SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6P2I7

- EBLN2_HUMAN

UniProt

Q6P2I7 - EBLN2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Endogenous Bornavirus-like nucleoprotein 2

Gene
EBLN2, GK006
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous Bornavirus-like nucleoprotein 2
Alternative name(s):
Endogenous Borna-like N element-2
Short name:
EBLN-2
Gene namesi
Name:EBLN2
ORF Names:GK006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:25493. EBLN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Endogenous Bornavirus-like nucleoprotein 2PRO_0000358716Add
BLAST

Proteomic databases

PRIDEiQ6P2I7.

PTM databases

PhosphoSiteiQ6P2I7.

Expressioni

Gene expression databases

BgeeiQ6P2I7.
GenevestigatoriQ6P2I7.

Interactioni

Protein-protein interaction databases

BioGridi120408. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6P2I7.
SMRiQ6P2I7. Positions 78-264.

Family & Domainsi

Phylogenomic databases

OMAiNENEERG.
OrthoDBiEOG7N63N4.
PhylomeDBiQ6P2I7.

Family and domain databases

Gene3Di1.10.3040.10. 1 hit.
InterProiIPR009441. P40_nucleoprot_BD-vir.
IPR015969. P40_nucleoprot_sub1_BD-vir.
[Graphical view]
PfamiPF06407. BDV_P40. 1 hit.
[Graphical view]
SUPFAMiSSF101399. SSF101399. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P2I7-1 [UniParc]FASTAAdd to Basket

« Hide

MGYFLKLYAY VNSHSLFVWV CDRSYKRSFR PMILNKIKEL SRNQFSTMSH    50
LRKDSQPSSP GDDAMDRSGL PDLQGRFELS GKNRQYPLDA LEPQPSIGDI 100
KDIKKAAKSM LDPAHKSHFH PVTPSLVFLC FIFDGLHQAL LSVGVSKRSN 150
TVVGNENEER GTPYASRFKD MPNFIALEKS SVLRHCCDLL IGIAAGSSDK 200
ICTSSLQVQR RFKAMMASIG RLSHGESADL LISCNAESAI GWISSRPWVG 250
ELMFTLLFGD FESPLHKLRK SS 272
Length:272
Mass (Da):30,450
Last modified:July 5, 2004 - v1
Checksum:i7937378569396D7D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761A → G in AAK83528. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY036895 mRNA. Translation: AAK83528.1.
AC103559 Genomic DNA. No translation available.
BC051316 mRNA. Translation: AAH51316.1.
BC064501 mRNA. Translation: AAH64501.1.
AK001075 mRNA. Translation: BAA91494.1.
CCDSiCCDS54608.1.
RefSeqiNP_060499.3. NM_018029.3.
UniGeneiHs.658858.

Genome annotation databases

EnsembliENST00000533473; ENSP00000432104; ENSG00000255423.
GeneIDi55096.
KEGGihsa:55096.
UCSCiuc003dpj.3. human.

Polymorphism databases

DMDMi74737218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY036895 mRNA. Translation: AAK83528.1 .
AC103559 Genomic DNA. No translation available.
BC051316 mRNA. Translation: AAH51316.1 .
BC064501 mRNA. Translation: AAH64501.1 .
AK001075 mRNA. Translation: BAA91494.1 .
CCDSi CCDS54608.1.
RefSeqi NP_060499.3. NM_018029.3.
UniGenei Hs.658858.

3D structure databases

ProteinModelPortali Q6P2I7.
SMRi Q6P2I7. Positions 78-264.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120408. 6 interactions.

PTM databases

PhosphoSitei Q6P2I7.

Polymorphism databases

DMDMi 74737218.

Proteomic databases

PRIDEi Q6P2I7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000533473 ; ENSP00000432104 ; ENSG00000255423 .
GeneIDi 55096.
KEGGi hsa:55096.
UCSCi uc003dpj.3. human.

Organism-specific databases

CTDi 55096.
GeneCardsi GC03P073111.
H-InvDB HIX0008034.
HGNCi HGNC:25493. EBLN2.
MIMi 613250. gene.
neXtProti NX_Q6P2I7.
GenAtlasi Search...

Phylogenomic databases

OMAi NENEERG.
OrthoDBi EOG7N63N4.
PhylomeDBi Q6P2I7.

Miscellaneous databases

GenomeRNAii 55096.
NextBioi 58685.
PROi Q6P2I7.
SOURCEi Search...

Gene expression databases

Bgeei Q6P2I7.
Genevestigatori Q6P2I7.

Family and domain databases

Gene3Di 1.10.3040.10. 1 hit.
InterProi IPR009441. P40_nucleoprot_BD-vir.
IPR015969. P40_nucleoprot_sub1_BD-vir.
[Graphical view ]
Pfami PF06407. BDV_P40. 1 hit.
[Graphical view ]
SUPFAMi SSF101399. SSF101399. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Xu X., Huang J., Rong Y., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hepatoma.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-272.
    Tissue: Embryo.
  5. Cited for: SIMILARITY WITH BORNAVIRUS NUCLEOCAPSID.

Entry informationi

Entry nameiEBLN2_HUMAN
AccessioniPrimary (citable) accession number: Q6P2I7
Secondary accession number(s): Q8WWH3, Q9NW89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-2 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi