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Protein

X-ray radiation resistance-associated protein 1

Gene

XRRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the response of cells to X-ray radiation.1 Publication

GO - Biological processi

  • response to X-ray Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
X-ray radiation resistance-associated protein 1
Gene namesi
Name:XRRA1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18868. XRRA1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988069.

Polymorphism and mutation databases

BioMutaiXRRA1.
DMDMi166919153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 792792X-ray radiation resistance-associated protein 1PRO_0000318130Add
BLAST

Proteomic databases

MaxQBiQ6P2D8.
PaxDbiQ6P2D8.
PeptideAtlasiQ6P2D8.
PRIDEiQ6P2D8.

PTM databases

iPTMnetiQ6P2D8.
PhosphoSiteiQ6P2D8.

Expressioni

Tissue specificityi

Expressed predominantly in testis followed by prostate and ovary. Low levels found in other tissues including peripheral blood leukocytes, spleen, thymus, small intestine and colon. Also expressed in neuroblastoma, glioma, breast, lung, leukemia, renal, ovarian, prostate and colorectal cancer cell lines.1 Publication

Inductioni

By X-ray irradiation immediately after exposure and is then down-regulated two-fold in an X-ray radiation-resistant cell clone. Responds differently to X-ray radiation in clones of varying radiation responses.1 Publication

Gene expression databases

BgeeiQ6P2D8.
CleanExiHS_XRRA1.
ExpressionAtlasiQ6P2D8. baseline and differential.
GenevisibleiQ6P2D8. HS.

Organism-specific databases

HPAiHPA039474.

Interactioni

Protein-protein interaction databases

BioGridi126811. 1 interaction.
IntActiQ6P2D8. 1 interaction.
STRINGi9606.ENSP00000339918.

Structurei

3D structure databases

ProteinModelPortaliQ6P2D8.
SMRiQ6P2D8. Positions 130-313, 372-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati104 – 12522LRR 1Add
BLAST
Repeati141 – 15515LRR 2Add
BLAST
Repeati164 – 18421LRR 3Add
BLAST
Repeati188 – 20922LRR 4Add
BLAST
Repeati229 – 25022LRR 5Add
BLAST
Repeati254 – 27522LRR 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili723 – 74523Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Sequence analysis

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016048.
HOGENOMiHOG000060299.
HOVERGENiHBG108685.
InParanoidiQ6P2D8.
OMAiGRGHWLV.
OrthoDBiEOG79GT5Z.
PhylomeDBiQ6P2D8.
TreeFamiTF329758.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: Q6P2D8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSGIYKLD DGKPYLNNCF PARNLLRVPE EGQGHWLVVQ KGNLKKKPKG
60 70 80 90 100
LVGAQAERRE SLKATSFEFK GKKESRRENQ VDLPGHILDQ AFLLKHHCVR
110 120 130 140 150
KPSDLCTINA KENDFKHFHS VIYINASENL LPLEAFHTFP ALKELDLAFN
160 170 180 190 200
GIKTIYVKYG DFKLLEFLDL SFNSLTVEAI CDLGILPHLR VLLLTGNGLT
210 220 230 240 250
SLPPNLAVAE QEASVTSLTS KRYILRFPAL ETLMLDDNRL SNPSCFASLA
260 270 280 290 300
GLRRLKKLSL DENRIIRIPY LQQVQLYDES VDWNGGRGSP HKEPQFMLQS
310 320 330 340 350
KPRMLEDSDE QLDYTVLPMK KDVDRTEVVF SSYPGFSTSE TTKICSLPPI
360 370 380 390 400
FEILPVKSLK ARNQTLAPPF PELRYLSLAY NKIAKEDAVL PVALFPSLCE
410 420 430 440 450
FVFHNNPLVA HTRGVPPLLK SFLQERLGIH LIRRKIVKPK HHVLMSRKES
460 470 480 490 500
WKVKSEIPKV PKQPLVLHHP RMTTTKSPSK DMLEPEAELA EDLPTTKSTS
510 520 530 540 550
VESEMPTENL EGHSPSCRTF VPLPPICSNS TVHSEETLSH LSDTTVRLSP
560 570 580 590 600
ERPSDEDSKS TESIFLTQVS ELPSSVIHKD DLELKEKDQK KPPTAPREVK
610 620 630 640 650
GTRRKLPTAF LPSKYHGYEE LLTAKPDPAF IEPKGIQKNA QALQQMLKHP
660 670 680 690 700
LLCHSSKPKL DTLQKPYVHK EKRAQRIPIP PPKKTRAQLL DDIFIRLRDP
710 720 730 740 750
RNITEAPLGA VLHQWTERRL VNHKQYLEAK RLLKEFQARY RQLVSGSLRT
760 770 780 790
VFGTTPLPMA CPALSESQPK FGHFLEFMDE FCQEPTASDS QG
Note: Gene model based on mouse cDNA data. No experimental confirmation available.Curated
Length:792
Mass (Da):89,864
Last modified:February 5, 2008 - v2
Checksum:i6EBEDF9540535BC2
GO
Isoform 21 Publication (identifier: Q6P2D8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-413: Missing.
     674-685: AQRIPIPPPKKT → VLSCTSGQNGGW
     686-792: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:598
Mass (Da):67,681
Checksum:i419CCB0A1EF88BE6
GO
Isoform 31 Publication (identifier: Q6P2D8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-340: Missing.

