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Q6P2I3 (FAH2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fumarylacetoacetate hydrolase domain-containing protein 2B
EC=3.-.-.-
Gene names
Name:FAHD2B
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have hydrolase activity By similarity.

Cofactor

Calcium Probable.

Magnesium Probable.

Sequence similarities

Belongs to the FAH family.

Ontologies

Keywords
   LigandCalcium
Magnesium
Metal-binding
   Molecular functionHydrolase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Fumarylacetoacetate hydrolase domain-containing protein 2B
PRO_0000289796

Amino acid modifications

Modified residue2031N6-acetyllysine Ref.5
Modified residue2341N6-acetyllysine Ref.5

Experimental info

Sequence conflict331R → W in CAD38727. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q6P2I3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 25B2BECA1CF7891F

FASTA31434,613
        10         20         30         40         50         60 
MLVSGRRRLL TALLQAQKWP FQPSRDMRLV QFRAPHLVGP HLGLETGNGG GVINLNAFDP 

        70         80         90        100        110        120 
TLPKTMTQFL EQGEATLSVA RRALAAQLPV LPWSEVTFLA PVTWPDKVVC VGMNYVDHCK 

       130        140        150        160        170        180 
EQNVPVPKEP IIFSKFASSI VGPYDEVVLP PQSQEVDWEV ELAVVIGKKG KHIKATDAMA 

       190        200        210        220        230        240 
HVAGFTVAHD VSARDWLTRR NGKQWLLGKT FDTFCPLGPA LVTKDSVADP HNLKICCRVN 

       250        260        270        280        290        300 
GEVVQSSNTN QMVFKTEDLI AWVSQFVTFY PGDVILTGTP PGVGVFRKPP VFLKKGDEVQ 

       310 
CEIEELGVII NKVV

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-314.
Tissue: Testis.
[5]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed: 19608861] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-203 AND LYS-234, MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC018892 Genomic DNA. Translation: AAY14641.1.
CH471207 Genomic DNA. Translation: EAW71310.1.
CH471207 Genomic DNA. Translation: EAW71311.1.
CH471207 Genomic DNA. Translation: EAW71312.1.
CH471207 Genomic DNA. Translation: EAW71313.1.
CH471207 Genomic DNA. Translation: EAW71314.1.
BC064511 mRNA. Translation: AAH64511.1.
AL833869 mRNA. Translation: CAD38727.1.
IPIIPI00301994.
RefSeqNP_955368.1. NM_199336.1.
UniGeneHs.567723.

3D structure databases

HSSPHSSP built from PDB template 1WZO based on UniProtKB Q5SJQ0.
ProteinModelPortalQ6P2I3.
SMRQ6P2I3. Positions 27-314.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6P2I3.

PTM databases

PhosphoSiteQ6P2I3.

Polymorphism databases

DMDM74737217.

Proteomic databases

PRIDEQ6P2I3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000272610; ENSP00000272610; ENSG00000144199.
ENST00000414820; ENSP00000410470; ENSG00000144199.
GeneID151313.
KEGGhsa:151313.
NMPDRfig|9606.3.peg.18324.
UCSCuc002sxm.1. human.

Organism-specific databases

CTD151313.
GeneCardsGC02M097748.
H-InvDBHIX0002286.
HGNCHGNC:25318. FAHD2B.
HPAHPA042145.
HPA044987.
neXtProtNX_Q6P2I3.
PharmGKBPA162385597.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG17313.
GeneTreeENSGT00530000063832.
HOGENOMHBG729228.
HOVERGENHBG104460.
InParanoidQ6P2I3.
OMAGMGIKPS.
OrthoDBEOG4VDQ06.
PhylomeDBQ6P2I3.

Gene expression databases

ArrayExpressQ6P2I3.
BgeeQ6P2I3.
GenevestigatorQ6P2I3.

Family and domain databases

InterProIPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
[Graphical view]
Gene3DG3DSA:3.90.850.10. Fumarylacetoacetase_C-rel. 1 hit.
PfamPF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMSSF56529. Fumarylacetoacetase_C-rel. 1 hit.
ProtoNetSearch...

Other

NextBio86674.

Entry information

Entry nameFAH2B_HUMAN
AccessionPrimary (citable) accession number: Q6P2I3
Secondary accession number(s): D3DXH7, Q8NDK1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents