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Protein

X-ray radiation resistance-associated protein 1

Gene

XRRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the response of cells to X-ray radiation.1 Publication

GO - Biological processi

  • response to X-ray Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
X-ray radiation resistance-associated protein 1
Gene namesi
Name:XRRA1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18868. XRRA1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166435.
PharmGKBiPA134988069.

Polymorphism and mutation databases

BioMutaiXRRA1.
DMDMi166919153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181301 – 792X-ray radiation resistance-associated protein 1Add BLAST792

Proteomic databases

PaxDbiQ6P2D8.
PeptideAtlasiQ6P2D8.
PRIDEiQ6P2D8.

PTM databases

iPTMnetiQ6P2D8.
PhosphoSitePlusiQ6P2D8.

Expressioni

Tissue specificityi

Expressed predominantly in testis followed by prostate and ovary. Low levels found in other tissues including peripheral blood leukocytes, spleen, thymus, small intestine and colon. Also expressed in neuroblastoma, glioma, breast, lung, leukemia, renal, ovarian, prostate and colorectal cancer cell lines.1 Publication

Inductioni

By X-ray irradiation immediately after exposure and is then down-regulated two-fold in an X-ray radiation-resistant cell clone. Responds differently to X-ray radiation in clones of varying radiation responses.1 Publication

Gene expression databases

BgeeiENSG00000166435.
CleanExiHS_XRRA1.
ExpressionAtlasiQ6P2D8. baseline and differential.
GenevisibleiQ6P2D8. HS.

Organism-specific databases

HPAiHPA039474.

Interactioni

Protein-protein interaction databases

BioGridi126811. 1 interactor.
IntActiQ6P2D8. 1 interactor.
STRINGi9606.ENSP00000339918.

Structurei

3D structure databases

ProteinModelPortaliQ6P2D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 125LRR 1Add BLAST22
Repeati141 – 155LRR 2Add BLAST15
Repeati164 – 184LRR 3Add BLAST21
Repeati188 – 209LRR 4Add BLAST22
Repeati229 – 250LRR 5Add BLAST22
Repeati254 – 275LRR 6Add BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili723 – 745Sequence analysisAdd BLAST23

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Sequence analysis

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016048.
HOGENOMiHOG000060299.
HOVERGENiHBG108685.
InParanoidiQ6P2D8.
OMAiFMDEFCQ.
OrthoDBiEOG091G0G3O.
PhylomeDBiQ6P2D8.
TreeFamiTF329758.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: Q6P2D8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSGIYKLD DGKPYLNNCF PARNLLRVPE EGQGHWLVVQ KGNLKKKPKG
60 70 80 90 100
LVGAQAERRE SLKATSFEFK GKKESRRENQ VDLPGHILDQ AFLLKHHCVR
110 120 130 140 150
KPSDLCTINA KENDFKHFHS VIYINASENL LPLEAFHTFP ALKELDLAFN
160 170 180 190 200
GIKTIYVKYG DFKLLEFLDL SFNSLTVEAI CDLGILPHLR VLLLTGNGLT
210 220 230 240 250
SLPPNLAVAE QEASVTSLTS KRYILRFPAL ETLMLDDNRL SNPSCFASLA
260 270 280 290 300
GLRRLKKLSL DENRIIRIPY LQQVQLYDES VDWNGGRGSP HKEPQFMLQS
310 320 330 340 350
KPRMLEDSDE QLDYTVLPMK KDVDRTEVVF SSYPGFSTSE TTKICSLPPI
360 370 380 390 400
FEILPVKSLK ARNQTLAPPF PELRYLSLAY NKIAKEDAVL PVALFPSLCE
410 420 430 440 450
FVFHNNPLVA HTRGVPPLLK SFLQERLGIH LIRRKIVKPK HHVLMSRKES
460 470 480 490 500
WKVKSEIPKV PKQPLVLHHP RMTTTKSPSK DMLEPEAELA EDLPTTKSTS
510 520 530 540 550
VESEMPTENL EGHSPSCRTF VPLPPICSNS TVHSEETLSH LSDTTVRLSP
560 570 580 590 600
ERPSDEDSKS TESIFLTQVS ELPSSVIHKD DLELKEKDQK KPPTAPREVK
610 620 630 640 650
GTRRKLPTAF LPSKYHGYEE LLTAKPDPAF IEPKGIQKNA QALQQMLKHP
660 670 680 690 700
LLCHSSKPKL DTLQKPYVHK EKRAQRIPIP PPKKTRAQLL DDIFIRLRDP
710 720 730 740 750
RNITEAPLGA VLHQWTERRL VNHKQYLEAK RLLKEFQARY RQLVSGSLRT
760 770 780 790
VFGTTPLPMA CPALSESQPK FGHFLEFMDE FCQEPTASDS QG
Note: Gene model based on mouse cDNA data. No experimental confirmation available.Curated
Length:792
Mass (Da):89,864
Last modified:February 5, 2008 - v2
Checksum:i6EBEDF9540535BC2
GO
Isoform 21 Publication (identifier: Q6P2D8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-413: Missing.
     674-685: AQRIPIPPPKKT → VLSCTSGQNGGW
     686-792: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:598
Mass (Da):67,681
Checksum:i419CCB0A1EF88BE6
GO
Isoform 31 Publication (identifier: Q6P2D8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-340: Missing.

Show »
Length:778
Mass (Da):88,346
Checksum:i8FE7939B3252DF38
GO
Isoform 4 (identifier: Q6P2D8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-382: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:736
Mass (Da):83,591
Checksum:iE73447E1D6D28B08
GO
Isoform 5 (identifier: Q6P2D8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.
     341-382: Missing.

