X-ray radiation resistance-associated protein 1

Preferred order of sections

Names and origin

Protein names

Recommended name:
X-ray radiation resistance-associated protein 1

Gene names

Name:

XRRA1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	792 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the response of cells to X-ray radiation. Ref.3
Subcellular location	Cytoplasm. Nucleus Ref.3.
Tissue specificity	Expressed predominantly in testis followed by prostate and ovary. Low levels found in other tissues including peripheral blood leukocytes, spleen, thymus, small intestine and colon. Also expressed in neuroblastoma, glioma, breast, lung, leukemia, renal, ovarian, prostate and colorectal cancer cell lines. Ref.3
Induction	By X-ray irradiation immediately after exposure and is then down-regulated two-fold in an X-ray radiation-resistant cell clone. Responds differently to X-ray radiation in clones of varying radiation responses. Ref.3
Sequence similarities	Contains 6 LRR (leucine-rich) repeats.
Sequence caution	The sequence AAO23657.1 differs from that shown. Reason: Frameshift at position 327. The sequence AAP97315.1 differs from that shown. Reason: Frameshift at position 327.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to X-ray Inferred from direct assay Ref.3. Source: UniProtKB
Cellular component	cytoplasm Inferred from direct assay Ref.3. Source: UniProtKB nucleus Inferred from direct assay Ref.3. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P2D8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Gene model based on mouse cDNA data. No experimental confirmation available.

Isoform 2 Ref.2 (identifier: Q6P2D8-2) The sequence of this isoform differs from the canonical sequence as follows: 327-413: Missing. 674-685: AQRIPIPPPKKT → VLSCTSGQNGGW 686-792: Missing.
Note: No experimental confirmation available.

Isoform 3 Ref.3 (identifier: Q6P2D8-3) The sequence of this isoform differs from the canonical sequence as follows: 327-340: Missing.

Isoform 4 Ref.4 (identifier: Q6P2D8-4) The sequence of this isoform differs from the canonical sequence as follows: 327-382: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 792

792

X-ray radiation resistance-associated protein 1

PRO_0000318130

Regions

Repeat

104 – 125

22

LRR 1

Repeat

141 – 155

15

LRR 2

Repeat

164 – 184

21

LRR 3

Repeat

188 – 209

22

LRR 4

Repeat

229 – 250

22

LRR 5

Repeat

254 – 275

22

LRR 6

Coiled coil

723 – 745

23

Potential

Natural variations

Alternative sequence

327 – 413

87

Missing in isoform 2. Ref.2

VSP_052670

Alternative sequence

327 – 382

56

Missing in isoform 4. Ref.4

VSP_052671

Alternative sequence

327 – 340

14

Missing in isoform 3. Ref.3

VSP_052672

Alternative sequence

674 – 685

12

AQRIP…PPKKT → VLSCTSGQNGGW in isoform 2. Ref.2

VSP_052673

Alternative sequence

686 – 792

107

Missing in isoform 2. Ref.2

VSP_052674

Natural variant

473

1

T → R. Ref.2
Corresponds to variant rs4944960 [ dbSNP | Ensembl ].

VAR_038693

Natural variant

480

1

K → E.
Corresponds to variant rs12291445 [ dbSNP | Ensembl ].

