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Protein

Zinc finger protein 1 homolog

Gene

ZFP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri184 – 206C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33061-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 1 homolog
Short name:
Zfp-1
Alternative name(s):
Zinc finger protein 475
Gene namesi
Name:ZFP1
Synonyms:ZNF475
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:23328. ZFP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi162239.
OpenTargetsiENSG00000184517.
PharmGKBiPA134882678.

Polymorphism and mutation databases

BioMutaiZFP1.
DMDMi59802892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472791 – 407Zinc finger protein 1 homologAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6P2D0.
MaxQBiQ6P2D0.
PaxDbiQ6P2D0.
PeptideAtlasiQ6P2D0.
PRIDEiQ6P2D0.

PTM databases

iPTMnetiQ6P2D0.
PhosphoSitePlusiQ6P2D0.

Expressioni

Gene expression databases

BgeeiENSG00000184517.
CleanExiHS_ZFP1.
ExpressionAtlasiQ6P2D0. baseline and differential.
GenevisibleiQ6P2D0. HS.

Organism-specific databases

HPAiHPA044916.
HPA062910.

Interactioni

Protein-protein interaction databases

BioGridi127811. 9 interactors.
IntActiQ6P2D0. 16 interactors.
STRINGi9606.ENSP00000377080.

Structurei

3D structure databases

ProteinModelPortaliQ6P2D0.
SMRiQ6P2D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 83KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri184 – 206C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132351.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P2D0.
KOiK09228.
OMAiCNGFGKA.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6P2D0.
TreeFamiTF336987.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P2D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKSQGSVSF TDVTVDFTQE EWEQLDPSQR ILYMDVMLEN YSNLLSVEVW
60 70 80 90 100
KADDQMERDH RNPDEQARQF LILKNQTPIE ERGDLFGKAL NLNTDFVSLR
110 120 130 140 150
QVPYKYDLYE KTLKYNSDLL NSNRSYAGKQ TDECNEFGKA LLYLKQEKTH
160 170 180 190 200
SGVEYSEYNK SGKALSHKAA IFKHQKIKNL VQPFICTYCD KAFSFKSLLI
210 220 230 240 250
SHKRIHTGEK PYECNVCKKT FSHKANLIKH QRIHTGEKPF ECPECGKAFT
260 270 280 290 300
HQSNLIVHQR AHMEKKPYEC SECGKTFAQK FELTTHQRIH TGERPYECNE
310 320 330 340 350
CAKTFFKKSN LIIHQKIHTG EKRYECSECG KSFIQNSQLI IHMRTHTGEK
360 370 380 390 400
PYECTECGKT FSQRSTLRLH LRIHTGEKPY ECSECGKAFS RKSRLSVHQR

VHIGEKP
Length:407
Mass (Da):47,516
Last modified:February 1, 2005 - v2
Checksum:iEAD9B780E65D618B
GO
Isoform 2 (identifier: Q6P2D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):41,073
Checksum:i00699C33DEC50F92
GO

Sequence cautioni

The sequence AAH33774 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126821 – 55Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094761 mRNA. Translation: BAC04417.1.
AK291372 mRNA. Translation: BAF84061.1.
AK296560 mRNA. Translation: BAG59181.1.
CH471114 Genomic DNA. Translation: EAW95663.1.
BC064604 mRNA. Translation: AAH64604.1.
BC033774 mRNA. Translation: AAH33774.1. Different initiation.
CCDSiCCDS10914.2. [Q6P2D0-1]
RefSeqiNP_001305398.1. NM_001318469.1. [Q6P2D0-1]
NP_001305400.1. NM_001318471.1.
NP_001305401.1. NM_001318472.1.
NP_001305402.1. NM_001318473.1. [Q6P2D0-2]
NP_001305403.1. NM_001318474.1. [Q6P2D0-2]
NP_001305404.1. NM_001318475.1.
NP_001305405.1. NM_001318476.1.
NP_710155.2. NM_153688.3. [Q6P2D0-1]
XP_016878473.1. XM_017022984.1. [Q6P2D0-1]
XP_016878474.1. XM_017022985.1. [Q6P2D0-1]
XP_016878476.1. XM_017022987.1. [Q6P2D0-2]
UniGeneiHs.388813.

