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Q6P286

- DHTK1_XENLA

UniProt

Q6P286 - DHTK1_XENLA

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Protein
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
Gene
dhtkd1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene namesi
Name:dhtkd1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-980614. dhtkd1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 927Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307941
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PRIDEiQ6P286.

Structurei

3D structure databases

ProteinModelPortaliQ6P286.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001892.
KOiK15791.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P286-1 [UniParc]FASTAAdd to Basket

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MNVFAHRCSS CRRAVVLWRP GLHRLYRTER GVYGYRPKIS AGSQLQESST    50
RGKQAASPTV DHGLARLVTA YREHGHKAAK INPLFTGQAV MDMVPEIQEI 100
MEILHGPFST TGLLNMGKSE ATIEEVLAYL DHTYCGQISI ETSQLQNYKE 150
REWFSRRFEE LKQESFSTEE RKHLARLMLE CQEFDHFLAT KFSTVKRYGG 200
EGAESMMGFF HEMLKMCSFG GVTDVIIGMP HRGRLNLLTG LLQFPPELMF 250
RKMRGLSEFP ENSPSIGDVL SHLTSSVDLD FGSHRPLHVT MLPNPSHLEA 300
INPVAVGKTR ARQQSLSDGD YSTESSAQPG DKVVCLQVHG DASISGQGIV 350
TETFTLSNLP HYRIGGSIHL IVNNQLGYTT PAERGRSSLY SSDVGKIVGC 400
AVIHVNGDDP EEVLRATRLA VEYQRCFRKD VIIDLLCYRQ WGHNELDEPF 450
FTNPSMYKII RSRKSIPDVY SERLIAEGLM TEEEATEIRT TYYSKFNDHL 500
SNMTLYSPPS TNLQAHWREM IEPSARTTTW DTGLPADLLK FIGAKSVEVP 550
EEFKMHSHLL KMHAQSRVQK LQEATKLDWA TAEALAFGSL LCQGFNIRIS 600
GQDVGRGTFS QRHAMLVCQE TNDTYIPLNH MTPDQKGFLE VSNSALSEEA 650
VLGFEYGMSI ESPKLLPIWE AQFGDFFNGA QIIFDTFISG GEAKWLLQSG 700
IVILLPHGYD GAGPEHSSCR IERFLQMCDS TEEGVDGDTV NMFVVHPTTP 750
AQYFHLLRRQ MVRSFRKPLI VASPKMLLRY PAAVSSLEDI APGKTFRSVI 800
GDSSADPKSV SKVILCSGKH YYALHKQREA LGEQGRSSAI IRVEELCPFP 850
LEALQQEIHR YPKAKDFIWS QEEPQNMGAW TFVAPRFEKQ LACKLRLVSR 900
PALPAPAVGI GTLHQQQQEE ITVKTLS 927
Length:927
Mass (Da):104,104
Last modified:July 5, 2004 - v1
Checksum:i43AEFD67A73A0EF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC064683 mRNA. Translation: AAH64683.1.
RefSeqiNP_001084395.1. NM_001090926.1.
UniGeneiXl.4843.

Genome annotation databases

GeneIDi403360.
KEGGixla:403360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC064683 mRNA. Translation: AAH64683.1 .
RefSeqi NP_001084395.1. NM_001090926.1.
UniGenei Xl.4843.

3D structure databases

ProteinModelPortali Q6P286.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6P286.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403360.
KEGGi xla:403360.

Organism-specific databases

CTDi 55526.
Xenbasei XB-GENE-980614. dhtkd1.

Phylogenomic databases

HOVERGENi HBG001892.
KOi K15791.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiDHTK1_XENLA
AccessioniPrimary (citable) accession number: Q6P286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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