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Protein
Submitted name:

ADAM metallopeptidase domain 2 (Fertilin beta), isoform CRA_b

Gene

ADAM2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
ADAM metallopeptidase domain 2 (Fertilin beta), isoform CRA_bImported
Submitted name:
ADAM2 proteinImported
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 2Imported
Gene namesi
Name:ADAM2Imported
ORF Names:hCG_38684Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:198. ADAM2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104755.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501014236017 – 579Sequence analysisAdd BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi205 ↔ 210PROSITE-ProRule annotation
Disulfide bondi319 ↔ 339PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000104755.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 249Peptidase M12BInterPro annotationAdd BLAST81
Domaini258 – 347DisintegrinInterPro annotationAdd BLAST90

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00880000137877.
HOGENOMiHOG000230883.
HOVERGENiHBG103628.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR033958. ADAM2.
IPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
PANTHERiPTHR11905:SF203. PTHR11905:SF203. 1 hit.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P2G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRVLFLLSG LGGLRMDSNF DSLPVQITVP EKIRSIIKEG IESQASYKIV
60 70 80 90 100
IEGKPYTVNL MQKNFLPHNF RVYSYSGTGI MKPLDQDFQN FCHYQGYIEG
110 120 130 140 150
YPKSVVMVST CTGLRGVLQF ENVSYGIEPL ESSVGFEHVI YQVKHKKADV
160 170 180 190 200
SLYNEKDIES RDLSFKLQSV EHPRTISLES LAVILAQLLS LSMGITYDDI
210 220 230 240 250
NKCQCSGAVC IMNPEAIHFS GVKIFSNCSF EDFAHFISKQ KSQCLHNQPR
260 270 280 290 300
LDPFFKQQAV CGNAKLEAGE ECDCGTEQDC ALIGETCCDI ATCRFKAGSN
310 320 330 340 350
CAEGPCCENC LFMSKERMCR PSFEECDLPE YCNGSSASCP ENHYVQTGHP
360 370 380 390 400
CGLNQWICID GVCMSGDKQC TDTFGKEVEF GPSECYSHLN SKTDVSGNCG
410 420 430 440 450
ISDSGYTQCE ADGHLCIAVE FASDHADSQK MWIKDGTSCG SNKVCRNQRC
460 470 480 490 500
VSSSYLGYDC TTDKCNDRGV CNNKKHCHCS ASYLPPDCSV QSDLWPGGSI
510 520 530 540 550
DSGNFPPVAI PARLPERRYI ENIYHSKPMR WPFFLFIPFF IIFCVLIAIM
560 570
VKVNFQRKKW RTEDYSSDEQ PESESEPKG
Length:579
Mass (Da):64,796
Last modified:July 5, 2004 - v1
Checksum:i1F7AF0CDA2A064F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136365 Genomic DNA. No translation available.
AC244257 Genomic DNA. No translation available.
AP005902 Genomic DNA. No translation available.
BC064547 mRNA. Translation: AAH64547.1.
CH471080 Genomic DNA. Translation: EAW63274.1.
RefSeqiXP_011542782.1. XM_011544480.1.
UniGeneiHs.177959.

Genome annotation databases

EnsembliENST00000379853; ENSP00000369182; ENSG00000104755.
ENST00000619491; ENSP00000480574; ENSG00000276286.
GeneIDi2515.
UCSCiuc003xnl.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136365 Genomic DNA. No translation available.
AC244257 Genomic DNA. No translation available.
AP005902 Genomic DNA. No translation available.
BC064547 mRNA. Translation: AAH64547.1.
CH471080 Genomic DNA. Translation: EAW63274.1.
RefSeqiXP_011542782.1. XM_011544480.1.
UniGeneiHs.177959.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379853; ENSP00000369182; ENSG00000104755.
ENST00000619491; ENSP00000480574; ENSG00000276286.
GeneIDi2515.
UCSCiuc003xnl.5. human.

Organism-specific databases

CTDi2515.
HGNCiHGNC:198. ADAM2.
OpenTargetsiENSG00000104755.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00880000137877.
HOGENOMiHOG000230883.
HOVERGENiHBG103628.

Miscellaneous databases

GenomeRNAii2515.

Gene expression databases

BgeeiENSG00000104755.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR033958. ADAM2.
IPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
PANTHERiPTHR11905:SF203. PTHR11905:SF203. 1 hit.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6P2G0_HUMAN
AccessioniPrimary (citable) accession number: Q6P2G0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.