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Protein

Enhancer of mRNA-decapping protein 4

Gene

EDC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-430039. mRNA decay by 5' to 3' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 4
Alternative name(s):
Autoantigen Ge-1
Autoantigen RCD-8
Human enhancer of decapping large subunit
Short name:
Hedls
Gene namesi
Name:EDC4
Synonyms:HEDLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:17157. EDC4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic mRNA processing body Source: MGI
  • cytosol Source: Reactome
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23644.
OpenTargetsiENSG00000038358.
PharmGKBiPA145148958.

Polymorphism and mutation databases

BioMutaiEDC4.
DMDMi74758241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002789622 – 1401Enhancer of mRNA-decapping protein 4Add BLAST1400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei125N6-acetyllysineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei676PhosphoserineBy similarity1
Modified residuei693PhosphothreonineCombined sources1
Modified residuei708PhosphoserineCombined sources1
Modified residuei723PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei727PhosphothreonineCombined sources1
Modified residuei729PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei821PhosphothreonineCombined sources1
Modified residuei844PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei887PhosphoserineBy similarity1
Modified residuei890PhosphoserineBy similarity1
Modified residuei892PhosphoserineCombined sources1
Modified residuei967PhosphoserineCombined sources1
Modified residuei1380PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6P2E9.
MaxQBiQ6P2E9.
PaxDbiQ6P2E9.
PeptideAtlasiQ6P2E9.
PRIDEiQ6P2E9.

PTM databases

iPTMnetiQ6P2E9.
PhosphoSitePlusiQ6P2E9.
SwissPalmiQ6P2E9.

Miscellaneous databases

PMAP-CutDBQ6P2E9.

Expressioni

Gene expression databases

BgeeiENSG00000038358.
CleanExiHS_EDC4.
ExpressionAtlasiQ6P2E9. baseline and differential.
GenevisibleiQ6P2E9. HS.

Organism-specific databases

HPAiHPA041164.

Interactioni

Subunit structurei

Part of a decapping complex consisting of DCP1A, DCP2, EDC3, EDC4 and probably DDX6. Part of a complex consisting of DCP1A, EDC3, EDC4 and DDX6. Part of a complex consisting of DCP1B, EDC3, EDC4 and DDX6. Interacts with DCP2. Interacts with RC3H1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
COASYQ130573EBI-1006038,EBI-745967
DCP2Q8IU604EBI-1006038,EBI-521577
EIF2AK2P195252EBI-1006038,EBI-640775

Protein-protein interaction databases

BioGridi117171. 61 interactors.
DIPiDIP-31192N.
IntActiQ6P2E9. 32 interactors.
MINTiMINT-5005241.
STRINGi9606.ENSP00000351811.

Structurei

3D structure databases

ProteinModelPortaliQ6P2E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati121 – 164WD 1Add BLAST44
Repeati167 – 206WD 2Add BLAST40
Repeati217 – 269WD 3Add BLAST53
Repeati287 – 326WD 4Add BLAST40
Repeati335 – 385WD 5Add BLAST51
Repeati389 – 426WD 6Add BLAST38
Repeati432 – 475WD 7Add BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni913 – 934Sufficient for nuclear localizationAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili954 – 1025Sequence analysisAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi602 – 676Ser-richAdd BLAST75