Note: No experimental confirmation available.
Show »
Length:517
Mass (Da):58,896
Checksum:i595372A542C8C506
GO

Sequence cautioni

The sequence AAO23657 differs from that shown. Reason: Frameshift at position 327.Curated
The sequence AAP97315 differs from that shown. Reason: Frameshift at position 327.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3F → L in AAH64584 (PubMed:15489334).Curated1
Sequence conflicti356V → M in AAO23657 (PubMed:12908878).Curated1
Sequence conflicti778M → V in BC037294 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038693473T → R.1 PublicationCorresponds to variant rs4944960dbSNPEnsembl.1
Natural variantiVAR_051492480K → E.Corresponds to variant rs12291445dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449881 – 233Missing in isoform 5. 1 PublicationAdd BLAST233
Alternative sequenceiVSP_052670327 – 413Missing in isoform 2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_052671327 – 382Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_052672327 – 340Missing in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_044989341 – 382Missing in isoform 5. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_052673674 – 685AQRIP…PPKKT → VLSCTSGQNGGW in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_052674686 – 792Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000560 Genomic DNA. No translation available.
AP001992 Genomic DNA. No translation available.
BC037294 mRNA. No translation available.
BC064584 mRNA. Translation: AAH64584.1.
AY163836 mRNA. Translation: AAO23657.1. Frameshift.
AF439934 mRNA. Translation: AAP97315.1. Frameshift.
BK000541 mRNA. Translation: DAA00367.1.
CCDSiCCDS44680.1. [Q6P2D8-1]
CCDS58159.1. [Q6P2D8-5]
CCDS58160.1. [Q6P2D8-2]
RefSeqiNP_001257309.1. NM_001270380.1. [Q6P2D8-2]
NP_001257310.1. NM_001270381.1. [Q6P2D8-5]
NP_892014.1. NM_182969.2. [Q6P2D8-1]
XP_016872722.1. XM_017017233.1.
XP_016872723.1. XM_017017234.1.
UniGeneiHs.370145.

Genome annotation databases

EnsembliENST00000321448; ENSP00000319303; ENSG00000166435. [Q6P2D8-5]
ENST00000340360; ENSP00000339918; ENSG00000166435. [Q6P2D8-1]
ENST00000527087; ENSP00000435838; ENSG00000166435. [Q6P2D8-2]
GeneIDi143570.
KEGGihsa:143570.
UCSCiuc001ovp.5. human. [Q6P2D8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000560 Genomic DNA. No translation available.
AP001992 Genomic DNA. No translation available.
BC037294 mRNA. No translation available.
BC064584 mRNA. Translation: AAH64584.1.
AY163836 mRNA. Translation: AAO23657.1. Frameshift.
AF439934 mRNA. Translation: AAP97315.1. Frameshift.
BK000541 mRNA. Translation: DAA00367.1.
CCDSiCCDS44680.1. [Q6P2D8-1]
CCDS58159.1. [Q6P2D8-5]
CCDS58160.1. [Q6P2D8-2]
RefSeqiNP_001257309.1. NM_001270380.1. [Q6P2D8-2]
NP_001257310.1. NM_001270381.1. [Q6P2D8-5]
NP_892014.1. NM_182969.2. [Q6P2D8-1]
XP_016872722.1. XM_017017233.1.
XP_016872723.1. XM_017017234.1.
UniGeneiHs.370145.

3D structure databases

ProteinModelPortaliQ6P2D8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126811. 1 interactor.
IntActiQ6P2D8. 1 interactor.
STRINGi9606.ENSP00000339918.

PTM databases

iPTMnetiQ6P2D8.
PhosphoSitePlusiQ6P2D8.

Polymorphism and mutation databases

BioMutaiXRRA1.
DMDMi166919153.

Proteomic databases

PaxDbiQ6P2D8.
PeptideAtlasiQ6P2D8.
PRIDEiQ6P2D8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321448; ENSP00000319303; ENSG00000166435. [Q6P2D8-5]
ENST00000340360; ENSP00000339918; ENSG00000166435. [Q6P2D8-1]
ENST00000527087; ENSP00000435838; ENSG00000166435. [Q6P2D8-2]
GeneIDi143570.
KEGGihsa:143570.
UCSCiuc001ovp.5. human. [Q6P2D8-1]

Organism-specific databases

CTDi143570.
GeneCardsiXRRA1.
H-InvDBHIX0009938.
HGNCiHGNC:18868. XRRA1.
HPAiHPA039474.
MIMi609788. gene.
neXtProtiNX_Q6P2D8.
OpenTargetsiENSG00000166435.
PharmGKBiPA134988069.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016048.
HOGENOMiHOG000060299.
HOVERGENiHBG108685.
InParanoidiQ6P2D8.
OMAiFMDEFCQ.
OrthoDBiEOG091G0G3O.
PhylomeDBiQ6P2D8.
TreeFamiTF329758.

Miscellaneous databases

ChiTaRSiXRRA1. human.
GenomeRNAii143570.
PROiQ6P2D8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166435.
CleanExiHS_XRRA1.
ExpressionAtlasiQ6P2D8. baseline and differential.
GenevisibleiQ6P2D8. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXRRA1_HUMAN
AccessioniPrimary (citable) accession number: Q6P2D8
Secondary accession number(s): B5MD90
, J3KNJ1, Q7RTT7, Q7Z463, Q7Z4U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.