Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6P1S4

- SYRC_XENTR

UniProt

Q6P1S4 - SYRC_XENTR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Arginine--tRNA ligase, cytoplasmic

Gene

rars

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.By similarity

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:rars
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-955966. rars.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Arginine--tRNA ligase, cytoplasmicPRO_0000250730Add
BLAST

Expressioni

Gene expression databases

BgeeiQ6P1S4.
ExpressionAtlasiQ6P1S4. baseline.

Interactioni

Subunit structurei

Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000054391.

Structurei

3D structure databases

ProteinModelPortaliQ6P1S4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7272Could be involved in the assembly of the multisynthetase complexBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi201 – 21212"HIGH" regionAdd
BLAST

Domaini

The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247212.
HOVERGENiHBG029238.
InParanoidiQ6P1S4.
KOiK01887.
OMAiPHIIFEN.
OrthoDBiEOG764725.
TreeFamiTF106111.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P1S4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELPVCFYEE RLRQQETEIK SLAAEIERLK NCGFVSETPS LEGLREENAK
60 70 80 90 100
LKYRLNILRK SLLEEKKKSS KSMININAQI QEIFGTAIGA AYPELQNAPL
110 120 130 140 150
AVTPSQQPKF GDYQCNSAMA ITQMLKAMNQ KVSPREIADK IVKNIPTNEL
160 170 180 190 200
VEKVDIAGPG FINVHLHKDF TSKQISKLLV NGVQPPVIWE RKKVVVDFSS
210 220 230 240 250
PNIAKEMHVG HLRSTVIGDS ICRLFEFVGH DVLRLNHLGD WGTQFGMLIA
260 270 280 290 300
HLQDKFPDYL TVSPPIGDLQ SFYKESKKRF DEDEEFKKRA YQCVVQLQNK
310 320 330 340 350
TPNFIQAWNL ICDVSRKEFQ KIYDCLDISI IDRGESFYQD RMIGVVKEFE
360 370 380 390 400
EKGLVQVDEG RKVVFPPGCS VPLTIVKSDG GFTYDTSDLA ALKQRLQEEK
410 420 430 440 450
ADMIIYVIDS GQAIHMQNVF SAGRMIGWYD PKVTRIEHAG FGVVLGEDKK
460 470 480 490 500
KFKTRSGDTV RLIDLLDEGL KRSMEKLKDK GRDKVLTAEE LLAAQTSVAF
510 520 530 540 550
GCIKYADLSH NRMNDYIFSF DKMLDDRGNT AAYLLYAYTR IRSIARLANI
560 570 580 590 600
SDEDLHKAAK ETEIILEHEK EWKLSKCILR FPEILQKILD DLLLHTLCDY
610 620 630 640 650
LYELATTFTE FYDNCYCVEK DRQTGQIVKV NMSRLLLCDA TAAVMAKGFD
660
ILGIKPVQKM
Length:660
Mass (Da):75,258
Last modified:July 5, 2004 - v1
Checksum:i062F300B7910F0B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC064888 mRNA. Translation: AAH64888.1.
RefSeqiNP_989403.1. NM_204072.1.
UniGeneiStr.23758.

Genome annotation databases

EnsembliENSXETT00000054391; ENSXETP00000054391; ENSXETG00000025551.
GeneIDi395040.
KEGGixtr:395040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC064888 mRNA. Translation: AAH64888.1 .
RefSeqi NP_989403.1. NM_204072.1.
UniGenei Str.23758.

3D structure databases

ProteinModelPortali Q6P1S4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000054391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000054391 ; ENSXETP00000054391 ; ENSXETG00000025551 .
GeneIDi 395040.
KEGGi xtr:395040.

Organism-specific databases

CTDi 5917.
Xenbasei XB-GENE-955966. rars.

Phylogenomic databases

eggNOGi COG0018.
GeneTreei ENSGT00530000063407.
HOGENOMi HOG000247212.
HOVERGENi HBG029238.
InParanoidi Q6P1S4.
KOi K01887.
OMAi PHIIFEN.
OrthoDBi EOG764725.
TreeFami TF106111.

Gene expression databases

Bgeei Q6P1S4.
ExpressionAtlasi Q6P1S4. baseline.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiSYRC_XENTR
AccessioniPrimary (citable) accession number: Q6P1S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3