Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endogenous Bornavirus-like nucleoprotein 2

Gene

EBLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous Bornavirus-like nucleoprotein 2
Alternative name(s):
Endogenous Borna-like N element-2
Short name:
EBLN-2
Gene namesi
Name:EBLN2
ORF Names:GK006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:25493. EBLN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Endogenous Bornavirus-like nucleoprotein 2PRO_0000358716Add
BLAST

Proteomic databases

PRIDEiQ6P2I7.

PTM databases

PhosphoSiteiQ6P2I7.

Expressioni

Gene expression databases

BgeeiQ6P2I7.
GenevestigatoriQ6P2I7.

Interactioni

Protein-protein interaction databases

BioGridi120408. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6P2I7.
SMRiQ6P2I7. Positions 78-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00490000044176.
OMAiNENEERG.
OrthoDBiEOG7N63N4.
PhylomeDBiQ6P2I7.

Family and domain databases

Gene3Di1.10.3040.10. 1 hit.
InterProiIPR009441. P40_nucleoprot_BD-vir.
IPR015969. P40_nucleoprot_sub1_BD-vir.
[Graphical view]
PfamiPF06407. BDV_P40. 1 hit.
[Graphical view]
SUPFAMiSSF101399. SSF101399. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P2I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYFLKLYAY VNSHSLFVWV CDRSYKRSFR PMILNKIKEL SRNQFSTMSH
60 70 80 90 100
LRKDSQPSSP GDDAMDRSGL PDLQGRFELS GKNRQYPLDA LEPQPSIGDI
110 120 130 140 150
KDIKKAAKSM LDPAHKSHFH PVTPSLVFLC FIFDGLHQAL LSVGVSKRSN
160 170 180 190 200
TVVGNENEER GTPYASRFKD MPNFIALEKS SVLRHCCDLL IGIAAGSSDK
210 220 230 240 250
ICTSSLQVQR RFKAMMASIG RLSHGESADL LISCNAESAI GWISSRPWVG
260 270
ELMFTLLFGD FESPLHKLRK SS
Length:272
Mass (Da):30,450
Last modified:July 5, 2004 - v1
Checksum:i7937378569396D7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761A → G in AAK83528 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY036895 mRNA. Translation: AAK83528.1.
AC103559 Genomic DNA. No translation available.
BC051316 mRNA. Translation: AAH51316.1.
BC064501 mRNA. Translation: AAH64501.1.
AK001075 mRNA. Translation: BAA91494.1.
CCDSiCCDS54608.1.
RefSeqiNP_060499.3. NM_018029.4.
UniGeneiHs.658858.

Genome annotation databases

EnsembliENST00000533473; ENSP00000432104; ENSG00000255423.
GeneIDi55096.
KEGGihsa:55096.
UCSCiuc003dpj.3. human.

Polymorphism databases

DMDMi74737218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY036895 mRNA. Translation: AAK83528.1.
AC103559 Genomic DNA. No translation available.
BC051316 mRNA. Translation: AAH51316.1.
BC064501 mRNA. Translation: AAH64501.1.
AK001075 mRNA. Translation: BAA91494.1.
CCDSiCCDS54608.1.
RefSeqiNP_060499.3. NM_018029.4.
UniGeneiHs.658858.

3D structure databases

ProteinModelPortaliQ6P2I7.
SMRiQ6P2I7. Positions 78-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120408. 6 interactions.

PTM databases

PhosphoSiteiQ6P2I7.

Polymorphism databases

DMDMi74737218.

Proteomic databases

PRIDEiQ6P2I7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000533473; ENSP00000432104; ENSG00000255423.
GeneIDi55096.
KEGGihsa:55096.
UCSCiuc003dpj.3. human.

Organism-specific databases

CTDi55096.
GeneCardsiGC03P073111.
H-InvDBHIX0008034.
HGNCiHGNC:25493. EBLN2.
MIMi613250. gene.
neXtProtiNX_Q6P2I7.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00490000044176.
OMAiNENEERG.
OrthoDBiEOG7N63N4.
PhylomeDBiQ6P2I7.

Miscellaneous databases

GenomeRNAii55096.
NextBioi58685.
PROiQ6P2I7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P2I7.
GenevestigatoriQ6P2I7.

Family and domain databases

Gene3Di1.10.3040.10. 1 hit.
InterProiIPR009441. P40_nucleoprot_BD-vir.
IPR015969. P40_nucleoprot_sub1_BD-vir.
[Graphical view]
PfamiPF06407. BDV_P40. 1 hit.
[Graphical view]
SUPFAMiSSF101399. SSF101399. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Xu X., Huang J., Rong Y., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hepatoma.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-272.
    Tissue: Embryo.
  5. Cited for: SIMILARITY WITH BORNAVIRUS NUCLEOCAPSID.

Entry informationi

Entry nameiEBLN2_HUMAN
AccessioniPrimary (citable) accession number: Q6P2I7
Secondary accession number(s): Q8WWH3, Q9NW89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-2 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.