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Protein

Uncharacterized protein C1orf94

Gene

C1orf94

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf94
Gene namesi
Name:C1orf94
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28250. C1orf94.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672478.

Polymorphism and mutation databases

BioMutaiC1orf94.
DMDMi357528782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Uncharacterized protein C1orf94PRO_0000280097Add
BLAST

Proteomic databases

PaxDbiQ6P1W5.
PRIDEiQ6P1W5.

Expressioni

Gene expression databases

BgeeiQ6P1W5.
CleanExiHS_C1orf94.
GenevisibleiQ6P1W5. HS.

Organism-specific databases

HPAiHPA045805.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R8Y43EBI-946029,EBI-10175581
AESQ081173EBI-946029,EBI-717810
AKAP9Q99996-23EBI-946029,EBI-9641546
ATRIPQ8WXE13EBI-946029,EBI-747353
ATXN1P542536EBI-946029,EBI-930964
BANPQ8N9N53EBI-946029,EBI-744695
BOLA1Q9Y3E23EBI-946029,EBI-1049556
BOLLQ8N9W63EBI-946029,EBI-998198
BYSLQ138953EBI-946029,EBI-358049
C1orf109Q9NX043EBI-946029,EBI-8643161
C6orf165Q8IYR04EBI-946029,EBI-749051
CARD9Q9H2573EBI-946029,EBI-751319
CCHCR1Q8TD31-34EBI-946029,EBI-10175300
CCNJLF6RF563EBI-946029,EBI-10177725
CDKN2DP552734EBI-946029,EBI-745859
DAB1O755533EBI-946029,EBI-7875264
DAZAP2Q150384EBI-946029,EBI-724310
DOK6Q6PKX43EBI-946029,EBI-2880244
DTX2Q86UW93EBI-946029,EBI-740376
FAM168AQ925673EBI-946029,EBI-7957930
FAM46DQ8NEK83EBI-946029,EBI-744726
GCC1Q96CN93EBI-946029,EBI-746252
GORASP2Q9H8Y83EBI-946029,EBI-739467
GRB2P629933EBI-946029,EBI-401755
GSE1Q146873EBI-946029,EBI-372619
HNRNPFP525973EBI-946029,EBI-352986
Hoxa1P090223EBI-946029,EBI-3957603From a different organism.
IPO11Q9UI263EBI-946029,EBI-748752
KLHL32Q5THT13EBI-946029,EBI-10247181
LMO2P257913EBI-946029,EBI-739696
MAGED1Q9Y5V33EBI-946029,EBI-716006
MAPK1IP1LQ8NDC04EBI-946029,EBI-741424
MAPK9P459843EBI-946029,EBI-713568
MEIS2O147703EBI-946029,EBI-2804934
NFKBIDQ8NI383EBI-946029,EBI-10271199
NGBQ9NPG23EBI-946029,EBI-10311409
OAZ3Q9UMX23EBI-946029,EBI-10281601
OIP5O434823EBI-946029,EBI-536879
PLEKHB2Q96CS73EBI-946029,EBI-373552
PRKAG1P546193EBI-946029,EBI-1181439
PRR20CP864793EBI-946029,EBI-10172814
R3HDM2Q9Y2K5-23EBI-946029,EBI-10326419
RAD51DO757713EBI-946029,EBI-1055693
RBFOX1Q9NWB13EBI-946029,EBI-945906
RBFOX2O432513EBI-946029,EBI-746056
RBM47B7ZLP73EBI-946029,EBI-10176148
RBPMSQ930624EBI-946029,EBI-740322
ROR2A1L4F53EBI-946029,EBI-10172778
SMAP2Q8WU793EBI-946029,EBI-2822515
TBX6O959473EBI-946029,EBI-2824328
TNPO2O147873EBI-946029,EBI-431907
TXNDC9O145303EBI-946029,EBI-707554
VENTXO952313EBI-946029,EBI-10191303
VPS37CA5D8V63EBI-946029,EBI-2559305
YES1P079473EBI-946029,EBI-515331

Protein-protein interaction databases

BioGridi124400. 72 interactions.
IntActiQ6P1W5. 62 interactions.
MINTiMINT-2855222.
STRINGi9606.ENSP00000435634.

Structurei

3D structure databases

ProteinModelPortaliQ6P1W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi467 – 4704Poly-Pro

Phylogenomic databases

eggNOGiENOG410IKBB. Eukaryota.
ENOG410YE9F. LUCA.
GeneTreeiENSGT00390000017672.
HOGENOMiHOG000049257.
HOVERGENiHBG080475.
InParanoidiQ6P1W5.
OMAiRMPYQQA.
OrthoDBiEOG7060R1.
PhylomeDBiQ6P1W5.
TreeFamiTF338566.

