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Reviewed, UniProtKB/Swiss-Prot Q6P2A1 (PRDM9_DANRE)

Last modified November 3, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histone-lysine N-methyltransferase PRDM9
    EC=2.1.1.43
Alternative name(s):
    PR domain zinc finger protein 9
    PR domain-containing protein 9
Gene names
Name: prdm9
ORF Names: zgc:63970
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

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Protein attributes

Sequence length853 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase By similarity.

Catalytic activity

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 15 C2H2-type zinc fingers.

Contains 1 SET domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 853853Histone-lysine N-methyltransferase PRDM9
PRO_0000363962

Regions

Domain85 – 201117SET
Zinc finger230 – 25324C2H2-type 1
Zinc finger337 – 36024C2H2-type 2
Zinc finger366 – 38823C2H2-type 3
Zinc finger405 – 42824C2H2-type 4
Zinc finger508 – 52821C2H2-type 5; degenerate
Zinc finger547 – 56923C2H2-type 6; degenerate
Zinc finger575 – 59824C2H2-type 7
Zinc finger604 – 62623C2H2-type 8
Zinc finger644 – 66623C2H2-type 9
Zinc finger689 – 71123C2H2-type 10; degenerate
Zinc finger717 – 73923C2H2-type 11
Zinc finger745 – 76723C2H2-type 12
Zinc finger773 – 79523C2H2-type 13
Zinc finger801 – 82323C2H2-type 14
Zinc finger829 – 85224C2H2-type 15

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Sequences

Sequence LengthMass (Da)Tools
Q6P2A1-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 44A40327A3F0BAC4

FASTA85397,136
        10         20         30         40         50         60 
MSLSPDLPPS EEQNLEIQGS ATNCYSVVII EEQDDTFNDQ PFYCEMCQQH FIDQCETHGP 

        70         80         90        100        110        120 
PSFTCDSPAA LGTPQRALLT LPQGLVIGRS SISHAGLGVF NQGQTVPLGM HFGPFDGEEI 

       130        140        150        160        170        180 
SEEKALDSAN SWVICRGNNQ YSYIDAEKDT HSNWMKFVVC SRSETEQNLV AFQQNGRILF 

       190        200        210        220        230        240 
RCCRPISPGQ EFRVWYAEEY AQGLGAIWDK IWDNKCISQG STEEQATQNC PCPFCHYSFP 

       250        260        270        280        290        300 
TLVYLHAHVK RTHPNEYAQF TQTHPLESEA HTPITEVEQC LVASDEALST QTQPVTESPQ 

       310        320        330        340        350        360 
EQISTQNGQP IHQTENSDEP DASDIYTAAG EISDEIHACV DCGRSFLRSC HLKRHQRTIH 

       370        380        390        400        410        420 
SKEKPYCCSQ CKKCFSQATG LKRHQHTHQE QEKNIESPDR PSDIYPCTKC TLSFVAKINL 

       430        440        450        460        470        480 
HQHLKRHHHG EYLRLVESGS LTAETEEDHT EVCFDKQDPN YEPPSRGRKS TKNSLKGRGC 

       490        500        510        520        530        540 
PKKVAVGRPR GRPPKNKNLE VEVQKISPIC TNCEQSFSDL ETLKTHQCPR RDDEGDNVEH 

       550        560        570        580        590        600 
PQEASQYICG ECIRAFSNLD LLKAHECIQQ GEGSYCCPHC DLYFNRMCNL RRHERTIHSK 

       610        620        630        640        650        660 
EKPYCCTVCL KSFTQSSGLK RHQQSHLRRK SHRQSSALFT AAIFPCAYCP FSFTDERYLY 

       670        680        690        700        710        720 
KHIRRHHPEM SLKYLSFQEG GVLSVEKPHS CSQCCKSFST IKGFKNHSCF KQGEKVYLCP 

       730        740        750        760        770        780 
DCGKAFSWFN SLKQHQRIHT GEKPYTCSQC GKSFVHSGQL NVHLRTHTGE KPFLCSQCGE 

       790        800        810        820        830        840 
SFRQSGDLRR HEQKHSGVRP CQCPDCGKSF SRPQSLKAHQ QLHVGTKLFP CTQCGKSFTR 

       850 
RYHLTRHHQK MHS

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References

« Hide 'large scale' references
[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[2]"Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes."
Sun X.-J., Xu P.-F., Zhou T., Hu M., Fu C.-T., Zhang Y., Jin Y., Chen Y., Chen S.-J., Huang Q.-H., Liu T.X., Chen Z.
PLoS ONE 3:E1499-E1499(2008) [PubMed: 18231586] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 763-853.

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Cross-references

Sequence databases

BC064665 mRNA. Translation: AAH64665.1.
DQ851831 mRNA. Translation: ABI34500.1.
IPIIPI00483837.
RefSeqNP_957196.1.
UniGeneDr.80491

3D structure databases

HSSPHSSP built from PDB template 1A1H based on UniProtKB P08046.
ModBaseSearch...

Proteomic databases

PRIDEQ6P2A1.

Genome annotation databases

EnsemblENSDART00000027321; ENSDARP00000026323; ENSDARG00000005382; Danio rerio. [Genome view]
GeneID393876.
KEGGdre:393876.

Organism-specific databases

CTD393876.
ZFINZDB-GENE-040426-1319. prdm9.

Phylogenomic databases

HOVERGENQ6P2A1.
OMAFRQSGDL.

Gene expression databases

ArrayExpressQ6P2A1.
BgeeQ6P2A1.

Family and domain databases

InterProIPR017956. AT_hook_DNA-bd_motif.
IPR001214. SET.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 5 hits.
PfamPF02178. AT_hook. 1 hit.
PF00096. zf-C2H2. 12 hits.
[Graphical view]
ProDomPD000003. Znf_C2H2. 4 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00384. AT_hook. 1 hit.
SM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePRDM9_DANRE
AccessionPrimary (citable) accession number: Q6P2A1
Secondary accession number(s): A5XCD9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 5, 2004
Last modified: November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents