Q6P1Y8 (INP4B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type II inositol-3,4-bisphosphate 4-phosphatase
EC=3.1.3.66

Alternative name(s):
Inositol polyphosphate 4-phosphatase type II

Gene names

Name:

Inpp4b

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	924 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate By similarity.
Catalytic activity	1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Enzyme regulation	Strongly inhibited by inositol hexakisphosphate By similarity.
Pathway	Signal transduction; phosphatidylinositol signaling pathway.
Sequence similarities	Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Inferred from electronic annotation. Source: EC phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 924	924	Type II inositol-3,4-bisphosphate 4-phosphatase		PRO_0000190237
Regions
	Domain	25 – 132	108	C2
Amino acid modifications
	Modified residue	470	1	Phosphoserine Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q6P1Y8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 09DF35368F4C1695	FASTA	924	104,531
	10 20 30 40 50 60 MEIKEEGTSE EGQHFLPAAQ ANDPEDIQFT SIQKIPNEPQ LEFILACRDL VAPVSDRKLN 70 80 90 100 110 120 TVVQISVIHP VEQTLTRYSS TEIVEGTKDP LFLTGVTFPP DYPIYEETRI KLTVYDVKDK 130 140 150 160 170 180 SHDTRSFLGC ASFKVGELLK SKEQLLSLSL RTSDGGKVVG TIEVSLVKMG EIEDGDTDHI 190 200 210 220 230 240 TTDVQGQKCA LMYESTAPES LSGKENLPFM NAVLRNPVCK LYRFPTSDNK WMRIREQMSE 250 260 270 280 290 300 SILSFHIPKE LISLHIKEDL CRNQELKELG DLSPHWDNLR KNVLSHCDQM VTMYQDILTE 310 320 330 340 350 360 LSKETGSSFK SSSSKGEKTL EFVPVNLHLQ RMQVHSPHLK DALYDVITVG APAAHFQGFK 370 380 390 400 410 420 NGGLRKLLHR FETERRNTGY QFIYYSPENT AKAKEVLSSI NQLQPLIATH ADLLLTSASQ 430 440 450 460 470 480 RSPDSLKSSL KLLSEKTELF VHAFKDQLVR SALLALYTAR PGGILKKPPS PNVSTEEKST 490 500 510 520 530 540 QHDTPQLRRQ DSIPHHSDYD EEEWDRVWAN VGKSLNCIIA KVDKLIERDS HNEEGAGGSS 550 560 570 580 590 600 SKDGEADHTL EDSITSHPRE DWYEQLHPLI LTLKECMGEV VNRAKQSLTF VLLQELAYSL 610 620 630 640 650 660 PQCLMLTLRR DIVFSQALAG LVCGFIIKLH TSLHDPGFLQ QLHTVGLIVQ YEGLLSTYSD 670 680 690 700 710 720 EIGMLEDMAV GISDLRKVAF KITEATSNDV LPVLTGRREH YVVEVKLPAT VFESLPLQIK 730 740 750 760 770 780 EGQLLHVYPV LFNVGINEQQ TLAERFGDVS LQESINQENF ELVQEYYSIF MEKMPPDYIS 790 800 810 820 830 840 HFQEQTDLKG LLDNLHQNIQ AKKRKNVEIM WLAATICRKL NGIRFTCCKS AKDRTSMSVT 850 860 870 880 890 900 LEQCSILRDE HQLHKDFFIR ALDCMRSRQT QGALNESDDP ETGCLTDNKP TSRHFYPVAL 910 920 LLVSSHLLVV WLILSLALLL AKYQ

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[2]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 19367708] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC064813 mRNA. Translation: AAH64813.1.
IPI	IPI00875164.
RefSeq	NP_001019788.1. NM_001024617.2.
UniGene	Mm.324468.
3D structure databases
ProteinModelPortal	Q6P1Y8.
SMR	Q6P1Y8. Positions 41-166.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6P1Y8.
PTM databases
PhosphoSite	Q6P1Y8.
Proteomic databases
PRIDE	Q6P1Y8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000042529; ENSMUSP00000044466; ENSMUSG00000037940.
GeneID	234515.
KEGG	mmu:234515.
UCSC	uc009mjh.1. mouse.
Organism-specific databases
CTD	8821.
MGI	MGI:2158925. Inpp4b.
Phylogenomic databases
eggNOG	roNOG06016.
GeneTree	ENSGT00390000002033.
HOVERGEN	HBG081796.
PhylomeDB	Q6P1Y8.
Gene expression databases
ArrayExpress	Q6P1Y8.
Bgee	Q6P1Y8.
CleanEx	MM_INPP4B.
Genevestigator	Q6P1Y8.
GermOnline	ENSMUSG00000037940. Mus musculus.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. [Graphical view]
KO	K01109.
SMART	SM00239. C2. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS50004. C2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	382201.
SOURCE	Search...

Entry information

Entry name

INP4B_MOUSE

Accession

Primary (citable) accession number: Q6P1Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program