VAR_051492

Experimental info

Sequence conflict

3

1

F → L in AAH64584. Ref.2

Sequence conflict

356

1

V → M in AAO23657. Ref.3

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: 6EBEDF9540535BC2 Show »	FASTA	792	89,864
10 20 30 40 50 60 MAFSGIYKLD DGKPYLNNCF PARNLLRVPE EGQGHWLVVQ KGNLKKKPKG LVGAQAERRE 70 80 90 100 110 120 SLKATSFEFK GKKESRRENQ VDLPGHILDQ AFLLKHHCVR KPSDLCTINA KENDFKHFHS 130 140 150 160 170 180 VIYINASENL LPLEAFHTFP ALKELDLAFN GIKTIYVKYG DFKLLEFLDL SFNSLTVEAI 190 200 210 220 230 240 CDLGILPHLR VLLLTGNGLT SLPPNLAVAE QEASVTSLTS KRYILRFPAL ETLMLDDNRL 250 260 270 280 290 300 SNPSCFASLA GLRRLKKLSL DENRIIRIPY LQQVQLYDES VDWNGGRGSP HKEPQFMLQS 310 320 330 340 350 360 KPRMLEDSDE QLDYTVLPMK KDVDRTEVVF SSYPGFSTSE TTKICSLPPI FEILPVKSLK 370 380 390 400 410 420 ARNQTLAPPF PELRYLSLAY NKIAKEDAVL PVALFPSLCE FVFHNNPLVA HTRGVPPLLK 430 440 450 460 470 480 SFLQERLGIH LIRRKIVKPK HHVLMSRKES WKVKSEIPKV PKQPLVLHHP RMTTTKSPSK 490 500 510 520 530 540 DMLEPEAELA EDLPTTKSTS VESEMPTENL EGHSPSCRTF VPLPPICSNS TVHSEETLSH 550 560 570 580 590 600 LSDTTVRLSP ERPSDEDSKS TESIFLTQVS ELPSSVIHKD DLELKEKDQK KPPTAPREVK 610 620 630 640 650 660 GTRRKLPTAF LPSKYHGYEE LLTAKPDPAF IEPKGIQKNA QALQQMLKHP LLCHSSKPKL 670 680 690 700 710 720 DTLQKPYVHK EKRAQRIPIP PPKKTRAQLL DDIFIRLRDP RNITEAPLGA VLHQWTERRL 730 740 750 760 770 780 VNHKQYLEAK RLLKEFQARY RQLVSGSLRT VFGTTPLPMA CPALSESQPK FGHFLEFMDE 790 FCQEPTASDS QG « Hide
Isoform 2 [UniParc]. Checksum: 419CCB0A1EF88BE6 Show »	FASTA	598	67,681
10 20 30 40 50 60 MAFSGIYKLD DGKPYLNNCF PARNLLRVPE EGQGHWLVVQ KGNLKKKPKG LVGAQAERRE 70 80 90 100 110 120 SLKATSFEFK GKKESRRENQ VDLPGHILDQ AFLLKHHCVR KPSDLCTINA KENDFKHFHS 130 140 150 160 170 180 VIYINASENL LPLEAFHTFP ALKELDLAFN GIKTIYVKYG DFKLLEFLDL SFNSLTVEAI 190 200 210 220 230 240 CDLGILPHLR VLLLTGNGLT SLPPNLAVAE QEASVTSLTS KRYILRFPAL ETLMLDDNRL 250 260 270 280 290 300 SNPSCFASLA GLRRLKKLSL DENRIIRIPY LQQVQLYDES VDWNGGRGSP HKEPQFMLQS 310 320 330 340 350 360 KPRMLEDSDE QLDYTVLPMK KDVDRTGVPP LLKSFLQERL GIHLIRRKIV KPKHHVLMSR 370 380 390 400 410 420 KESWKVKSEI PKVPKQPLVL HHPRMTTTKS PSKDMLEPEA ELAEDLPTTK STSVESEMPT 430 440 450 460 470 480 ENLEGHSPSC RTFVPLPPIC SNSTVHSEET LSHLSDTTVR LSPERPSDED SKSTESIFLT 490 500 510 520 530 540 QVSELPSSVI HKDDLELKEK DQKKPPTAPR EVKGTRRKLP TAFLPSKYHG YEELLTAKPD 550 560 570 580 590 PAFIEPKGIQ KNAQALQQML KHPLLCHSSK PKLDTLQKPY VHKEKRVLSC TSGQNGGW « Hide
Isoform 3 [UniParc]. Checksum: 8FE7939B3252DF38 Show »	FASTA	778	88,346
10 20 30 40 50 60 MAFSGIYKLD DGKPYLNNCF PARNLLRVPE EGQGHWLVVQ KGNLKKKPKG LVGAQAERRE 70 80 90 100 110 120 SLKATSFEFK GKKESRRENQ VDLPGHILDQ AFLLKHHCVR KPSDLCTINA KENDFKHFHS 130 140 150 160 170 180 VIYINASENL LPLEAFHTFP ALKELDLAFN GIKTIYVKYG DFKLLEFLDL SFNSLTVEAI 190 200 210 220 230 240 CDLGILPHLR VLLLTGNGLT SLPPNLAVAE QEASVTSLTS KRYILRFPAL ETLMLDDNRL 250 260 270 280 290 300 SNPSCFASLA GLRRLKKLSL DENRIIRIPY LQQVQLYDES VDWNGGRGSP HKEPQFMLQS 310 320 330 340 350 360 KPRMLEDSDE QLDYTVLPMK KDVDRTTTKI CSLPPIFEIL PVKSLKARNQ TLAPPFPELR 370 380 390 400 410 420 YLSLAYNKIA KEDAVLPVAL FPSLCEFVFH NNPLVAHTRG VPPLLKSFLQ ERLGIHLIRR 430 440 450 460 470 480 KIVKPKHHVL MSRKESWKVK SEIPKVPKQP LVLHHPRMTT TKSPSKDMLE PEAELAEDLP 490 500 510 520 530 540 TTKSTSVESE MPTENLEGHS PSCRTFVPLP PICSNSTVHS EETLSHLSDT TVRLSPERPS 550 560 570 580 590 600 DEDSKSTESI FLTQVSELPS SVIHKDDLEL KEKDQKKPPT APREVKGTRR KLPTAFLPSK 610 620 630 640 650 660 YHGYEELLTA KPDPAFIEPK GIQKNAQALQ QMLKHPLLCH SSKPKLDTLQ KPYVHKEKRA 670 680 690 700 710 720 QRIPIPPPKK TRAQLLDDIF IRLRDPRNIT EAPLGAVLHQ WTERRLVNHK QYLEAKRLLK 730 740 750 760 770 EFQARYRQLV SGSLRTVFGT TPLPMACPAL SESQPKFGHF LEFMDEFCQE PTASDSQG « Hide