Show »
Length:778
Mass (Da):88,346
Checksum:i8FE7939B3252DF38
GO
Isoform 4 (identifier: Q6P2D8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-382: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:736
Mass (Da):83,591
Checksum:iE73447E1D6D28B08
GO
Isoform 5 (identifier: Q6P2D8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.
     341-382: Missing.

Note: No experimental confirmation available.
Show »
Length:517
Mass (Da):58,896
Checksum:i595372A542C8C506
GO

Sequence cautioni

The sequence AAO23657.1 differs from that shown. Reason: Frameshift at position 327. Curated
The sequence AAP97315.1 differs from that shown. Reason: Frameshift at position 327. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31F → L in AAH64584 (PubMed:15489334).Curated
Sequence conflicti356 – 3561V → M in AAO23657 (PubMed:12908878).Curated
Sequence conflicti778 – 7781M → V in BC037294 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti473 – 4731T → R.1 Publication
Corresponds to variant rs4944960 [ dbSNP | Ensembl ].
VAR_038693
Natural varianti480 – 4801K → E.
Corresponds to variant rs12291445 [ dbSNP | Ensembl ].
VAR_051492

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 233233Missing in isoform 5. 1 PublicationVSP_044988Add
BLAST
Alternative sequencei327 – 41387Missing in isoform 2. 1 PublicationVSP_052670Add
BLAST
Alternative sequencei327 – 38256Missing in isoform 4. 1 PublicationVSP_052671Add
BLAST
Alternative sequencei327 – 34014Missing in isoform 3. 1 PublicationVSP_052672Add
BLAST
Alternative sequencei341 – 38242Missing in isoform 5. 1 PublicationVSP_044989Add
BLAST
Alternative sequencei674 – 68512AQRIP…PPKKT → VLSCTSGQNGGW in isoform 2. 1 PublicationVSP_052673Add
BLAST
Alternative sequencei686 – 792107Missing in isoform 2. 1 PublicationVSP_052674Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000560 Genomic DNA. No translation available.
AP001992 Genomic DNA. No translation available.
BC037294 mRNA. No translation available.
BC064584 mRNA. Translation: AAH64584.1.
AY163836 mRNA. Translation: AAO23657.1. Frameshift.
AF439934 mRNA. Translation: AAP97315.1. Frameshift.
BK000541 mRNA. Translation: DAA00367.1.
CCDSiCCDS44680.1. [Q6P2D8-1]
CCDS58159.1. [Q6P2D8-5]
CCDS58160.1. [Q6P2D8-2]
RefSeqiNP_001257309.1. NM_001270380.1. [Q6P2D8-2]
NP_001257310.1. NM_001270381.1. [Q6P2D8-5]
NP_892014.1. NM_182969.2. [Q6P2D8-1]
XP_011543071.1. XM_011544769.1.
UniGeneiHs.370145.