Family and domain databases

InterProiIPR031496. DUF4688.
[Graphical view]
PfamiPF15752. DUF4688. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P1W5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGGGGCVLA LGGQRGFQKE RRRMASGNGL PSSSALVAKG PCALGPFPRY
60 70 80 90 100
IWIHQDTPQD SLDKTCHEIW KRVQGLPEAS QPWTSMEQLS VPVVGTLRGN
110 120 130 140 150
ELSFQEEALE LSSGKDEISL LVEQEFLSLT KEHSILVEES SGELEVPGSS
160 170 180 190 200
PEGTRELAPC ILAPPLVAGS NERPRASIIV GDKLLKQKVA MPVISSRQDC
210 220 230 240 250
DSATSTVTDI LCAAEVKSSK GTEDRGRILG DSNLQVSKLL SQFPLKSTET
260 270 280 290 300
SKVPDNKNVL DKTRVTKDFL QDNLFSGPGP KEPTGLSPFL LLPPRPPPAR
310 320 330 340 350
PDKLPELPAQ KRQLPVFAKI CSKPKADPAV ERHHLMEWSP GTKEPKKGQG
360 370 380 390 400
SLFLSQWPQS QKDACGEEGC CDAVGTASLT LPPKKPTCPA EKNLLYEFLG
410 420 430 440 450
ATKNPSGQPR LRNKVEVDGP ELKFNAPVTV ADKNNPKYTG NVFTPHFPTA
460 470 480 490 500
MTSATLNQPL WLNLNYPPPP VFTNHSTFLQ YQGLYPQQAA RMPYQQALHP
510 520 530 540 550
QLGCYSQQVM PYNPQQMGQQ IFRSSYTPLL SYIPFVQPNY PYPQRTPPKM
560 570 580 590
SANPRDPPLM AGDGPQYLFP QGYGFGSTSG GPLMHSPYFS SSGNGINF
Length:598
Mass (Da):65,353
Last modified:November 16, 2011 - v2
Checksum:iAAD349072B925A8E
GO
Isoform 2 (identifier: Q6P1W5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-190: Missing.

Show »
Length:408
Mass (Da):44,902
Checksum:i5B1E356339E5941C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351Q → E.1 Publication
Corresponds to variant rs1382602 [ dbSNP | Ensembl ].
VAR_031051
Natural varianti302 – 3021D → E.1 Publication
Corresponds to variant rs1414474 [ dbSNP | Ensembl ].
VAR_031052
Natural varianti438 – 4381Y → H.
Corresponds to variant rs17556981 [ dbSNP | Ensembl ].
VAR_050702

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 190190Missing in isoform 2. 2 PublicationsVSP_042032Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123355 mRNA. Translation: BAG53893.1.
AC115286 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07445.1.
CH471059 Genomic DNA. Translation: EAX07446.1.
BC007637 mRNA. Translation: AAH07637.1.
BC064845 mRNA. Translation: AAH64845.1.
CCDSiCCDS381.1. [Q6P1W5-2]
CCDS44108.1. [Q6P1W5-1]
RefSeqiNP_001128206.1. NM_001134734.1. [Q6P1W5-1]
NP_116273.2. NM_032884.4. [Q6P1W5-2]
UniGeneiHs.194610.

Genome annotation databases

EnsembliENST00000373374; ENSP00000362472; ENSG00000142698. [Q6P1W5-2]
ENST00000488417; ENSP00000435634; ENSG00000142698. [Q6P1W5-1]
GeneIDi84970.
KEGGihsa:84970.
UCSCiuc001bxs.6. human. [Q6P1W5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123355 mRNA. Translation: BAG53893.1.
AC115286 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07445.1.
CH471059 Genomic DNA. Translation: EAX07446.1.
BC007637 mRNA. Translation: AAH07637.1.
BC064845 mRNA. Translation: AAH64845.1.
CCDSiCCDS381.1. [Q6P1W5-2]
CCDS44108.1. [Q6P1W5-1]
RefSeqiNP_001128206.1. NM_001134734.1. [Q6P1W5-1]
NP_116273.2. NM_032884.4. [Q6P1W5-2]
UniGeneiHs.194610.

3D structure databases

ProteinModelPortaliQ6P1W5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124400. 72 interactions.
IntActiQ6P1W5. 62 interactions.
MINTiMINT-2855222.
STRINGi9606.ENSP00000435634.

Polymorphism and mutation databases

BioMutaiC1orf94.
DMDMi357528782.

Proteomic databases

PaxDbiQ6P1W5.
PRIDEiQ6P1W5.

Protocols and materials databases

DNASUi84970.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373374; ENSP00000362472; ENSG00000142698. [Q6P1W5-2]
ENST00000488417; ENSP00000435634; ENSG00000142698. [Q6P1W5-1]
GeneIDi84970.
KEGGihsa:84970.
UCSCiuc001bxs.6. human. [Q6P1W5-1]

Organism-specific databases

CTDi84970.
GeneCardsiC1orf94.
HGNCiHGNC:28250. C1orf94.
HPAiHPA045805.
neXtProtiNX_Q6P1W5.
PharmGKBiPA142672478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKBB. Eukaryota.
ENOG410YE9F. LUCA.
GeneTreeiENSGT00390000017672.
HOGENOMiHOG000049257.
HOVERGENiHBG080475.
InParanoidiQ6P1W5.
OMAiRMPYQQA.
OrthoDBiEOG7060R1.
PhylomeDBiQ6P1W5.
TreeFamiTF338566.

Miscellaneous databases

GenomeRNAii84970.
NextBioi75514.
PROiQ6P1W5.

Gene expression databases

BgeeiQ6P1W5.
CleanExiHS_C1orf94.
GenevisibleiQ6P1W5. HS.

Family and domain databases

InterProiIPR031496. DUF4688.
[Graphical view]
PfamiPF15752. DUF4688. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Caudate nucleus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-235 AND GLU-302.
    Tissue: Muscle and Testis.

Entry informationi

Entry nameiCA094_HUMAN
AccessioniPrimary (citable) accession number: Q6P1W5
Secondary accession number(s): B3KVT1
, D3DPR3, E9PJ76, Q96IC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 16, 2011
Last modified: May 11, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.