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Q6P286

- DHTK1_XENLA

UniProt

Q6P286 - DHTK1_XENLA

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Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

dhtkd1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene namesi
Name:dhtkd1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-980614. dhtkd1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 927Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307941
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PRIDEiQ6P286.

Structurei

3D structure databases

ProteinModelPortaliQ6P286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001892.
KOiK15791.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P286 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNVFAHRCSS CRRAVVLWRP GLHRLYRTER GVYGYRPKIS AGSQLQESST
60 70 80 90 100
RGKQAASPTV DHGLARLVTA YREHGHKAAK INPLFTGQAV MDMVPEIQEI
110 120 130 140 150
MEILHGPFST TGLLNMGKSE ATIEEVLAYL DHTYCGQISI ETSQLQNYKE
160 170 180 190 200
REWFSRRFEE LKQESFSTEE RKHLARLMLE CQEFDHFLAT KFSTVKRYGG
210 220 230 240 250
EGAESMMGFF HEMLKMCSFG GVTDVIIGMP HRGRLNLLTG LLQFPPELMF
260 270 280 290 300
RKMRGLSEFP ENSPSIGDVL SHLTSSVDLD FGSHRPLHVT MLPNPSHLEA
310 320 330 340 350
INPVAVGKTR ARQQSLSDGD YSTESSAQPG DKVVCLQVHG DASISGQGIV
360 370 380 390 400
TETFTLSNLP HYRIGGSIHL IVNNQLGYTT PAERGRSSLY SSDVGKIVGC
410 420 430 440 450
AVIHVNGDDP EEVLRATRLA VEYQRCFRKD VIIDLLCYRQ WGHNELDEPF
460 470 480 490 500
FTNPSMYKII RSRKSIPDVY SERLIAEGLM TEEEATEIRT TYYSKFNDHL
510 520 530 540 550
SNMTLYSPPS TNLQAHWREM IEPSARTTTW DTGLPADLLK FIGAKSVEVP
560 570 580 590 600
EEFKMHSHLL KMHAQSRVQK LQEATKLDWA TAEALAFGSL LCQGFNIRIS
610 620 630 640 650
GQDVGRGTFS QRHAMLVCQE TNDTYIPLNH MTPDQKGFLE VSNSALSEEA
660 670 680 690 700
VLGFEYGMSI ESPKLLPIWE AQFGDFFNGA QIIFDTFISG GEAKWLLQSG
710 720 730 740 750
IVILLPHGYD GAGPEHSSCR IERFLQMCDS TEEGVDGDTV NMFVVHPTTP
760 770 780 790 800
AQYFHLLRRQ MVRSFRKPLI VASPKMLLRY PAAVSSLEDI APGKTFRSVI
810 820 830 840 850
GDSSADPKSV SKVILCSGKH YYALHKQREA LGEQGRSSAI IRVEELCPFP
860 870 880 890 900
LEALQQEIHR YPKAKDFIWS QEEPQNMGAW TFVAPRFEKQ LACKLRLVSR
910 920
PALPAPAVGI GTLHQQQQEE ITVKTLS
Length:927
Mass (Da):104,104
Last modified:July 5, 2004 - v1
Checksum:i43AEFD67A73A0EF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC064683 mRNA. Translation: AAH64683.1.
RefSeqiNP_001084395.1. NM_001090926.1.
UniGeneiXl.4843.

Genome annotation databases

GeneIDi403360.
KEGGixla:403360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC064683 mRNA. Translation: AAH64683.1 .
RefSeqi NP_001084395.1. NM_001090926.1.
UniGenei Xl.4843.

3D structure databases

ProteinModelPortali Q6P286.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6P286.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403360.
KEGGi xla:403360.

Organism-specific databases

CTDi 55526.
Xenbasei XB-GENE-980614. dhtkd1.

Phylogenomic databases

HOVERGENi HBG001892.
KOi K15791.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiDHTK1_XENLA
AccessioniPrimary (citable) accession number: Q6P286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3