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Protein

Type II inositol 3,4-bisphosphate 4-phosphatase

Gene

Inpp4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.By similarity

Catalytic activityi

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

Enzyme regulationi

Strongly inhibited by inositol hexakisphosphate.By similarity

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: MGI
  • inositol phosphate dephosphorylation Source: MGI
  • negative regulation of osteoclast differentiation Source: MGI
  • phosphatidylinositol dephosphorylation Source: MGI
  • regulation of bone remodeling Source: MGI
  • regulation of nucleocytoplasmic transport Source: MGI
  • regulation of protein kinase B signaling Source: MGI

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-1660516 Synthesis of PIPs at the early endosome membrane
R-MMU-1855183 Synthesis of IP2, IP, and Ins in the cytosol
UniPathwayiUPA00944

Names & Taxonomyi

Protein namesi
Recommended name:
Type II inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.66)
Alternative name(s):
Inositol polyphosphate 4-phosphatase type II
Gene namesi
Name:Inpp4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2158925 Inpp4b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902371 – 924Type II inositol 3,4-bisphosphate 4-phosphataseAdd BLAST924

Proteomic databases

EPDiQ6P1Y8
MaxQBiQ6P1Y8
PaxDbiQ6P1Y8
PRIDEiQ6P1Y8

PTM databases

iPTMnetiQ6P1Y8
PhosphoSitePlusiQ6P1Y8

Expressioni

Gene expression databases

BgeeiENSMUSG00000037940
CleanExiMM_INPP4B
ExpressionAtlasiQ6P1Y8 baseline and differential
GenevisibleiQ6P1Y8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044466

Structurei

3D structure databases

ProteinModelPortaliQ6P1Y8
SMRiQ6P1Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 132C2Add BLAST108

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4428 Eukaryota
ENOG410YV83 LUCA
GeneTreeiENSGT00390000002033
HOGENOMiHOG000113075
HOVERGENiHBG081796
InParanoidiQ6P1Y8
KOiK01109
PhylomeDBiQ6P1Y8
TreeFamiTF325637

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf

Sequencei

Sequence statusi: Complete.

Q6P1Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIKEEGTSE EGQHFLPAAQ ANDPEDIQFT SIQKIPNEPQ LEFILACRDL
60 70 80 90 100
VAPVSDRKLN TVVQISVIHP VEQTLTRYSS TEIVEGTKDP LFLTGVTFPP
110 120 130 140 150
DYPIYEETRI KLTVYDVKDK SHDTRSFLGC ASFKVGELLK SKEQLLSLSL
160 170 180 190 200
RTSDGGKVVG TIEVSLVKMG EIEDGDTDHI TTDVQGQKCA LMYESTAPES
210 220 230 240 250
LSGKENLPFM NAVLRNPVCK LYRFPTSDNK WMRIREQMSE SILSFHIPKE
260 270 280 290 300
LISLHIKEDL CRNQELKELG DLSPHWDNLR KNVLSHCDQM VTMYQDILTE
310 320 330 340 350
LSKETGSSFK SSSSKGEKTL EFVPVNLHLQ RMQVHSPHLK DALYDVITVG
360 370 380 390 400
APAAHFQGFK NGGLRKLLHR FETERRNTGY QFIYYSPENT AKAKEVLSSI
410 420 430 440 450
NQLQPLIATH ADLLLTSASQ RSPDSLKSSL KLLSEKTELF VHAFKDQLVR
460 470 480 490 500
SALLALYTAR PGGILKKPPS PNVSTEEKST QHDTPQLRRQ DSIPHHSDYD
510 520 530 540 550
EEEWDRVWAN VGKSLNCIIA KVDKLIERDS HNEEGAGGSS SKDGEADHTL
560 570 580 590 600
EDSITSHPRE DWYEQLHPLI LTLKECMGEV VNRAKQSLTF VLLQELAYSL
610 620 630 640 650
PQCLMLTLRR DIVFSQALAG LVCGFIIKLH TSLHDPGFLQ QLHTVGLIVQ
660 670 680 690 700
YEGLLSTYSD EIGMLEDMAV GISDLRKVAF KITEATSNDV LPVLTGRREH
710 720 730 740 750
YVVEVKLPAT VFESLPLQIK EGQLLHVYPV LFNVGINEQQ TLAERFGDVS
760 770 780 790 800
LQESINQENF ELVQEYYSIF MEKMPPDYIS HFQEQTDLKG LLDNLHQNIQ
810 820 830 840 850
AKKRKNVEIM WLAATICRKL NGIRFTCCKS AKDRTSMSVT LEQCSILRDE
860 870 880 890 900
HQLHKDFFIR ALDCMRSRQT QGALNESDDP ETGCLTDNKP TSRHFYPVAL
910 920
LLVSSHLLVV WLILSLALLL AKYQ
Length:924
Mass (Da):104,531
Last modified:July 5, 2004 - v1
Checksum:i09DF35368F4C1695
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064813 mRNA Translation: AAH64813.1
CCDSiCCDS22446.1
RefSeqiNP_001019788.1, NM_001024617.3
UniGeneiMm.324468

Genome annotation databases

EnsembliENSMUST00000042529; ENSMUSP00000044466; ENSMUSG00000037940
GeneIDi234515
KEGGimmu:234515
UCSCiuc009mjh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiINP4B_MOUSE
AccessioniPrimary (citable) accession number: Q6P1Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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