeneCardsi GC03P073111.
    H-InvDB HIX0008034.
    HGNCi HGNC:25493. EBLN2.
    MIMi 613250. gene.
    neXtProti NX_Q6P2I7.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi NENEERG.
    OrthoDBi EOG7N63N4.
    PhylomeDBi Q6P2I7.

    Miscellaneous databases

    GenomeRNAii 55096.
    NextBioi 58685.
    PROi Q6P2I7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P2I7.
    Genevestigatori Q6P2I7.

    Family and domain databases

    Gene3Di 1.10.3040.10. 1 hit.
    InterProi IPR009441. P40_nucleoprot_BD-vir.
    IPR015969. P40_nucleoprot_sub1_BD-vir.
    [Graphical view ]
    Pfami PF06407. BDV_P40. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101399. SSF101399. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Xu X., Huang J., Rong Y., Xiao H., Chen Z., Han Z.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hepatoma.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-272.
      Tissue: Embryo.
    5. Cited for: SIMILARITY WITH BORNAVIRUS NUCLEOCAPSID.

    Entry informationi

    Entry nameiEBLN2_HUMAN
    AccessioniPrimary (citable) accession number: Q6P2I7
    Secondary accession number(s): Q8WWH3, Q9NW89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-2 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3