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Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

dhtkd1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene namesi
Name:dhtkd1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-980614. dhtkd1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 927Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307941
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PRIDEiQ6P286.

Structurei

3D structure databases

ProteinModelPortaliQ6P286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001892.
KOiK15791.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVFAHRCSS CRRAVVLWRP GLHRLYRTER GVYGYRPKIS AGSQLQESST
60 70 80 90 100
RGKQAASPTV DHGLARLVTA YREHGHKAAK INPLFTGQAV MDMVPEIQEI
110 120 130 140 150
MEILHGPFST TGLLNMGKSE ATIEEVLAYL DHTYCGQISI ETSQLQNYKE
160 170 180 190 200
REWFSRRFEE LKQESFSTEE RKHLARLMLE CQEFDHFLAT KFSTVKRYGG
210 220 230 240 250
EGAESMMGFF HEMLKMCSFG GVTDVIIGMP HRGRLNLLTG LLQFPPELMF
260 270 280 290 300
RKMRGLSEFP ENSPSIGDVL SHLTSSVDLD FGSHRPLHVT MLPNPSHLEA
310 320 330 340 350
INPVAVGKTR ARQQSLSDGD YSTESSAQPG DKVVCLQVHG DASISGQGIV
360 370 380 390 400
TETFTLSNLP HYRIGGSIHL IVNNQLGYTT PAERGRSSLY SSDVGKIVGC
410 420 430 440 450
AVIHVNGDDP EEVLRATRLA VEYQRCFRKD VIIDLLCYRQ WGHNELDEPF
460 470 480 490 500
FTNPSMYKII RSRKSIPDVY SERLIAEGLM TEEEATEIRT TYYSKFNDHL
510 520 530 540 550
SNMTLYSPPS TNLQAHWREM IEPSARTTTW DTGLPADLLK FIGAKSVEVP
560 570 580 590 600
EEFKMHSHLL KMHAQSRVQK LQEATKLDWA TAEALAFGSL LCQGFNIRIS
610 620 630 640 650
GQDVGRGTFS QRHAMLVCQE TNDTYIPLNH MTPDQKGFLE VSNSALSEEA
660 670 680 690 700
VLGFEYGMSI ESPKLLPIWE AQFGDFFNGA QIIFDTFISG GEAKWLLQSG
710 720 730 740 750
IVILLPHGYD GAGPEHSSCR IERFLQMCDS TEEGVDGDTV NMFVVHPTTP
760 770 780 790 800
AQYFHLLRRQ MVRSFRKPLI VASPKMLLRY PAAVSSLEDI APGKTFRSVI
810 820 830 840 850
GDSSADPKSV SKVILCSGKH YYALHKQREA LGEQGRSSAI IRVEELCPFP
860 870 880 890 900
LEALQQEIHR YPKAKDFIWS QEEPQNMGAW TFVAPRFEKQ LACKLRLVSR
910 920
PALPAPAVGI GTLHQQQQEE ITVKTLS
Length:927
Mass (Da):104,104
Last modified:July 5, 2004 - v1
Checksum:i43AEFD67A73A0EF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064683 mRNA. Translation: AAH64683.1.
RefSeqiNP_001084395.1. NM_001090926.1.
UniGeneiXl.4843.

Genome annotation databases

GeneIDi403360.
KEGGixla:403360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064683 mRNA. Translation: AAH64683.1.
RefSeqiNP_001084395.1. NM_001090926.1.
UniGeneiXl.4843.

3D structure databases

ProteinModelPortaliQ6P286.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6P286.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403360.
KEGGixla:403360.

Organism-specific databases

CTDi55526.
XenbaseiXB-GENE-980614. dhtkd1.

Phylogenomic databases

HOVERGENiHBG001892.
KOiK15791.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiDHTK1_XENLA
AccessioniPrimary (citable) accession number: Q6P286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.