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Q6P286

- DHTK1_XENLA

UniProt

Q6P286 - DHTK1_XENLA

Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

dhtkd1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    Dehydrogenase E1 and transketolase domain-containing protein 1
    Gene namesi
    Name:dhtkd1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-980614. dhtkd1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 927Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307941
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PRIDEiQ6P286.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P286.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG001892.
    KOiK15791.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P286-1 [UniParc]FASTAAdd to Basket

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    MNVFAHRCSS CRRAVVLWRP GLHRLYRTER GVYGYRPKIS AGSQLQESST    50
    RGKQAASPTV DHGLARLVTA YREHGHKAAK INPLFTGQAV MDMVPEIQEI 100
    MEILHGPFST TGLLNMGKSE ATIEEVLAYL DHTYCGQISI ETSQLQNYKE 150
    REWFSRRFEE LKQESFSTEE RKHLARLMLE CQEFDHFLAT KFSTVKRYGG 200
    EGAESMMGFF HEMLKMCSFG GVTDVIIGMP HRGRLNLLTG LLQFPPELMF 250
    RKMRGLSEFP ENSPSIGDVL SHLTSSVDLD FGSHRPLHVT MLPNPSHLEA 300
    INPVAVGKTR ARQQSLSDGD YSTESSAQPG DKVVCLQVHG DASISGQGIV 350
    TETFTLSNLP HYRIGGSIHL IVNNQLGYTT PAERGRSSLY SSDVGKIVGC 400
    AVIHVNGDDP EEVLRATRLA VEYQRCFRKD VIIDLLCYRQ WGHNELDEPF 450
    FTNPSMYKII RSRKSIPDVY SERLIAEGLM TEEEATEIRT TYYSKFNDHL 500
    SNMTLYSPPS TNLQAHWREM IEPSARTTTW DTGLPADLLK FIGAKSVEVP 550
    EEFKMHSHLL KMHAQSRVQK LQEATKLDWA TAEALAFGSL LCQGFNIRIS 600
    GQDVGRGTFS QRHAMLVCQE TNDTYIPLNH MTPDQKGFLE VSNSALSEEA 650
    VLGFEYGMSI ESPKLLPIWE AQFGDFFNGA QIIFDTFISG GEAKWLLQSG 700
    IVILLPHGYD GAGPEHSSCR IERFLQMCDS TEEGVDGDTV NMFVVHPTTP 750
    AQYFHLLRRQ MVRSFRKPLI VASPKMLLRY PAAVSSLEDI APGKTFRSVI 800
    GDSSADPKSV SKVILCSGKH YYALHKQREA LGEQGRSSAI IRVEELCPFP 850
    LEALQQEIHR YPKAKDFIWS QEEPQNMGAW TFVAPRFEKQ LACKLRLVSR 900
    PALPAPAVGI GTLHQQQQEE ITVKTLS 927
    Length:927
    Mass (Da):104,104
    Last modified:July 5, 2004 - v1
    Checksum:i43AEFD67A73A0EF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC064683 mRNA. Translation: AAH64683.1.
    RefSeqiNP_001084395.1. NM_001090926.1.
    UniGeneiXl.4843.

    Genome annotation databases

    GeneIDi403360.
    KEGGixla:403360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC064683 mRNA. Translation: AAH64683.1 .
    RefSeqi NP_001084395.1. NM_001090926.1.
    UniGenei Xl.4843.

    3D structure databases

    ProteinModelPortali Q6P286.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6P286.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403360.
    KEGGi xla:403360.

    Organism-specific databases

    CTDi 55526.
    Xenbasei XB-GENE-980614. dhtkd1.

    Phylogenomic databases

    HOVERGENi HBG001892.
    KOi K15791.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiDHTK1_XENLA
    AccessioniPrimary (citable) accession number: Q6P286
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3