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Protein

WD repeat-containing protein 93

Gene

WDR93

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 93
Gene namesi
Name:WDR93
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26924. WDR93.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi56964.
OpenTargetsiENSG00000140527.
PharmGKBiPA162409188.

Polymorphism and mutation databases

BioMutaiWDR93.
DMDMi74737189.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003196031 – 686WD repeat-containing protein 93Add BLAST686

Proteomic databases

EPDiQ6P2C0.
PaxDbiQ6P2C0.
PeptideAtlasiQ6P2C0.
PRIDEiQ6P2C0.

PTM databases

iPTMnetiQ6P2C0.
PhosphoSitePlusiQ6P2C0.

Expressioni

Gene expression databases

BgeeiENSG00000140527.
CleanExiHS_WDR93.
ExpressionAtlasiQ6P2C0. baseline and differential.
GenevisibleiQ6P2C0. HS.

Organism-specific databases

HPAiHPA046196.
HPA048112.

Structurei

3D structure databases

ProteinModelPortaliQ6P2C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati410 – 449WDAdd BLAST40

Sequence similaritiesi

Contains 1 WD repeat.Curated

Keywords - Domaini

WD repeat

Phylogenomic databases

eggNOGiENOG410IFH0. Eukaryota.
ENOG4111FWX. LUCA.
GeneTreeiENSGT00390000009995.
HOGENOMiHOG000090259.
HOVERGENiHBG095609.
InParanoidiQ6P2C0.
OMAiGQNMYPE.
OrthoDBiEOG091G0C9P.
PhylomeDBiQ6P2C0.
TreeFamiTF336347.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR006885. NADH_UbQ_FeS_4_mit.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12219. PTHR12219. 1 hit.
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P2C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFPRGSQTQ KIKHPIGTRK GPLEVPPPTE KDWPKDDEQD HVLVDPDEEL
60 70 80 90 100
DSLPQPYRMI NKLVNLLFDQ SWEIIEERNA LREAESSQIQ PTVYPPLGEI
110 120 130 140 150
QLNKMPNCMA VSQDYVFIGG AKGFSIYNLY SAKQIYAWEK LKVDVTSIWA
160 170 180 190 200
TDLGNEILIA PVDEMGIIRL FYFYKEGLYL VKAINEVDDT SKQTTCIKME
210 220 230 240 250
ISQGGDFAAF LLQGAGDIWL DVYKLPKETW LKKLEHPQLT SNPKKKVRQP
260 270 280 290 300
QLNSLGPISA DPLEMDANVS FKGDIKLSLP VYIMKIKPPK PVTGTTFKSP
310 320 330 340 350
LEVFAKIKDC YGLGSGQNHF IKDSQWEQQA EIFNASYKKY LDREWEEEPL
360 370 380 390 400
STATFYFLLP SCLFAMPPEV KGPSGMACVL GIHWTRSHNF FLYSLNRTLK
410 420 430 440 450
DKADPEGVWP CAAPIAVSQL SCSSSYLVLA CEDGVLTLWD LAKGFPLGVA
460 470 480 490 500
ALPQGCFCQS IHFLKYFSVH KGQNMYPEGQ VKSQMKCVVL CTDASLHLVE
510 520 530 540 550
ASGTQGPTIS VLVERPVKHL DKTICAVAPV PALPGMVLIF SKNGSVCLMD
560 570 580 590 600
VAKREIICAF APPGAFPLEV PWKPVFAVSP DHPCFLLRGD YSHETASTDD
610 620 630 640 650
AGIQYSVFYF NFEACPLLEN ISKNCTIPQR DLDNMAFPQA LPLEKRCERF
660 670 680
LQKSYRKLEK NPEKEEEHWA RLQRYSLSLQ RENFKK
Length:686
Mass (Da):77,378
Last modified:July 5, 2004 - v1
Checksum:i7838E1EFE6BDCE3A
GO
Isoform 2 (identifier: Q6P2C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-470: Missing.