Genome annotation databases

EnsembliENST00000393430; ENSP00000377080; ENSG00000184517. [Q6P2D0-1]
ENST00000570010; ENSP00000457044; ENSG00000184517. [Q6P2D0-1]
GeneIDi162239.
KEGGihsa:162239.
UCSCiuc002fdo.4. human. [Q6P2D0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094761 mRNA. Translation: BAC04417.1.
AK291372 mRNA. Translation: BAF84061.1.
AK296560 mRNA. Translation: BAG59181.1.
CH471114 Genomic DNA. Translation: EAW95663.1.
BC064604 mRNA. Translation: AAH64604.1.
BC033774 mRNA. Translation: AAH33774.1. Different initiation.
CCDSiCCDS10914.2. [Q6P2D0-1]
RefSeqiNP_001305398.1. NM_001318469.1. [Q6P2D0-1]
NP_001305400.1. NM_001318471.1.
NP_001305401.1. NM_001318472.1.
NP_001305402.1. NM_001318473.1. [Q6P2D0-2]
NP_001305403.1. NM_001318474.1. [Q6P2D0-2]
NP_001305404.1. NM_001318475.1.
NP_001305405.1. NM_001318476.1.
NP_710155.2. NM_153688.3. [Q6P2D0-1]
XP_016878473.1. XM_017022984.1. [Q6P2D0-1]
XP_016878474.1. XM_017022985.1. [Q6P2D0-1]
XP_016878476.1. XM_017022987.1. [Q6P2D0-2]
UniGeneiHs.388813.

3D structure databases

ProteinModelPortaliQ6P2D0.
SMRiQ6P2D0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127811. 9 interactors.
IntActiQ6P2D0. 16 interactors.
STRINGi9606.ENSP00000377080.

PTM databases

iPTMnetiQ6P2D0.
PhosphoSitePlusiQ6P2D0.

Polymorphism and mutation databases

BioMutaiZFP1.
DMDMi59802892.

Proteomic databases

EPDiQ6P2D0.
MaxQBiQ6P2D0.
PaxDbiQ6P2D0.
PeptideAtlasiQ6P2D0.
PRIDEiQ6P2D0.

Protocols and materials databases

DNASUi162239.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393430; ENSP00000377080; ENSG00000184517. [Q6P2D0-1]
ENST00000570010; ENSP00000457044; ENSG00000184517. [Q6P2D0-1]
GeneIDi162239.
KEGGihsa:162239.
UCSCiuc002fdo.4. human. [Q6P2D0-1]

Organism-specific databases

CTDi162239.
DisGeNETi162239.
GeneCardsiZFP1.
HGNCiHGNC:23328. ZFP1.
HPAiHPA044916.
HPA062910.
neXtProtiNX_Q6P2D0.
OpenTargetsiENSG00000184517.
PharmGKBiPA134882678.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132351.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P2D0.
KOiK09228.
OMAiCNGFGKA.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6P2D0.
TreeFamiTF336987.

Enzyme and pathway databases

BioCyciZFISH:G66-33061-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZFP1. human.
GenomeRNAii162239.
PROiQ6P2D0.

Gene expression databases

BgeeiENSG00000184517.
CleanExiHS_ZFP1.
ExpressionAtlasiQ6P2D0. baseline and differential.
GenevisibleiQ6P2D0. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFP1_HUMAN
AccessioniPrimary (citable) accession number: Q6P2D0
Secondary accession number(s): A8K5Q7
, B4DKG9, Q8N188, Q8N9F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.