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Q6P286 (DHTK1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

EC=1.2.4.2
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene names
Name:dhtkd1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length927 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandThiamine pyrophosphate
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxoglutarate dehydrogenase (succinyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 927Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307941

Sequences

Sequence LengthMass (Da)Tools
Q6P286 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 43AEFD67A73A0EF3

FASTA927104,104
        10         20         30         40         50         60 
MNVFAHRCSS CRRAVVLWRP GLHRLYRTER GVYGYRPKIS AGSQLQESST RGKQAASPTV 

        70         80         90        100        110        120 
DHGLARLVTA YREHGHKAAK INPLFTGQAV MDMVPEIQEI MEILHGPFST TGLLNMGKSE 

       130        140        150        160        170        180 
ATIEEVLAYL DHTYCGQISI ETSQLQNYKE REWFSRRFEE LKQESFSTEE RKHLARLMLE 

       190        200        210        220        230        240 
CQEFDHFLAT KFSTVKRYGG EGAESMMGFF HEMLKMCSFG GVTDVIIGMP HRGRLNLLTG 

       250        260        270        280        290        300 
LLQFPPELMF RKMRGLSEFP ENSPSIGDVL SHLTSSVDLD FGSHRPLHVT MLPNPSHLEA 

       310        320        330        340        350        360 
INPVAVGKTR ARQQSLSDGD YSTESSAQPG DKVVCLQVHG DASISGQGIV TETFTLSNLP 

       370        380        390        400        410        420 
HYRIGGSIHL IVNNQLGYTT PAERGRSSLY SSDVGKIVGC AVIHVNGDDP EEVLRATRLA 

       430        440        450        460        470        480 
VEYQRCFRKD VIIDLLCYRQ WGHNELDEPF FTNPSMYKII RSRKSIPDVY SERLIAEGLM 

       490        500        510        520        530        540 
TEEEATEIRT TYYSKFNDHL SNMTLYSPPS TNLQAHWREM IEPSARTTTW DTGLPADLLK 

       550        560        570        580        590        600 
FIGAKSVEVP EEFKMHSHLL KMHAQSRVQK LQEATKLDWA TAEALAFGSL LCQGFNIRIS 

       610        620        630        640        650        660 
GQDVGRGTFS QRHAMLVCQE TNDTYIPLNH MTPDQKGFLE VSNSALSEEA VLGFEYGMSI 

       670        680        690        700        710        720 
ESPKLLPIWE AQFGDFFNGA QIIFDTFISG GEAKWLLQSG IVILLPHGYD GAGPEHSSCR 

       730        740        750        760        770        780 
IERFLQMCDS TEEGVDGDTV NMFVVHPTTP AQYFHLLRRQ MVRSFRKPLI VASPKMLLRY 

       790        800        810        820        830        840 
PAAVSSLEDI APGKTFRSVI GDSSADPKSV SKVILCSGKH YYALHKQREA LGEQGRSSAI 

       850        860        870        880        890        900 
IRVEELCPFP LEALQQEIHR YPKAKDFIWS QEEPQNMGAW TFVAPRFEKQ LACKLRLVSR 

       910        920 
PALPAPAVGI GTLHQQQQEE ITVKTLS 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC064683 mRNA. Translation: AAH64683.1.
RefSeqNP_001084395.1. NM_001090926.1.
UniGeneXl.4843.

3D structure databases

ProteinModelPortalQ6P286.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6P286.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403360.
KEGGxla:403360.

Organism-specific databases

CTD55526.
XenbaseXB-GENE-980614. dhtkd1.

Phylogenomic databases

HOVERGENHBG001892.
KOK15791.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDHTK1_XENLA
AccessionPrimary (citable) accession number: Q6P286
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families