Genome annotation databases

EnsembliENST00000321448; ENSP00000319303; ENSG00000166435. [Q6P2D8-5]
ENST00000340360; ENSP00000339918; ENSG00000166435. [Q6P2D8-1]
ENST00000527087; ENSP00000435838; ENSG00000166435. [Q6P2D8-2]
GeneIDi143570.
KEGGihsa:143570.
UCSCiuc001ovp.5. human. [Q6P2D8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000560 Genomic DNA. No translation available.
AP001992 Genomic DNA. No translation available.
BC037294 mRNA. No translation available.
BC064584 mRNA. Translation: AAH64584.1.
AY163836 mRNA. Translation: AAO23657.1. Frameshift.
AF439934 mRNA. Translation: AAP97315.1. Frameshift.
BK000541 mRNA. Translation: DAA00367.1.
CCDSiCCDS44680.1. [Q6P2D8-1]
CCDS58159.1. [Q6P2D8-5]
CCDS58160.1. [Q6P2D8-2]
RefSeqiNP_001257309.1. NM_001270380.1. [Q6P2D8-2]
NP_001257310.1. NM_001270381.1. [Q6P2D8-5]
NP_892014.1. NM_182969.2. [Q6P2D8-1]
XP_011543071.1. XM_011544769.1.
UniGeneiHs.370145.

3D structure databases

ProteinModelPortaliQ6P2D8.
SMRiQ6P2D8. Positions 130-313, 372-408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126811. 1 interaction.
IntActiQ6P2D8. 1 interaction.
STRINGi9606.ENSP00000339918.

PTM databases

iPTMnetiQ6P2D8.
PhosphoSiteiQ6P2D8.

Polymorphism and mutation databases

BioMutaiXRRA1.
DMDMi166919153.

Proteomic databases

MaxQBiQ6P2D8.
PaxDbiQ6P2D8.
PeptideAtlasiQ6P2D8.
PRIDEiQ6P2D8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321448; ENSP00000319303; ENSG00000166435. [Q6P2D8-5]
ENST00000340360; ENSP00000339918; ENSG00000166435. [Q6P2D8-1]
ENST00000527087; ENSP00000435838; ENSG00000166435. [Q6P2D8-2]
GeneIDi143570.
KEGGihsa:143570.
UCSCiuc001ovp.5. human. [Q6P2D8-1]

Organism-specific databases

CTDi143570.
GeneCardsiXRRA1.
H-InvDBHIX0009938.
HGNCiHGNC:18868. XRRA1.
HPAiHPA039474.
MIMi609788. gene.
neXtProtiNX_Q6P2D8.
PharmGKBiPA134988069.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016048.
HOGENOMiHOG000060299.
HOVERGENiHBG108685.
InParanoidiQ6P2D8.
OMAiGRGHWLV.
OrthoDBiEOG79GT5Z.
PhylomeDBiQ6P2D8.
TreeFamiTF329758.

Miscellaneous databases

ChiTaRSiXRRA1. human.
GenomeRNAii143570.
PROiQ6P2D8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P2D8.
CleanExiHS_XRRA1.
ExpressionAtlasiQ6P2D8. baseline and differential.
GenevisibleiQ6P2D8. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), VARIANT ARG-473.
    Tissue: BrainImported and Testis.
  3. "Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis."
    Mesak F.M., Osada N., Hashimoto K., Liu Q.Y., Ng C.E.
    BMC Genomics 4:32-32(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 229-380 (ISOFORM 3), IDENTIFICATION (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    Tissue: Colon cancer1 Publication.
  4. Guo J.H., Zan Q., Yu L.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 293-792 (ISOFORM 4).

Entry informationi

Entry nameiXRRA1_HUMAN
AccessioniPrimary (citable) accession number: Q6P2D8
Secondary accession number(s): B5MD90
, J3KNJ1, Q7RTT7, Q7Z463, Q7Z4U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.