Note: No experimental confirmation available.
Show »
Length:658
Mass (Da):74,301
Checksum:i88DB89FB4CB76BBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti343R → G in BAC05088 (PubMed:14702039).Curated1
Sequence conflicti553K → R in BAC05088 (PubMed:14702039).Curated1
Sequence conflicti556Missing in CAB98209 (Ref. 4) Curated1
Sequence conflicti556Missing in CAB98208 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03901766L → H.Corresponds to variant rs4287542dbSNPEnsembl.1
Natural variantiVAR_039018254S → T.Corresponds to variant rs7163367dbSNPEnsembl.1
Natural variantiVAR_039019352T → M.Corresponds to variant rs7178234dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031512443 – 470Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097525 mRNA. Translation: BAC05088.1.
CH471101 Genomic DNA. Translation: EAX02063.1.
BC064626 mRNA. Translation: AAH64626.1.
AL390084 mRNA. Translation: CAB98208.1.
AL390085 mRNA. Translation: CAB98209.1.
CCDSiCCDS32326.1. [Q6P2C0-1]
CCDS66862.1. [Q6P2C0-2]
RefSeqiNP_001271324.1. NM_001284395.1. [Q6P2C0-2]
NP_001271325.1. NM_001284396.1.
NP_064597.1. NM_020212.1. [Q6P2C0-1]
UniGeneiHs.177557.

Genome annotation databases

EnsembliENST00000268130; ENSP00000268130; ENSG00000140527. [Q6P2C0-1]
ENST00000560294; ENSP00000453971; ENSG00000140527. [Q6P2C0-2]
GeneIDi56964.
KEGGihsa:56964.
UCSCiuc002boj.3. human. [Q6P2C0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097525 mRNA. Translation: BAC05088.1.
CH471101 Genomic DNA. Translation: EAX02063.1.
BC064626 mRNA. Translation: AAH64626.1.
AL390084 mRNA. Translation: CAB98208.1.
AL390085 mRNA. Translation: CAB98209.1.
CCDSiCCDS32326.1. [Q6P2C0-1]
CCDS66862.1. [Q6P2C0-2]
RefSeqiNP_001271324.1. NM_001284395.1. [Q6P2C0-2]
NP_001271325.1. NM_001284396.1.
NP_064597.1. NM_020212.1. [Q6P2C0-1]
UniGeneiHs.177557.

3D structure databases

ProteinModelPortaliQ6P2C0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6P2C0.
PhosphoSitePlusiQ6P2C0.

Polymorphism and mutation databases

BioMutaiWDR93.
DMDMi74737189.

Proteomic databases

EPDiQ6P2C0.
PaxDbiQ6P2C0.
PeptideAtlasiQ6P2C0.
PRIDEiQ6P2C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268130; ENSP00000268130; ENSG00000140527. [Q6P2C0-1]
ENST00000560294; ENSP00000453971; ENSG00000140527. [Q6P2C0-2]
GeneIDi56964.
KEGGihsa:56964.
UCSCiuc002boj.3. human. [Q6P2C0-1]

Organism-specific databases

CTDi56964.
DisGeNETi56964.
GeneCardsiWDR93.
HGNCiHGNC:26924. WDR93.
HPAiHPA046196.
HPA048112.
neXtProtiNX_Q6P2C0.
OpenTargetsiENSG00000140527.
PharmGKBiPA162409188.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFH0. Eukaryota.
ENOG4111FWX. LUCA.
GeneTreeiENSGT00390000009995.
HOGENOMiHOG000090259.
HOVERGENiHBG095609.
InParanoidiQ6P2C0.
OMAiGQNMYPE.
OrthoDBiEOG091G0C9P.
PhylomeDBiQ6P2C0.
TreeFamiTF336347.

Miscellaneous databases

GenomeRNAii56964.
PROiQ6P2C0.

Gene expression databases

BgeeiENSG00000140527.
CleanExiHS_WDR93.
ExpressionAtlasiQ6P2C0. baseline and differential.
GenevisibleiQ6P2C0. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR006885. NADH_UbQ_FeS_4_mit.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12219. PTHR12219. 1 hit.
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR93_HUMAN
AccessioniPrimary (citable) accession number: Q6P2C0
Secondary accession number(s): Q8N7Y8, Q9NP89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.