Sequence similaritiesi

Belongs to the WD repeat EDC4 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1916. Eukaryota.
ENOG410XP6V. LUCA.
GeneTreeiENSGT00510000047791.
HOVERGENiHBG053855.
InParanoidiQ6P2E9.
KOiK12616.
OMAiSAHLDCQ.
OrthoDBiEOG091G036X.
PhylomeDBiQ6P2E9.
TreeFamiTF350715.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR032401. EDC4_WD40.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16529. Ge1_WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P2E9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASCASIDIE DATQHLRDIL KLDRPAGGPS AESPRPSSAY NGDLNGLLVP
60 70 80 90 100
DPLCSGDSTS ANKTGLRTMP PINLQEKQVI CLSGDDSSTC IGILAKEVEI
110 120 130 140 150
VASSDSSISS KARGSNKVKI QPVAKYDWEQ KYYYGNLIAV SNSFLAYAIR
160 170 180 190 200
AANNGSAMVR VISVSTSERT LLKGFTGSVA DLAFAHLNSP QLACLDEAGN
210 220 230 240 250
LFVWRLALVN GKIQEEILVH IRQPEGTPLN HFRRIIWCPF IPEESEDCCE
260 270 280 290 300
ESSPTVALLH EDRAEVWDLD MLRSSHSTWP VDVSQIKQGF IVVKGHSTCL
310 320 330 340 350
SEGALSPDGT VLATASHDGY VKFWQIYIEG QDEPRCLHEW KPHDGRPLSC
360 370 380 390 400
LLFCDNHKKQ DPDVPFWRFL ITGADQNREL KMWCTVSWTC LQTIRFSPDI
410 420 430 440 450
FSSVSVPPSL KVCLDLSAEY LILSDVQRKV LYVMELLQNQ EEGHACFSSI
460 470 480 490 500
SEFLLTHPVL SFGIQVVSRC RLRHTEVLPA EEENDSLGAD GTHGAGAMES
510 520 530 540 550
AAGVLIKLFC VHTKALQDVQ IRFQPQLNPD VVAPLPTHTA HEDFTFGESR
560 570 580 590 600
PELGSEGLGS AAHGSQPDLR RIVELPAPAD FLSLSSETKP KLMTPDAFMT
610 620 630 640 650
PSASLQQITA SPSSSSSGSS SSSSSSSSSL TAVSAMSSTS AVDPSLTRPP
660 670 680 690 700
EELTLSPKLQ LDGSLTMSSS GSLQASPRGL LPGLLPAPAD KLTPKGPGQV
710 720 730 740 750
PTATSALSLE LQEVEPLGLP QASPSRTRSP DVISSASTAL SQDIPEIASE
760 770 780 790 800
ALSRGFGSSA PEGLEPDSMA SAASALHLLS PRPRPGPELG PQLGLDGGPG
810 820 830 840 850
DGDRHNTPSL LEAALTQEAS TPDSQVWPTA PDITRETCST LAESPRNGLQ
860 870 880 890 900
EKHKSLAFHR PPYHLLQQRD SQDASAEQSD HDDEVASLAS ASGGFGTKVP
910 920 930 940 950
APRLPAKDWK TKGSPRTSPK LKRKSKKDDG DAAMGSRLTE HQVAEPPEDW
960 970 980 990 1000
PALIWQQQRE LAELRHSQEE LLQRLCTQLE GLQSTVTGHV ERALETRHEQ
1010 1020 1030 1040 1050
EQRRLERALA EGQQRGGQLQ EQLTQQLSQA LSSAVAGRLE RSIRDEIKKT
1060 1070 1080 1090 1100
VPPCVSRSLE PMAGQLSNSV ATKLTAVEGS MKENISKLLK SKNLTDAIAR
1110 1120 1130 1140 1150
AAADTLQGPM QAAYREAFQS VVLPAFEKSC QAMFQQINDS FRLGTQEYLQ
1160 1170 1180 1190 1200
QLESHMKSRK AREQEAREPV LAQLRGLVST LQSATEQMAA TVAGSVRAEV
1210 1220 1230 1240 1250
QHQLHVAVGS LQESILAQVQ RIVKGEVSVA LKEQQAAVTS SIMQAMRSAA
1260 1270 1280 1290 1300
GTPVPSAHLD CQAQQAHILQ LLQQGHLNQA FQQALTAADL NLVLYVCETV
1310 1320 1330 1340 1350
DPAQVFGQPP CPLSQPVLLS LIQQLASDLG TRTDLKLSYL EEAVMHLDHS
1360 1370 1380 1390 1400
DPITRDHMGS VMAQVRQKLF QFLQAEPHNS LGKAARRLSL MLHGLVTPSL

P
Length:1,401
Mass (Da):151,661
Last modified:July 5, 2004 - v1
Checksum:i0790BB8ADF488356
GO
Isoform 2 (identifier: Q6P2E9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: Missing.

