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Protein

Zinc finger protein 529

Gene

ZNF529

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 22123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 529
Gene namesi
Name:ZNF529
Synonyms:KIAA1615
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29328. ZNF529.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910867.

Polymorphism and mutation databases

BioMutaiZNF529.
DMDMi519668652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Zinc finger protein 529PRO_0000280419Add
BLAST

Proteomic databases

MaxQBiQ6P280.
PaxDbiQ6P280.
PRIDEiQ6P280.

PTM databases

iPTMnetiQ6P280.
PhosphoSiteiQ6P280.

Expressioni

Gene expression databases

BgeeiQ6P280.
CleanExiHS_ZNF529.
ExpressionAtlasiQ6P280. baseline and differential.
GenevisibleiQ6P280. HS.

Organism-specific databases

HPAiHPA031311.
HPA061854.

Interactioni

Protein-protein interaction databases

BioGridi121735. 2 interactions.
STRINGi9606.ENSP00000465578.

Structurei

3D structure databases

ProteinModelPortaliQ6P280.
SMRiQ6P280. Positions 39-78, 169-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 11981KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 22123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P280.
KOiK09228.
OMAiRNDWQSK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6P280.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSSFIGDH VHGAPHAVMP EVEFPDQFFT VLTMDHELVT LRDVVINFSQ
60 70 80 90 100
EEWEYLDSAQ RNLYWDVMME NYSNLLSLDL ESRNETKHLS VGKDIIQNTG
110 120 130 140 150
SQWEVMESSK LCGLEGSIFR NDWQSKSKID LQGPEVGYFS QMKIISENVP
160 170 180 190 200
SYKTHESLTL PRRTHDSEKP YEYKEYEKVF SCDLEFDEYQ KIHTGGKNYE
210 220 230 240 250
CNQCWKTFGI DNSSMLQLNI HTGVKPCKYM EYGNTCSFYK DFNVYQKIHN
260 270 280 290 300
EKFYKCKEYR RTFERVGKVT PLQRVHDGEK HFECSFCGKS FRVHAQLTRH
310 320 330 340 350
QKIHTDEKTY KCMECGKDFR FHSQLTEHQR IHTGEKPYKC MHCEKVFRIS
360 370 380 390 400
SQLIEHQRIH TGEKPYACKE CGKAFGVCRE LARHQRIHTG KKPYECKACG
410 420 430 440 450
KVFRNSSSLT RHQRIHTGEK PYKCKECEKA FGVGSELTRH ERIHSGQKPY
460 470 480 490 500
ECKECGKFFR LTSALIQHQR IHSGEKPYEC KVCGKAFRHS SALTEHQRIH
510 520 530 540 550
TGEKPYECKA CGKAFRHSSS FTKHQRIHTD DKPYECKECG NSFSVVGHLT
560
CQPKIYTGEK SFD
Length:563
Mass (Da):65,865
Last modified:June 26, 2013 - v2
Checksum:iF59AA85D249C1A9E
GO

Sequence cautioni

The sequence AAH64690.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15068.1 differs from that shown. Reason: Frameshift at position 78. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791D → N in BAB15068 (PubMed:14702039).Curated
Sequence conflicti101 – 1011S → P in BAB13441 (PubMed:15057824).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti131 – 1311L → V.2 Publications
Corresponds to variant rs2912444 [ dbSNP | Ensembl ].
VAR_031147

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025110 mRNA. Translation: BAB15068.1. Frameshift.
AC092295 Genomic DNA. No translation available.
BC064690 mRNA. Translation: AAH64690.1. Different initiation.
AB046835 mRNA. Translation: BAB13441.1.
CCDSiCCDS54256.1.
RefSeqiNP_001139121.1. NM_001145649.1.
NP_066002.3. NM_020951.4.
XP_006723365.1. XM_006723302.2.
XP_011525466.1. XM_011527164.1.
XP_011525469.1. XM_011527167.1.
UniGeneiHs.654960.

Genome annotation databases

EnsembliENST00000591340; ENSP00000465578; ENSG00000186020.
GeneIDi57711.
KEGGihsa:57711.
UCSCiuc002oeg.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025110 mRNA. Translation: BAB15068.1. Frameshift.
AC092295 Genomic DNA. No translation available.
BC064690 mRNA. Translation: AAH64690.1. Different initiation.
AB046835 mRNA. Translation: BAB13441.1.
CCDSiCCDS54256.1.
RefSeqiNP_001139121.1. NM_001145649.1.
NP_066002.3. NM_020951.4.
XP_006723365.1. XM_006723302.2.
XP_011525466.1. XM_011527164.1.
XP_011525469.1. XM_011527167.1.
UniGeneiHs.654960.

3D structure databases

ProteinModelPortaliQ6P280.
SMRiQ6P280. Positions 39-78, 169-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121735. 2 interactions.
STRINGi9606.ENSP00000465578.

PTM databases

iPTMnetiQ6P280.
PhosphoSiteiQ6P280.

Polymorphism and mutation databases

BioMutaiZNF529.
DMDMi519668652.

Proteomic databases

MaxQBiQ6P280.
PaxDbiQ6P280.
PRIDEiQ6P280.

Protocols and materials databases

DNASUi57711.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000591340; ENSP00000465578; ENSG00000186020.
GeneIDi57711.
KEGGihsa:57711.
UCSCiuc002oeg.5. human.

Organism-specific databases

CTDi57711.
GeneCardsiZNF529.
HGNCiHGNC:29328. ZNF529.
HPAiHPA031311.
HPA061854.
neXtProtiNX_Q6P280.
PharmGKBiPA134910867.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P280.
KOiK09228.
OMAiRNDWQSK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6P280.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF529. human.
GenomeRNAii57711.
PROiQ6P280.

Gene expression databases

BgeeiQ6P280.
CleanExiHS_ZNF529.
ExpressionAtlasiQ6P280. baseline and differential.
GenevisibleiQ6P280. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-131.
    Tissue: Placenta.
  4. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-563, VARIANT VAL-131.
    Tissue: Brain.

Entry informationi

Entry nameiZN529_HUMAN
AccessioniPrimary (citable) accession number: Q6P280
Secondary accession number(s): K7EKE1, Q9H731, Q9HCF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 26, 2013
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.