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Protein

tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

Gene

DUS1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.By similarity

Cofactori

FMNBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79FMNBy similarity1
Active sitei108Proton donorBy similarity1
Binding sitei147FMNBy similarity1
Binding sitei175FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 25FMNBy similarity3
Nucleotide bindingi208 – 210FMNBy similarity3
Nucleotide bindingi232 – 233FMNBy similarity2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Flavoprotein, FMN

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC:1.3.1.-)
Alternative name(s):
tRNA-dihydrouridine synthase 1-like
Gene namesi
Name:DUS1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30086. DUS1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169718.
PharmGKBiPA142671936.

Polymorphism and mutation databases

BioMutaiDUS1L.
DMDMi74749069.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472261 – 473tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-likeAdd BLAST473

Proteomic databases

EPDiQ6P1R4.
MaxQBiQ6P1R4.
PaxDbiQ6P1R4.
PeptideAtlasiQ6P1R4.
PRIDEiQ6P1R4.

PTM databases

iPTMnetiQ6P1R4.
PhosphoSitePlusiQ6P1R4.

Expressioni

Gene expression databases

BgeeiENSG00000169718.
CleanExiHS_DUS1L.
ExpressionAtlasiQ6P1R4. baseline and differential.
GenevisibleiQ6P1R4. HS.

Organism-specific databases

HPAiHPA023384.

Interactioni

Protein-protein interaction databases

BioGridi122073. 1 interactor.
IntActiQ6P1R4. 5 interactors.
STRINGi9606.ENSP00000303515.

Structurei

3D structure databases

ProteinModelPortaliQ6P1R4.
SMRiQ6P1R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family. Dus1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2335. Eukaryota.
COG0042. LUCA.
GeneTreeiENSGT00550000075089.
HOGENOMiHOG000203649.
HOVERGENiHBG061241.
InParanoidiQ6P1R4.
KOiK05542.
OMAiCYSPMYH.
OrthoDBiEOG091G05BU.
PhylomeDBiQ6P1R4.
TreeFamiTF313398.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P1R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLQGFEFW SRTLRGARHV VAPMVDQSEL AWRLLSRRHG AQLCYTPMLH
60 70 80 90 100
AQVFVRDANY RKENLYCEVC PEDRPLIVQF CANDPEVFVQ AALLAQDYCD
110 120 130 140 150
AIDLNLGCPQ MIAKRGHYGA FLQDEWDLLQ RMILLAHEKL SVPVTCKIRV
160 170 180 190 200
FPEIDKTVRY AQMLEKAGCQ LLTVHGRTKE QKGPLSGAAS WEHIKAVRKA
210 220 230 240 250
VAIPVFANGN IQCLQDVERC LRDTGVQGVM SAEGNLHNPA LFEGRSPAVW
260 270 280 290 300
ELAEEYLDIV REHPCPLSYV RAHLFKLWHH TLQVHQELRE ELAKVKTLEG
310 320 330 340 350
IAAVSQELKL RCQEEISRQE GAKPTGDLPF HWICQPYIRP GPREGSKEKA
360 370 380 390 400
GARSKRALEE EEGGTEVLSK NKQKKQLRNP HKTFDPSLKP KYAKCDQCGN
410 420 430 440 450
PKGNRCVFSL CRGCCKKRAS KETADCPGHG LLFKTKLEKS LAWKEAQPEL
460 470
QEPQPAAPGT PGGFSEVMGS ALA
Length:473
Mass (Da):53,230
Last modified:July 5, 2004 - v1
Checksum:i9765C2BD7B0C6157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135056 Genomic DNA. No translation available.
BC017081 mRNA. Translation: AAH17081.4.
BC062566 mRNA. Translation: AAH62566.1.
BC064918 mRNA. Translation: AAH64918.1.
CCDSiCCDS32775.1.
RefSeqiNP_071439.3. NM_022156.4.
UniGeneiHs.514599.
Hs.741994.

Genome annotation databases

EnsembliENST00000306796; ENSP00000303515; ENSG00000169718.
ENST00000354321; ENSP00000346280; ENSG00000169718.
GeneIDi64118.
KEGGihsa:64118.
UCSCiuc002kdq.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135056 Genomic DNA. No translation available.
BC017081 mRNA. Translation: AAH17081.4.
BC062566 mRNA. Translation: AAH62566.1.
BC064918 mRNA. Translation: AAH64918.1.
CCDSiCCDS32775.1.
RefSeqiNP_071439.3. NM_022156.4.
UniGeneiHs.514599.
Hs.741994.

3D structure databases

ProteinModelPortaliQ6P1R4.
SMRiQ6P1R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122073. 1 interactor.
IntActiQ6P1R4. 5 interactors.
STRINGi9606.ENSP00000303515.

PTM databases

iPTMnetiQ6P1R4.
PhosphoSitePlusiQ6P1R4.

Polymorphism and mutation databases

BioMutaiDUS1L.
DMDMi74749069.

Proteomic databases

EPDiQ6P1R4.
MaxQBiQ6P1R4.
PaxDbiQ6P1R4.
PeptideAtlasiQ6P1R4.
PRIDEiQ6P1R4.

Protocols and materials databases

DNASUi64118.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306796; ENSP00000303515; ENSG00000169718.
ENST00000354321; ENSP00000346280; ENSG00000169718.
GeneIDi64118.
KEGGihsa:64118.
UCSCiuc002kdq.5. human.

Organism-specific databases

CTDi64118.
GeneCardsiDUS1L.
H-InvDBHIX0039074.
HGNCiHGNC:30086. DUS1L.
HPAiHPA023384.
neXtProtiNX_Q6P1R4.
OpenTargetsiENSG00000169718.
PharmGKBiPA142671936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2335. Eukaryota.
COG0042. LUCA.
GeneTreeiENSGT00550000075089.
HOGENOMiHOG000203649.
HOVERGENiHBG061241.
InParanoidiQ6P1R4.
KOiK05542.
OMAiCYSPMYH.
OrthoDBiEOG091G05BU.
PhylomeDBiQ6P1R4.
TreeFamiTF313398.

Miscellaneous databases

ChiTaRSiDUS1L. human.
GenomeRNAii64118.
PROiQ6P1R4.

Gene expression databases

BgeeiENSG00000169718.
CleanExiHS_DUS1L.
ExpressionAtlasiQ6P1R4. baseline and differential.
GenevisibleiQ6P1R4. HS.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUS1L_HUMAN
AccessioniPrimary (citable) accession number: Q6P1R4
Secondary accession number(s): A6NHV4, Q96AI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.