Note: No experimental confirmation available.
Show »
Length:1,020
Mass (Da):109,728
Checksum:i45357808C08C8555
GO

Sequence cautioni

The sequence AAA21833 differs from that shown. Reason: Frameshift at position 1189.Curated
The sequence AAB51444 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH53598 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271 – 272ML → IV in AAA21833 (PubMed:7520377).Curated2
Sequence conflicti621S → N in AAB51444 (PubMed:9067524).Curated1
Sequence conflicti1018 – 1019QL → HW in AAA21833 (PubMed:7520377).Curated2
Sequence conflicti1160 – 1161KA → NG in AAA21833 (PubMed:7520377).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0234121 – 381Missing in isoform 2. 1 PublicationAdd BLAST381

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26339 mRNA. Translation: AAA21833.1. Frameshift.
AK128582 mRNA. No translation available.
AK291049 mRNA. Translation: BAF83738.1.
AC040162 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83183.1.
BC043616 mRNA. Translation: AAH43616.1.
BC053598 mRNA. Translation: AAH53598.1. Different initiation.
BC064567 mRNA. Translation: AAH64567.1.
U17474 mRNA. Translation: AAB51444.1. Different initiation.
CCDSiCCDS10849.1. [Q6P2E9-1]
PIRiI52882.
RefSeqiNP_055144.3. NM_014329.4. [Q6P2E9-1]
UniGeneiHs.75682.

Genome annotation databases

EnsembliENST00000358933; ENSP00000351811; ENSG00000038358. [Q6P2E9-1]
GeneIDi23644.
KEGGihsa:23644.
UCSCiuc002eur.4. human. [Q6P2E9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26339 mRNA. Translation: AAA21833.1. Frameshift.
AK128582 mRNA. No translation available.
AK291049 mRNA. Translation: BAF83738.1.
AC040162 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83183.1.
BC043616 mRNA. Translation: AAH43616.1.
BC053598 mRNA. Translation: AAH53598.1. Different initiation.
BC064567 mRNA. Translation: AAH64567.1.
U17474 mRNA. Translation: AAB51444.1. Different initiation.
CCDSiCCDS10849.1. [Q6P2E9-1]
PIRiI52882.
RefSeqiNP_055144.3. NM_014329.4. [Q6P2E9-1]
UniGeneiHs.75682.

3D structure databases

ProteinModelPortaliQ6P2E9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117171. 61 interactors.
DIPiDIP-31192N.
IntActiQ6P2E9. 32 interactors.
MINTiMINT-5005241.
STRINGi9606.ENSP00000351811.

PTM databases

iPTMnetiQ6P2E9.
PhosphoSitePlusiQ6P2E9.
SwissPalmiQ6P2E9.

Polymorphism and mutation databases

BioMutaiEDC4.
DMDMi74758241.

Proteomic databases

EPDiQ6P2E9.
MaxQBiQ6P2E9.
PaxDbiQ6P2E9.
PeptideAtlasiQ6P2E9.
PRIDEiQ6P2E9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358933; ENSP00000351811; ENSG00000038358. [Q6P2E9-1]
GeneIDi23644.
KEGGihsa:23644.
UCSCiuc002eur.4. human. [Q6P2E9-1]

Organism-specific databases

CTDi23644.
DisGeNETi23644.
GeneCardsiEDC4.
HGNCiHGNC:17157. EDC4.
HPAiHPA041164.
MIMi606030. gene.
neXtProtiNX_Q6P2E9.
OpenTargetsiENSG00000038358.
PharmGKBiPA145148958.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1916. Eukaryota.
ENOG410XP6V. LUCA.
GeneTreeiENSGT00510000047791.
HOVERGENiHBG053855.
InParanoidiQ6P2E9.
KOiK12616.
OMAiSAHLDCQ.
OrthoDBiEOG091G036X.
PhylomeDBiQ6P2E9.
TreeFamiTF350715.

Enzyme and pathway databases

ReactomeiR-HSA-430039. mRNA decay by 5' to 3' exoribonuclease.

Miscellaneous databases

ChiTaRSiEDC4. human.
GenomeRNAii23644.
PMAP-CutDBQ6P2E9.
PROiQ6P2E9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000038358.
CleanExiHS_EDC4.
ExpressionAtlasiQ6P2E9. baseline and differential.
GenevisibleiQ6P2E9. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR032401. EDC4_WD40.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16529. Ge1_WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDC4_HUMAN
AccessioniPrimary (citable) accession number: Q6P2E9
Secondary accession number(s): A6NGM1
, A8K4T4, Q13025, Q13826, Q6ZR12, Q7Z6H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.