Reviewed, UniProtKB/Swiss-Prot Q6P1S4 (SYRC_XENTR)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase, cytoplasmic
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:

rars

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	660 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).
Subunit structure	Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro By similarity.
Subcellular location	Cytoplasm By similarity.
Domain	The N-terminal (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 660	660	Arginyl-tRNA synthetase, cytoplasmic		PRO_0000250730
Regions
	Region	1 – 72	72	Could be involved in the assembly of the multisynthetase complex By similarity
	Motif	201 – 212	12	"HIGH" region

Sequences

	Sequence		Length	Mass (Da)
	Q6P1S4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 062F300B7910F0B2	FASTA	660	75,258
	10 20 30 40 50 60 MELPVCFYEE RLRQQETEIK SLAAEIERLK NCGFVSETPS LEGLREENAK LKYRLNILRK 70 80 90 100 110 120 SLLEEKKKSS KSMININAQI QEIFGTAIGA AYPELQNAPL AVTPSQQPKF GDYQCNSAMA 130 140 150 160 170 180 ITQMLKAMNQ KVSPREIADK IVKNIPTNEL VEKVDIAGPG FINVHLHKDF TSKQISKLLV 190 200 210 220 230 240 NGVQPPVIWE RKKVVVDFSS PNIAKEMHVG HLRSTVIGDS ICRLFEFVGH DVLRLNHLGD 250 260 270 280 290 300 WGTQFGMLIA HLQDKFPDYL TVSPPIGDLQ SFYKESKKRF DEDEEFKKRA YQCVVQLQNK 310 320 330 340 350 360 TPNFIQAWNL ICDVSRKEFQ KIYDCLDISI IDRGESFYQD RMIGVVKEFE EKGLVQVDEG 370 380 390 400 410 420 RKVVFPPGCS VPLTIVKSDG GFTYDTSDLA ALKQRLQEEK ADMIIYVIDS GQAIHMQNVF 430 440 450 460 470 480 SAGRMIGWYD PKVTRIEHAG FGVVLGEDKK KFKTRSGDTV RLIDLLDEGL KRSMEKLKDK 490 500 510 520 530 540 GRDKVLTAEE LLAAQTSVAF GCIKYADLSH NRMNDYIFSF DKMLDDRGNT AAYLLYAYTR 550 560 570 580 590 600 IRSIARLANI SDEDLHKAAK ETEIILEHEK EWKLSKCILR FPEILQKILD DLLLHTLCDY 610 620 630 640 650 660 LYELATTFTE FYDNCYCVEK DRQTGQIVKV NMSRLLLCDA TAAVMAKGFD ILGIKPVQKM

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC064888 mRNA. Translation: AAH64888.1.
RefSeq	NP_989403.1.
UniGene	Str.23758
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6P1S4.
Genome annotation databases
Ensembl	ENSXETT00000054391; ENSXETP00000054391; ENSXETG00000025551; Xenopus tropicalis. [Genome view]
GeneID	395040.
KEGG	xtr:395040.
Organism-specific databases
CTD	395040.
Xenbase	XB-FEAT-955965. rars.
Phylogenomic databases
HOVERGEN	Q6P1S4.
OMA	HMGFGTM.
Enzyme and pathway databases
BRENDA	6.1.1.19. 279072.
Gene expression databases
Bgee	Q6P1S4.
Family and domain databases
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYRC_XENTR

Accession

Primary (citable) accession number: Q6P1S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project