Isoform 4 [UniParc]. Checksum: E73447E1D6D28B08 Show »	FASTA	736	83,591
10 20 30 40 50 60 MAFSGIYKLD DGKPYLNNCF PARNLLRVPE EGQGHWLVVQ KGNLKKKPKG LVGAQAERRE 70 80 90 100 110 120 SLKATSFEFK GKKESRRENQ VDLPGHILDQ AFLLKHHCVR KPSDLCTINA KENDFKHFHS 130 140 150 160 170 180 VIYINASENL LPLEAFHTFP ALKELDLAFN GIKTIYVKYG DFKLLEFLDL SFNSLTVEAI 190 200 210 220 230 240 CDLGILPHLR VLLLTGNGLT SLPPNLAVAE QEASVTSLTS KRYILRFPAL ETLMLDDNRL 250 260 270 280 290 300 SNPSCFASLA GLRRLKKLSL DENRIIRIPY LQQVQLYDES VDWNGGRGSP HKEPQFMLQS 310 320 330 340 350 360 KPRMLEDSDE QLDYTVLPMK KDVDRTIAKE DAVLPVALFP SLCEFVFHNN PLVAHTRGVP 370 380 390 400 410 420 PLLKSFLQER LGIHLIRRKI VKPKHHVLMS RKESWKVKSE IPKVPKQPLV LHHPRMTTTK 430 440 450 460 470 480 SPSKDMLEPE AELAEDLPTT KSTSVESEMP TENLEGHSPS CRTFVPLPPI CSNSTVHSEE 490 500 510 520 530 540 TLSHLSDTTV RLSPERPSDE DSKSTESIFL TQVSELPSSV IHKDDLELKE KDQKKPPTAP 550 560 570 580 590 600 REVKGTRRKL PTAFLPSKYH GYEELLTAKP DPAFIEPKGI QKNAQALQQM LKHPLLCHSS 610 620 630 640 650 660 KPKLDTLQKP YVHKEKRAQR IPIPPPKKTR AQLLDDIFIR LRDPRNITEA PLGAVLHQWT 670 680 690 700 710 720 ERRLVNHKQY LEAKRLLKEF QARYRQLVSG SLRTVFGTTP LPMACPALSE SQPKFGHFLE 730 FMDEFCQEPT ASDSQG « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-473. Tissue: Brain.
[3]	"Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis." Mesak F.M., Osada N., Hashimoto K., Liu Q.Y., Ng C.E. BMC Genomics 4:32-32(2003) [PubMed: 12908878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 229-380 (ISOFORM 3), IDENTIFICATION (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION. Tissue: Colon cancer.
[4]	Guo J.H., Zan Q., Yu L. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 293-792 (ISOFORM 4).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000560 Genomic DNA. No translation available. AP001992 Genomic DNA. No translation available. BC064584 mRNA. Translation: AAH64584.1. AY163836 mRNA. Translation: AAO23657.1. Frameshift. AF439934 mRNA. Translation: AAP97315.1. Frameshift. BK000541 mRNA. Translation: DAA00367.1.
IPI	IPI00440153. IPI00853095. IPI00884929. IPI00884978.
RefSeq	NP_892014.1. NM_182969.1.
UniGene	Hs.370145.
3D structure databases
ProteinModelPortal	Q6P2D8.
SMR	Q6P2D8. Positions 104-269, 369-410.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6P2D8.
Polymorphism databases
DMDM	166919153.
Proteomic databases
PRIDE	Q6P2D8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321448; ENSP00000319303; ENSG00000166435.
GeneID	143570.
KEGG	hsa:143570.
UCSC	uc001ovp.2. human. uc001ovq.2. human. uc009yub.1. human.
Organism-specific databases
CTD	143570.
GeneCards	GC11M074551.
H-InvDB	HIX0009938.
HGNC	HGNC:18868. XRRA1.
HPA	HPA039474.
MIM	609788. gene.
neXtProt	NX_Q6P2D8.
PharmGKB	PA134988069.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG505379.
HOVERGEN	HBG108685.
InParanoid	Q6P2D8.
OMA	DEFCQEP.
PhylomeDB	Q6P2D8.
Gene expression databases
ArrayExpress	Q6P2D8.
Bgee	Q6P2D8.
CleanEx	HS_XRRA1.
Genevestigator	Q6P2D8.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. [Graphical view]
Pfam	PF00560. LRR_1. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	84744.
SOURCE	Search...

Entry information

Entry name

XRRA1_HUMAN

Accession

Primary (citable) accession number: Q6P2D8
Secondary accession number(s): B5MD90

Q7Z4U0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents