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Protein

Arginine--tRNA ligase, cytoplasmic

Gene

rars

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.By similarity

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei211L-arginineBy similarity1
Binding sitei384L-arginineBy similarity1
Binding sitei388L-arginineBy similarity1
Binding sitei412L-arginineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19By similarity)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:rars
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-955966 rars

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002507301 – 660Arginine--tRNA ligase, cytoplasmicAdd BLAST660

Proteomic databases

PaxDbiQ6P1S4
PRIDEiQ6P1S4

Expressioni

Gene expression databases

BgeeiENSXETG00000025551
ExpressionAtlasiQ6P1S4 baseline

Interactioni

Subunit structurei

Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000054391

Structurei

3D structure databases

ProteinModelPortaliQ6P1S4
SMRiQ6P1S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 72Could be involved in the assembly of the multisynthetase complexBy similarityAdd BLAST72
Regioni200 – 202L-arginine bindingBy similarity3
Regioni529 – 543Interaction with tRNABy similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi201 – 212"HIGH" regionAdd BLAST12

Domaini

The alpha-helical N-terminus (residues 1-72) mediates interaction with AIMP1 and thereby contributes to the assembly of the multisynthetase complex.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1195 Eukaryota
COG0018 LUCA
GeneTreeiENSGT00530000063407
HOGENOMiHOG000247212
HOVERGENiHBG029238
InParanoidiQ6P1S4
KOiK01887
OMAiKSAHIGH
TreeFamiTF106111

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.701 hit
3.40.50.6201 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P1S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPVCFYEE RLRQQETEIK SLAAEIERLK NCGFVSETPS LEGLREENAK
60 70 80 90 100
LKYRLNILRK SLLEEKKKSS KSMININAQI QEIFGTAIGA AYPELQNAPL
110 120 130 140 150
AVTPSQQPKF GDYQCNSAMA ITQMLKAMNQ KVSPREIADK IVKNIPTNEL
160 170 180 190 200
VEKVDIAGPG FINVHLHKDF TSKQISKLLV NGVQPPVIWE RKKVVVDFSS
210 220 230 240 250
PNIAKEMHVG HLRSTVIGDS ICRLFEFVGH DVLRLNHLGD WGTQFGMLIA
260 270 280 290 300
HLQDKFPDYL TVSPPIGDLQ SFYKESKKRF DEDEEFKKRA YQCVVQLQNK
310 320 330 340 350
TPNFIQAWNL ICDVSRKEFQ KIYDCLDISI IDRGESFYQD RMIGVVKEFE
360 370 380 390 400
EKGLVQVDEG RKVVFPPGCS VPLTIVKSDG GFTYDTSDLA ALKQRLQEEK
410 420 430 440 450
ADMIIYVIDS GQAIHMQNVF SAGRMIGWYD PKVTRIEHAG FGVVLGEDKK
460 470 480 490 500
KFKTRSGDTV RLIDLLDEGL KRSMEKLKDK GRDKVLTAEE LLAAQTSVAF
510 520 530 540 550
GCIKYADLSH NRMNDYIFSF DKMLDDRGNT AAYLLYAYTR IRSIARLANI
560 570 580 590 600
SDEDLHKAAK ETEIILEHEK EWKLSKCILR FPEILQKILD DLLLHTLCDY
610 620 630 640 650
LYELATTFTE FYDNCYCVEK DRQTGQIVKV NMSRLLLCDA TAAVMAKGFD
660
ILGIKPVQKM
Length:660
Mass (Da):75,258
Last modified:July 5, 2004 - v1
Checksum:i062F300B7910F0B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064888 mRNA Translation: AAH64888.1
RefSeqiNP_989403.1, NM_204072.1
UniGeneiStr.23758

Genome annotation databases

EnsembliENSXETT00000054391; ENSXETP00000054391; ENSXETG00000025551
GeneIDi395040
KEGGixtr:395040

Similar proteinsi

Entry informationi

Entry nameiSYRC_XENTR
AccessioniPrimary (citable) accession number: Q6P1S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome