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Q6P1S4 (SYRC_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase, cytoplasmic

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:rars
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length660 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis By similarity. HAMAP-Rule MF_00123

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Domain

The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly By similarity. HAMAP-Rule MF_00123

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 660660Arginine--tRNA ligase, cytoplasmic HAMAP-Rule MF_00123
PRO_0000250730

Regions

Region1 – 7272Could be involved in the assembly of the multisynthetase complex By similarity
Motif201 – 21212"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q6P1S4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 062F300B7910F0B2

FASTA66075,258
        10         20         30         40         50         60 
MELPVCFYEE RLRQQETEIK SLAAEIERLK NCGFVSETPS LEGLREENAK LKYRLNILRK 

        70         80         90        100        110        120 
SLLEEKKKSS KSMININAQI QEIFGTAIGA AYPELQNAPL AVTPSQQPKF GDYQCNSAMA 

       130        140        150        160        170        180 
ITQMLKAMNQ KVSPREIADK IVKNIPTNEL VEKVDIAGPG FINVHLHKDF TSKQISKLLV 

       190        200        210        220        230        240 
NGVQPPVIWE RKKVVVDFSS PNIAKEMHVG HLRSTVIGDS ICRLFEFVGH DVLRLNHLGD 

       250        260        270        280        290        300 
WGTQFGMLIA HLQDKFPDYL TVSPPIGDLQ SFYKESKKRF DEDEEFKKRA YQCVVQLQNK 

       310        320        330        340        350        360 
TPNFIQAWNL ICDVSRKEFQ KIYDCLDISI IDRGESFYQD RMIGVVKEFE EKGLVQVDEG 

       370        380        390        400        410        420 
RKVVFPPGCS VPLTIVKSDG GFTYDTSDLA ALKQRLQEEK ADMIIYVIDS GQAIHMQNVF 

       430        440        450        460        470        480 
SAGRMIGWYD PKVTRIEHAG FGVVLGEDKK KFKTRSGDTV RLIDLLDEGL KRSMEKLKDK 

       490        500        510        520        530        540 
GRDKVLTAEE LLAAQTSVAF GCIKYADLSH NRMNDYIFSF DKMLDDRGNT AAYLLYAYTR 

       550        560        570        580        590        600 
IRSIARLANI SDEDLHKAAK ETEIILEHEK EWKLSKCILR FPEILQKILD DLLLHTLCDY 

       610        620        630        640        650        660 
LYELATTFTE FYDNCYCVEK DRQTGQIVKV NMSRLLLCDA TAAVMAKGFD ILGIKPVQKM 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC064888 mRNA. Translation: AAH64888.1.
RefSeqNP_989403.1. NM_204072.1.
UniGeneStr.23758.

3D structure databases

ProteinModelPortalQ6P1S4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000054391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000054391; ENSXETP00000054391; ENSXETG00000025551.
GeneID395040.
KEGGxtr:395040.

Organism-specific databases

CTD5917.
XenbaseXB-GENE-955966. rars.

Phylogenomic databases

eggNOGCOG0018.
GeneTreeENSGT00530000063407.
HOGENOMHOG000247212.
HOVERGENHBG029238.
InParanoidQ6P1S4.
KOK01887.
OMAKPFGIGH.
OrthoDBEOG764725.
TreeFamTF106111.

Gene expression databases

BgeeQ6P1S4.

Family and domain databases

Gene3D3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase_Ia.
IPR015945. Arg-tRNA-synth_Ia_core.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYRC_XENTR
AccessionPrimary (citable) accession number: Q6P1S4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries