Q6P1W5 (CA094_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C1orf94

Gene names

Name:

C1orf94

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	598 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	3	EBI-946029,EBI-930964

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P1W5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P1W5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-190: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 598	598	Uncharacterized protein C1orf94		PRO_0000280097
Regions
	Compositional bias	467 – 470	4	Poly-Pro
Natural variations
	Alternative sequence	1 – 190	190	Missing in isoform 2.		VSP_042032
	Natural variant	235	1	Q → E. Ref.4 Corresponds to variant rs1382602 [ dbSNP | Ensembl ].		VAR_031051
	Natural variant	302	1	D → E. Ref.4 Corresponds to variant rs1414474 [ dbSNP | Ensembl ].		VAR_031052
	Natural variant	438	1	Y → H. Corresponds to variant rs17556981 [ dbSNP | Ensembl ].		VAR_050702

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 16, 2011. Version 2. Checksum: AAD349072B925A8E	FASTA	598	65,353
	10 20 30 40 50 60 MRGGGGCVLA LGGQRGFQKE RRRMASGNGL PSSSALVAKG PCALGPFPRY IWIHQDTPQD 70 80 90 100 110 120 SLDKTCHEIW KRVQGLPEAS QPWTSMEQLS VPVVGTLRGN ELSFQEEALE LSSGKDEISL 130 140 150 160 170 180 LVEQEFLSLT KEHSILVEES SGELEVPGSS PEGTRELAPC ILAPPLVAGS NERPRASIIV 190 200 210 220 230 240 GDKLLKQKVA MPVISSRQDC DSATSTVTDI LCAAEVKSSK GTEDRGRILG DSNLQVSKLL 250 260 270 280 290 300 SQFPLKSTET SKVPDNKNVL DKTRVTKDFL QDNLFSGPGP KEPTGLSPFL LLPPRPPPAR 310 320 330 340 350 360 PDKLPELPAQ KRQLPVFAKI CSKPKADPAV ERHHLMEWSP GTKEPKKGQG SLFLSQWPQS 370 380 390 400 410 420 QKDACGEEGC CDAVGTASLT LPPKKPTCPA EKNLLYEFLG ATKNPSGQPR LRNKVEVDGP 430 440 450 460 470 480 ELKFNAPVTV ADKNNPKYTG NVFTPHFPTA MTSATLNQPL WLNLNYPPPP VFTNHSTFLQ 490 500 510 520 530 540 YQGLYPQQAA RMPYQQALHP QLGCYSQQVM PYNPQQMGQQ IFRSSYTPLL SYIPFVQPNY 550 560 570 580 590 PYPQRTPPKM SANPRDPPLM AGDGPQYLFP QGYGFGSTSG GPLMHSPYFS SSGNGINF
	Isoform 2 [UniParc]. Checksum: 5B1E356339E5941C	FASTA	408	44,902
	10 20 30 40 50 60 MPVISSRQDC DSATSTVTDI LCAAEVKSSK GTEDRGRILG DSNLQVSKLL SQFPLKSTET 70 80 90 100 110 120 SKVPDNKNVL DKTRVTKDFL QDNLFSGPGP KEPTGLSPFL LLPPRPPPAR PDKLPELPAQ 130 140 150 160 170 180 KRQLPVFAKI CSKPKADPAV ERHHLMEWSP GTKEPKKGQG SLFLSQWPQS QKDACGEEGC 190 200 210 220 230 240 CDAVGTASLT LPPKKPTCPA EKNLLYEFLG ATKNPSGQPR LRNKVEVDGP ELKFNAPVTV 250 260 270 280 290 300 ADKNNPKYTG NVFTPHFPTA MTSATLNQPL WLNLNYPPPP VFTNHSTFLQ YQGLYPQQAA 310 320 330 340 350 360 RMPYQQALHP QLGCYSQQVM PYNPQQMGQQ IFRSSYTPLL SYIPFVQPNY PYPQRTPPKM 370 380 390 400 SANPRDPPLM AGDGPQYLFP QGYGFGSTSG GPLMHSPYFS SSGNGINF

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Caudate nucleus.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-235 AND GLU-302. Tissue: Muscle and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK123355 mRNA. Translation: BAG53893.1. AC115286 Genomic DNA. No translation available. CH471059 Genomic DNA. Translation: EAX07445.1. CH471059 Genomic DNA. Translation: EAX07446.1. BC007637 mRNA. Translation: AAH07637.1. BC064845 mRNA. Translation: AAH64845.1.
IPI	IPI00645901.
RefSeq	NP_001128206.1. NM_001134734.1. NP_116273.2. NM_032884.3.
UniGene	Hs.194610.
3D structure databases
ProteinModelPortal	Q6P1W5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6P1W5. 8 interactions.
MINT	MINT-2855222.
STRING	Q6P1W5.
Polymorphism databases
DMDM	74758237.
Proteomic databases
PRIDE	Q6P1W5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373374; ENSP00000362472; ENSG00000142698. ENST00000398041; ENSP00000381121; ENSG00000251514.
GeneID	84970.
KEGG	hsa:84970.
UCSC	uc001bxs.2. human.
Organism-specific databases
CTD	84970.
GeneCards	GC01P034632.
HGNC	HGNC:28250. C1orf94.
HPA	HPA045805.
neXtProt	NX_Q6P1W5.
PharmGKB	PA142672478.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12523.
GeneTree	ENSGT00390000017672.
HOGENOM	HBG506161.
HOVERGEN	HBG080475.
InParanoid	Q6P1W5.
OrthoDB	EOG4JT054.
PhylomeDB	Q6P1W5.
Gene expression databases
ArrayExpress	Q6P1W5.
Bgee	Q6P1W5.
CleanEx	HS_C1orf94.
Genevestigator	Q6P1W5.
Family and domain databases
ProtoNet	Search...
Other
NextBio	75514.

Entry information

Entry name

CA094_HUMAN

Accession

Primary (citable) accession number: Q6P1W5
Secondary accession number(s): B3KVT1 , D3DPR3, E9PJ76, Q96IC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	November 16, 2011
Last modified:	January 25, 2012
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.