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Protein

Type II inositol 3,4-bisphosphate 4-phosphatase

Gene

Inpp4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.By similarity

Catalytic activityi

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

Enzyme regulationi

Strongly inhibited by inositol hexakisphosphate.By similarity

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: MGI
  • inositol phosphate dephosphorylation Source: MGI
  • negative regulation of osteoclast differentiation Source: MGI
  • phosphatidylinositol dephosphorylation Source: MGI
  • regulation of bone remodeling Source: MGI
  • regulation of nucleocytoplasmic transport Source: MGI
  • regulation of protein kinase B signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660499. Synthesis of PIPs at the plasma membrane.
R-MMU-1660516. Synthesis of PIPs at the early endosome membrane.
R-MMU-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
UniPathwayiUPA00944.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.66)
Alternative name(s):
Inositol polyphosphate 4-phosphatase type II
Gene namesi
Name:Inpp4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2158925. Inpp4b.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 924924Type II inositol 3,4-bisphosphate 4-phosphatasePRO_0000190237Add
BLAST

Proteomic databases

EPDiQ6P1Y8.
MaxQBiQ6P1Y8.
PaxDbiQ6P1Y8.
PRIDEiQ6P1Y8.

PTM databases

iPTMnetiQ6P1Y8.
PhosphoSiteiQ6P1Y8.

Expressioni

Gene expression databases

BgeeiQ6P1Y8.
CleanExiMM_INPP4B.
ExpressionAtlasiQ6P1Y8. baseline and differential.
GenevisibleiQ6P1Y8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044466.

Structurei

3D structure databases

ProteinModelPortaliQ6P1Y8.
SMRiQ6P1Y8. Positions 43-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 132108C2Add
BLAST

Sequence similaritiesi

Contains 1 C2 domain.Curated

Phylogenomic databases

eggNOGiKOG4428. Eukaryota.
ENOG410YV83. LUCA.
GeneTreeiENSGT00390000002033.
HOGENOMiHOG000113075.
HOVERGENiHBG081796.
InParanoidiQ6P1Y8.
KOiK01109.
PhylomeDBiQ6P1Y8.
TreeFamiTF325637.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P1Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIKEEGTSE EGQHFLPAAQ ANDPEDIQFT SIQKIPNEPQ LEFILACRDL
60 70 80 90 100
VAPVSDRKLN TVVQISVIHP VEQTLTRYSS TEIVEGTKDP LFLTGVTFPP
110 120 130 140 150
DYPIYEETRI KLTVYDVKDK SHDTRSFLGC ASFKVGELLK SKEQLLSLSL
160 170 180 190 200
RTSDGGKVVG TIEVSLVKMG EIEDGDTDHI TTDVQGQKCA LMYESTAPES
210 220 230 240 250
LSGKENLPFM NAVLRNPVCK LYRFPTSDNK WMRIREQMSE SILSFHIPKE
260 270 280 290 300
LISLHIKEDL CRNQELKELG DLSPHWDNLR KNVLSHCDQM VTMYQDILTE
310 320 330 340 350
LSKETGSSFK SSSSKGEKTL EFVPVNLHLQ RMQVHSPHLK DALYDVITVG
360 370 380 390 400
APAAHFQGFK NGGLRKLLHR FETERRNTGY QFIYYSPENT AKAKEVLSSI
410 420 430 440 450
NQLQPLIATH ADLLLTSASQ RSPDSLKSSL KLLSEKTELF VHAFKDQLVR
460 470 480 490 500
SALLALYTAR PGGILKKPPS PNVSTEEKST QHDTPQLRRQ DSIPHHSDYD
510 520 530 540 550
EEEWDRVWAN VGKSLNCIIA KVDKLIERDS HNEEGAGGSS SKDGEADHTL
560 570 580 590 600
EDSITSHPRE DWYEQLHPLI LTLKECMGEV VNRAKQSLTF VLLQELAYSL
610 620 630 640 650
PQCLMLTLRR DIVFSQALAG LVCGFIIKLH TSLHDPGFLQ QLHTVGLIVQ
660 670 680 690 700
YEGLLSTYSD EIGMLEDMAV GISDLRKVAF KITEATSNDV LPVLTGRREH
710 720 730 740 750
YVVEVKLPAT VFESLPLQIK EGQLLHVYPV LFNVGINEQQ TLAERFGDVS
760 770 780 790 800
LQESINQENF ELVQEYYSIF MEKMPPDYIS HFQEQTDLKG LLDNLHQNIQ
810 820 830 840 850
AKKRKNVEIM WLAATICRKL NGIRFTCCKS AKDRTSMSVT LEQCSILRDE
860 870 880 890 900
HQLHKDFFIR ALDCMRSRQT QGALNESDDP ETGCLTDNKP TSRHFYPVAL
910 920
LLVSSHLLVV WLILSLALLL AKYQ
Length:924
Mass (Da):104,531
Last modified:July 5, 2004 - v1
Checksum:i09DF35368F4C1695
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064813 mRNA. Translation: AAH64813.1.
CCDSiCCDS22446.1.
RefSeqiNP_001019788.1. NM_001024617.3.
UniGeneiMm.324468.

Genome annotation databases

EnsembliENSMUST00000042529; ENSMUSP00000044466; ENSMUSG00000037940.
GeneIDi234515.
KEGGimmu:234515.
UCSCiuc009mjh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064813 mRNA. Translation: AAH64813.1.
CCDSiCCDS22446.1.
RefSeqiNP_001019788.1. NM_001024617.3.
UniGeneiMm.324468.

3D structure databases

ProteinModelPortaliQ6P1Y8.
SMRiQ6P1Y8. Positions 43-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044466.

PTM databases

iPTMnetiQ6P1Y8.
PhosphoSiteiQ6P1Y8.

Proteomic databases

EPDiQ6P1Y8.
MaxQBiQ6P1Y8.
PaxDbiQ6P1Y8.
PRIDEiQ6P1Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042529; ENSMUSP00000044466; ENSMUSG00000037940.
GeneIDi234515.
KEGGimmu:234515.
UCSCiuc009mjh.2. mouse.

Organism-specific databases

CTDi8821.
MGIiMGI:2158925. Inpp4b.

Phylogenomic databases

eggNOGiKOG4428. Eukaryota.
ENOG410YV83. LUCA.
GeneTreeiENSGT00390000002033.
HOGENOMiHOG000113075.
HOVERGENiHBG081796.
InParanoidiQ6P1Y8.
KOiK01109.
PhylomeDBiQ6P1Y8.
TreeFamiTF325637.

Enzyme and pathway databases

UniPathwayiUPA00944.
ReactomeiR-MMU-1660499. Synthesis of PIPs at the plasma membrane.
R-MMU-1660516. Synthesis of PIPs at the early endosome membrane.
R-MMU-1855183. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

ChiTaRSiInpp4b. mouse.
NextBioi382201.
PROiQ6P1Y8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P1Y8.
CleanExiMM_INPP4B.
ExpressionAtlasiQ6P1Y8. baseline and differential.
GenevisibleiQ6P1Y8. MM.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiINP4B_MOUSE
AccessioniPrimary (citable) accession number: Q6P1Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.