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Protein

Zinc finger protein 1 homolog

Gene

ZFP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri184 – 206C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 1 homolog
Short name:
Zfp-1
Alternative name(s):
Zinc finger protein 475
Gene namesi
Name:ZFP1
Synonyms:ZNF475
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000184517.11
HGNCiHGNC:23328 ZFP1
MIMi617230 gene
neXtProtiNX_Q6P2D0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi162239
OpenTargetsiENSG00000184517
PharmGKBiPA134882678

Polymorphism and mutation databases

BioMutaiZFP1
DMDMi59802892

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472791 – 407Zinc finger protein 1 homologAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki74Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6P2D0
MaxQBiQ6P2D0
PaxDbiQ6P2D0
PeptideAtlasiQ6P2D0
PRIDEiQ6P2D0

PTM databases

iPTMnetiQ6P2D0
PhosphoSitePlusiQ6P2D0

Expressioni

Gene expression databases

BgeeiENSG00000184517
CleanExiHS_ZFP1
ExpressionAtlasiQ6P2D0 baseline and differential
GenevisibleiQ6P2D0 HS

Organism-specific databases

HPAiHPA044916
HPA062910

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PROP1O753604EBI-2555749,EBI-9027467

Protein-protein interaction databases

BioGridi127811, 10 interactors
IntActiQ6P2D0, 25 interactors
STRINGi9606.ENSP00000377080

Structurei

3D structure databases

ProteinModelPortaliQ6P2D0
SMRiQ6P2D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 83KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri184 – 206C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000141051
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6P2D0
KOiK09228
OMAiCNGFGKA
OrthoDBiEOG091G02KC
PhylomeDBiQ6P2D0
TreeFamiTF336987

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P2D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKSQGSVSF TDVTVDFTQE EWEQLDPSQR ILYMDVMLEN YSNLLSVEVW
60 70 80 90 100
KADDQMERDH RNPDEQARQF LILKNQTPIE ERGDLFGKAL NLNTDFVSLR
110 120 130 140 150
QVPYKYDLYE KTLKYNSDLL NSNRSYAGKQ TDECNEFGKA LLYLKQEKTH
160 170 180 190 200
SGVEYSEYNK SGKALSHKAA IFKHQKIKNL VQPFICTYCD KAFSFKSLLI
210 220 230 240 250
SHKRIHTGEK PYECNVCKKT FSHKANLIKH QRIHTGEKPF ECPECGKAFT
260 270 280 290 300
HQSNLIVHQR AHMEKKPYEC SECGKTFAQK FELTTHQRIH TGERPYECNE
310 320 330 340 350
CAKTFFKKSN LIIHQKIHTG EKRYECSECG KSFIQNSQLI IHMRTHTGEK
360 370 380 390 400
PYECTECGKT FSQRSTLRLH LRIHTGEKPY ECSECGKAFS RKSRLSVHQR

VHIGEKP
Length:407
Mass (Da):47,516
Last modified:February 1, 2005 - v2
Checksum:iEAD9B780E65D618B
GO
Isoform 2 (identifier: Q6P2D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):41,073
Checksum:i00699C33DEC50F92
GO

Sequence cautioni

The sequence AAH33774 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126821 – 55Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094761 mRNA Translation: BAC04417.1
AK291372 mRNA Translation: BAF84061.1
AK296560 mRNA Translation: BAG59181.1
CH471114 Genomic DNA Translation: EAW95663.1
BC064604 mRNA Translation: AAH64604.1
BC033774 mRNA Translation: AAH33774.1 Different initiation.
CCDSiCCDS10914.2 [Q6P2D0-1]
RefSeqiNP_001305398.1, NM_001318469.1 [Q6P2D0-1]
NP_001305400.1, NM_001318471.1
NP_001305401.1, NM_001318472.1
NP_001305402.1, NM_001318473.1 [Q6P2D0-2]
NP_001305403.1, NM_001318474.1 [Q6P2D0-2]
NP_001305404.1, NM_001318475.1
NP_001305405.1, NM_001318476.1
NP_710155.2, NM_153688.3 [Q6P2D0-1]
XP_016878473.1, XM_017022984.1 [Q6P2D0-1]
XP_016878474.1, XM_017022985.1 [Q6P2D0-1]
XP_016878476.1, XM_017022987.1 [Q6P2D0-2]
UniGeneiHs.388813

Genome annotation databases

EnsembliENST00000393430; ENSP00000377080; ENSG00000184517 [Q6P2D0-1]
ENST00000570010; ENSP00000457044; ENSG00000184517 [Q6P2D0-1]
GeneIDi162239
KEGGihsa:162239
UCSCiuc002fdo.4 human [Q6P2D0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZFP1_HUMAN
AccessioniPrimary (citable) accession number: Q6P2D0
Secondary accession number(s): A8K5Q7
, B4DKG9, Q8N188, Q8N9F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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